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Literature for peptidase S09.001: prolyl oligopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Kaiser-Graf,D., Domenig,O., Poglitsch,M., Kreutz,R. and Bolbrinker,J.
    Upregulation of angiotensin-(1-7) formation in human podocytes - enzyme activity assay upon fluid flow shear stress
    PLoS ONE (2026) 21, e0339874-e0339874. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Jia,K., Cheng,B., Huang,L., Xu,J., Liu,F., Liao,X., Liao,K. and Lu,H.
    Activation of prep expression by Tet2 promotes the proliferation of bipotential progenitor cells during liver regeneration
    Development (2025) PubMed  Europe PubMed DOI
  3. Peng,H., Guo,Z., Wang,W.L., Yin,D., Zou,S., Asbell,T., Ullman,B.R., Thakar,M., Zhang,F., Hong,S.Y., Rao,A.V.S., Wang,K., Zhang,S., Wu,Z., Li,X., Margolis,S.S., Matsui,W.H., Gocke,C.B., Mao,Y. and Liu,J.O.
    Rapaprotin is Activated by an Endopeptidase to Disassemble 26S Proteasome
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  4. Van Elzen,R., Waumans,Y., Nath,S., Van der Veken,P., Kerckhoff,S., Van Dijk,E., Morawski,M., Rossner,S., Engelborghs,Y., De Meester,I. and Lambeir,A.M.
    The prolyl oligopeptidase and alpha-synuclein connection revisited
    Biochimie (2025) PubMed  Europe PubMed DOI
    5. 2024
  5. Briot,J., Pons,C., Foucher,A., Goudouneche,D., Gaudenzio,N., Donovan,M., Bernard,D., Mechin,M.C. and Simon,M.
    Prolyl Endopeptidase PREP Is Involved in Filaggrinolysis and Cornification
    J Invest Dermatol (2024) 145, 98-108. PubMed  Europe PubMed DOI
  6. Walczewska-Szewc,K. and Rydzewski,J.
    Structural visualization of inhibitor binding in prolyl oligopeptidase
    Biophys Rev (Melville) (2024) 5, 032105-032105. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2023
  7. Kilpelainen,T.P., Patsi,H.T., Svarcbahs,R., Julku,U.H., Etelainen,T.S., Cui,H., Auno,S., Sipari,N., Norrbacka,S., Leino,T.O., Jantti,M., Myohanen,T.T. and Wallen,E.A.A.
    Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease
    J Med Chem (2023) 66, 7475-7496. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2022
  8. Baharin,A., Ting,T.Y. and Goh,H.H.
    Post-Proline Cleaving Enzymes (PPCEs): Classification, Structure, Molecular Properties, and Applications
    Plants (Basel) (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC  V
  9. Plescia,J., Hedou,D., Pousse,M.E., Labarre,A., Dufresne,C., Mittermaier,A. and Moitessier,N.
    Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-alpha for different indications
    Eur J Med Chem (2022) 240, 114543-114543. PubMed  Europe PubMed DOI
    10. 2021
  10. Cui,H., Norrbacka,S. and Myohanen,T.T.
    Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy
    Biochem Pharmacol (2021) 197, 114899-114899. PubMed  Europe PubMed DOI  K
  11. Julku,U.H., Jantti,M., Svarcbahs,R. and Myohanen,T.T.
    Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  12. Kulkarni,A.M., Rampogu,S. and Lee,K.W.
    Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase
    Evid Based Complement Alternat Med (2021) 2021, 6687572-6687572. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Patsi,H.T., Kilpelainen,T.P., Auno,S., Dillemuth,P.M.J., Arja,K., Lahtela-Kakkonen,M.K., Myohanen,T.T. and Wallen,E.A.A.
    2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors
    ACS Med Chem Lett (2021) 12, 1578-1584. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Payne,G.A., Sharma,N.S., Lal,C.V., Song,C., Guo,L., Margaroli,C., Viera,L., Kumar,S., Li,J., Bosley,M., Xing,D., Xu,X., Wells,J.M., George,J.F., Tallaj,J.A., Leesar,M., Blalock,J.E. and Gaggar,A.
