Literature for peptidase S09.001: prolyl oligopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Kaiser-Graf,D., Domenig,O., Poglitsch,M., Kreutz,R. and Bolbrinker,J. Upregulation of angiotensin-(1-7) formation in human podocytes - enzyme activity assay upon fluid flow shear stress PLoS ONE (2026) 21, e0339874-e0339874. PubMed Europe PubMed DOI PMC EPMC

2025

Jia,K., Cheng,B., Huang,L., Xu,J., Liu,F., Liao,X., Liao,K. and Lu,H. Activation of prep expression by Tet2 promotes the proliferation of bipotential progenitor cells during liver regeneration Development (2025) PubMed Europe PubMed DOI
Peng,H., Guo,Z., Wang,W.L., Yin,D., Zou,S., Asbell,T., Ullman,B.R., Thakar,M., Zhang,F., Hong,S.Y., Rao,A.V.S., Wang,K., Zhang,S., Wu,Z., Li,X., Margolis,S.S., Matsui,W.H., Gocke,C.B., Mao,Y. and Liu,J.O. Rapaprotin is Activated by an Endopeptidase to Disassemble 26S Proteasome bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC
Van Elzen,R., Waumans,Y., Nath,S., Van der Veken,P., Kerckhoff,S., Van Dijk,E., Morawski,M., Rossner,S., Engelborghs,Y., De Meester,I. and Lambeir,A.M. The prolyl oligopeptidase and alpha-synuclein connection revisited Biochimie (2025) PubMed Europe PubMed DOI

2024

Briot,J., Pons,C., Foucher,A., Goudouneche,D., Gaudenzio,N., Donovan,M., Bernard,D., Mechin,M.C. and Simon,M. Prolyl Endopeptidase PREP Is Involved in Filaggrinolysis and Cornification J Invest Dermatol (2024) 145, 98-108. PubMed Europe PubMed DOI
Walczewska-Szewc,K. and Rydzewski,J. Structural visualization of inhibitor binding in prolyl oligopeptidase Biophys Rev (Melville) (2024) 5, 032105-032105. PubMed Europe PubMed DOI PMC EPMC

2023

Kilpelainen,T.P., Patsi,H.T., Svarcbahs,R., Julku,U.H., Etelainen,T.S., Cui,H., Auno,S., Sipari,N., Norrbacka,S., Leino,T.O., Jantti,M., Myohanen,T.T. and Wallen,E.A.A. Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease J Med Chem (2023) 66, 7475-7496. PubMed Europe PubMed DOI PMC EPMC

2022

Baharin,A., Ting,T.Y. and Goh,H.H. Post-Proline Cleaving Enzymes (PPCEs): Classification, Structure, Molecular Properties, and Applications Plants (Basel) (2022) 11 PubMed Europe PubMed DOI PMC EPMC V
Plescia,J., Hedou,D., Pousse,M.E., Labarre,A., Dufresne,C., Mittermaier,A. and Moitessier,N. Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-alpha for different indications Eur J Med Chem (2022) 240, 114543-114543. PubMed Europe PubMed DOI

2021

Cui,H., Norrbacka,S. and Myohanen,T.T. Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy Biochem Pharmacol (2021) 197, 114899-114899. PubMed Europe PubMed DOI K
Julku,U.H., Jantti,M., Svarcbahs,R. and Myohanen,T.T. Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC
Kulkarni,A.M., Rampogu,S. and Lee,K.W. Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase Evid Based Complement Alternat Med (2021) 2021, 6687572-6687572. PubMed Europe PubMed DOI PMC EPMC
Patsi,H.T., Kilpelainen,T.P., Auno,S., Dillemuth,P.M.J., Arja,K., Lahtela-Kakkonen,M.K., Myohanen,T.T. and Wallen,E.A.A. 2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors ACS Med Chem Lett (2021) 12, 1578-1584. PubMed Europe PubMed DOI PMC EPMC
Payne,G.A., Sharma,N.S., Lal,C.V., Song,C., Guo,L., Margaroli,C., Viera,L., Kumar,S., Li,J., Bosley,M., Xing,D., Xu,X., Wells,J.M., George,J.F., Tallaj,J.A., Leesar,M., Blalock,J.E. and Gaggar,A. Prolyl Endopeptidase contributes to early neutrophilic inflammation in acute cardiac transplant rejection JCI Insight (2021) PubMed Europe PubMed DOI
Simkova,A., Ormsby,T., Sidej,N., Slavetinska,L.P., Brynda,J., Beranova,J., Sacha,P., Majer,P. and Konvalinka,J. Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with alpha-ketoamide warheads Eur J Med Chem (2021) 224, 113717-113717. PubMed Europe PubMed DOI I
Triposkiadis,F., Starling,R.C., Xanthopoulos,A., Butler,J. and Boudoulas,H. Renin-angiotensin-system inhibition in the context of corona virus disease-19: experimental evidence, observational studies, and clinical implications Heart Fail Rev (2021) 26, 381-389. PubMed Europe PubMed DOI PMC EPMC
Zolotov,N.N., Schepetkin,I.A., Voronina,T.A., Pozdnev,V.F., Khlebnikov,A.I., Krylova,I.V. and Quinn,M.T. Therapeutic Effect of Novel Cyanopyrrolidine-Based Prolyl Oligopeptidase Inhibitors in Rat Models of Amnesia Front Chem (2021) 9, 780958-780958. PubMed Europe PubMed DOI PMC EPMC I

2020

Da'adoosh,B., Kaito,K., Miyashita,K., Sakaguchi,M. and Goldblum,A. Computational design of substrate selective inhibition PLoS Comput Biol (2020) 16, e1007713-e1007713. PubMed Europe PubMed DOI
Dunaevsky,Y.E., Tereshchenkova,V.F., Oppert,B., Belozersky,M.A., Filippova,I.Y. and Elpidina,E.N. Human proline specific peptidases: a comprehensive analysis Biochim Biophys Acta Gen Subj (2020) 1864, 129636-129636. PubMed Europe PubMed DOI V
He,Z., Long,P., Fang,F., Li,S., Zhang,P. and Chen,Z. Diversity of MSDIN family members in amanitin-producing mushrooms and the phylogeny of the MSDIN and prolyl oligopeptidase genes BMC Genomics (2020) 21, 440-440. PubMed Europe PubMed DOI PMC EPMC
Jiang,D.X., Zhang,J.B., Li,M.T., Lin,S.Z., Wang,Y.Q., Chen,Y.W. and Fan,J.G. Prolyl endopeptidase gene disruption attenuates high fat diet-induced nonalcoholic fatty liver disease in mice by improving hepatic steatosis and inflammation Ann Transl Med (2020) 8, 218-218. PubMed Europe PubMed DOI PMC EPMC K
Kilpelainen,T.P., Hellinen,L., Vrijdag,J., Yan,X., Svarcbahs,R., Vellonen,K.S., Lambeir,A.M., Huttunen,H., Urtti,A., Wallen,E.A.A. and Myohanen,T.T. The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy Biomed Pharmacother (2020) 128, 110253-110253. PubMed Europe PubMed DOI I
Retzl,B., Hellinger,R., Muratspahic,E., Pinto,M.E.F., Bolzani,V.S. and Gruber,C.W. Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides J Nat Prod (2020) PubMed Europe PubMed DOI
Rostami,J., Jantti,M., Cui,H., Rinne,M.K., Kukkonen,J.P., Falk,A., Erlandsson,A. and Myohanen,T. Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells Biomed Pharmacother (2020) 131, 110788-110788. PubMed Europe PubMed DOI I
Serfozo,P., Wysocki,J., Gulua,G., Schulze,A., Ye,M., Liu,P., Jin,J., Bader,M., Myohanen,T., Garcia-Horsman,J.A. and Batlle,D. Ang II (Angiotensin II) Conversion to angiotensin-(1-7) in the circulation is POP (prolyloligopeptidase)-dependent and ACE2 (angiotensin-converting enzyme 2)-independent Hypertension (2020) 75, 173-182. PubMed Europe PubMed DOI
Shrivastava,A., Srivastava,S., Malik,R., Alam,M.M., Shaqiquzamman,M. and Akhter,M. Identification of novel small molecule non-peptidomimetic inhibitor for prolyl oligopeptidase through in silico and in vitro approaches J Biomol Struct Dyn (2020) 38, 1292-1305. PubMed Europe PubMed DOI I
Sobolova,K., Hrabinova,M., Hepnarova,V., Kucera,T., Kobrlova,T., Benkova,M., Janockova,J., Dolezal,R., Prchal,L., Benek,O., Mezeiova,E., Jun,D., Soukup,O. and Korabecny,J. Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile Eur J Med Chem (2020) 203, 112593-112593. PubMed Europe PubMed DOI I
Svarcbahs,R., Jantti,M., Kilpelainen,T., Julku,U.H., Urvas,L., Kivioja,S., Norrbacka,S. and Myohanen,T.T. Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A Pharmacol Res (2020) 151, 104558-104558. PubMed Europe PubMed DOI

