EMD-74471

Single-particle
2.7 Å
EMD-74471
3D View Gallery
Deposition: 15/12/2025
Map released: 30/09/2026
Last modified: 30/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-74471

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9zo8 summary report (pdf.gz) Map-9zo8 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of RyR1 in presence of rosuvastatin (including auxiliary transmembrane helices TMx1 and TMx2; Ca2+/CFF/ATP dataset; closed pore)

EMD-74471

Single-particle
2.7 Å
EMD-74471
3D View Gallery
Deposition: 15/12/2025
Map released: 30/09/2026
Last modified: 30/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Oryctolagus cuniculus
Sample: Complex of RyR1 with Calstabin-1 in presence of rosuvastatin (Ca2+/CFF/ATP condition)
Fitted models: 9zo8

Deposition Authors: Weninger G, Marks AR
Structural basis for rosuvastatin-induced activation of skeletal muscle ryanodine receptor 1
Weninger G, Reiken S, Yuan Q, Miotto MC, Chang A, Liu Y, Wronska A, Dridi H, Marks AR
(2026) Nat Commun
DOI: doi:10.1038/s41467-026-77372-9
ISSN: 2041-1723