    Prolyl Endopeptidase contributes to early neutrophilic inflammation in acute cardiac transplant rejection
    JCI Insight (2021) PubMed  Europe PubMed DOI
  15. Simkova,A., Ormsby,T., Sidej,N., Slavetinska,L.P., Brynda,J., Beranova,J., Sacha,P., Majer,P. and Konvalinka,J.
    Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with alpha-ketoamide warheads
    Eur J Med Chem (2021) 224, 113717-113717. PubMed  Europe PubMed DOI  I
  16. Triposkiadis,F., Starling,R.C., Xanthopoulos,A., Butler,J. and Boudoulas,H.
    Renin-angiotensin-system inhibition in the context of corona virus disease-19: experimental evidence, observational studies, and clinical implications
    Heart Fail Rev (2021) 26, 381-389. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Zolotov,N.N., Schepetkin,I.A., Voronina,T.A., Pozdnev,V.F., Khlebnikov,A.I., Krylova,I.V. and Quinn,M.T.
    Therapeutic Effect of Novel Cyanopyrrolidine-Based Prolyl Oligopeptidase Inhibitors in Rat Models of Amnesia
    Front Chem (2021) 9, 780958-780958. PubMed  Europe PubMed DOI  PMC  EPMC  I
    18. 2020
  18. Da'adoosh,B., Kaito,K., Miyashita,K., Sakaguchi,M. and Goldblum,A.
    Computational design of substrate selective inhibition
    PLoS Comput Biol (2020) 16, e1007713-e1007713. PubMed  Europe PubMed DOI
  19. Dunaevsky,Y.E., Tereshchenkova,V.F., Oppert,B., Belozersky,M.A., Filippova,I.Y. and Elpidina,E.N.
    Human proline specific peptidases: a comprehensive analysis
    Biochim Biophys Acta Gen Subj (2020) 1864, 129636-129636. PubMed  Europe PubMed DOI  V
  20. He,Z., Long,P., Fang,F., Li,S., Zhang,P. and Chen,Z.
    Diversity of MSDIN family members in amanitin-producing mushrooms and the phylogeny of the MSDIN and prolyl oligopeptidase genes
    BMC Genomics (2020) 21, 440-440. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Jiang,D.X., Zhang,J.B., Li,M.T., Lin,S.Z., Wang,Y.Q., Chen,Y.W. and Fan,J.G.
    Prolyl endopeptidase gene disruption attenuates high fat diet-induced nonalcoholic fatty liver disease in mice by improving hepatic steatosis and inflammation
    Ann Transl Med (2020) 8, 218-218. PubMed  Europe PubMed DOI  PMC  EPMC  K
  22. Kilpelainen,T.P., Hellinen,L., Vrijdag,J., Yan,X., Svarcbahs,R., Vellonen,K.S., Lambeir,A.M., Huttunen,H., Urtti,A., Wallen,E.A.A. and Myohanen,T.T.
    The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy
    Biomed Pharmacother (2020) 128, 110253-110253. PubMed  Europe PubMed DOI  I
  23. Retzl,B., Hellinger,R., Muratspahic,E., Pinto,M.E.F., Bolzani,V.S. and Gruber,C.W.
    Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides
    J Nat Prod (2020) PubMed  Europe PubMed DOI
  24. Rostami,J., Jantti,M., Cui,H., Rinne,M.K., Kukkonen,J.P., Falk,A., Erlandsson,A. and Myohanen,T.
    Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells
    Biomed Pharmacother (2020) 131, 110788-110788. PubMed  Europe PubMed DOI  I
  25. Serfozo,P., Wysocki,J., Gulua,G., Schulze,A., Ye,M., Liu,P., Jin,J., Bader,M., Myohanen,T., Garcia-Horsman,J.A. and Batlle,D.
    Ang II (Angiotensin II) Conversion to angiotensin-(1-7) in the circulation is POP (prolyloligopeptidase)-dependent and ACE2 (angiotensin-converting enzyme 2)-independent
    Hypertension (2020) 75, 173-182. PubMed  Europe PubMed DOI
  26. Shrivastava,A., Srivastava,S., Malik,R., Alam,M.M., Shaqiquzamman,M. and Akhter,M.
    Identification of novel small molecule non-peptidomimetic inhibitor for prolyl oligopeptidase through in silico and in vitro approaches
    J Biomol Struct Dyn (2020) 38, 1292-1305. PubMed  Europe PubMed DOI  I
  27. Sobolova,K., Hrabinova,M., Hepnarova,V., Kucera,T., Kobrlova,T., Benkova,M., Janockova,J., Dolezal,R., Prchal,L., Benek,O., Mezeiova,E., Jun,D., Soukup,O. and Korabecny,J.
    Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
    Eur J Med Chem (2020) 203, 112593-112593. PubMed  Europe PubMed DOI  I
  28. Svarcbahs,R., Jantti,M., Kilpelainen,T., Julku,U.H., Urvas,L., Kivioja,S., Norrbacka,S. and Myohanen,T.T.
    Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A
    Pharmacol Res (2020) 151, 104558-104558. PubMed  Europe PubMed DOI
    29. 2019
  29. Bandyopadhyay,A.K., Islam,R.N.U., Mitra,D., Banerjee,S. and Goswami,A.
    Analysis of salt-bridges in prolyl oligopeptidase from Pyrococcus furiosus and Homo sapiens
    Bioinformation (2019) 15, 214-225. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Bracke,A., Van Elzen,R., Van der Veken,P., Augustyns,K., De Meester,I. and Lambeir,A.M.
    The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma
    Clin Chim Acta (2019) 495, 154-160. PubMed  Europe PubMed DOI  A
  31. Kilpelainen,T.P., Tyni,J.K., Lahtela-Kakkonen,M.K., Etelainen,T.S., Myohanen,T.T. and Wallen,E.A.A.
    Tetrazole as a replacement of the electrophilic group in characteristic prolyl oligopeptidase inhibitors
    ACS Med Chem Lett (2019) 10, 1635-1640. PubMed  Europe PubMed DOI  PMC  EPMC  I
  32. Kumar,R., Parameswaran,S., Bavi,R., Baek,A., Son,M., Rampogu,S., Park,C., Lee,G., Zeb,A., Parate,S., Rana,R.M. and Lee,K.W.
    Investigation of novel chemical scaffolds targeting prolyl oligopeptidase for neurological therapeutics
    J Mol Graph Model (2019) 88, 92-103. PubMed  Europe PubMed DOI  I
  33. Maruyama,Y. and Kimura,A.P.
    A molecular mechanism of mouse placental spongiotrophoblast differentiation regulated by prolyl oligopeptidase
    Zygote (2019) 27, 49-53. PubMed  Europe PubMed DOI  I
  34. Natunen,T.A., Gynther,M., Rostalski,H., Jaako,K. and Jalkanen,A.J.
    Extracellular prolyl oligopeptidase derived from activated microglia is a potential neuroprotection target
    Basic Clin Pharmacol Toxicol (2019) 124, 40-49. PubMed  Europe PubMed DOI  I
  35. Plescia,J., De Cesco,S., Patrascu,M.B., Kurian,J., Di Trani,J., Dufresne,C., Wahba,A.S., Janmamode,N., Mittermaier,A.K. and Moitessier,N.
    Integrated synthetic, biophysical, and computational investigations of covalent inhibitors of prolyl oligopeptidase and fibroblast activation protein alpha
    J Med Chem (2019) 62, 7874-7884. PubMed  Europe PubMed DOI  I
  36. Plescia,J., Dufresne,C., Janmamode,N., Wahba,A.S., Mittermaier,A.K. and Moitessier,N.
    Discovery of covalent prolyl oligopeptidase boronic ester inhibitors
    Eur J Med Chem (2019) , 111783-111783. PubMed  Europe PubMed DOI  I
  37. Svarcbahs,R., Julku,U., Kilpelainen,T., Kyyro,M., Jantti,M. and Myohanen,T.T.
    New tricks of prolyl oligopeptidase inhibitors - a common drug therapy for several neurodegenerative diseases
    Biochem Pharmacol (2019) 161, 113-120. PubMed  Europe PubMed DOI  I
  38. Venditti,M. and Minucci,S.
    Subcellular localization of prolyl endopeptidase during the first wave of rat spermatogenesis and in rat and human sperm