2019

Bandyopadhyay,A.K., Islam,R.N.U., Mitra,D., Banerjee,S. and Goswami,A. Analysis of salt-bridges in prolyl oligopeptidase from Pyrococcus furiosus and Homo sapiens Bioinformation (2019) 15, 214-225. PubMed Europe PubMed DOI PMC EPMC
Bracke,A., Van Elzen,R., Van der Veken,P., Augustyns,K., De Meester,I. and Lambeir,A.M. The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma Clin Chim Acta (2019) 495, 154-160. PubMed Europe PubMed DOI A
Kilpelainen,T.P., Tyni,J.K., Lahtela-Kakkonen,M.K., Etelainen,T.S., Myohanen,T.T. and Wallen,E.A.A. Tetrazole as a replacement of the electrophilic group in characteristic prolyl oligopeptidase inhibitors ACS Med Chem Lett (2019) 10, 1635-1640. PubMed Europe PubMed DOI PMC EPMC I
Kumar,R., Parameswaran,S., Bavi,R., Baek,A., Son,M., Rampogu,S., Park,C., Lee,G., Zeb,A., Parate,S., Rana,R.M. and Lee,K.W. Investigation of novel chemical scaffolds targeting prolyl oligopeptidase for neurological therapeutics J Mol Graph Model (2019) 88, 92-103. PubMed Europe PubMed DOI I
Maruyama,Y. and Kimura,A.P. A molecular mechanism of mouse placental spongiotrophoblast differentiation regulated by prolyl oligopeptidase Zygote (2019) 27, 49-53. PubMed Europe PubMed DOI I
Natunen,T.A., Gynther,M., Rostalski,H., Jaako,K. and Jalkanen,A.J. Extracellular prolyl oligopeptidase derived from activated microglia is a potential neuroprotection target Basic Clin Pharmacol Toxicol (2019) 124, 40-49. PubMed Europe PubMed DOI I
Plescia,J., De Cesco,S., Patrascu,M.B., Kurian,J., Di Trani,J., Dufresne,C., Wahba,A.S., Janmamode,N., Mittermaier,A.K. and Moitessier,N. Integrated synthetic, biophysical, and computational investigations of covalent inhibitors of prolyl oligopeptidase and fibroblast activation protein alpha J Med Chem (2019) 62, 7874-7884. PubMed Europe PubMed DOI I
Plescia,J., Dufresne,C., Janmamode,N., Wahba,A.S., Mittermaier,A.K. and Moitessier,N. Discovery of covalent prolyl oligopeptidase boronic ester inhibitors Eur J Med Chem (2019) , 111783-111783. PubMed Europe PubMed DOI I
Svarcbahs,R., Julku,U., Kilpelainen,T., Kyyro,M., Jantti,M. and Myohanen,T.T. New tricks of prolyl oligopeptidase inhibitors - a common drug therapy for several neurodegenerative diseases Biochem Pharmacol (2019) 161, 113-120. PubMed Europe PubMed DOI I
Venditti,M. and Minucci,S. Subcellular localization of prolyl endopeptidase during the first wave of rat spermatogenesis and in rat and human sperm J Histochem Cytochem (2019) 67, 229-243. PubMed Europe PubMed DOI
Xu,P., Bao,R., Zhang,Y., Lu,E., Feng,F., Zhang,L., Li,J., Wang,J., Tan,X., Tang,M., Hu,C., Li,G. and Zhang,C. Prolyl oligopeptidase regulates progesterone secretion via the ERK signaling pathway in murine luteal cells Mol Reprod Dev (2019) 86, 714-726. PubMed Europe PubMed DOI I

2018

Becker,B., Nazir,F.H., Brinkmalm,G., Camporesi,E., Kvartsberg,H., Portelius,E., Bostrom,M., Kalm,M., Hoglund,K., Olsson,M., Zetterberg,H. and Blennow,K. Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by calpain-1 and prolyl endopeptidase Mol Neurodegener (2018) 13, 47-47. PubMed Europe PubMed DOI PMC EPMC
Di Trani,J.M., De Cesco,S., O'Leary,R., Plescia,J., do Nascimento,C.J., Moitessier,N. and Mittermaier,A.K. Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry Nat Commun (2018) 9, 893-893. PubMed Europe PubMed DOI PMC EPMC I
Fu,P., Sun,W., Lai,J., Shen,Y.H. and Zhang,Z. Identification of two isoforms of Pop in the domestic silkworm, Bombyx mori: cloning, characterization and expression analysis Gene (2018) 667, 101-111. PubMed Europe PubMed DOI I
Guardiola,S., Prades,R., Mendieta,L., Brouwer,A.J., Streefkerk,J., Nevola,L., Tarrago,T., Liskamp,R.M.J. and Giralt,E. Targeted covalent inhibition of prolyl oligopeptidase (POP): discovery of sulfonylfluoride peptidomimetics Cell Chem Biol (2018) 25, 1031-1037. PubMed Europe PubMed DOI I
Julku,U.H., Panhelainen,A.E., Tiilikainen,S.E., Svarcbahs,R., Tammimaki,A.E., Piepponen,T.P., Savolainen,M.H. and Myohanen,T.T. Prolyl oligopeptidase regulates dopamine transporter phosphorylation in the nigrostriatal pathway of mouse Mol Neurobiol (2018) 55, 470-482. PubMed Europe PubMed DOI
Manzanares,P., Martinez,R., Garrigues,S., Genoves,S., Ramon,D., Marcos,J.F. and Martorell,P. Tryptophan-containing dual neuroprotective peptides: prolyl endopeptidase inhibition and Caenorhabditis elegans protection from beta-amyloid peptide toxicity Int J Mol Sci (2018) 19 DOI I
Takahashi,S., Kawano,T., Nakajima,N., Suda,Y., Usukhbayar,N., Kimura,K.I. and Koshino,H. Synthesis of polyozellin, a prolyl oligopeptidase inhibitor, and its structural revision Bioorg Med Chem Lett (2018) 28, 930-933. PubMed Europe PubMed DOI I
Wadhawan,M., Tiwari,S., Sharma,S. and Rathaur,S. Identification and characterization of a novel prolyl oligopeptidase in filarial parasite Setaria cervi Biochem Biophys Res Commun (2018) 495, 2235-2241. PubMed Europe PubMed DOI I

2017

Babkova,K., Korabecny,J., Soukup,O., Nepovimova,E., Jun,D. and Kuca,K. Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors Future Med Chem (2017) 9, 1015-1038. PubMed Europe PubMed DOI I
Guest,P.C., Krishnamurthy,D. and Rahmoune,H. Development of an assay for measuring proprotein-conversion activity on a multiplex magnetic bead-based array platform Adv Exp Med Biol (2017) 974, 321-326. PubMed Europe PubMed DOI A
Kumar,R., Bavi,R., Jo,M.G., Arulalapperumal,V., Baek,A., Rampogu,S., Kim,M.O. and Lee,K.W. New compounds identified through in silico approaches reduce the alpha-synuclein expression by inhibiting prolyl oligopeptidase in vitro Sci Rep (2017) 7, 10827-10827. PubMed Europe PubMed DOI PMC EPMC I
Lim,P.Y., Tan,L.L., Ow,D.S. and Wong,F.T. A propeptide toolbox for secretion optimization of Flavobacterium meningosepticum endopeptidase in Lactococcus lactis Microb Cell Fact (2017) 16, 221-221. PubMed Europe PubMed DOI PMC EPMC E
Mannisto,P.T. and Garcia-Horsman,J.A. Mechanism of action of prolyl oligopeptidase (PREP) in degenerative brain diseases: has peptidase activity only a modulatory role on the interactions of PREP with proteins? Front Aging Neurosci (2017) 9, 27-27. PubMed Europe PubMed DOI PMC EPMC
Prades,R., Munarriz-Cuezva,E., Uriguen,L., Gil-Pisa,I., Gomez,L., Mendieta,L., Royo,S., Giralt,E., Tarrago,T. and Meana,J.J. The prolyl oligopeptidase inhibitor IPR19 ameliorates cognitive deficits in mouse models of schizophrenia Eur Neuropsychopharmacol (2017) 27, 180-191. PubMed Europe PubMed DOI I
Tsirigotaki,A., Elzen,R.V., Veken,P.V., Lambeir,A.M. and Economou,A. Dynamics and ligand-induced conformational changes in human prolyl oligopeptidase analyzed by hydrogen/deuterium exchange mass spectrometry Sci Rep (2017) 7, 2456-2456. PubMed Europe PubMed DOI PMC EPMC
Van Elzen,R., Schoenmakers,E., Brandt,I., Van der Veken,P. and Lambeir,A.M. Ligand-induced conformational changes in prolyl oligopeptidase: a kinetic approach Protein Eng Des Sel (2017) 30, 217-224. PubMed Europe PubMed DOI
Wang,X.D., Jiang,T., Yu,X.W. and Xu,Y. Effects of UPR and ERAD pathway on the prolyl endopeptidase production in Pichia pastoris by controlling of nitrogen source J Ind Microbiol Biotechnol (2017) 44, 1053-1063. PubMed Europe PubMed DOI E
Zhou,D., Wang,J., He,L.N., Li,B.H., Ding,Y.N., Chen,Y.W. and Fan,J.G. Prolyl oligopeptidase attenuates hepatic stellate cell activation through induction of Smad7 and PPAR-gamma Exp Ther Med (2017) 13, 780-786. PubMed Europe PubMed DOI PMC EPMC I

