EMD-78289

Single-particle
3.2 Å
EMD-78289
3D View Gallery
Deposition: 25/07/2026
Map released: 30/09/2026
Last modified: 30/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-78289

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-37lu summary report (pdf.gz) Map-37lu FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

NPC1-NPC2 complex with bis-sterol molecule JM046, pH 5.5

EMD-78289

Single-particle
3.2 Å
EMD-78289
3D View Gallery
Deposition: 25/07/2026
Map released: 30/09/2026
Last modified: 30/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of NPC1, NPC2, and bis-sterol molecule JM046
Fitted models: 37lu

Deposition Authors: Wu X, Yan N

Conformation switch of NPC1 epitomizes a lumen-to-membrane alternating access for nonpolar substrates
Wu X, Dehghani-Ghahnaviyeh S, Rasouli A, Malona J, Antalek M, Jones LH, Fan X, Peng A, Tajkhorshid E, Qian H, Yan N
To Be Published
Grant Support: