Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity

Cryo-EM structure of Candida glabrata GPI mannosyltransferase I bound to Dol-P-Man

PSI from Chromera velia

Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain

Human chondroitin sulfate polymerase complex CHSY3-CHPF

EloB/EloC/VHL/CV2a/14-3-3zeta/ERa pose 2.1

Local refinement of EloB/EloC/VHL/CV2a/14-3-3zeta/ERa from pose 1

Nonameric Ena1C ring of Bacillus cereus

Cryo EM structure of RC-dLH complex model II from Gemmatimonas groenlandica

EloB/EloC/VHL/CV2a/14-3-3zeta/ERa pose 1

double helical p62/SQSTM1 filament

Consensus map of CHSY3-CHPF complex

The Cullin 2 RING VHL E3 ligase dimerised by the homoPROTAC CM11

EloB/EloC/VHL/CV2a/14-3-3zeta/ERa pose 2.2

EloB/EloC/VHL/CV2a/14-3-3zeta/ERa pose 3

Focused refinement map of CHSY3-CHPF complex: N-terminal part

Focused refinement map of CHSY3-CHPF complex: C-terminal part

Structure of the HCV IRES-dependent 48S translation initiation complex with eIF5B and eIF3

Cryo-EM structure of the HCV IRES-dependently initiated CMV-stalled 80S ribosome (non-rotated state) in complexed with eIF3

Cryo-EM structure of the HCV IRES-dependently initiated CMV-stalled 80S ribosome (rotated state) in complexed with eIF3

The Cullin 2 RING VHL E3 ligase dimerized by the homoPROTAC CM11, C1 symmetry

Cryo-EM structure of E373A mutant RIG-I with 5'p-RNA

Structure of Dynein-Dynactin-NuMA-LIS1

Structure of the HCV IRES-dependent pre-48S translation initiation complex with eIF1A, eIF5B, and eIF3

Structure of the human 40S ribosome complexed with HCV IRES and eIF3

Structure of the human 40S ribosome complexed with HCV IRES, eIF1A and eIF3

Cryo-EM structure of wild type RIG-I with 5'p-RNA

Munc13-4-Rab27a complex consensus map

Avian reovirus nonstructural protein sigmaNS

Dynactin pointed end in complex with NuMA

Structure of shaker-IR-I384R

Thermothelomyces thermophilus SAM complex open conformation

RAD51 filament in complex with magnesium and ATP

RAD51 filament in complex with magnesium and ADP

RAD51 filament in complex with calcium and ATP bound by the RAD51AP1 C-terminus

AB Spike of RHDV mutant N15

RAD51 filament in complex with magnesium and ATP bound by the RAD51AP1 C-terminus

Cryo-EM Structure of Pig Ryanodine Receptor 1 R615C Mutant: Atorvastatin Bound Open Conformation Composite Map

Thermothelomyces thermophilus SAM complex closed conformation

The Kaggle CryoET Object Identification Challenge: first place 80S ribosome

Cryo-EM Structure of Rabbit Ryanodine Receptor 1: Atorvastatin Bound Closed Conformation Composite Map

Cryo-EM Structure of Rabbit Ryanodine Receptor 1: DMSO Control Composite Map

Human OCTN2 bound to ipratropium in an inward-facing conformation

The Kaggle CryoET Object Identification Challenge: ground truth 80S ribosome

Human IMPDH2 mutant - S160del, treated with GTP, ATP, IMP, and NAD+; interfacial octamer reconstruction

Human OCTN2 bound to carnitine in the occluded conformation

Human IMPDH2 mutant - S160del, treated with GTP, ATP, IMP, and NAD+; tetramer reconstruction

Thermothelomyces thermophilus SAM complex bound to darobactin A

The Kaggle CryoET Object Identification Challenge: ground truth beta-galactosidase

The Kaggle CryoET Object Identification Challenge: first place beta-galactosidase

The Kaggle CryoET Object Identification Challenge: first place apo-ferritin

The Kaggle CryoET Object Identification Challenge: ground truth virus-like-particle

The Kaggle CryoET Object Identification Challenge: ground truth apo-ferritin

The Kaggle CryoET Object Identification Challenge: first place virus-like-particle

The Kaggle CryoET Object Identification Challenge: ground truth beta-amylase

The Kaggle CryoET Object Identification Challenge: ground truth thyroglobulin

The Kaggle CryoET Object Identification Challenge: first place thyroglobulin

The Kaggle CryoET Object Identification Challenge: first place beta-amylase

Focused map of Tra1 module of ctSAGA

Tra1, Core and minimal HAT modules of ctSAGA, composite.

