EMD-52411

Single-particle
2.97 Å
EMD-52411
3D View Gallery
Deposition: 22/12/2024
Map released: 25/02/2026
Last modified: 25/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52411
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9hug summary report (pdf.gz) Map and 9hug FULL report (pdf.gz)
EMICSS annotations (xml)

Inward-open structure of human glycine transporter 2 in substrate-free state

EMD-52411

Single-particle
2.97 Å
EMD-52411
3D View Gallery
Deposition: 22/12/2024
Map released: 25/02/2026
Last modified: 25/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human glycine transporter GlyT2 in substrate-free state
Fitted models: 9hug

Deposition Authors: Cantwell Chater RP , Peiser-Oliver J, Pati TK, Quinn AS, Lotsaris I , Frangos ZJ , Anderson KE , Tischer AE , Williams-Noonan BJ, Aubrey KR , O Mara ML, Michaelides M , Mohammadi SA , Cioffi CL , Vandenberg RJ , Shahsavar A
A reversible allosteric inhibitor of GlyT2 for neuropathic pain without on-target side effects.
Cantwell Chater RP , Peiser-Oliver J, Pati TK, Quinn AS, Lotsaris I , Frangos ZJ , Anderson KE , Tischer AE , Williams-Noonan BJ, Aubrey KR , O'Mara ML , Michaelides M , Mohammadi SA , Cioffi CL , Vandenberg RJ , Shahsavar A
(2026) Nat Commun
PUBMED: 41698908
DOI: doi:10.1038/s41467-026-69616-5
ISSN: 2041-1723