EMD-53509

Single-particle
3.02 Å
EMD-53509
3D View Gallery
Deposition: 26/04/2025
Map released: 25/02/2026
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-53509
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9r1h summary report (pdf.gz) Map and 9r1h FULL report (pdf.gz)
EMICSS annotations (xml)

Inward-occluded structure of human glycine transporter 2 bound to substrate glycine

EMD-53509

Single-particle
3.02 Å
EMD-53509
3D View Gallery
Deposition: 26/04/2025
Map released: 25/02/2026
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human glycine transporter GlyT2 bound to substrate glycine
Fitted models: 9r1h

Deposition Authors: Cantwell Chater RP , Peiser-Oliver J , Pati TK , Quinn AS, Lotsaris I , Frangos ZJ , Anderson KE, Tischer AE , Williams-Noonan BJ , Aubrey KR, O Mara ML, Michaelides M , Mohammadi SA , Cioffi CL , Vandenberg RJ , Shahsavar A
A reversible allosteric inhibitor of GlyT2 alleviates neuropathic pain without on-target side effects.
Cantwell Chater RP , Peiser-Oliver J , Pati TK , Quinn AS, Lotsaris I , Frangos ZJ , Anderson KE, Tischer AE , Williams-Noonan BJ , Aubrey KR, O'Mara ML , Michaelides M , Mohammadi SA , Cioffi CL , Vandenberg RJ , Shahsavar A
(2025) bioRxiv
PUBMED: 41332641
DOI: doi:10.1101/2025.04.21.649698
ISSN: 2692-8205