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Literature for peptidase S09.001: prolyl oligopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Kilpelainen,T.P., Patsi,H.T., Svarcbahs,R., Julku,U.H., Etelainen,T.S., Cui,H., Auno,S., Sipari,N., Norrbacka,S., Leino,T.O., Jantti,M., Myohanen,T.T. and Wallen,E.A.A. \<br\>Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease\<br\>J Med Chem (2023) 66, 7475-7496. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2022
  2. Baharin,A., Ting,T.Y. and Goh,H.H. \<br\>Post-Proline Cleaving Enzymes (PPCEs): Classification, Structure, Molecular Properties, and Applications\<br\>Plants (Basel) (2022) 11, PubMed  Europe PubMed DOI  PMC  EPMC  V
  3. Plescia,J., Hedou,D., Pousse,M.E., Labarre,A., Dufresne,C., Mittermaier,A. and Moitessier,N. \<br\>Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-alpha for different indications\<br\>Eur J Med Chem (2022) 240, 114543. PubMed  Europe PubMed DOI
    4. 2021
  4. Julku,U.H., Jantti,M., Svarcbahs,R. and Myohanen,T.T. \<br\>Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner\<br\>Int J Mol Sci (2021) 22, PubMed  Europe PubMed DOI  PMC  EPMC
  5. Kulkarni,A.M., Rampogu,S. and Lee,K.W. \<br\>Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase\<br\>Evid Based Complement Alternat Med (2021) 2021, 6687572. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Simkova,A., Ormsby,T., Sidej,N., Slavetinska,L.P., Brynda,J., Beranova,J., Sacha,P., Majer,P. and Konvalinka,J. \<br\>Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with alpha-ketoamide warheads\<br\>Eur J Med Chem (2021) 224, 113717. PubMed  Europe PubMed DOI  I
    7. 2020
  7. Da'adoosh,B., Kaito,K., Miyashita,K., Sakaguchi,M. and Goldblum,A. \<br\>Computational design of substrate selective inhibition\<br\>PLoS Comput Biol (2020) 16, e1007713. PubMed  Europe PubMed DOI
  8. Dunaevsky,Y.E., Tereshchenkova,V.F., Oppert,B., Belozersky,M.A., Filippova,I.Y. and Elpidina,E.N. \<br\>Human proline specific peptidases: a comprehensive analysis\<br\>Biochim Biophys Acta (2020) 1864, 129636. PubMed  Europe PubMed DOI  V
  9. He,Z., Long,P., Fang,F., Li,S., Zhang,P. and Chen,Z. \<br\>Diversity of MSDIN family members in amanitin-producing mushrooms and the phylogeny of the MSDIN and prolyl oligopeptidase genes\<br\>BMC Genomics (2020) 21, 440. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Jiang,D.X., Zhang,J.B., Li,M.T., Lin,S.Z., Wang,Y.Q., Chen,Y.W. and Fan,J.G. \<br\>Prolyl endopeptidase gene disruption attenuates high fat diet-induced nonalcoholic fatty liver disease in mice by improving hepatic steatosis and inflammation\<br\>Ann Transl Med (2020) 8, 218. PubMed  Europe PubMed DOI  PMC  EPMC  K
  11. Kilpelainen,T.P., Hellinen,L., Vrijdag,J., Yan,X., Svarcbahs,R., Vellonen,K.S., Lambeir,A.M., Huttunen,H., Urtti,A., Wallen,E.A.A. and Myohanen,T.T. \<br\>The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy\<br\>Biomed Pharmacother (2020) 128, 110253. PubMed  Europe PubMed DOI  I
  12. Retzl,B., Hellinger,R., Muratspahic,E., Pinto,M.E.F., Bolzani,V.S. and Gruber,C.W. \<br\>Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides\<br\>J Nat Prod (2020) PubMed  Europe PubMed DOI
  13. Rostami,J., Jantti,M., Cui,H., Rinne,M.K., Kukkonen,J.P., Falk,A., Erlandsson,A. and Myohanen,T. \<br\>Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells\<br\>Biomed Pharmacother (2020) 131, 110788. PubMed  Europe PubMed DOI  I