2016

Hayes,M., Moen,L.F., Auty,M.A. and Lea,T.E. Transport of a prolyl endopeptidase inhibitory peptide across the blood-brain barrier demonstrated using the hCMEC/D3 cell line transcytosis assay J Agric Food Chem (2016) 64, 146-150. PubMed Europe PubMed DOI I
Hofling,C., Kulesskaya,N., Jaako,K., Peltonen,I., Mannisto,P.T., Nurmi,A., Vartiainen,N., Morawski,M., Zharkovsky,A., Voikar,V., Rossner,S. and Garcia-Horsman,J.A. Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume Eur Neuropsychopharmacol (2016) 26, 1048-1061. PubMed Europe PubMed DOI K
Jaako,K., Waniek,A., Parik,K., Klimaviciusa,L., Aonurm-Helm,A., Noortoots,A., Anier,K., Van Elzen,R., Gerard,M., Lambeir,A.M., Rossner,S., Morawski,M. and Zharkovsky,A. Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro J Cell Sci (2016) 129, 3792-3802. PubMed Europe PubMed DOI
Kumar,N., Nakagawa,P., Janic,B., Romero,C.A., Worou,M.E., Monu,S.R., Peterson,E.L., Shaw,J., Valeriote,F., Ongeri,E.M., Niyitegeka,J.M., Rhaleb,N.E. and Carretero,O.A. The anti-inflammatory peptide Ac-SDKP is released from thymosin-beta4 by renal meprin-alpha and prolyl oligopeptidase Am J Physiol Renal Physiol (2016) 310, F1026-F1034. PubMed Europe PubMed DOI
Lopez,A., Vilaseca,M., Madurga,S., Varese,M., Tarrago,T. and Giralt,E. Analyzing slowly exchanging protein conformations by ion mobility mass spectrometry: study of the dynamic equilibrium of prolyl oligopeptidase J Mass Spectrom (2016) 51, 504-511. PubMed Europe PubMed DOI
Mariaule,G., De Cesco,S., Airaghi,F., Kurian,J., Schiavini,P., Rocheleau,S., Huskic,I., Auclair,K., Mittermaier,A. and Moitessier,N. 3-Oxo-hexahydro-1H-isoindole-4-carboxylic acid as a drug chiral bicyclic scaffold: structure-based design and preparation of conformationally constrained covalent and noncovalent prolyl oligopeptidase inhibitors J Med Chem (2016) 59, 4221-4234. PubMed Europe PubMed DOI I
Saidi,M., Kamali,S. and Beaudry,F. Characterization of substance P processing in mouse spinal cord S9 fractions using high-resolution quadrupole-orbitrap mass spectrometry Neuropeptides (2016) 59, 47-55. PubMed Europe PubMed DOI
Svarcbahs,R., Julku,U.H. and Myohanen,T.T. Inhibition of prolyl oligopeptidase restores spontaneous motor behavior in the alpha-synuclein virus vector-based Parkinson's disease mouse model by decreasing alpha-synuclein oligomeric species in mouse brain J Neurosci (2016) 36, 12485-12497. PubMed Europe PubMed DOI I

2015

Cahlikova,L., Hulova,L., Hrabinova,M., Chlebek,J., Hostalkova,A., Adamcova,M., Safratova,M., Jun,D., Opletal,L., Locarek,M. and Macakova,K. Isoquinoline alkaloids as prolyl oligopeptidase inhibitors Fitoterapia (2015) 103, 192-196. PubMed Europe PubMed DOI I
Fajtova,P., Stefanic,S., Hradilek,M., Dvorak,J., Vondrasek,J., Jilkova,A., Ulrychova,L., McKerrow,J.H., Caffrey,C.R., Mares,M. and Horn,M. Prolyl oligopeptidase from the blood fluke Schistosoma mansoni: from functional analysis to anti-schistosomal inhibitors PLoS Negl Trop Dis (2015) 9, e0003827-e0003827. PubMed Europe PubMed DOI PMC EPMC
Hellinger,R., Koehbach,J., Puigpinos,A., Clark,R.J., Tarrago,T., Giralt,E. and Gruber,C.W. Inhibition of human prolyl oligopeptidase activity by the cyclotide psysol 2 isolated from Psychotria solitudinum J Nat Prod (2015) 78, 1073-1082. PubMed Europe PubMed DOI I
Ikuma,Y., Hochigai,H., Kimura,H., Nunami,N., Kobayashi,T., Uchiyama,K., Umezome,T., Sakurai,Y., Sawada,N., Tadano,J., Sugaru,E., Ono,M., Hirose,Y. and Nakahira,H. Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors: use of a carboxylate prodrug to improve bioavailability Bioorg Med Chem (2015) 23, 779-790. PubMed Europe PubMed DOI I
Jackson,K.W., Christiansen,V.J., Yadav,V.R., Silasi-Mansat,R., Lupu,F., Awasthi,V., Zhang,R.R. and McKee,P.A. Suppression of tumor growth in mice by rationally designed pseudopeptide inhibitors of fibroblast activation protein and prolyl oligopeptidase Neoplasia (2015) 17, 43-54. PubMed Europe PubMed DOI PMC EPMC I
Kotev,M., Lecina,D., Tarrago,T., Giralt,E. and Guallar,V. Unveiling prolyl oligopeptidase ligand migration by comprehensive computational techniques Biophys J (2015) 108, 116-125. PubMed Europe PubMed DOI PMC EPMC S I
Savolainen,M.H., Yan,X., Myohanen,T.T. and Huttunen,H.J. Prolyl oligopeptidase enhances alpha-synuclein dimerization via direct protein-protein interaction J Biol Chem (2015) 290, 5117-5126. PubMed Europe PubMed DOI I
Schiavini,P., Pottel,J., Moitessier,N. and Auclair,K. Metabolic instability of cyanothiazolidine-based prolyl oligopeptidase inhibitors: a structural assignment challenge and potential medicinal chemistry implications ChemMedChem (2015) 10, 1174-1183. PubMed Europe PubMed DOI I

2014

Abdul Roda,M., Sadik,M., Gaggar,A., Hardison,M.T., Jablonsky,M.J., Braber,S., Blalock,J.E., Redegeld,F.A., Folkerts,G. and Jackson,P.L. Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation PLoS ONE (2014) 9, e97594-e97594. PubMed Europe PubMed DOI PMC EPMC I
Dokleja,L., Hannula,M.J. and Myohanen,T.T. Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers Neurosci Lett (2014) 583, 37-42. PubMed Europe PubMed DOI I
Jalkanen,A.J., Leikas,J.V. and Forsberg,M.M. KYP-2047 Penetrates mouse brain and effectively inhibits mouse prolyl oligopeptidase Basic Clin Pharmacol Toxicol (2014) 114, 460-463. PubMed Europe PubMed DOI I
Kallinen,A., Todorov,B., Kallionpaa,R., Back,S., Sarparanta,M., Raki,M., Garcia-Horsman,J.A., Bergstrom,K.A., Wallen,E.A., Mannisto,P.T. and Airaksinen,A.J. Synthesis and biological evaluation of novel (123)I-labeled 4-(4-iodophenyl)butanoyl-l-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo Eur J Med Chem (2014) 79, 436-445. PubMed Europe PubMed DOI L I
Kaushik,S., Etchebest,C. and Sowdhamini,R. Decoding the structural events in substrate-gating mechanism of eukaryotic prolyl oligopeptidase using normal mode analysis and molecular dynamics simulations Proteins (2014) 82, 1428-1443. PubMed Europe PubMed DOI
Kim,J.D., Toda,C., D'Agostino,G., Zeiss,C.J., DiLeone,R.J., Elsworth,J.D., Kibbey,R.G., Chan,O., Harvey,B.K., Richie,C.T., Savolainen,M., Myohannen,T., Jeong,J.K. and Diano,S. Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice Proc Natl Acad Sci U S A (2014) 111, 11876-11881. PubMed Europe PubMed DOI K I
Safratova,M., Novak,Z., Kulhankova,A., Kunes,J., Hrabinova,M., Jun,D., Macakova,K., Opletal,L. and Cahlikova,L. Revised NMR data for 9-O-demethylgalanthine: an alkaloid from Zephyranthes robusta (Amaryllidaceae) and its biological activity Nat Prod Commun (2014) 9, 787-788. PubMed Europe PubMed I
Savolainen,M.H., Richie,C.T., Harvey,B.K., Mannisto,P.T., Maguire-Zeiss,K.A. and Myohanen,T.T. The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse Neurobiol Dis (2014) 68, 1-15. PubMed Europe PubMed DOI I
Suzuki,K., Sakaguchi,M., Tanaka,S., Yoshimoto,T. and Takaoka,M. Prolyl oligopeptidase inhibition-induced growth arrest of human gastric cancer cells Biochem Biophys Res Commun (2014) 443, 91-96. PubMed Europe PubMed DOI K I
Takahashi,S., Yoshida,A., Uesugi,S., Hongo,Y., Kimura,K., Matsuoka,K. and Koshino,H. Structural revision of kynapcin-12 by total synthesis, and inhibitory activities against prolyl oligopeptidase and cancer cells Bioorg Med Chem Lett (2014) 24, 3373-3376. PubMed Europe PubMed DOI I

