EMD-53509
Inward-occluded structure of human glycine transporter 2 bound to substrate glycine
EMD-53509
Single-particle3.02 Å
Deposition: 26/04/2025Map released: 25/02/2026
Last modified: 19/08/2026
Sample Organism:
Homo sapiens
Sample: Human glycine transporter GlyT2 bound to substrate glycine
Fitted models: 9r1h
Deposition Authors: Cantwell Chater RP
,
Peiser-Oliver J ,
Pati TK ,
Quinn AS,
Lotsaris I ,
Frangos ZJ ,
Anderson KE,
Tischer AE ,
Williams-Noonan BJ ,
Aubrey KR,
O Mara ML,
Michaelides M ,
Mohammadi SA ,
Cioffi CL ,
Vandenberg RJ ,
Shahsavar A
Sample: Human glycine transporter GlyT2 bound to substrate glycine
Fitted models: 9r1h
Deposition Authors: Cantwell Chater RP
,
Peiser-Oliver J ,
Pati TK ,
Quinn AS,
Lotsaris I ,
Frangos ZJ ,
Anderson KE,
Tischer AE ,
Williams-Noonan BJ ,
Aubrey KR,
O Mara ML,
Michaelides M ,
Mohammadi SA ,
Cioffi CL ,
Vandenberg RJ ,
Shahsavar A
A reversible allosteric inhibitor of GlyT2 alleviates neuropathic pain without on-target side effects.
Cantwell Chater RP ,
Peiser-Oliver J ,
Pati TK ,
Quinn AS,
Lotsaris I ,
Frangos ZJ ,
Anderson KE,
Tischer AE ,
Williams-Noonan BJ ,
Aubrey KR,
O'Mara ML ,
Michaelides M ,
Mohammadi SA ,
Cioffi CL ,
Vandenberg RJ ,
Shahsavar A
(2025) bioRxiv
,
Peiser-Oliver J ,
Pati TK ,
Quinn AS,
Lotsaris I ,
Frangos ZJ ,
Anderson KE,
Tischer AE ,
Williams-Noonan BJ ,
Aubrey KR,
O'Mara ML ,
Michaelides M ,
Mohammadi SA ,
Cioffi CL ,
Vandenberg RJ ,
Shahsavar A
(2025) bioRxiv
Grant Support:
- Lundbeckfonden: R368-2021-522 (Denmark)
- Novo Nordisk Foundation: NNF23OC0087107 (Denmark)
- National Institutes of Health/National Institute on Drug Abuse (NIH/NIDA): R01DA048879 (United States)