    J Histochem Cytochem (2019) 67, 229-243. PubMed  Europe PubMed DOI
  39. Xu,P., Bao,R., Zhang,Y., Lu,E., Feng,F., Zhang,L., Li,J., Wang,J., Tan,X., Tang,M., Hu,C., Li,G. and Zhang,C.
    Prolyl oligopeptidase regulates progesterone secretion via the ERK signaling pathway in murine luteal cells
    Mol Reprod Dev (2019) 86, 714-726. PubMed  Europe PubMed DOI  I
    40. 2018
  40. Becker,B., Nazir,F.H., Brinkmalm,G., Camporesi,E., Kvartsberg,H., Portelius,E., Bostrom,M., Kalm,M., Hoglund,K., Olsson,M., Zetterberg,H. and Blennow,K.
    Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by calpain-1 and prolyl endopeptidase
    Mol Neurodegener (2018) 13, 47-47. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Di Trani,J.M., De Cesco,S., O'Leary,R., Plescia,J., do Nascimento,C.J., Moitessier,N. and Mittermaier,A.K.
    Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry
    Nat Commun (2018) 9, 893-893. PubMed  Europe PubMed DOI  PMC  EPMC  I
  42. Fu,P., Sun,W., Lai,J., Shen,Y.H. and Zhang,Z.
    Identification of two isoforms of Pop in the domestic silkworm, Bombyx mori: cloning, characterization and expression analysis
    Gene (2018) 667, 101-111. PubMed  Europe PubMed DOI  I
  43. Guardiola,S., Prades,R., Mendieta,L., Brouwer,A.J., Streefkerk,J., Nevola,L., Tarrago,T., Liskamp,R.M.J. and Giralt,E.
    Targeted covalent inhibition of prolyl oligopeptidase (POP): discovery of sulfonylfluoride peptidomimetics
    Cell Chem Biol (2018) 25, 1031-1037. PubMed  Europe PubMed DOI  I
  44. Julku,U.H., Panhelainen,A.E., Tiilikainen,S.E., Svarcbahs,R., Tammimaki,A.E., Piepponen,T.P., Savolainen,M.H. and Myohanen,T.T.
    Prolyl oligopeptidase regulates dopamine transporter phosphorylation in the nigrostriatal pathway of mouse
    Mol Neurobiol (2018) 55, 470-482. PubMed  Europe PubMed DOI
  45. Manzanares,P., Martinez,R., Garrigues,S., Genoves,S., Ramon,D., Marcos,J.F. and Martorell,P.
    Tryptophan-containing dual neuroprotective peptides: prolyl endopeptidase inhibition and Caenorhabditis elegans protection from beta-amyloid peptide toxicity
    Int J Mol Sci (2018) 19 DOI  I
  46. Takahashi,S., Kawano,T., Nakajima,N., Suda,Y., Usukhbayar,N., Kimura,K.I. and Koshino,H.
    Synthesis of polyozellin, a prolyl oligopeptidase inhibitor, and its structural revision
    Bioorg Med Chem Lett (2018) 28, 930-933. PubMed  Europe PubMed DOI  I
  47. Wadhawan,M., Tiwari,S., Sharma,S. and Rathaur,S.
    Identification and characterization of a novel prolyl oligopeptidase in filarial parasite Setaria cervi
    Biochem Biophys Res Commun (2018) 495, 2235-2241. PubMed  Europe PubMed DOI  I
    48. 2017
  48. Babkova,K., Korabecny,J., Soukup,O., Nepovimova,E., Jun,D. and Kuca,K.
    Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors
    Future Med Chem (2017) 9, 1015-1038. PubMed  Europe PubMed DOI  I
  49. Guest,P.C., Krishnamurthy,D. and Rahmoune,H.
    Development of an assay for measuring proprotein-conversion activity on a multiplex magnetic bead-based array platform
    Adv Exp Med Biol (2017) 974, 321-326. PubMed  Europe PubMed DOI  A
  50. Kumar,R., Bavi,R., Jo,M.G., Arulalapperumal,V., Baek,A., Rampogu,S., Kim,M.O. and Lee,K.W.
    New compounds identified through in silico approaches reduce the alpha-synuclein expression by inhibiting prolyl oligopeptidase in vitro
    Sci Rep (2017) 7, 10827-10827. PubMed  Europe PubMed DOI  PMC  EPMC  I
  51. Lim,P.Y., Tan,L.L., Ow,D.S. and Wong,F.T.
    A propeptide toolbox for secretion optimization of Flavobacterium meningosepticum endopeptidase in Lactococcus lactis
    Microb Cell Fact (2017) 16, 221-221. PubMed  Europe PubMed DOI  PMC  EPMC  E
  52. Mannisto,P.T. and Garcia-Horsman,J.A.
    Mechanism of action of prolyl oligopeptidase (PREP) in degenerative brain diseases: has peptidase activity only a modulatory role on the interactions of PREP with proteins?