2013

Adolpho,L.O., Marin,D., Puigpinos,A., Mendieta,L., Tarrago,T., Morel,A.F., Giralt,E. and Dalcol,I.I. In vitro evaluation of caffeoyl and cinnamoyl derivatives as potential prolyl oligopeptidase inhibitors Planta Med (2013) 79, 1531-1535. PubMed Europe PubMed DOI I
Albrecht,A., Rahmoune,H., Leedjarv,K., Knorpp,T., Joos,T., Stocki,P., Guest,P.C. and Bahn,S. Development of a novel assay for proprotein converting enzyme activity on a multiplex bead-based array system Proteomics (2013) 13, 2976-2979. PubMed Europe PubMed DOI A
Christiansen,V.J., Jackson,K.W., Lee,K.N., Downs,T.D. and McKee,P.A. Targeting inhibition of fibroblast activation protein-alpha and prolyl oligopeptidase activities on cells common to metastatic tumor microenvironments Neoplasia (2013) 15, 348-358. PubMed Europe PubMed PMC EPMC P
D'Agostino,G., Kim,J.D., Liu,Z.W., Jeong,J.K., Suyama,S., Calignano,A., Gao,X.B., Schwartz,M. and Diano,S. Prolyl endopeptidase-deficient mice have reduced synaptic spine density in the CA1 region of the hippocampus, impaired LTP, and spatial learning and memory Cereb Cortex (2013) 23, 2007-2014. PubMed Europe PubMed DOI K
Lopez,A., Mendieta,L., Prades,R., Royo,S., Tarrago,T. and Giralt,E. Peptide POP inhibitors for the treatment of the cognitive symptoms of schizophrenia Future Med Chem (2013) 5, 1509-1523. PubMed Europe PubMed DOI T
Matsubara,S., Maruyama,Y. and Kimura,A.P. A 914-bp promoter is sufficient to reproduce the endogenous prolyl oligopeptidase gene localization in the mouse placenta if not subject to position effect Gene (2013) 524, 114-123. PubMed Europe PubMed DOI
Matsuda,T., Sakaguchi,M., Tanaka,S., Yoshimoto,T. and Takaoka,M. Prolyl oligopeptidase is a glyceraldehyde-3-phosphate dehydrogenase-binding protein that regulates genotoxic stress-induced cell death Int J Biochem Cell Biol (2013) 45, 850-857. PubMed Europe PubMed DOI I
Rentzsch,A., Kahlert,V., Jahreis,G., Schlott,B., Schutkowski,M., Malesevic,M. and Fischer,G. Identification of prolyl oligopeptidase as a cyclosporine-sensitive protease by screening of mouse liver extracts Biol Chem (2013) 394, 1057-1067. PubMed Europe PubMed DOI I
Szeltner,Z., Juhasz,T., Szamosi,I., Rea,D., Fulop,V., Modos,K., Juliano,L. and Polgar,L. The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity Biochim Biophys Acta (2013) 1834, 98-111. PubMed Europe PubMed DOI

2012

De Cesco,S., Deslandes,S., Therrien,E., Levan,D., Cueto,M., Schmidt,R., Cantin,L.D., Mittermaier,A., Juillerat-Jeanneret,L. and Moitessier,N. Virtual screening and computational optimization for the discovery of covalent prolyl oligopeptidase inhibitors with activity in human cells J Med Chem (2012) 55, 6306-6315. PubMed Europe PubMed DOI I
Filho,A.G., Morel,A.F., Adolpho,L., Ilha,V., Giralt,E., Tarrago,T. and Dalcol,I.I. Inhibitory effect of verbascoside isolated from Buddleja brasiliensis Jacq. ex Spreng on prolyl oligopeptidase activity Phytother Res (2012) 26, 1472-1475. PubMed Europe PubMed DOI I
Ito,K., Nakajima,Y. and Yoshimoto,T. Prolyl oligopeptidase [ISSN:978-0-12-407742-3] (2012) 3, 3360-3364. DOI
Jambunathan,K., Watson,D.S., Endsley,A.N., Kodukula,K. and Galande,A.K. Comparative analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein alpha FEBS Lett (2012) 586, 2507-2512. PubMed Europe PubMed DOI P
Kaszuba,K., Rog,T., Danne,R., Canning,P., Fulop,V., Juhasz,T., Szeltner,Z., St Pierre,J.F., Garcia-Horsman,A., Mannisto,P.T., Karttunen,M., Hokkanen,J. and Bunker,A. Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase Biochimie (2012) 94, 1398-1411. PubMed Europe PubMed DOI
Khlebnikova,N.N., Krupina,N.A., Kushnareva,E.Yu., Zolotov,N.N. and Kryzhanovskii,G.N. Effect of imipramine and prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine on activity of proline-specific peptidases in the brain of rats with experimental anxious-depressive syndrome Bull Exp Biol Med (2012) 152, 409-412. PubMed Europe PubMed DOI I
Klimaviciusa,L., Jain,R.K., Jaako,K., Van Elzen,R., Gerard,M., Van der Veken,P., Lambeir,A.M. and Zharkovsky,A. In situ prolyl oligopeptidase activity assay in neural cell cultures J Neurosci Methods (2012) 204, 104-110. PubMed Europe PubMed DOI A I
Van der Veken,P., Fulop,V., Rea,D., Gerard,M., Van Elzen,R., Joossens,J., Cheng,J.D., Baekelandt,V., De Meester,I., Lambeir,A.M. and Augustyns,K. P2-Substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy J Med Chem (2012) 55, 9856-9867. PubMed Europe PubMed DOI I
Wang,M.X., Zhong,C., Cai,Q.F., Liu,G.M., Zhang,L., Hara,K., Su,W.J. and Cao,M.J. Study on a prolyl endopeptidase from the skeletal muscle of common carp (Cyprinus carpio) Process Biochem (2012) 47, 2211-2218. DOI I

2011

Cummins,P.M., Dowling,O. and O'Connor,B.F. Ion-exchange chromatography: basic principles and application to the partial purification of soluble mammalian prolyl oligopeptidase Methods Mol Biol (2011) 681, 215-228. PubMed Europe PubMed DOI
Fuhrmann,G. and Leroux,J.C. In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract Proc Natl Acad Sci U S A (2011) 108, 9032-9037. PubMed Europe PubMed DOI U
Lopez,A., Tarrago,T. and Giralt,E. Low molecular weight inhibitors of prolyl oligopeptidase: a review of compounds patented from 2003 to 2010 Expert Opin Ther Pat (2011) 21, 1023-1044. PubMed Europe PubMed DOI T I
Myohanen,T., Tenorio-Laranga,J., Jokinen,B., Vazquez-Sanchez,R., Moreno-Baylach,M., Garcia-Horsman,J. and Mannisto,P. Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner Br J Pharmacol (2011) 163, 1666-1678. PubMed Europe PubMed DOI I
Peltonen,I., Myohanen,T.T. and Mannisto,P.T. Association of prolyl oligopeptidase with conventional neurotransmitters in the brain CNS Neurol Disord Drug Targets (2011) 10, 311-318. PubMed Europe PubMed
Penttinen,A., Tenorio-Laranga,J., Siikanen,A., Morawski,M., Rossner,S. and Garcia-Horsman,J.A. Prolyl oligopeptidase: a rising star on the stage of neuroinflammation research CNS Neurol Disord Drug Targets (2011) 10, 340-348. PubMed Europe PubMed V
Rea,D. and Fulop,V. Prolyl oligopeptidase structure and dynamics CNS Neurol Disord Drug Targets (2011) 10, 306-310. PubMed Europe PubMed V
Robic,S., Linscott,K.B., Aseem,M., Humphreys,E.A. and McCartha,S.R. Bile acids as modulators of enzyme activity and stability Protein J (2011) 30, 539-545. PubMed Europe PubMed DOI U
Sakaguchi,M., Matsuda,T., Matsumura,E., Yoshimoto,T. and Takaoka,M. Prolyl oligopeptidase participates in cell cycle progression in a human neuroblastoma cell line Biochem Biophys Res Commun (2011) 409, 693-698. PubMed Europe PubMed DOI I
Tenorio-Laranga,J., Mannisto,P.T. and Garcia-Horsman,J.A. Hunting for peptide substrates of prolyl oligopeptidase: classical versus non-classical bioactive peptides CNS Neurol Disord Drug Targets (2011) 10, 319-326. PubMed Europe PubMed