Focused map of core module of ctSAGA complex

Focused map of HAT module Bromodomain region

Tra1 and Core Module of ctSAGA

Focused map of Tra1 module of ctSAGA

Histone Acetyl Transferase (HAT) module of ctSAGA

Tra1 module of ctSAGA

Focused map of core module of ctSAGA complex

Focused map of core module of ctSAGA complex

Focused map of Tra1 module of ctSAGA complex

Tra1 and core modules including core tip of ctSAGA complex

Core module of ctSAGA

Cryo ET of Native Hippocampal Glutamatergic Synapses Using Dimeric AuNP Labeling

Cryo ET of Native Hippocampal Glutamatergic Synapses Using Dimeric AuNP Labeling 6

Cryo ET of Native Hippocampal Glutamatergic Synapses Using Dimeric AuNP Labeling 7

ECD focus refined map of Non-active state Gly/Glu/PS bound hGluN1a-2B NMDAR

Venezuelan Equine Encephalitis Virus in complex with the single domain antibody V2B3

Consensus map of Closed state Gly/Glu/24S-HC bound hGluN1a-2B NMDAR

Venezuelan Equine Encephalitis Virus in complex with the single domain antibody V3A8f

Cryo ET of Native Hippocampal Glutamatergic Synapses Using Dimeric AuNP Labeling 2

Cryo ET of Native Hippocampal Glutamatergic Synapses without AuNP label

Cryo ET of Native Hippocampal Glutamatergic Synapses Using Dimeric AuNP Labeling 5

ECD focused map of open state Gly/Glu/24S-HC bound hGluN1a-2B NMDAR

Cryo ET of Native Hippocampal Glutamatergic Synapses without AuNP label 3

Cryo ET of Native Hippocampal Glutamatergic Synapses Using Dimeric AuNP Labeling 4

Human OCTN2 in an inward-facing conformation

Venezuelan Equine Encephalitis Virus in complex with the single domain antibody V2C3

Cryo ET of Native Hippocampal Glutamatergic Synapses without AuNP label 4

Cryo ET of Native Hippocampal Glutamatergic Synapses without AuNP label 2

Cryo ET of Native Hippocampal Glutamatergic Synapses Using Dimeric AuNP Labeling 3

TMD focus refined map of Non-active state Gly/Glu/PS bound hGluN1a-2B NMDAR

ECD focus refined map of Closed state Gly/Glu/24S-HC bound hGluN1a-2B NMDAR

Consensus map of pre-active state Gly/Glu/PS bound hGluN1a-2B NMDAR

ECD focus refined map of preactive state Gly/Glu/PS bound hGluN1a-2B NMDAR

TMD focus refined Closed state Gly/Glu/24S-HC bound hGluN1a-2B NMDAR

Consensus map of Non-active state Gly/Glu/PS bound hGluN1a-2B NMDAR

TMD focused refined open state Gly/Glu/24S-HC bound hGluN1a-2B NMDAR

TMD focus refined map of preactive state Gly/Glu/PS bound hGluN1a-2B NMDAR

Consensus map of open state Gly/Glu/24S-HC bound hGluN1a-2B NMDAR

Structure of HTTQ23-HAP40 complex bound to a small molecule ligand

E. coli MaeB holo form

Cryo-EM Structure of NPFFR1 in complex with peptide RFRP-3

CryoEM structure of H7 hemagglutinin in complex with a human neutralizing antibody 6Y13

B. bacteriovorus MaeB holo form

structure of bundle-shaped PBS with short rod

Local map of Cryo-EM Structure of NPFFR1 in complex with peptide NPFF

Consensus map of Cryo-EM Structure of NPFFR1 in complex with peptide RFRP-3

Cryo-EM structure of bicarbonate transporter SbtA in complex with PII-like signaling protein SbtB (T-loop truncation) from Synechocystis sp. PCC 6803