  14. Serfozo,P., Wysocki,J., Gulua,G., Schulze,A., Ye,M., Liu,P., Jin,J., Bader,M., Myohanen,T., Garcia-Horsman,J.A. and Batlle,D. \<br\>Ang II (Angiotensin II) Conversion to angiotensin-(1-7) in the circulation is POP (prolyloligopeptidase)-dependent and ACE2 (angiotensin-converting enzyme 2)-independent\<br\>Hypertension (2020) 75, 173-182. PubMed  Europe PubMed DOI
  15. Shrivastava,A., Srivastava,S., Malik,R., Alam,M.M., Shaqiquzamman,M. and Akhter,M. \<br\>Identification of novel small molecule non-peptidomimetic inhibitor for prolyl oligopeptidase through in silico and in vitro approaches\<br\>J Biomol Struct Dyn (2020) 38, 1292-1305. PubMed  Europe PubMed DOI  I
  16. Sobolova,K., Hrabinova,M., Hepnarova,V., Kucera,T., Kobrlova,T., Benkova,M., Janockova,J., Dolezal,R., Prchal,L., Benek,O., Mezeiova,E., Jun,D., Soukup,O. and Korabecny,J. \<br\>Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile\<br\>Eur J Med Chem (2020) 203, 112593. PubMed  Europe PubMed DOI  I
  17. Svarcbahs,R., Jantti,M., Kilpelainen,T., Julku,U.H., Urvas,L., Kivioja,S., Norrbacka,S. and Myohanen,T.T. \<br\>Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A\<br\>Pharmacol Res (2020) 151, 104558. PubMed  Europe PubMed DOI
  18. Triposkiadis,F., Starling,R.C., Xanthopoulos,A., Butler,J. and Boudoulas,H. \<br\>Renin-angiotensin-system inhibition in the context of corona virus disease-19: experimental evidence, observational studies, and clinical implications\<br\>Heart Fail Rev (2020) PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2019
  19. Bandyopadhyay,A.K., Islam,R.N.U., Mitra,D., Banerjee,S. and Goswami,A. \<br\>Analysis of salt-bridges in prolyl oligopeptidase from Pyrococcus furiosus and Homo sapiens\<br\>Bioinformation (2019) 15, 214-225. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Bracke,A., Van Elzen,R., Van der Veken,P., Augustyns,K., De Meester,I. and Lambeir,A.M. \<br\>The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma\<br\>Clin Chim Acta (2019) 495, 154-160. PubMed  Europe PubMed DOI  A
  21. Kilpelainen,T.P., Tyni,J.K., Lahtela-Kakkonen,M.K., Etelainen,T.S., Myohanen,T.T. and Wallen,E.A.A. \<br\>Tetrazole as a replacement of the electrophilic group in characteristic prolyl oligopeptidase inhibitors\<br\>ACS Med Chem Lett (2019) 10, 1635-1640. PubMed  Europe PubMed DOI  PMC  EPMC  I
  22. Kumar,R., Parameswaran,S., Bavi,R., Baek,A., Son,M., Rampogu,S., Park,C., Lee,G., Zeb,A., Parate,S., Rana,R.M. and Lee,K.W. \<br\>Investigation of novel chemical scaffolds targeting prolyl oligopeptidase for neurological therapeutics\<br\>J Mol Graph Model (2019) 88, 92-103. PubMed  Europe PubMed DOI  I
  23. Maruyama,Y. and Kimura,A.P. \<br\>A molecular mechanism of mouse placental spongiotrophoblast differentiation regulated by prolyl oligopeptidase\<br\>Zygote (2019) 27, 49-53. PubMed  Europe PubMed DOI  I
  24. Natunen,T.A., Gynther,M., Rostalski,H., Jaako,K. and Jalkanen,A.J. \<br\>Extracellular prolyl oligopeptidase derived from activated microglia is a potential neuroprotection target\<br\>Basic Clin Pharmacol Toxicol (2019) 124, 40-49. PubMed  Europe PubMed DOI  I
