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Peptidase

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Substrates for peptidase M04.005: pseudolysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Abz-Ala-Gly-Leu-Ala-Nba Abz-Ala-Gly+Leu-Ala-Nba S - Abz Ala Gly Leu Ala Nba - Kessler & Ohman, 2004
alpha-1-antichymotrypsin P01011 24-423 peptide-Ala362+Leu-peptide N Leu Leu Ser Ala Leu Val Glu Thr 16454
alpha-1-peptidase inhibitor P01009 25-418 peptide-Pro357+Met-peptide N Glu Ala Ile Pro Met Ser Ile Pro Morihara et al., 1984 19105
Antitrypsin P22922 17-392 Peptide-Ala351+Phe-Peptide P NT Ala Ala Asn Ala Phe Thr Met Thr Sasaki et al., 1990
Antitrypsin P22922 17-392 Peptide-Tyr361+Val-Peptide P NT Ser Lys Val Tyr Val Arg Pro Pro Sasaki et al., 1990
cathelicidin antimicrobial peptide P49913 132-170 peptide-Lys145+Ile-peptide N Ser Lys Glu Lys Ile Gly Lys Glu Schmidtchen et al.,2002
cathelicidin antimicrobial peptide P49913 132-170 peptide-Glu149+Phe-peptide N Ile Gly Lys Glu Phe Lys Arg Ile Schmidtchen et al.,2002
cathelicidin antimicrobial peptide P49913 132-170 peptide-Arg152+Ile-peptide N Glu Phe Lys Arg Ile Val Gln Arg Schmidtchen et al.,2002
cathelicidin antimicrobial peptide P49913 132-170 peptide-Arg156+Ile-peptide N Ile Val Gln Arg Ile Lys Asp Phe Schmidtchen et al.,2002
cathelicidin antimicrobial peptide P49913 132-170 peptide-Asp159+Phe-peptide N Arg Ile Lys Asp Phe Leu Arg Asn Schmidtchen et al.,2002
cathelicidin antimicrobial peptide P49913 132-170 peptide-Asn163+Leu-peptide N Phe Leu Arg Asn Leu Val Pro Arg Schmidtchen et al.,2002
Dabcyl-Ser-Phe-EDANS Dabcyl-Ser+Phe-EDANS S - - Dab Ser Phe Ens - - Weimer et al., 2006
elafin P19957 61-117 peptide-Met85+Leu-peptide N Arg Cys Ala Met Leu Asn Pro Pro Guyot et al., 2010
FA-Gly-Leu-NH2 FA-Gly+Leu-NH2 S - - FA Gly Leu NH2 - - Morihara, 1995
furylacryloyl-Gly-Leu-Ala-NH2 furylacryloyl-Gly+Leu-Ala-NH2 S - - FA Gly Leu Ala NH2 - Kessler & Ohman, 2004
furylacryloyl-Gly-Leu-NH2 furylacryloyl-Gly+Leu-NH2 S - - FA Gly Leu NH2 - - Kessler & Ohman, 2004
H-Phe-Gly-Gly-Leu-Ala H-Phe-Gly-Gly+Leu-Ala S - Phe Gly Gly Leu Ala - - Morihara & Tsuzuki, 1971
H-Phe-Gly-Leu-Ala H-Phe-Gly+Leu-Ala S - - Phe Gly Leu Ala - - Morihara & Tsuzuki, 1971
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His+Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Val Asn Gln His Leu Cya Gly Ser Dumont et al., 1994 24067
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Cya Gly Ser His Leu Val Glu Ala Dumont et al., 1994 24068
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val Dumont et al., 1994 24069
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Glu Ala Leu Tyr Leu Val Cya Gly Dumont et al., 1994 24070
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu+Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Ala Leu Tyr Leu Val Cya Gly Glu Dumont et al., 1994 24071
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly+Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Gly Glu Arg Gly Phe Phe Tyr Thr Dumont et al., 1994 24072
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala N Glu Arg Gly Phe Phe Tyr Thr Pro Dumont et al., 1994 24073
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe+Tyr-Thr-Pro-Lys-Ala N Arg Gly Phe Phe Tyr Thr Pro Lys Dumont et al., 1994 24074
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys+Ala N Tyr Thr Pro Lys Ala - - - Dumont et al., 1994 24075
matrix metallopeptidase-1 precursor P03956 20-469 peptide-Val101+Leu-peptide N Ala Gln Phe Val Leu Thr Glu Gly Okamoto et al., 1997 19812
matrix metallopeptidase-1 precursor P03956 peptide-Pro269+-peptide N Pro Val Gln Pro - - - - Okamoto et al., 1997
matrix metallopeptidase-9 P14780 peptide-Thr109+Phe-peptide N Arg Phe Gln Thr Phe Glu Gly Asp Okamoto et al., 1997 19816
probable aminopeptidase Q9HZQ8 25-536 peptide-Ser517+Leu-peptide P NT Gln Ser Arg Ser Leu Gln Met Gln Sarnovsky et al., 2009
proteinase-activated receptor 2 P55085 26-397 peptide-Ser37+Leu-peptide N Lys Gly Arg Ser Leu Ile Gly Lys Leduc et al., 2005 26228
proteinase-activated receptor 2 P55085 26-397 peptide-Gly52+Val-peptide N Thr Gly Lys Gly Val Thr Val Glu Leduc et al., 2005 26229
proteinase-activated receptor 2 Q63645 26-397 peptide-Ser37+Leu-peptide P Lys Gly Arg Ser Leu Ile Gly Arg Leduc et al., 2005 26230
pseudolysin P14756 24-498 peptide-His197+Ala-peptide P NT Gly Leu Ala His Ala Glu Ala Gly McIver et al., 1991
pulmonary surfactant-associated protein D P35248 20-374 peptide-Gly111+Ile-peptide P Gly Ser Pro Gly Ile Ser Gly Pro Alcorn & Wright, 2004 19755
pulmonary surfactant-associated protein D P35248 20-374 peptide-Ser258+Val-peptide P Asp Gly Gln Ser Val Gly Asp Lys Alcorn & Wright, 2004 19756
pulmonary surfactant-associated protein D P35248 20-374 peptide-Ala266+Ala-peptide P Ile Phe Arg Ala Ala Asn Ser Glu Alcorn & Wright, 2004 19757
pulmonary surfactant-associated protein D P35248 20-374 peptide-Lys322+Phe-peptide P Thr Glu Gly Lys Phe Thr Tyr Pro Alcorn & Wright, 2004 19758
pulmonary surfactant-associated protein D P35248 20-374 peptide-Asn335+Trp-peptide P Val Tyr Ser Asn Trp Ala Pro Gly Alcorn & Wright, 2004 19759
Suc-Ala-Ala-Ala-NHPhNO2 Suc-Ala+Ala-Ala-NHPhNO2 S - - Suc Ala Ala Ala NAN - Kessler & Ohman, 2004
Suc-Ala-Ala-Pro-Phe-NHPhNO2 Suc-Ala-Ala-Pro+Phe-NHPhNO2 S Suc Ala Ala Pro Phe NAN - - Kessler & Ohman, 2004