Local map of Cryo-EM Structure of NPFFR1 in complex with peptide RFRP-3

Consensus map of Cryo-EM Structure of NPFFR1 in complex with peptide NPFF

B. bacteriovorus MaeB acetyl-CoA bound form

Cryo-EM Structure of NPFFR1 in complex with peptide NPFF

Cryo-EM structure of the TIA-1 prion-like domain amyloid fibril, G355R

Cryo-EM structure of the TIA-1 prion-like domain amyloid fibril, WT

Human UPF1 in complex with the histone stem loop RNA

Chlamydomonas nuclear envelope-bound ribosome

Cryo-EM structure of hTUT4_mini:hLin28A:pre-let-7g miRNA_UUU, conformation 2

Cryo-EM structure of hTUT4_mini:hLin28A:pre-let-7g miRNA_UUU, conformation 1

Cryo-EM structure of COP9 signalosome in complex with CSN5i-1a

In situ cryo-ET tomogram of HeLa TMEM192-3xHA Control cell showcasing an endolysosomal structure.

In situ cryo-ET tomogram of HeLa TMEM192-3xHA ASAH1-/- cell showcasing an endolysosomal structure

Human Kv1.3 mutant - G427H with A0194009G09 nanobodies

Cryo-EM structure of COP9 signalosome deneddylation state with cullin-5

Cryo-EM structure of COP9 signalosome

Cryo-EM structure of CSN-N8 in complex with CSN5i-3

Focused map of COP9 signalosome deneddylation state with cullin-5

Cryo-EM structure of COP9 signalosome in complex with CSN5i-3

Focused map of COP9 signalosome precatalytic state with neddylated cullin-1

Cryo-EM structure of COP9 signalosome precatalytic state with neddylated cullin-1

Cryo-EM structure of COP9 signalosome deneddylation state of cullin-4A

Focused map of COP9 signalosome deneddylation complex with cullin-2

Cryo-EM structure of COP9 signalosome deneddylation complex with cullin-2

Focused map of COP9 signalosome deneddylation complex with neddylated cullin-3

Cryo-EM structure of COP9 signalosome deneddylation complex with cullin-3

Focused map of CSN-N8CUL1 in complex with CSN5i-3

Cryo-EM structure of CSN-N8CUL1 complex with CSN5i-3

Cryo-EM structure of COP9 signalosome precatalytic state with neddylated cullin-1

Cryo-EM structure of COP9 signalosome precatalytic state with neddylated cullin-2

1-methyl-pseudouridine L-21 ScaI Tetrahymena Ribozyme

Cryo-EM structure of CSN-N8CUL1 in complex with CSN5i-3

Cryo-EM structure of COP9 signalosome precatalytic state with neddylated cullin-4A

1-methyl-pseudouridine L-21 ScaI Tetrahymena Ribozyme - extended conformation

COP9 signalosome deneddylation complex with cullin-5

Cryo-EM structure of COP9 signalosome precatalytic state with neddylated cullin-3

DDB1-CRBN with Ikaros(ZF2) and DEG-47: composite map and model submission

Cryo-EM structure of Candida albicans fluoride channel FEX in complex with Fab fragment

Initial respirasome complex map (consensus map)

Complex IV with HIGD2A density and incoming NDUFA4 (class 2)

Cryo-EM structure of human MON1A-CCZ1-RAB7A

Cryo-EM structure of [Pen5]-urotensin (4-11)-bounded human Urotensin receptor (UTS2R)-Gq complex

Cryo-EM structure of HIGD2A bound complex IV

Local refinement of complex IV (whole map)

Cryo-EM structure of NDUFA4 bound complex IV within the respirasome complex

local refinement map of human complex I

NDUFA4 bound complex IV with weak density from HIGD2A

Structure of the Human Peptide-Loading Complex Arrested by HCMV US6

cryoEM structure of ptuA-ptuB complex in Retron-Eco7 anti-phage system

Cryo-EM structure of alpha-synuclein fibrils formed in artificial cerebrospinal fluid (aCSF)

