Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P62328

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-44	P		NT	<%Agarwal et al., 2012[]%>
5	peptidyl-Asp metallopeptidase	2-44	P		CS	Cavasin et al., 2004
5	prolyl oligopeptidase	2-44	P		CS	Cavasin et al., 2004
6	meprin alpha subunit	3-15	N		MS	Becker-Pauly et al., 2011
22	astacin	19-32	N		MS	Becker-Pauly et al., 2011
22	meprin alpha subunit	19-32	N		MS	Becker-Pauly et al., 2011
25	meprin alpha subunit	22-39	N		MS	Becker-Pauly et al., 2011
26	meprin alpha subunit	23-39	N		MS	Becker-Pauly et al., 2011