    Front Aging Neurosci (2017) 9, 27-27. PubMed  Europe PubMed DOI  PMC  EPMC
  53. Prades,R., Munarriz-Cuezva,E., Uriguen,L., Gil-Pisa,I., Gomez,L., Mendieta,L., Royo,S., Giralt,E., Tarrago,T. and Meana,J.J.
    The prolyl oligopeptidase inhibitor IPR19 ameliorates cognitive deficits in mouse models of schizophrenia
    Eur Neuropsychopharmacol (2017) 27, 180-191. PubMed  Europe PubMed DOI  I
  54. Tsirigotaki,A., Elzen,R.V., Veken,P.V., Lambeir,A.M. and Economou,A.
    Dynamics and ligand-induced conformational changes in human prolyl oligopeptidase analyzed by hydrogen/deuterium exchange mass spectrometry
    Sci Rep (2017) 7, 2456-2456. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Van Elzen,R., Schoenmakers,E., Brandt,I., Van der Veken,P. and Lambeir,A.M.
    Ligand-induced conformational changes in prolyl oligopeptidase: a kinetic approach
    Protein Eng Des Sel (2017) 30, 217-224. PubMed  Europe PubMed DOI
  56. Wang,X.D., Jiang,T., Yu,X.W. and Xu,Y.
    Effects of UPR and ERAD pathway on the prolyl endopeptidase production in Pichia pastoris by controlling of nitrogen source
    J Ind Microbiol Biotechnol (2017) 44, 1053-1063. PubMed  Europe PubMed DOI  E
  57. Zhou,D., Wang,J., He,L.N., Li,B.H., Ding,Y.N., Chen,Y.W. and Fan,J.G.
    Prolyl oligopeptidase attenuates hepatic stellate cell activation through induction of Smad7 and PPAR-gamma
    Exp Ther Med (2017) 13, 780-786. PubMed  Europe PubMed DOI  PMC  EPMC  I
    58. 2016
  58. Hayes,M., Moen,L.F., Auty,M.A. and Lea,T.E.
    Transport of a prolyl endopeptidase inhibitory peptide across the blood-brain barrier demonstrated using the hCMEC/D3 cell line transcytosis assay
    J Agric Food Chem (2016) 64, 146-150. PubMed  Europe PubMed DOI  I
  59. Hofling,C., Kulesskaya,N., Jaako,K., Peltonen,I., Mannisto,P.T., Nurmi,A., Vartiainen,N., Morawski,M., Zharkovsky,A., Voikar,V., Rossner,S. and Garcia-Horsman,J.A.
    Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume
    Eur Neuropsychopharmacol (2016) 26, 1048-1061. PubMed  Europe PubMed DOI  K
  60. Jaako,K., Waniek,A., Parik,K., Klimaviciusa,L., Aonurm-Helm,A., Noortoots,A., Anier,K., Van Elzen,R., Gerard,M., Lambeir,A.M., Rossner,S., Morawski,M. and Zharkovsky,A.
    Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro
    J Cell Sci (2016) 129, 3792-3802. PubMed  Europe PubMed DOI
  61. Kumar,N., Nakagawa,P., Janic,B., Romero,C.A., Worou,M.E., Monu,S.R., Peterson,E.L., Shaw,J., Valeriote,F., Ongeri,E.M., Niyitegeka,J.M., Rhaleb,N.E. and Carretero,O.A.