  25. Plescia,J., De Cesco,S., Patrascu,M.B., Kurian,J., Di Trani,J., Dufresne,C., Wahba,A.S., Janmamode,N., Mittermaier,A.K. and Moitessier,N. \<br\>Integrated synthetic, biophysical, and computational investigations of covalent inhibitors of prolyl oligopeptidase and fibroblast activation protein alpha\<br\>J Med Chem (2019) 62, 7874-7884. PubMed  Europe PubMed DOI  I
  26. Plescia,J., Dufresne,C., Janmamode,N., Wahba,A.S., Mittermaier,A.K. and Moitessier,N. \<br\>Discovery of covalent prolyl oligopeptidase boronic ester inhibitors\<br\>Eur J Med Chem (2019) 111783. PubMed  Europe PubMed DOI  I
  27. Svarcbahs,R., Julku,U., Kilpelainen,T., Kyyro,M., Jantti,M. and Myohanen,T.T. \<br\>New tricks of prolyl oligopeptidase inhibitors - a common drug therapy for several neurodegenerative diseases\<br\>Biochem Pharmacol (2019) 161, 113-120. PubMed  Europe PubMed DOI  I
  28. Venditti,M. and Minucci,S. \<br\>Subcellular localization of prolyl endopeptidase during the first wave of rat spermatogenesis and in rat and human sperm\<br\>J Histochem Cytochem (2019) 67, 229-243. PubMed  Europe PubMed DOI
  29. Xu,P., Bao,R., Zhang,Y., Lu,E., Feng,F., Zhang,L., Li,J., Wang,J., Tan,X., Tang,M., Hu,C., Li,G. and Zhang,C. \<br\>Prolyl oligopeptidase regulates progesterone secretion via the ERK signaling pathway in murine luteal cells\<br\>Mol Reprod Dev (2019) 86, 714-726. PubMed  Europe PubMed DOI  I
    30. 2018
  30. Becker,B., Nazir,F.H., Brinkmalm,G., Camporesi,E., Kvartsberg,H., Portelius,E., Bostrom,M., Kalm,M., Hoglund,K., Olsson,M., Zetterberg,H. and Blennow,K. \<br\>Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by calpain-1 and prolyl endopeptidase\<br\>Mol Neurodegener (2018) 13, 47. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Di Trani,J.M., De Cesco,S., O'Leary,R., Plescia,J., do Nascimento,C.J., Moitessier,N. and Mittermaier,A.K. \<br\>Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry\<br\>Nat Commun (2018) 9, 893. PubMed  Europe PubMed DOI  PMC  EPMC  I
  32. Fu,P., Sun,W., Lai,J., Shen,Y.H. and Zhang,Z. \<br\>Identification of two isoforms of Pop in the domestic silkworm, Bombyx mori: cloning, characterization and expression analysis\<br\>Gene (2018) 667, 101-111. PubMed  Europe PubMed DOI  I
  33. Guardiola,S., Prades,R., Mendieta,L., Brouwer,A.J., Streefkerk,J., Nevola,L., Tarrago,T., Liskamp,R.M.J. and Giralt,E. \<br\>Targeted covalent inhibition of prolyl oligopeptidase (POP): discovery of sulfonylfluoride peptidomimetics\<br\>Cell Chem Biol (2018) 25, 1031-1037. PubMed  Europe PubMed DOI  I
  34. Julku,U.H., Panhelainen,A.E., Tiilikainen,S.E., Svarcbahs,R., Tammimaki,A.E., Piepponen,T.P., Savolainen,M.H. and Myohanen,T.T. \<br\>Prolyl oligopeptidase regulates dopamine transporter phosphorylation in the nigrostriatal pathway of mouse\<br\>Mol Neurobiol (2018) 55, 470-482. PubMed  Europe PubMed DOI
  35. Manzanares,P., Martinez,R., Garrigues,S., Genoves,S., Ramon,D., Marcos,J.F. and Martorell,P. \<br\>Tryptophan-containing dual neuroprotective peptides: prolyl endopeptidase inhibition and Caenorhabditis elegans protection from beta-amyloid peptide toxicity\<br\>Int J Mol Sci (2018) 19, DOI  I
  36. Takahashi,S., Kawano,T., Nakajima,N., Suda,Y., Usukhbayar,N., Kimura,K.I. and Koshino,H. \<br\>Synthesis of polyozellin, a prolyl oligopeptidase inhibitor, and its structural revision\<br\>Bioorg Med Chem Lett (2018) 28, 930-933. PubMed  Europe PubMed DOI  I
