Cryo-EM structure of the glucose-specific PTS transporter IIC from V. cholerae in the inward-facing conformation

Ku70/80 bound to 147 bp nucleosome

DNA-PK bound to a 153 bp H2AX nucleosome model 1

Ku70/80 with Ku70 linker and SAP domain bound to a 153 bp H2AX nucleosome

DNA-PK bound to 153 bp H2AX nucleosome model 2

CryoEM structure of the microtubule-AKAP13 C1 domain complex

Ku70/80 bound to 153 bp nucleosome

Ku70/80 bound to a 153 bp H2AX nucleosome

Ku80 mediated DNA-PK dimer bound to 153 bp H2AX nucleosome

Constituent EM map: Focused refinement on TaF/TMD/CTD of mouse RyR1 (Ca2+/CFF/ATP dataset; open pore)

DNA-PK bound to 153 bp H2AX nucleosome with ATPyS

Constituent EM map: Focused refinement on TaF/TMD/CTD of mouse RyR1 (Ca2+/CFF/ATP dataset; closed pore)

Raw consensus map of mouse RyR1 (Ca2+/CFF/ATP dataset; open pore)

L. pneumophila 3-methylcrotonyl-CoA carboxylase A1B6

Constituent EM map: Focused refinement on S2S3 of mouse RyR1 (Ca2+/CFF/ATP dataset; closed pore)

Raw consensus map of mouse RyR1 with simvastatin (Ca2+/CFF/ATP dataset; open pore)

Raw consensus map of mouse RyR1 (Ca2+/CFF/ATP dataset; closed pore)

Constituent EM map: Focused refinement on S2S3 of mouse RyR1 (Ca2+/CFF/ATP dataset; open pore)

Constituent EM map: Focused refinement on TaF/TMD/CTD of mouse RyR1 with simvastatin (Ca2+/CFF/ATP dataset; open pore)

Constituent EM map: Focused refinement on S2S3 of mouse RyR1 with simvastatin (Ca2+/CFF/ATP dataset; open pore)

Raw consensus map of mouse RyR1 with simvastatin (Ca2+/CFF/ATP dataset; closed pore)

Constituent EM map: Focused refinement on TaF/TMD/CTD of mouse RyR1 with simvastatin (Ca2+/CFF/ATP dataset; closed pore)

Raw consensus map of mouse RyR1 (including auxiliary transmembrane helix TMx; EGTA-only dataset)

Constituent EM map: Focused refinement on TaF/TMD/CTD of mouse RyR1 (Ca2+/CFF/ATP dataset; closed pore)

Constituent EM map: Focused refinement on S2S3 of mouse RyR1 (including auxiliary transmembrane helix TMx; EGTA-only dataset)

Megrivirus E 3' internal ribosome entry site (IRES) RNA core region bound to rabbit ribosome

Constituent EM map: Focused refinement on S2S3 of mouse RyR1 with simvastatin (Ca2+/CFF/ATP dataset; closed pore)

Pseudomonas putida Pore-Forming Toxin Tke5 in complex with its cognate Type VI adaptor protein Tap3

Cryo-EM structure of sarkosyl insoluble amyloid-beta 42 filaments extracted from human brain tissue

Cryo-EM structure of the poly(4-styrenesulfonic acid-co-maleic acid) [PSCMA]-extractable amyloid-beta 42 oligomer from human brain tissue (Conformation 2)

Low resolution cryo-EM reconstruction of the DY2 collagen mimetic fibrils

Trm10-tRNA complex (open conformation)

XZ440 integrase inhibitor bound to Wild-type HIV-1 intasome

AK01 integrase inhibitor bound to Wild-type HIV-1 intasome

Trm10-tRNA complex (closed conformation)

Trm10-tRNA complex (Two Trm10 monomers bound to one tRNA)

Helical Reconstruction of the Complex of Pseudo-Acetylated Human Cardiac Actin (K326/328Q) and Tropomyosin

Helical Reconstruction of the Human Cardiac F-Actin-Tropomyosin Complex

CNGA1 channel closed state in nanodisc with diC8-PIP2 cGMP-free

CNGA1 channel closed state in nanodisc cGMP-free

CNGA1 channel intermediate state in nanodisc with brain PIP2 cGMP-bound

CNGA1 channel closed state in nanodisc with brain PIP2 cGMP-free

CNGA1 channel intermediate state in nanodisc cGMP-bound

CNGA1 channel intermediate state in nanodisc with diC8-PIP2 cGMP-bound

CNGA1 channel open state in nanodisc cGMP-bound

Structure of disulfide-crosslinked S. cerevisiae Hrd1 dimer bound to one copy of Hrd3 in MSP1D1 nanodisc