urokinase plasminogen activator surface receptor Q03405 23-305 peptide-Ala106+Val-peptide N Ser Gly Arg Ala Val Thr Tyr Ser Leduc et al., 2007 24111
urokinase plasminogen activator surface receptor Q03405 23-305 peptide-Thr108+Tyr-peptide N Arg Ala Val Thr Tyr Ser Arg Ser Leduc et al., 2007 24110
urokinase plasminogen activator surface receptor Q03405 23-305 peptide-Gln301+Tyr-peptide N Leu Asp Val Gln Tyr Arg Ser Gly Leduc et al., 2007 24112
urokinase-type plasminogen activator P00749 21-431 peptide-Lys178+Ile-peptide N Pro Arg Phe Lys Ile Ile Gly Gly Beaufort et al.,2010
Z-Ala-Ala-Phe-Ala-NH2 Z-Ala-Ala+Phe-Ala-NH2 S - Z Ala Ala Phe Ala NH2 - Kessler & Ohman, 2004
Z-Ala-Gly-Gly-Leu-Ala Z-Ala-Gly-Gly+Leu-Ala S Z Ala Gly Gly Leu Ala - - Morihara & Tsuzuki, 1971
Z-Ala-Gly-Leu-Ala Z-Ala-Gly+Leu-Ala S - Z Ala Gly Leu Ala - - Morihara & Tsuzuki, 1971
Z-Ala-Leu-Ala Z-Ala+Leu-Ala S - - Z Ala Leu Ala - - Morihara & Tsuzuki, 1971
Z-D-Ala-Gly-Gly-Leu-Ala Z-D-Ala-Gly-Gly+Leu-Ala S Z DAl Gly Gly Leu Ala - - Morihara & Tsuzuki, 1971
Z-D-Ala-Gly-Leu-Ala Z-D-Ala-Gly+Leu-Ala S - Z DAl Gly Leu Ala - - Morihara & Tsuzuki, 1971
Z-Gly-Gly-Leu-Ala Z-Gly-Gly+Leu-Ala S - Z Gly Gly Leu Ala - - Morihara & Tsuzuki, 1971
Z-Gly-Leu-Ala Z-Gly+Leu-Ala S - - Z Gly Leu Ala - - Morihara & Tsuzuki, 1971
Z-Gly-Leu-Gly Z-Gly+Leu-Gly S - - Z Gly Leu Gly - - Morihara & Tsuzuki, 1971
Z-Gly-Leu-Gly-Ala Z-Gly+Leu-Gly-Ala S - - Z Gly Leu Gly Ala - Morihara & Tsuzuki, 1971
Z-Gly-Leu-Gly-Gly Z-Gly+Leu-Gly-Gly S - - Z Gly Leu Gly Gly - Morihara & Tsuzuki, 1971
Z-Gly-Leu-Gly-Gly-Ala Z-Gly+Leu-Gly-Gly-Ala S - - Z Gly Leu Gly Gly Ala Morihara & Tsuzuki, 1971
Z-Gly-Leu-Gly-Gly-D-Ala Z-Gly+Leu-Gly-Gly-D-Ala S - - Z Gly Leu Gly Gly DAl Morihara & Tsuzuki, 1971
Z-Gly-Leu-Gly-Phe Z-Gly+Leu-Gly-Phe S - - Z Gly Leu Gly Phe - Morihara & Tsuzuki, 1971
Z-Gly-Leu-Leu Z-Gly+Leu-Leu S - - Z Gly Leu Leu - - Morihara & Tsuzuki, 1971
Z-Gly-Leu-Phe Z-Gly+Leu-Phe S - - Z Gly Leu Phe - - Morihara & Tsuzuki, 1971
Z-Gly-Phe-NH2 Z-Gly+Phe-NH2 S - - Z Gly Phe NH2 - - Morihara & Tsuzuki, 1971
Z-Phe-Gly-Gly-Leu-Ala Z-Phe-Gly-Gly+Leu-Ala S Z Phe Gly Gly Leu Ala - - Morihara & Tsuzuki, 1971
Z-Phe-Gly-Leu-Ala Z-Phe-Gly+Leu-Ala S - Z Phe Gly Leu Ala - - Morihara & Tsuzuki, 1971
Z-Phe-Ile-Ala Z-Phe+Ile-Ala S - - Z Phe Ile Ala - - Kessler & Ohman, 2004
Z-Phe-Leu-Ala Z-Phe+Leu-Ala S - - Z Phe Leu Ala - - Kessler & Ohman, 2004
Z-Phe-Phe-Ala Z-Phe+Phe-Ala S - - Z Phe Phe Ala - - Kessler & Ohman, 2004
Z-Phe-Tyr-Ala Z-Phe+Tyr-Ala S - - Z Phe Tyr Ala - - Kessler & Ohman, 2004
Z-Phe-Val-Ala Z-Phe+Val-Ala S - - Z Phe Val Ala - - Kessler & Ohman, 2004

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