2010

Agirregoitia,N., Bizet,P., Agirregoitia,E., Boutelet,I., Peralta,L., Vaudry,H. and Jegou,S. Prolyl endopeptidase mRNA expression in the central nervous system during rat development J Chem Neuroanat (2010) 40, 53-62. PubMed Europe PubMed DOI
Kichik,N., Tarrago,T. and Giralt,E. Simultaneous (19)F NMR screening of prolyl oligopeptidase and dipeptidyl peptidase IV inhibitors Chembiochem (2010) 11, 1115-1119. PubMed Europe PubMed DOI I
Li,M., Chen,C., Davies,D.R. and Chiu,T.K. Induced-fit mechanism for prolyl endopeptidase J Biol Chem (2010) 285, 21487-21495. PubMed Europe PubMed DOI PMC EPMC
Lone,A.M., Nolte,W.M., Tinoco,A.D. and Saghatelian,A. Peptidomics of the prolyl peptidases AAPS J (2010) 12, 483-491. PubMed Europe PubMed DOI P
Marques,M.R., Stuker,C., Kichik,N., Tarrago,T., Giralt,E., Morel,A.F. and Dalcol,I.I. Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers Fitoterapia (2010) 81, 552-556. PubMed Europe PubMed DOI I
Matsubara,S., Takahashi,T. and Kimura,A.P. Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression Gene (2010) 465, 17-29. PubMed Europe PubMed DOI
Szeltner,Z., Morawski,M., Juhasz,T., Szamosi,I., Liliom,K., Csizmok,V., Tolgyesi,F. and Polgar,L. GAP43 shows partial co-localisation but no strong physical interaction with prolyl oligopeptidase Biochim Biophys Acta (2010) 1804, 2162-2176. PubMed Europe PubMed DOI

2009

Comellas,G., Kaczmarska,Z., Tarrago,T., Teixido,M. and Giralt,E. Exploration of the one-bead one-compound methodology for the design of prolyl oligopeptidase substrates PLoS ONE (2009) 4, e6222-e6222. PubMed Europe PubMed DOI PMC EPMC
Di Daniel,E., Glover,C.P., Grot,E., Chan,M.K., Sanderson,T.H., White,J.H., Ellis,C.L., Gallagher,K.T., Uney,J., Thomas,J., Maycox,P.R. and Mudge,A.W. Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity Mol Cell Neurosci (2009) 41, 373-382. PubMed Europe PubMed DOI
Luo,H., Hallen-Adams,H.E. and Walton,J.D. Processing of the phalloidin proprotein by prolyl oligopeptidase from the mushroom Conocybe albipes J Biol Chem (2009) 284, 18070-18077. PubMed Europe PubMed DOI PMC EPMC
Nolte,W.M., Tagore,D.M., Lane,W.S. and Saghatelian,A. Peptidomics of prolyl endopeptidase in the central nervous system Biochemistry (2009) 48, 11971-11981. PubMed Europe PubMed DOI P
O'Reilly,P.J., Hardison,M.T., Jackson,P.L., Xu,X., Snelgrove,R.J., Gaggar,A., Galin,F.S. and Blalock,J.E. Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen J Neuroimmunol (2009) 217, 51-54. PubMed Europe PubMed DOI
Perroud,B., Alvarado,R.J., Espinal,G.M., Morado,A.R., Phinney,B.S. and Warden,C.H. In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice Mol Brain (2009) 2, 14-14. PubMed Europe PubMed DOI PMC EPMC K
Sabido,E., Tarrago,T., Niessen,S., Cravatt,B.F. and Giralt,E. Activity-based probes for monitoring postproline protease activity Chembiochem (2009) 10, 2361-2366. PubMed Europe PubMed DOI
Tarrago,T., Martin-Benito,J., Sabido,E., Claasen,B., Madurga,S., Gairi,M., Valpuesta,J.M. and Giralt,E. A new side opening on prolyl oligopeptidase revealed by electron microscopy FEBS Lett (2009) 583, 3344-3348. PubMed Europe PubMed DOI S
Warden,C.H., Fisler,J.S., Espinal,G., Graham,J., Havel,P.J. and Perroud,B. Maternal influence of prolyl endopeptidase on fat mass of adult progeny Int J Obes (Lond) (2009) 33, 1013-1022. PubMed Europe PubMed DOI PMC EPMC M

2008

Ehren,J., Govindarajan,S., Moron,B., Minshull,J. and Khosla,C. Protein engineering of improved prolyl endopeptidases for celiac sprue therapy Protein Eng Des Sel (2008) 21, 699-707. PubMed Europe PubMed DOI PMC EPMC U
Haffner,C.D., Diaz,C.J., Miller,A.B., Reid,R.A., Madauss,K.P., Hassell,A., Hanlon,M.H., Porter,D.J., Becherer,J.D. and Carter,L.H. Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP) Bioorg Med Chem Lett (2008) 18, 4360-4363. PubMed Europe PubMed DOI S I
Szeltner,Z. and Polgar,L. Structure, function and biological relevance of prolyl oligopeptidase Curr Protein Pept Sci (2008) 9, 96-107. PubMed Europe PubMed DOI V
Tarrago,T., Kichik,N., Claasen,B., Prades,R., Teixido,M. and Giralt,E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor Bioorg Med Chem (2008) 16, 7516-7524. PubMed Europe PubMed DOI T I
Tarrago,T., Masdeu,C., Gomez,E., Isambert,N., Lavilla,R. and Giralt,E. Benzimidazolium salts as small, nonpeptidic and BBB-permeable human prolyl oligopeptidase inhibitors ChemMedChem (2008) 3, 1558-1565. PubMed Europe PubMed DOI I
Tenorio-Laranga,J., Venalainen,J.I., Mannisto,P.T. and Garcia-Horsman,J.A. Characterization of membrane-bound prolyl endopeptidase from brain FEBS J (2008) 275, 4415-4427. PubMed Europe PubMed DOI

2007

Cerf-Bensussan,N., Matysiak-Budnik,T., Cellier,C. and Heyman,M. Oral proteases: a new approach to managing coeliac disease Gut (2007) 56, 157-160. PubMed Europe PubMed DOI U
Garcia-Horsman,J.A., Mannisto,P.T. and Venalainen,J.I. On the role of prolyl oligopeptidase in health and disease Neuropeptides (2007) 41, 1-24. PubMed Europe PubMed DOI V
Lee,S.H., Jun,M., Choi,J.Y., Yang,E.J., Hur,J.M., Bae,K., Seong,Y.H., Huh,T.L. and Song,K.S. Plant phenolics as prolyl endopeptidase inhibitors Arch Pharm Res (2007) 30, 827-833. PubMed Europe PubMed I
Mannisto,P.T., Venalainen,J., Jalkanen,A. and Garcia-Horsman,J.A. Prolyl oligopeptidase: a potential target for the treatment of cognitive disorders Drug News Perspect (2007) 20, 293-305. PubMed Europe PubMed DOI T
Tarrago,T., Kichik,N., Segui,J. and Giralt,E. The Natural Product Berberine is a Human Prolyl Oligopeptidase Inhibitor ChemMedChem (2007) 2, 354-359. PubMed Europe PubMed DOI I
Tran,T., Quan,C., Edosada,C.Y., Mayeda,M., Wiesmann,C., Sutherlin,D. and Wolf,B.B. Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP Bioorg Med Chem Lett (2007) 17, 1438-1442. PubMed Europe PubMed DOI I

2006

[YEAR:4-1-2006]Leprince,J., Cosquer,D., Bellemere,G., Chatenet,D., Tollemer,H., Jegou,S., Tonon,M.C. and Vaudry,H. Catabolism of the octadecaneuropeptide ODN by prolyl endopeptidase: identification of an unusual cleavage site Peptides (4-1-2006) 27, 1561-1569. PubMed Europe PubMed DOI T I
[YEAR:4-1-2006]Venalainen,J.I., Garcia-Horsman,J.A., Forsberg,M.M., Jalkanen,A., Wallen,E.A., Jarho,E.M., Christiaans,J.A., Gynther,J. and Mannisto,P.T. Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors Biochem Pharmacol (4-1-2006) 71, 683-692. PubMed Europe PubMed DOI T I

2005

Brandt,I., De Vriendt,K., Devreese,B., Van Beeumen,J., Van Dongen,W., Augustyns,K., De Meester,I., Scharpe,S. and Lambeir,A.M. Search for substrates for prolyl oligopeptidase in porcine brain Peptides (2005) 26, 2536-2546. PubMed Europe PubMed DOI
[YEAR:21-6-2005]Fuxreiter,M., Magyar,C., Juhasz,T., Szeltner,Z., Polgar,L. and Simon,I. Flexibility of prolyl oligopeptidase: molecular dynamics and molecular framework analysis of the potential substrate pathways Proteins (21-6-2005) 60, 504-512. PubMed Europe PubMed DOI
[YEAR:25-2-2005]Juhasz,T., Szeltner,Z., Fulop,V. and Polgar,L. Unclosed beta-propellers display stable structures: implications for substrate access to the active site of prolyl oligopeptidase J Mol Biol (25-2-2005) 346, 907-917. PubMed Europe PubMed DOI
[YEAR:9-9-2005]Marti,T., Molberg,O., Li,Q., Gray,G.M., Khosla,C. and Sollid,L.M. Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization J Pharmacol Exp Ther (9-9-2005) 312, 19-26. PubMed Europe PubMed DOI