HCV Chiron E1E2 complexed with AR3A and AR4A Fabs

Cryo-EM structure of F-ATP synthase from Mycobacteroides abscessus (Rotational State 3)

Cryo-EM structure of F-ATP synthase c-ring from Mycobacteroides abscessus (Backbone)

Cryo-EM structure of F-ATP synthase from Mycobacteroides abscessus (Rotational State 1)

Cryo-EM structure of F-ATP synthase from Mycobacteroides abscessus (Rotational State 2)

Cryo-EM map of influenza hemagglutinin (A/Hong Kong/1/1968, H3N2) jetted control sample

Cryo-EM structure of KCa3.1_I/calmodulin channel in complex with SKA111.

Dimeric structure of GM4951

Identification and non-clinical characterization of SAR444200, a novel anti-GPC3 T-cell engager for the treatment of GPC3+ solid tumors

Cryo-EM structure of KCa3.1_II/calmodulin channel in complex with SKA31.

Cryo-EM structure of KCa3.1_I/calmodulin channel in complex with SKA31.

syNOS monomer bound to NADPH

Asymmetric syNOS

Focused refinement of syNOS Asymmetric Locked state- Region 2

Cereblon Ternary Complex with Blimp1 and compound 5

syNOS Turnover State

syNOS Asymmetric Locked State (Composite)

Focused refinement of syNOS Asymmetric Locked state- Region 1

Symmetric Inactivated Locked State

sigE_carD_Native_RNA6_Unswivel

Structural Basis of Pausing During Transcription Initiation in Mycobacterium tuberculosis

CP/MBL pathways C3 convertase C4b2a and C3 complex

sigE_CarD_Natvie_RNA7_swivel

AP pathways C3 convertase C3bBbP and C3 complex

C3 convertases zymogen C4b2 in loading state

Structural Basis of Pausing During Transcription Initiation in Mycobacterium tuberculosis

sigE_carD_Native_RNA7_Unswivel

C3 convertases zymogen C4b2 in activation state

Structural Basis of Pausing During Transcription Initiation in Mycobacterium tuberculosis

The 1:1 cryo-EM structure of BAP1/ASXL1-K351Ub in complex with H2AK119Ub nucleosome

BaCas12a3 ternary complex

Bottlenose dolphin coronavirus spike glycoprotein

BaCas12a3 binary complex

HCoV-229E S2P bound by one DH1533 Fab, focused map

HCoV-229E S2P bound by one DH1533 Fab, consensus map

SPA of purified HIV-1 CA protein in vitro assembled with IP6 (mature morphology). 50 uM LEN was added post assembly.

DOI-NBOMe-bound Serotonin 2A (5-HT2A) receptor-Gq complex

DOI-bound Serotonin 2A (5-HT2A) receptor-Gi complex

Ariadne-bound Serotonin 2A (5-HT2A) receptor-Gq complex

DOI-bound Serotonin 2A (5-HT2A) receptor-Gq complex

cryo-EM structure of gastric proton pump bound to YK01

Psilocin-bound Serotonin 2A (5-HT2A) receptor-Gi complex

Cryo-EM structure of human 80S ribosome in complex with montanine

cryo-EM density map of SFTSV virus complexed with with hA5-6 (W30B/W53) Fab

CryoEM structure of the tetrahedral M42 aminopeptidase from M. jannaschii

Cryo-EM structure of hIAPP fibrils extracted from a donor with T2D and pancreatic cancer

reconstructed map of the 3-fold axis region of SFTSV virus complexed with hA5-6 (W30B/W53) Fab

Cryo-EM map of hIAPP fibrils extracted from a donor with T2D and pancreatic cancer

The cryo-EM structure of gRNA-bound SPARDA complex

Cryo-EM map of hIAPP fibrils extracted from a donor with T2D and Intraductal Papillary Mucinous Neoplasm

Helical structure of gRNA-tDNA SPARDA complex

The structure of the FIPV-1146 S trimer with mixed D0 conformations

Cryo-EM structure of KCa3.1_II/calmodulin channel in complex with SKA111.

Cryo-EM structure of KCa2.2/calmodulin channel in complex with SKA31.