  37. Wadhawan,M., Tiwari,S., Sharma,S. and Rathaur,S. \<br\>Identification and characterization of a novel prolyl oligopeptidase in filarial parasite Setaria cervi\<br\>Biochem Biophys Res Commun (2018) 495, 2235-2241. PubMed  Europe PubMed DOI  I
    38. 2017
  38. Babkova,K., Korabecny,J., Soukup,O., Nepovimova,E., Jun,D. and Kuca,K. \<br\>Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors\<br\>Future Med Chem (2017) 9, 1015-1038. PubMed  Europe PubMed DOI  I
  39. Guest,P.C., Krishnamurthy,D. and Rahmoune,H. \<br\>Development of an assay for measuring proprotein-conversion activity on a multiplex magnetic bead-based array platform\<br\>Adv Exp Med Biol (2017) 974, 321-326. PubMed  Europe PubMed DOI  A
  40. Kumar,R., Bavi,R., Jo,M.G., Arulalapperumal,V., Baek,A., Rampogu,S., Kim,M.O. and Lee,K.W. \<br\>New compounds identified through in silico approaches reduce the alpha-synuclein expression by inhibiting prolyl oligopeptidase in vitro\<br\>Sci Rep (2017) 7, 10827. PubMed  Europe PubMed DOI  PMC  EPMC  I
  41. Lim,P.Y., Tan,L.L., Ow,D.S. and Wong,F.T. \<br\>A propeptide toolbox for secretion optimization of Flavobacterium meningosepticum endopeptidase in Lactococcus lactis\<br\>Microb Cell Fact (2017) 16, 221. PubMed  Europe PubMed DOI  PMC  EPMC  E
  42. Mannisto,P.T. and Garcia-Horsman,J.A. \<br\>Mechanism of action of prolyl oligopeptidase (PREP) in degenerative brain diseases: has peptidase activity only a modulatory role on the interactions of PREP with proteins?\<br\>Front Aging Neurosci (2017) 9, 27. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Prades,R., Munarriz-Cuezva,E., Uriguen,L., Gil-Pisa,I., Gomez,L., Mendieta,L., Royo,S., Giralt,E., Tarrago,T. and Meana,J.J. \<br\>The prolyl oligopeptidase inhibitor IPR19 ameliorates cognitive deficits in mouse models of schizophrenia\<br\>Eur Neuropsychopharmacol (2017) 27, 180-191. PubMed  Europe PubMed DOI  I
  44. Tsirigotaki,A., Elzen,R.V., Veken,P.V., Lambeir,A.M. and Economou,A. \<br\>Dynamics and ligand-induced conformational changes in human prolyl oligopeptidase analyzed by hydrogen/deuterium exchange mass spectrometry\<br\>Sci Rep (2017) 7, 2456. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Van Elzen,R., Schoenmakers,E., Brandt,I., Van der Veken,P. and Lambeir,A.M. \<br\>Ligand-induced conformational changes in prolyl oligopeptidase: a kinetic approach\<br\>Protein Eng Des Sel (2017) 30, 217-224. PubMed  Europe PubMed DOI
  46. Wang,X.D., Jiang,T., Yu,X.W. and Xu,Y. \<br\>Effects of UPR and ERAD pathway on the prolyl endopeptidase production in Pichia pastoris by controlling of nitrogen source\<br\>J Ind Microbiol Biotechnol (2017) 44, 1053-1063. PubMed  Europe PubMed DOI  E
  47. Zhou,D., Wang,J., He,L.N., Li,B.H., Ding,Y.N., Chen,Y.W. and Fan,J.G. \<br\>Prolyl oligopeptidase attenuates hepatic stellate cell activation through induction of Smad7 and PPAR-gamma\<br\>Exp Ther Med (2017) 13, 780-786. PubMed  Europe PubMed DOI  PMC  EPMC  I
    48. 2016
  48. Hayes,M., Moen,L.F., Auty,M.A. and Lea,T.E. \<br\>Transport of a prolyl endopeptidase inhibitory peptide across the blood-brain barrier demonstrated using the hCMEC/D3 cell line transcytosis assay\<br\>J Agric Food Chem (2016) 64, 146-150. PubMed  Europe PubMed DOI  I
  49. Hofling,C., Kulesskaya,N., Jaako,K., Peltonen,I., Mannisto,P.T., Nurmi,A., Vartiainen,N., Morawski,M., Zharkovsky,A., Voikar,V., Rossner,S. and Garcia-Horsman,J.A. \<br\>Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume\<br\>Eur Neuropsychopharmacol (2016) 26, 1048-1061. PubMed  Europe PubMed DOI  K
