EMD-75514

Helical reconstruction
3.18 Å
EMD-75514
3D View Gallery
Deposition: 11/02/2026
Map released: 25/02/2026
Last modified: 25/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75514
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 10xu summary report (pdf.gz) Map and 10xu FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of amplified aSyn filament by using seed amplification assay (SAA) from MSA patient CSF.

EMD-75514

Helical reconstruction
3.18 Å
EMD-75514
3D View Gallery
Deposition: 11/02/2026
Map released: 25/02/2026
Last modified: 25/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Alpha-synuclein protein filament
Fitted models: 10xu

Deposition Authors: Banerjee V, Wang F, Baker ML, Serysheva II, Soto C
Seed amplification of MSA alpha-synuclein aggregates preserves the biological and structural properties of brain-derived aggregates.
Wang F, Banerjee V, Barria C, Ramirez S, Allison T, Gorski D, Evans H, Nguyen Q, Harrison D, Al-Lahham R, De Gregorio Carbonell N, Pinho M, Kaalund S, Folke J, Aznar S, Concha-Marambio L, Ishtikhar M, Mallampalli VK, Pritzkow S, Shahnawaz M, Baker ML, Serysheva I, Soto C
(2025) Nat Commun , 16 , 11266 - 11266
PUBMED: 41372188
DOI: doi:10.1038/s41467-025-66146-4
ISSN: 2041-1723