Cryo-EM Structure of csy1-4 with crRNA

Cryo-EM Structure of D-RNA

Cryo-EM Structure of rRNA

Cryo-EM Structure of CRISPR

Cryo-EM Structure of RNA

Cryo-EM structure of csy3 with crRNA

Cryo-EM structure of csy3 with crRNA

Localized reconstruction of packaging hexamer P4 from polar region of transcribing double-layered particle of bacteriophage phi6

Transcribing double-layered particle of bacteriophage phi6 reconstructed with icosahedral symmetry

Localized reconstruction of packaging hexamer P4 from equatorial region of transcribing single-layered particle of bacteriophage phi6

Structure of CliM-stalled Bacillus subtilis 70S ribosome with empty A-site

Localized reconstruction of packaging hexamer P4 from polar region of transcribing single-layered particle of bacteriophage phi6

Structure of CliM-stalled Bacillus subtilis 70S ribosome with release factor bound in the A-site

Structure of CliM-stalled Bacillus subtilis 70S ribosome with tRNA-Tyr in the A-site

Cryo-EM structure of the adhesion GPCR ADGRV1 in complex with a nanobody

CRYO-EM STRUCTURE OF HCT15 POLYSOMES BOUND TO EEF2, EBP1, AND SERBP1

Transcribing single-layered particle of bacteriophage phi6 reconstructed with icosahedral symmetry

Localized reconstruction of polymerase P2 from transcribing single-layered particle of bacteriophage phi6 in stage C

Localized reconstruction of polymerase P2 from transcribing single-layered particle of bacteriophage phi6 in stage B

Localized reconstruction of polymerase P2 from transcribing double-layered particle of bacteriophage phi6 in stage A1

Localized reconstruction consensus map of minor protein P7 from transcribing particles of bacteriophage phi6

Localized reconstruction of polymerase P2 from transcribing double-layered particle of bacteriophage phi6 in stage A3

Localized reconstruction of packaging hexamer P4 from equatorial region of transcribing double-layered particle of bacteriophage phi6

Localized reconstruction of polymerase P2 from transcribing double-layered particle of bacteriophage phi6 in stage A2

Asymmetric reconstruction of transcribing double-layered particle of bacteriophage phi6, disassembly intermediate 1

Asymmetric reconstruction of transcribing double-layered particle of bacteriophage phi6, disassembly intermediate 2

Transcription-arrested single-layered particle of bacteriophage phi6 reconstructed with D3 symmetry

The one:one complex of gephyrin and collybistin

Transcription-arrested double-layered particle of bacteriophage phi6 reconstructed with icosahedral symmetry

Transcription-arrested single-layered particle of bacteriophage phi6 reconstructed with icosahedral symmetry

Localized reconstruction of asymmetric unit from transcribing double-layered particle of bacteriophage phi6

Asymmetric reconstruction of transcribing double-layered particle of bacteriophage phi6, disassembly intermediate 3

Asymmetric reconstruction of transcribing double-layered particle of bacteriophage phi6, disassembly intermediate 4

Dimer of the one:one complex of gephyrin and collybistin

Transcription-arrested double-layered particle of bacteriophage phi6 reconstructed with D3 symmetry

Localized reconstruction of asymmetric unit from transcribing single-layered particle of bacteriophage phi6

Localized reconstruction of asymmetric unit from transcribing single-layered particle of bacteriophage phi6 in an over-expanded state

Structure of WT E.coli ribosome with complexed filament nascent chain at length 47, with P-site tRNA

Gephyrin (higher oligomer) filament

a5b3 GABAAR bound to GABA and Mb25 in a desensitized state in saposin nanodiscs after short GABA treatment

The four:one complex of gephyrin and collybistin

Structure of WT E.coli ribosome with complexed filament nascent chain at length 31, with P-site tRNAs

Gephyrin E-domain dimer with additional density on top of the dimer interface

Gephyrin E-domain dimer with additional density on the side of the dimer interface

CryoEM map of the large glutamate dehydrogenase composed of 180 kDa subunits from Mycobacterium smegmatis obtained in the presence of NAD+ and L-glutamate. Closed2 tetramer

CryoEM map of the large glutamate dehydrogenase composed of 180 kDa subunits from Mycobacterium smegmatis obtained in the presence of NAD+ and L-glutamate. Open Tetramer

CryoEM map of the large glutamate dehydrogenase composed of 180 kDa subunits from Mycobacterium smegmatis obtained in the presence of NAD+ and L-glutamate. Closed1 tetramer.