2004

Cavasin,M.A., Rhaleb,N.E., Yang,X.P. and Carretero,O.A. Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP Hypertension (2004) 43, 1140-1145. PubMed Europe PubMed DOI I
[YEAR:25-5-2004]Heinis,C., Alessi,P. and Neri,D. Engineering a thermostable human prolyl endopeptidase for antibody-directed enzyme prodrug therapy Biochemistry (25-5-2004) 43, 6293-6303. PubMed Europe PubMed DOI
Ito,K., Kitazono,A.A. and Yoshimoto,T. Prolyl oligopeptidase [ISSN:0-12-079610-4] (2004) 2, 1897-1900. V
[YEAR:9-7-2004]Szeltner,Z., Rea,D., Juhasz,T., Renner,V., Fulop,V. and Polgar,L. Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding J Mol Biol (9-7-2004) 340, 627-637. PubMed Europe PubMed DOI
[YEAR:15-9-2004]Venalainen,J.I., Juvonen,R.O., Garcia-Horsman,J.A., Wallen,E.A., Christiaans,J.A., Jarho,E.M., Gynther,J. and Mannisto,P.T. Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site Biochem J (15-9-2004) 382, 1003-1008. PubMed Europe PubMed DOI PMC EPMC T I

2003

Bellemere,G., Morain,P., Vaudry,H. and Jegou,S. Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain J Neurochem (2003) 84, 919-929. PubMed Europe PubMed DOI T I
[YEAR:5-12-2003]Szeltner,Z., Rea,D., Renner,V., Juliano,L., Fulop,V. and Polgar,L. Electrostatic environment at the active site of prolyl oligopeptidase is highly influential during substrate binding J Biol Chem (5-12-2003) 278, 48786-48793. PubMed Europe PubMed DOI
[YEAR:9-10-2003]Wallen,E.A., Christiaans,J.A., Jarho,E.M., Forsberg,M.M., Venalainen,J.I., Mannisto,P.T. and Gynther,J. New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides J Med Chem (9-10-2003) 46, 4543-4551. PubMed Europe PubMed DOI I

2002

Esumi,Y., Suzuki,Y., Itoh,Y., Uramoto,M., Kimura,K., Goto,M., Yoshihama,M. and Ichikawa,T. Propeptin, a new inhibitor of prolyl endopeptidase produced by Microbispora II. Determination of chemical structure J Antibiot (Tokyo) (2002) 55, 296-300. PubMed Europe PubMed I
Kimura,A., Matsui,H. and Takahashi,T. Expression and localization of prolyl oligopeptidase in mouse testis and its possible involvement in sperm motility Zoolog Sci (2002) 19, 93-102. PubMed Europe PubMed DOI I
Morain,P., Lestage,P., de Nanteuil,G., Jochemsen,R., Robin,J.L., Guez,D. and Boyer,P.A. S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies CNS Drug Rev (2002) 8, 31-52. PubMed Europe PubMed T I
[YEAR:13-2-2002]Odaka,C., Mizuochi,T., Shirasawa,T., Morain,P. and Checler,F. Murine T cells expressing high activity of prolyl endopeptidase are susceptible to activation-induced cell death FEBS Lett (13-2-2002) 512, 163-167. PubMed Europe PubMed DOI I
Schneider,J.S., Giardiniere,M. and Morain,P. Effects of the prolyl endopeptidase inhibitor S 17092 on cognitive deficits in chronic low dose MPTP-treated monkeys Neuropsychopharmacology (2002) 26, 176-182. PubMed Europe PubMed DOI T I
Schulz,I., Gerhartz,B., Neubauer,A., Holloschi,A., Heiser,U., Hafner,M. and Demuth,H.U. Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition Eur J Biochem (2002) 269, 5813-5820. PubMed Europe PubMed DOI
[YEAR:22-11-2002]Szeltner,Z., Rea,D., Juhasz,T., Renner,V., Mucsi,Z., Orosz,G., Fulop,V. and Polgar,L. Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase J Biol Chem (22-11-2002) 277, 44597-44605. PubMed Europe PubMed DOI
[YEAR:8-11-2002]Szeltner,Z., Rea,D., Renner,V., Fulop,V. and Polgar,L. Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site J Biol Chem (8-11-2002) 277, 42613-42622. PubMed Europe PubMed DOI
[YEAR:1-8-2002]Venalainen,J.I., Juvonen,R.O., Forsberg,M.M., Garcia-Horsman,A., Poso,A., Wallen,E.A., Gynther,J. and Mannisto,P.T. Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819 Biochem Pharmacol (1-8-2002) 64, 463-471. PubMed Europe PubMed DOI I

2001

[YEAR:12-1-2001]Fulop,V., Szeltner,Z., Renner,V. and Polgar,L. Structures of prolyl oligopeptidase substrate/inhibitor complexes. Use of inhibitor binding for titration of the catalytic histidine residue J Biol Chem (12-1-2001) 276, 1262-1266. PubMed Europe PubMed DOI S I
Hasebe,T., Hua,J., Someya,A., Morain,P., Checler,F. and Nagaoka,I. Involvement of cytosolic prolyl endopeptidase in degradation of p40-phox splice variant protein in myeloid cells J Leukoc Biol (2001) 69, 963-968. PubMed Europe PubMed I

2000

Fulop,V., Szeltner,Z. and Polgar,L. Catalysis of serine oligopeptidases is controlled by a gating filter mechanism EMBO Rep (2000) 1, 277-281. PubMed Europe PubMed DOI PMC EPMC S
Marighetto,A., Touzani,K., Etchamendy,N., Torrea,C.C., de Nanteuil,G., Guez,D., Jaffard,R. and Morain,P. Further evidence for a dissociation between different forms of mnemonic expressions in a mouse model of age-related cognitive decline: effects of tacrine and S 17092, a novel prolyl endopeptidase inhibitor Learn Mem (2000) 7, 159-169. PubMed Europe PubMed DOI PMC EPMC I
Morain,P., Robin,J.L., de Nanteuil,G., Jochemsen,R., Heidet,V. and Guez,D. Pharmacodynamic and pharmacokinetic profile of S 17092, a new orally active prolyl endopeptidase inhibitor, in elderly healthy volunteers. A phase I study Br J Clin Pharmacol (2000) 50, 350-359. PubMed Europe PubMed DOI PMC EPMC I
[YEAR:15-6-2000]Stockel-Maschek,A., Mrestani-Klaus,C., Stiebitz,B., Demuth,H. and Neubert,K. Thioxo amino acid pyrrolidides and thiazolidides: new inhibitors of proline specific peptidases Biochim Biophys Acta (15-6-2000) 1479, 15-31. PubMed Europe PubMed DOI I
[YEAR:19-5-2000]Szeltner,Z., Renner,V. and Polgar,L. The noncatalytic beta-propeller domain of prolyl oligopeptidase enhances the catalytic capability of the peptidase domain J Biol Chem (19-5-2000) 275, 15000-15005. PubMed Europe PubMed DOI
Szeltner,Z., Renner,V. and Polgar,L. Substrate- and pH-dependent contribution of oxyanion binding site to the catalysis of prolyl oligopeptidase, a paradigm of the serine oligopeptidase family Protein Sci (2000) 9, 353-360. PubMed Europe PubMed DOI PMC EPMC I

1999

Amin,A., Li,Y. and Finkelstein,R. Identification of a Drosophila prolyl endopeptidase and analysis of its expression DNA Cell Biol (1999) 18, 605-610. PubMed Europe PubMed DOI
[YEAR:21-4-1999]Barelli,H., Petit,A., Hirsch,E., Wilk,S., de Nanteuil,G., Morain,P. and Checler,F. S 17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase Biochem Biophys Res Commun (21-4-1999) 257, 657-661. PubMed Europe PubMed DOI I
Feher,M., Kanai,K., Hermecz,I., Lopata,A. and Novak,I. A 3D-QSAR analysis of prolyl endopeptidase inhibitors Quant Struct -Act Relatsh (1999) 18, 456-463. DOI S I
[YEAR:15-2-1999]Shinoda,M., Miyazaki,A. and Toide,K. Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and on cholinergic and peptidergic neurons in rats with ibotenate-induced lesions of the nucleus basalis magnocellularis Behav Brain Res (15-2-1999) 99, 17-25. PubMed Europe PubMed DOI I
[YEAR:14-5-1999]Shishido,Y., Furushiro,M., Tanabe,S., Shibata,S., Hashimoto,S. and Yokokura,T. Effects of prolyl endopeptidase inhibitors and neuropeptides on delayed neuronal death in rats Eur J Pharmacol (14-5-1999) 372, 135-142. PubMed Europe PubMed DOI I
Umemura,K., Kondo,K., Ikeda,Y., Nishimoto,M., Hiraga,Y., Yoshida,Y. and Nakashima,M. Pharmacokinetics and safety of Z-321, a novel specific orally active prolyl endopeptidase inhibitor, in healthy male volunteers J Clin Pharmacol (1999) 39, 462-470. PubMed Europe PubMed I
[YEAR:17-5-1999]Williams,R.S., Eames,M., Ryves,W.J., Viggars,J. and Harwood,A.J. Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate EMBO J (17-5-1999) 18, 2734-2745. PubMed Europe PubMed DOI PMC EPMC
Yoshida,K., Inaba,K., Ohtake,H. and Morisawa,M. Purification and characterization of prolyl endopeptidase from the Pacific herring, Clupea pallasi, and its role in the activation of sperm motility Dev Growth Differ (1999) 41, 217-225. PubMed Europe PubMed DOI I