Cryo-ET reconstruction of a regenerating axon after axotomy showing polymerizing microtubules (primary mouse thalamus neuronal explant)

Cryo-ET reconstruction of a regenerating axon 24 h after axotomy (primary mouse thalamus neuronal explant)

Cryo-ET reconstruction of a regenerating axon after axotomy showing branching microtubules (primary mouse thalamus neuronal explant)

Cryo-ET reconstruction of a regenerating axon after axotomy showing branching microtubules (primary mouse thalamus neuronal explant, control)

Cryo-EM structure of conoid fiber from Toxoplasma gondii (24-nm repeat)

Cryo-ET subtomogram averaging of a stress fiber from a regenerating axon

Cryo-ET reconstruction of a regenerating axon 24 h after axotomy (primary mouse thalamus neuronal explant)

HCoV-229E S2P bound by three DH1533 Fabs

HCoV-229E S2P bound by one DH1533 Fab

Structure of Chikungunya virus infectious particles, 2f block.

HCoV-229E S2P bound by two DH1533 Fabs

Cryo-EM structure of intraconoidal microtubule 1 (ICMT1) from Toxoplasma gondii (8-nm repeat)

Cryo-EM structure of the apical region of subpellicular microtubule (SPMT) from Toxoplasma gondii (8-nm repeat)

Cryo-EM structure of intraconoidal microtubule 2 (ICMT2) from Toxoplasma gondii (8-nm repeat)

A Cryo_EM structure of 5_HT1A complex with TMT

A Cryo_EM structure of 5_HT1A complex with DMT

A Cryo_EM structure of 5_HT1A complex with 5-Meo-DMT

Cryo-EM structure of Leptospirillum ferriphilum helicase Dda

Structure of TauT in the apo state

FusA (ferredoxin receptor from Pectobacterium atrosepticum) in the presence of Ra-LPS

Structure of TauT in complex with taurine

Structure of TauT in complex with GABA

Structure of TauT in complex with taurine

Structure of TauT in complex with Guanidinoethyl sulfonate

Molecular Architecture of Human Glycogen Debranching Enzyme: Insights into Glycogen Storage Disease III Pathogenesis

Consensus Map of PI4KA/TTC7B/FAM126A/F3IN Nanobody

Local Refinement A of PI4KA/TTC7B/FAM126A/F3IN Nanobody

Cryo-EM structure of the PI4KA complex bound to an EFR3 interfering nanobody (F3IN)

Local Refinement B of PI4KA/TTC7B/FAM126A/F3IN nanbody

Cryo-EM structure of CtpA from Helicobacter pylori in conformation I

Subtomogram average of the mtHsp60:mtHsp10 Football complex from HeLa

Subtomogram average of the mtHsp60:mtHsp10 half-football complex from HeLa

Subtomogram average of the mtHsp60 singlering complex from HeLa

Cryo-EM structure of CtpA from Helicobacter pylori in an all-resting state

Cryo-EM map of carboxysomal midi-shell: T = 16 shell under C1 symmetry

Cryo-EM structure of DDB1dB-CRBN-MRT-0031619, conformation 2

Cryo-EM structure of DDB1dB-CRBN-MRT-0031619, conformation 1

structure of the FliD cap

Subtomogram average of the 39S mitochondrial ribosome from HeLa

Subtomogram average of the 55S mitochondrial ribosome from HeLa

Cryo-EM map of carboxysomal midi-shell: T = 9 shell under C1 symmetry

Cryo-EM structure of CtpA from Helicobacter pylori in conformation II

the flagellar filament cap FliD in complex with FlgL

the flagellar filament cap FliD in complex with FliC

Cryo-EM structure of CtpA S300A/K325A/Q329A mutant from Helicobacter pylori

transport C

Cryo-EM structure of Adriforant-bound Histamine receptor 4 H4R at inactive state

transport AD

Structure of the wild-type PSI-9VCPI supercomplex in Nannochloropsis oceanica

Structure of the wild-type PSI-8VCPI supercomplex in Nannochloropsis oceanica