Substrates for peptidase M10.007: matrix metallopeptidase-11

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
40S ribosomal protein S21	P63220	1-83	peptide-Glu7+Phe-peptide	N	Asp	Ala	Gly	Glu	Phe	Val	Asp	Leu	Kleifeld et al., 2010
actin, aortic smooth muscle	P62736	3-377	peptide-Leu106+Leu-peptide	N	His	Pro	Thr	Leu	Leu	Thr	Glu	Ala	Kleifeld et al., 2010
actin, aortic smooth muscle	P62736	3-377	peptide-Ser237+Leu-peptide	N	Ser	Ser	Ser	Ser	Leu	Glu	Lys	Ser	Kleifeld et al., 2010
actin, cytoplasmic 1	P60709	1-375	peptide-Asn296+Thr-peptide	N	Leu	Tyr	Ala	Asn	Thr	Val	Leu	Ser	Kleifeld et al., 2010
alpha-1-peptidase inhibitor	P01009	25-418	peptide-Ala350+Met-peptide	P	Ala	Ala	Gly	Ala	Met	Phe	Leu	Glu	Pei et al., 1994	16617
alpha-2-antiplasmin	P08697	40-491	peptide-Ala395+Ala-peptide	P	Glu	Ala	Ala	Ala	Ala	Thr	Ser	Ile	Pei et al., 1994	18209
alpha-2-antiplasmin	P08697	40-491	peptide-Thr397+Ser-peptide	P	Ala	Ala	Ala	Thr	Ser	Ile	Ala	Met	Pei et al., 1994	18210
clusterin	P10909	228-449	peptide-Ala266+Phe-peptide	N	His	Ser	Pro	Ala	Phe	Gln	His	Pro	Kleifeld et al., 2010
dansyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg-NH2			dansyl-Pro-Leu-Ala+Leu-Trp-Ala-Arg-NH2	S	Dns	Pro	Leu	Ala	Leu	Trp	Ala	Arg	Pei & Weiss, 2004
heat shock protein beta-1	P04792	1-205	peptide-Ala62+Ile-peptide	N	Pro	Pro	Ala	Ala	Ile	Glu	Ser	Pro	Kleifeld et al., 2010
heat shock protein HSP 90-alpha	P07900	2-732	peptide-Ala670+Leu-peptide	N	Tyr	Glu	Thr	Ala	Leu	Leu	Ser	Ser	Kleifeld et al., 2010
heat shock protein HSP 90-beta	P08238	2-724	peptide-Ala662+Leu-peptide	N	Phe	Glu	Thr	Ala	Leu	Leu	Ser	Ser	Kleifeld et al., 2010
insulin-like growth factor-binding protein 1	P08833	26-259	peptide-His140+Val-peptide	P	Lys	Ala	Leu	His	Val	Thr	Asn	Ile	Mañes et al., 1997	18523
latexin	Q9BS40	1-222	peptide-Asn19+Tyr-peptide	N	Val	Ala	Gln	Asn	Tyr	Ile	Asn	Tyr	Kleifeld et al., 2010
peptidyl-prolyl cis-trans isomerase A	P62937	2-165	peptide-Phe7+Phe-peptide	N	Pro	Thr	Val	Phe	Phe	Asp	Ile	Ala	Kleifeld et al., 2010
polypyrimidine tract-binding protein 1	P26599	1-531	peptide-His305+Gly-peptide	N	Pro	Asn	Val	His	Gly	Ala	Leu	Ala	Kleifeld et al., 2010
signal transducing adapter molecule 2	O75886	1-525	peptide-Ser417+Tyr-peptide	N	Val	Ala	Gln	Ser	Tyr	Ser	Leu	Gly	Kleifeld et al., 2010
stress-induced-phosphoprotein 1	P31948	1-543	peptide-Cys420+Ile-peptide	N	Cys	Glu	Glu	Cys	Ile	Gln	Leu	Glu	Kleifeld et al., 2010
stromelysin-3	P24347	98-488	peptide-Pro284+Leu-peptide	N	Glu	Ile	Ala	Pro	Leu	Glu	Pro	Asp	Kleifeld et al., 2010
stromelysin-3	P24347	98-488	peptide-Ala439+Phe-peptide	N	Ile	Asp	Ala	Ala	Phe	Gln	Asp	Ala	Kleifeld et al., 2010
UV excision repair protein RAD23 homolog A	P54725	1-363	peptide-Asn312+Tyr-peptide	N	Pro	Gln	Met	Asn	Tyr	Ile	Gln	Val	Kleifeld et al., 2010