CryoEM map of the large glutamate dehydrogenase composed of 180 kDa subunits from Mycobacterium smegmatis obtained in the presence of NAD+ and L-glutamate. Empty monomer.

CryoEM map of the large glutamate dehydrogenase composed of 180 kDa subunits from Mycobacterium smegmatis obtained in the presence of NAD+ and L-glutamate. cofactor-monomer.

CryoEM map of the large glutamate dehydrogenase composed of 180 kDa subunits from Mycobacterium smegmatis obtained in the presence of NAD+ and L-glutamate. Cofactor/ligand-monomer

CryoEM map of the large glutamate dehydrogenase composed of 180 kDa subunits from Mycobacterium smegmatis obtained in the presence of NAD+ and L-glutamate. cofactor/ligand-monomer in Closed2 tetramer.

CryoEM map of the large glutamate dehydrogenase composed of 180 kDa subunits from Mycobacterium smegmatis obtained in the presence of NAD+ and L-glutamate. Closed2 tetramer with cofactor/ligand-monomer.

CryoEM map of the large glutamate dehydrogenase composed of 180 kDa subunits from Mycobacterium smegmatis obtained in the presence of NAD+ and L-glutamate. Total-monomer

CryoEM map of the large glutamate dehydrogenase composed of 180 kDa subunits from Mycobacterium smegmatis obtained in the presence of NAD+ and L-glutamate. cofactor/ligand-monomer in Closed1 tetramer.

Cryo-EM structure of human separase-SCC1 (1-631) fusion protein

CryoEM map of the large glutamate dehydrogenase composed of 180 kDa subunits from Mycobacterium smegmatis obtained in the presence of NAD+ and L-glutamate. cofactor/ligand-monomer in Open tetramer.

Structure of Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase embedded in nanodisc

Structure of the Cytochrome o ubiquinol oxidase embedded in the nanodisc

Structure of the co-purified multidrug transporter subunit ACRB in nandisc

3D cryoEM map of the BSAP-1 and B1RS complex

The structure of ADGRL4 in the active-state

Icosahedral reconstruction of Semliki Forest virus in complex with ApoER2 LA5

Semliki Forest virus trimer 1 in complex with ApoER2 LA5

Composite density map of Semliki Forest virus in complex with ApoER2 LA5

Semliki Forest virus trimer 1 in complex with ApoER2 ligand-binding domain

Icosahedral reconstruction of Semliki Forest virus in complex with ApoER2 ligand-binding domain

Semliki Forest virus trimer 2 in complex with ApoER2 LA5

Semliki Forest virus trimer 2 in complex with ApoER2 ligand-binding domain

Composite density map of Semliki Forest virus in complex with ApoER2 ligand-binding domain

Co-chaperone Bag1-bound human 26S proteasome in SBag2 state

S315T KatG mutant two Heme

S315I KatG mutant no Heme

S315I KatG mutant two Heme

S315N KatG mutant one Heme

S315R KatG mutant one Heme

S315R KatG mutant two Heme

S315G KatG mutant one Heme

S315G KatG mutant no Heme

S315N KatG mutant no heme

S315I KatG mutant one heme

In situ structure of wild-type HIV-1 CA hexamer prior to nuclear import

In situ structure of N74D HIV-1 CA hexamer post nuclear import

In situ structure of wild-type HIV-1 CA hexamer post nuclear import

In situ structure of the H1-bound nucleosome

In situ structure of stacking H1-bound nucleosomes

In situ structure of the open-linker H1-bound nucleosome

In situ structure of the H1-bound nucleosome in stacking nucleosomes

In situ structure of the core nucleosome

in situ nucleosome,closed state

Cryo-EM structure of Z-DNA binding antibody Z-D11 in complex with left-handed Z-DNA

in situ nucleosome, open state

Cryo-EM structure of Z22 antibody in complex with left-handed Z-DNA (trimer)

Cryo-EM structure of Z22 mAb in complex with left-handed Z-DNA (dimer of trimer)

PSI trimer of Synechocystis sp. PCC 6803

Hexamer Msp1 from S.cerevisiae (with a catalytic dead mutation) in complex with an unknown peptide substrate

Cyro-EM structure of prefusion RSV fusion glycoprotein in complex with Ziresovir and motavizumab Fab