EMD-75514
Structure of amplified aSyn filament by using seed amplification assay (SAA) from MSA patient CSF.
EMD-75514
Helical reconstruction3.18 Å
Deposition: 11/02/2026Map released: 25/02/2026
Last modified: 04/03/2026
Sample Organism:
Homo sapiens
Sample: Alpha-synuclein protein filament
Fitted models: 10xu
Deposition Authors: Banerjee V
,
Wang F,
Baker ML ,
Serysheva II,
Soto C
Sample: Alpha-synuclein protein filament
Fitted models: 10xu
Deposition Authors: Banerjee V
,
Wang F,
Baker ML ,
Serysheva II,
Soto C
Seed amplification of MSA alpha-synuclein aggregates preserves the biological and structural properties of brain-derived aggregates.
Wang F,
Banerjee V ,
Barria C,
Ramirez S,
Allison T ,
Gorski D,
Evans H,
Nguyen Q,
Harrison D ,
Al-Lahham R,
De Gregorio Carbonell N ,
Pinho M,
Kaalund S ,
Folke J ,
Aznar S ,
Concha-Marambio L ,
Ishtikhar M,
Mallampalli VK,
Pritzkow S,
Shahnawaz M,
Baker ML ,
Serysheva I,
Soto C
(2025) Nat Commun , 16 , 11266 - 11266
,
Barria C,
Ramirez S,
Allison T ,
Gorski D,
Evans H,
Nguyen Q,
Harrison D ,
Al-Lahham R,
De Gregorio Carbonell N ,
Pinho M,
Kaalund S ,
Folke J ,
Aznar S ,
Concha-Marambio L ,
Ishtikhar M,
Mallampalli VK,
Pritzkow S,
Shahnawaz M,
Baker ML ,
Serysheva I,
Soto C
(2025) Nat Commun , 16 , 11266 - 11266
Grant Support:
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): (United States)
- Michael J. Fox Foundation: (United States)