1998

[YEAR:24-7-1998]Fulop,V., Bocskei,Z. and Polgar,L. Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis Cell (24-7-1998) 94, 161-170. PubMed Europe PubMed DOI S
Ishino,T., Ohtsuki,S., Homma,K. and Natori,S. cDNA cloning of mouse prolyl endopeptidase and its involvement in DNA synthesis by Swiss 3T3 cells J Biochem (1998) 123, 540-545. PubMed Europe PubMed
[YEAR:1-10-1998]Kabashima,T., Fujii,M., Meng,Y., Ito,K. and Yoshimoto,T. Prolyl endopeptidase from Sphingomonas capsulata: Isolation and characterization of the enzyme and nucleotide sequence of the gene Arch Biochem Biophys (1-10-1998) 358, 141-148. PubMed Europe PubMed DOI
Miyazaki,A., Toide,K., Sasaki,Y., Ichitani,Y. and Iwasaki,T. Effect of a prolyl endopeptidase inhibitor, JTP-4819, on radial maze performance in hippocampal-lesioned rats Pharmacol Biochem Behav (1998) 59, 361-368. PubMed Europe PubMed DOI I
Toide,K., Shinoda,M. and Miyazaki,A. A novel prolyl endopeptidase inhibitor, JTP-4819 - its behavioral and neurochemical properties for the treatment of Alzheimer's disease Rev Neurosci (1998) 9, 17-29. PubMed Europe PubMed I

1997

[YEAR:15-11-1997]Goossens,F., Vanhoof,G., De Meester,I., Augustyns,K., Borloo,M., Tourwe,D., Haemers,A. and Scharpe,S. Development and evaluation of peptide-based prolyl oligopeptidase inhibitors - introduction of N-benzyloxycarbonyl-prolyl-3-fluoropyrrolidine as a lead in inhibitor design Eur J Biochem (15-11-1997) 250, 177-183. PubMed Europe PubMed I
Kahyaoglu,A., Haghjoo,K., Guo,F., Jordan,F., Kettner,C., Felfoldi,F. and Polgar,L. Low barrier hydrogen bond is absent in the catalytic triads in the ground state but is present in a transition-state complex in the prolyl oligopeptidase family of serine proteases J Biol Chem (1997) 272, 25547-25554. PubMed Europe PubMed DOI I
Kahyaoglu,A., Haghjoo,K., Kraicsovits,F., Jordan,F. and Polgar,L. Benzyloxycarbonylprolylprolinal, a transition-state analogue for prolyl oligopeptidase, forms a tetrahedral adduct with catalytic serine, not a reactive cysteine Biochem J (1997) 322, 839-843. PubMed Europe PubMed PMC EPMC I
[YEAR:27-6-1997]Shinoda,M., Toide,K., Ohsawa,I. and Kohsaka,S. Specific inhibitor for prolyl endopeptidase suppresses the generation of amyloid beta protein in NG108-15 cells Biochem Biophys Res Commun (27-6-1997) 235, 641-645. PubMed Europe PubMed DOI I
Toide,K., Shinoda,M., Fujiwara,T. and Iwamoto,Y. Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and central cholinergic neurons in aged rats Pharmacol Biochem Behav (1997) 56, 427-434. PubMed Europe PubMed DOI I
Toide,K., Shinoda,M., Iwamoto,Y., Fujiwara,T., Okamiya,K. and Uemura,A. A novel prolyl endopeptidase inhibitor, JTP-4819, with potential for treating Alzheimer's disease Behav Brain Res (1997) 83, 147-151. PubMed Europe PubMed DOI T I

1996

Li,J., Wilk,E. and Wilk,S. Inhibition of prolyl oligopeptidase by Fmoc-aminoacylpyrrolidine-2-nitriles J Neurochem (1996) 66, 2105-2112. PubMed Europe PubMed I
[YEAR:7-6-1996]Portevin,B., Benoist,A., Remond,G., Herve,Y., Vincent,M., Lepagnol,J. and de Nanteuil,G. New prolyl endopeptidase inhibitors: in vitro and in vivo activities of azabicyclo[2.2.2]octane, azabicyclo[2.2.1]heptane, and perhydroindole derivatives J Med Chem (7-6-1996) 39, 2379-2391. PubMed Europe PubMed DOI T I
[YEAR:3-6-1996]Shinoda,M., Matsuo,A. and Toide,K. Pharmacological studies of a novel prolyl endopeptidase inhibitor, JTP-4819, in rats with middle cerebral artery occlusion Eur J Pharmacol (3-6-1996) 305, 31-38. PubMed Europe PubMed DOI I
Toide,K., Fujiwara,T., Iwamoto,Y., Shinoda,M., Okamiya,K. and Kato,T. Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain Naunyn Schmiedebergs Arch Pharmacol (1996) 353, 355-362. PubMed Europe PubMed DOI I
Tsuda,M., Muraoka,Y., Nagai,M., Aoyagi,T. and Takeuchi,T. Poststatin, a new inhibitor of prolyl endopeptidase. VII. N-Cycloalkylamide analogues J Antibiot (Tokyo) (1996) 49, 909-920. PubMed Europe PubMed I
Tsuda,M., Muraoka,Y., Nagai,M., Aoyagi,T. and Takeuchi,T. Poststatin, a new inhibitor of prolyl endopeptidase. VIII. Endopeptidase inhibitory activity of non-peptidyl poststatin analogues J Antibiot (Tokyo) (1996) 49, 1022-1030. PubMed Europe PubMed I
Tsuda,M., Muraoka,Y., Nagai,M., Takeuchi,T. and Aoyagi,T. Poststatin, a new inhibitor of prolyl endopeptidase. IV. The chemical synthesis of poststatin J Antibiot (Tokyo) (1996) 49, 287-291. PubMed Europe PubMed I
Tsuda,M., Muraoka,Y., Nagai,M., Aoyagi,T. and Takeuchi,T. Poststatin, a new inhibitor of prolyl endopeptidase. III. Optical resolution of 3-amino-2-hydroxyvaleric acid and absolute configuration of poststatin J Antibiot (Tokyo) (1996) 49, 281-286. PubMed Europe PubMed I

1995

Borloo,M., Augustyns,K., Belyaev,A., De Meester,I., Lambeir,A.M., Goossens,F., Bollaert,W., Rajan,P., Scharpe,S. and Haemers,A. Synthesis and evaluation of azaproline peptides as potential inhibitors of dipeptidyl peptidase IV and prolyl oligopeptidase Lett Pept Sci (1995) 2, 198-202. DOI I
Goossens,F., De Meester,I., Vanhoof,G., Hendriks,D., Vriend,G. and Scharpe,S. The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha/beta hydrolase fold family Eur J Biochem (1995) 233, 432-441. PubMed Europe PubMed
Shinoda,M., Okamiya,K. and Toide,K. Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on thyrotropin-releasing hormone-like immunoreactivity in the cerebral cortex and hippocampus of aged rats Jpn J Pharmacol (1995) 69, 273-276. PubMed Europe PubMed I
Toide,K., Iwamoto,Y., Fujiwara,T. and Abe,H. JTP-4819: a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer J Pharmacol Exp Ther (1995) 274, 1370-1378. PubMed Europe PubMed I
Toide,K., Okamiya,K., Iwamoto,Y. and Kato,T. Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on prolyl endopeptidase activity and substance P- and arginine-vasopressin-like immunoreactivity in the brains of aged rats J Neurochem (1995) 65, 234-240. PubMed Europe PubMed I

