Substrates for peptidase M10.029: matrix metallopeptidase-26

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
alpha-1-peptidase inhibitor	P01009	25-418	peptide-Phe376+Leu-peptide	P	Gly	Ala	Met	Phe	Leu	Glu	Ala	Ile	Park et al., 2002	16659
alpha-1-peptidase inhibitor	P01009	25-418	peptide-Pro381+Met-peptide	P	Glu	Ala	Ile	Pro	Met	Ser	Ile	Pro	Park et al., 2002	16660
fibrinogen alpha chain	P02671	36-866	peptide-Lys397+Leu-peptide	P	His	Thr	Glu	Lys	Leu	Val	Thr	Ser	Park et al., 2002	16662
fibrinogen alpha chain	P02671	36-866	peptide-Glu4061+Leu-peptide	P	Gly	Asp	Lys	Glu	Leu	Arg	Thr	Gly	Park et al., 2002	20890
fibrinogen gamma chain	P02679	27-453	peptide-Asn103+Met-peptide	P	Ser	Lys	Pro	Asn	Met	Ile	Asp	Ala	Park et al., 2002	16663
fibronectin	Q8IVI8	32-2386	peptide-Ala13+Val-peptide	P	Ser	Pro	Val	Ala	Val	Ser	Gln	Ser	Park et al., 2002	16664
insulin-like growth factor-binding protein 1	P08833	26-259	peptide-His165+Val-peptide	P	Lys	Ala	Leu	His	Val	Thr	Asn	Ile	Park et al., 2002	4039
matrix metallopeptidase-9	P14780	20-707	peptide-Ala93+Met-peptide	P	Thr	Leu	Lys	Ala	Met	Arg	Thr	Pro	Zhao et al., 2003	4042
matrix metalloproteinase-26 precursor	Q9NRE1	18-261	peptide-Leu31+Thr-peptide	P	Ser	Pro	Leu	Leu	Thr	Gln	Glu	Thr	Lee et al., 2006	16666
matrix metalloproteinase-26 precursor	Q9NRE1	18-261	peptide-Ala58+Leu-peptide	P	Gln	Met	His	Ala	Leu	Leu	His	Gln	Lee et al., 2006	16665
matrix metalloproteinase-26 precursor	Q9NRE1	18-261	peptide-Gln59+Gln-peptide	P	Gln	Leu	Leu	Gln	Gln	Phe	His	Arg	Park et al., 2002	19827
Mca-Pro-Leu-Ala-Tyr-Trp-Ala-Arg-OH			Mca-Pro-Leu-Ala+Tyr-Trp-Ala-Arg-OH	S	Mca	Pro	Leu	Ala	Tyr	Trp	Ala	Arg	Park et al., 2002
Mca-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-OH			Mca-Pro-Leu-Gly+Leu-Trp-Ala-D-Arg-OH	S	Mca	Pro	Leu	Gly	Leu	Trp	Ala	DAr	Park et al., 2002
QF-24			Mca-Pro-Leu-Gly+Leu-Dpa-Ala-Arg-NH2	S	Mca	Pro	Leu	Gly	Leu	Dpa	Ala	Arg	Park et al., 2002
QF-35			Mca-Pro-Leu-Ala+norvaline-Dpa-Ala-Arg-NH2	S	Mca	Pro	Leu	Ala	Nva	Dpa	Ala	Arg	Park et al., 2002
QF-41			Mca-Pro-Cha-Gly+norvaline-His-Ala-Dpa-NH2	S	Mca	Pro	Cha	Gly	Nva	His	Ala	Dpa	Park et al., 2002
vitronectin	P04004	20-478	peptide-Gly115+Ile-peptide	P	Lys	Pro	Glu	Gly	Ile	Asp	Ser	Arg	Park et al., 2002	16667