    The anti-inflammatory peptide Ac-SDKP is released from thymosin-beta4 by renal meprin-alpha and prolyl oligopeptidase
    Am J Physiol Renal Physiol (2016) 310, F1026-F1034. PubMed  Europe PubMed DOI
  62. Lopez,A., Vilaseca,M., Madurga,S., Varese,M., Tarrago,T. and Giralt,E.
    Analyzing slowly exchanging protein conformations by ion mobility mass spectrometry: study of the dynamic equilibrium of prolyl oligopeptidase
    J Mass Spectrom (2016) 51, 504-511. PubMed  Europe PubMed DOI
  63. Mariaule,G., De Cesco,S., Airaghi,F., Kurian,J., Schiavini,P., Rocheleau,S., Huskic,I., Auclair,K., Mittermaier,A. and Moitessier,N.
    3-Oxo-hexahydro-1H-isoindole-4-carboxylic acid as a drug chiral bicyclic scaffold: structure-based design and preparation of conformationally constrained covalent and noncovalent prolyl oligopeptidase inhibitors
    J Med Chem (2016) 59, 4221-4234. PubMed  Europe PubMed DOI  I
  64. Saidi,M., Kamali,S. and Beaudry,F.
    Characterization of substance P processing in mouse spinal cord S9 fractions using high-resolution quadrupole-orbitrap mass spectrometry
    Neuropeptides (2016) 59, 47-55. PubMed  Europe PubMed DOI
  65. Svarcbahs,R., Julku,U.H. and Myohanen,T.T.
    Inhibition of prolyl oligopeptidase restores spontaneous motor behavior in the alpha-synuclein virus vector-based Parkinson's disease mouse model by decreasing alpha-synuclein oligomeric species in mouse brain
    J Neurosci (2016) 36, 12485-12497. PubMed  Europe PubMed DOI  I
    66. 2015
  66. Cahlikova,L., Hulova,L., Hrabinova,M., Chlebek,J., Hostalkova,A., Adamcova,M., Safratova,M., Jun,D., Opletal,L., Locarek,M. and Macakova,K.
    Isoquinoline alkaloids as prolyl oligopeptidase inhibitors
    Fitoterapia (2015) 103, 192-196. PubMed  Europe PubMed DOI  I
  67. Fajtova,P., Stefanic,S., Hradilek,M., Dvorak,J., Vondrasek,J., Jilkova,A., Ulrychova,L., McKerrow,J.H., Caffrey,C.R., Mares,M. and Horn,M.
    Prolyl oligopeptidase from the blood fluke Schistosoma mansoni: from functional analysis to anti-schistosomal inhibitors
    PLoS Negl Trop Dis (2015) 9, e0003827-e0003827. PubMed  Europe PubMed DOI  PMC  EPMC
  68. Hellinger,R., Koehbach,J., Puigpinos,A., Clark,R.J., Tarrago,T., Giralt,E. and Gruber,C.W.
    Inhibition of human prolyl oligopeptidase activity by the cyclotide psysol 2 isolated from Psychotria solitudinum
    J Nat Prod (2015) 78, 1073-1082. PubMed  Europe PubMed DOI  I
  69. Ikuma,Y., Hochigai,H., Kimura,H., Nunami,N., Kobayashi,T., Uchiyama,K., Umezome,T., Sakurai,Y., Sawada,N., Tadano,J., Sugaru,E., Ono,M., Hirose,Y. and Nakahira,H.
    Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors: use of a carboxylate prodrug to improve bioavailability
    Bioorg Med Chem (2015) 23, 779-790. PubMed  Europe PubMed DOI  I
  70. Jackson,K.W., Christiansen,V.J., Yadav,V.R., Silasi-Mansat,R., Lupu,F., Awasthi,V., Zhang,R.R. and McKee,P.A.
    Suppression of tumor growth in mice by rationally designed pseudopeptide inhibitors of fibroblast activation protein and prolyl oligopeptidase
    Neoplasia (2015) 17, 43-54. PubMed  Europe PubMed DOI  PMC  EPMC  I
  71. Kotev,M., Lecina,D., Tarrago,T., Giralt,E. and Guallar,V.
    Unveiling prolyl oligopeptidase ligand migration by comprehensive computational techniques
    Biophys J (2015) 108, 116-125. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  72. Savolainen,M.H., Yan,X., Myohanen,T.T. and Huttunen,H.J.
    Prolyl oligopeptidase enhances alpha-synuclein dimerization via direct protein-protein interaction
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