1994

Makinen,P.L., Makinen,K.K. and Syed,S.A. An endo-acting proline-specific oligopeptidase from Treponema denticola ATCC 35405: evidence of hydrolysis of human bioactive peptides Infect Immun (1994) 62, 4938-4947. PubMed Europe PubMed PMC EPMC P
Polgar,L. Prolyl oligopeptidases Methods Enzymol (1994) 244, 188-200. PubMed Europe PubMed DOI V
Salers,P. Evidence for the presence of prolyl oligopeptidase and its endogenous inhibitor in neonatal rat pancreatic beta-cells Regul Pept (1994) 50, 235-245. PubMed Europe PubMed DOI
Tanaka,Y., Niwa,S., Nishioka,H., Yamanaka,T., Torizuka,M., Yoshinaga,K., Kobayashi,N., Ikeda,Y. and Arai,H. New potent prolyl endopeptidase inhibitors: synthesis and structure-activity relationships of indan and tetralin derivatives and their analogues J Med Chem (1994) 37, 2071-2078. PubMed Europe PubMed DOI I
Vanhoof,G., Goossens,F., Hendriks,L., De Meester,I., Hendriks,D., Vriend,G., Van Broeckhoven,C. and Scharpe,S. Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase Gene (1994) 149, 363-366. PubMed Europe PubMed DOI

1993

Diefenthal,T., Dargatz,H., Witte,V., Reipen,G. and Svendsen,I. Cloning of proline-specific endopeptidase gene from Flavobacterium meningosepticum: Expression in Escherichia coli and purification of the heterologous protein Appl Microbiol Biotechnol (1993) 40, 90-97. PubMed Europe PubMed
Kanatani,A., Yoshimoto,T., Kitazono,A., Kokubo,T. and Tsuru,D. Prolyl endopeptidase from Aeromonas hydrophila: cloning, sequencing, and expression of the enzyme gene, and characterization of the expressed enzyme J Biochem (1993) 113, 790-796. PubMed Europe PubMed
Polgar,L., Kollt,E. and Hollosi,M. Prolyl oligopeptidase catalysis. Reactions with thiono substrates reveal substrate-induced conformational change to be the rate-limiting step FEBS Lett (1993) 322, 227-230. PubMed Europe PubMed DOI

1992

Barrett,A.J. and Rawlings,N.D. Oligopeptidases, and the emergence of the prolyl oligopeptidase family Biol Chem Hoppe Seyler (1992) 373, 353-360. PubMed Europe PubMed
Chevallier,S., Goeltz,P., Thibault,P., Banville,D. and Gagnon,J. Characterization of a prolyl endopeptidase from Flavobacterium meningosepticum. Complete sequence and localization of the active-site serine J Biol Chem (1992) 267, 8192-8199. PubMed Europe PubMed
Kamei,H., Ueki,T., Obi,Y., Fukagawa,Y. and Oki,T. Protective effect of eurystatins A and B, new prolyl endopeptidase inhibitors, on scopolamine-induced amnesia in rats Jpn J Pharmacol (1992) 60, 377-380. PubMed Europe PubMed I
Medeiros,M.S., Iazigi,N., Camargo,A.C. and Oliveira,E.B. Distribution and properties of endo-oligopeptidases A and B in the human neuroendocrine system J Endocrinol (1992) 135, 579-588. PubMed Europe PubMed
Polgar,L. Structural relationship between lipases and peptidases of the prolyl oligopeptidase family FEBS Lett (1992) 311, 281-284. PubMed Europe PubMed DOI
[YEAR:1-5-1992]Stone,S.R., Rennex,D., Wikstrom,P., Shaw,E. and Hofsteenge,J. Peptidyldiazomethanes. A novel mechanism of interaction with prolyl endopeptidase Biochem J (1-5-1992) 283, 871-876. PubMed Europe PubMed PMC EPMC I

1991

Aoyagi,T., Nagai,M., Ogawa,K., Kojima,F., Okada,M., Ikeda,T., Hamada,M. and Takeuchi,T. Poststatin, a new inhibitor of prolyl endopeptidase, produced by Streptomyces viridochromogenes MH534-30F3. I. Taxonomy, production, isolation, physico-chemical properties and biological activities J Antibiot (Tokyo) (1991) 44, 949-955. PubMed Europe PubMed I
Atack,J.R., Suman-Chauhan,N., Dawson,G. and Kulagowski,J.J. In vitro and in vivo inhibition of prolyl endopeptidase Eur J Pharmacol (1991) 205, 157-163. PubMed Europe PubMed I
Kalwant,S. and Porter,A.G. Purification and characterization of human brain prolyl endopeptidase Biochem J (1991) 276, 237-244. PubMed Europe PubMed PMC EPMC
Rennex,D., Hemmings,B.A., Hofsteenge,J. and Stone,S.R. cDNA cloning of porcine brain prolyl endopeptidase and identification of the active-site seryl residue Biochemistry (1991) 30, 2195-2203. PubMed Europe PubMed I
Stone,S.R., Rennex,D., Wikstrom,P., Shaw,E. and Hofsteenge,J. Inactivation of prolyl endopeptidase by a peptidylchloromethane. Kinetics of inactivation and identification of sites of modification Biochem J (1991) 276, 837-840. PubMed Europe PubMed PMC EPMC I
Takkinen,K., Peranen,J. and Kaariainen,L. Proteolytic processing of Semliki Forest virus-specific non-structural polyprotein J Gen Virol (1991) 72, 1627-1633. PubMed Europe PubMed

1988

Heins,J., Welker,P., Schonlein,C., Born,I., Hartrodt,B., Neubert,K., Tsuru,D. and Barth,A. Mechanism of proline-specific proteinases: (I) Substrate specificity of dipeptidyl peptidase IV from pig kidney and proline-specific endopeptidase from Flavobacterium meningosepticum Biochim Biophys Acta (1988) 954, 161-169. PubMed Europe PubMed P
Moriyama,A., Nakanishi,M. and Sasaki,M. Porcine muscle prolyl endopeptidase and its endogenous substrates J Biochem (1988) 104, 112-117. PubMed Europe PubMed

1987

Yoshimoto,T., Abdus Sattar,A.K.M., Hirose,W. and Tsuru,D. Studies on prolyl endopeptidase from carrot (Daucus carota): purification and enzymatic properties Biochim Biophys Acta (1987) 916, 29-37.

1986

Friedman,T.C. and Wilk,S. Delineation of a particulate thyrotropin-releasing hormone-degrading enzyme in rat brain by the use of specific inhibitors of prolyl endopeptidase and pyroglutamyl peptide hydrolase J Neurochem (1986) 46, 1231-1239. PubMed Europe PubMed I
Knisatschek,H. and Bauer,K. Specific inhibition of post proline cleaving enzyme by benzyloxycarbonyl-Gly-Pro-diazomethyl ketone Biochem Biophys Res Commun (1986) 134, 888-894. PubMed Europe PubMed I
Nomura,K. Specificity of prolyl endopeptidase FEBS Lett (1986) 209, 235-237. PubMed Europe PubMed P

1985

Yoshimoto,T., Kawahara,K., Matsubara,F., Kado,K. and Tsuru,D. Comparison of inhibitory effects of prolinal-containing peptide derivatives on prolyl endopeptidases from bovine brain and Flavobacterium J Biochem (1985) 98, 975-979. PubMed Europe PubMed I

1984

Friedman,T.C., Orlowski,M. and Wilk,S. Prolyl endopeptidase: inhibition in vivo by N-benzyloxycarbonyl-prolyl-prolinal J Neurochem (1984) 42, 237-241. PubMed Europe PubMed I

1983

Camargo,A.C., Caldo,H. and Emson,P.C. Degradation of neurotensin by rabbit brain endo-oligopeptidase A and endo-oligopeptidase B (proline-endopeptidase) Biochem Biophys Res Commun (1983) 116, 1151-1159. PubMed Europe PubMed
Moriyama,A. and Sasaki,M. Porcine liver succinyltrialanine p-nitroanilide hydrolytic enzyme. Its purification and characterization as a post-proline cleaving enzyme J Biochem (1983) 94, 1387-1397. PubMed Europe PubMed
Wilk,S. and Orlowski,M. Inhibition of rabbit brain prolyl endopeptidase by N-benzyloxycarbonyl-prolyl-prolinal, a transition state aldehyde inhibitor J Neurochem (1983) 41, 69-75. PubMed Europe PubMed I

1982

Greene,L.J., Spadaro,A.C., Martins,A.R., Perussi De Jesus,W.D. and Camargo,A.C. Brain endo-oligopeptidase B: a post-proline cleaving enzyme that inactivates angiotensin I and II Hypertension (1982) 4, 178-184. PubMed Europe PubMed
Yoshimoto,T., Tsukumo,K., Takatsuka,N. and Tsuru,D. An inhibitor for post-proline cleaving enzyme; distribution and partial purification from porcine pancreas J Pharmacobiodyn (1982) 5, 734-740. PubMed Europe PubMed

1980

Andrews,P.C., Hines,C.M. and Dixon,J.E. Characterization of proline endopeptidase from rat brain Biochemistry (1980) 19, 5494-5500. PubMed Europe PubMed

1977

Yoshimoto,T. and Walter,R. Post-proline dipeptidyl aminopeptidase (dipeptidyl aminopeptidase IV) from lamb kidney. Purification and some enzymatic properties Biochim Biophys Acta (1977) 485, 391-401. PubMed Europe PubMed