  50. Jaako,K., Waniek,A., Parik,K., Klimaviciusa,L., Aonurm-Helm,A., Noortoots,A., Anier,K., Van Elzen,R., Gerard,M., Lambeir,A.M., Rossner,S., Morawski,M. and Zharkovsky,A. \<br\>Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro\<br\>J Cell Sci (2016) 129, 3792-3802. PubMed  Europe PubMed DOI
  51. Kumar,N., Nakagawa,P., Janic,B., Romero,C.A., Worou,M.E., Monu,S.R., Peterson,E.L., Shaw,J., Valeriote,F., Ongeri,E.M., Niyitegeka,J.M., Rhaleb,N.E. and Carretero,O.A. \<br\>The anti-inflammatory peptide Ac-SDKP is released from thymosin-beta4 by renal meprin-alpha and prolyl oligopeptidase\<br\>Am J Physiol Renal Physiol (2016) 310, F1026-F1034. PubMed  Europe PubMed DOI
  52. Lopez,A., Vilaseca,M., Madurga,S., Varese,M., Tarrago,T. and Giralt,E. \<br\>Analyzing slowly exchanging protein conformations by ion mobility mass spectrometry: study of the dynamic equilibrium of prolyl oligopeptidase\<br\>J Mass Spectrom (2016) 51, 504-511. PubMed  Europe PubMed DOI
  53. Mariaule,G., De Cesco,S., Airaghi,F., Kurian,J., Schiavini,P., Rocheleau,S., Huskic,I., Auclair,K., Mittermaier,A. and Moitessier,N. \<br\>3-Oxo-hexahydro-1H-isoindole-4-carboxylic acid as a drug chiral bicyclic scaffold: structure-based design and preparation of conformationally constrained covalent and noncovalent prolyl oligopeptidase inhibitors\<br\>J Med Chem (2016) 59, 4221-4234. PubMed  Europe PubMed DOI  I
  54. Saidi,M., Kamali,S. and Beaudry,F. \<br\>Characterization of substance P processing in mouse spinal cord S9 fractions using high-resolution quadrupole-orbitrap mass spectrometry\<br\>Neuropeptides (2016) 59, 47-55. PubMed  Europe PubMed DOI
  55. Svarcbahs,R., Julku,U.H. and Myohanen,T.T. \<br\>Inhibition of prolyl oligopeptidase restores spontaneous motor behavior in the alpha-synuclein virus vector-based Parkinson's disease mouse model by decreasing alpha-synuclein oligomeric species in mouse brain\<br\>J Neurosci (2016) 36, 12485-12497. PubMed  Europe PubMed DOI  I
    56. 2015
  56. Cahlikova,L., Hulova,L., Hrabinova,M., Chlebek,J., Hostalkova,A., Adamcova,M., Safratova,M., Jun,D., Opletal,L., Locarek,M. and Macakova,K. \<br\>Isoquinoline alkaloids as prolyl oligopeptidase inhibitors\<br\>Fitoterapia (2015) 103, 192-196. PubMed  Europe PubMed DOI  I
  57. Fajtova,P., Stefanic,S., Hradilek,M., Dvorak,J., Vondrasek,J., Jilkova,A., Ulrychova,L., McKerrow,J.H., Caffrey,C.R., Mares,M. and Horn,M. \<br\>Prolyl oligopeptidase from the blood fluke Schistosoma mansoni: from functional analysis to anti-schistosomal inhibitors\<br\>PLoS Negl Trop Dis (2015) 9, e0003827. PubMed  Europe PubMed DOI  PMC  EPMC
  58. Hellinger,R., Koehbach,J., Puigpinos,A., Clark,R.J., Tarrago,T., Giralt,E. and Gruber,C.W. \<br\>Inhibition of human prolyl oligopeptidase activity by the cyclotide psysol 2 isolated from Psychotria solitudinum\<br\>J Nat Prod (2015) 78, 1073-1082. PubMed  Europe PubMed DOI  I
  59. Ikuma,Y., Hochigai,H., Kimura,H., Nunami,N., Kobayashi,T., Uchiyama,K., Umezome,T., Sakurai,Y., Sawada,N., Tadano,J., Sugaru,E., Ono,M., Hirose,Y. and Nakahira,H. \<br\>Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors: use of a carboxylate prodrug to improve bioavailability\<br\>Bioorg Med Chem (2015) 23, 779-790. PubMed  Europe PubMed DOI  I
  60. Jackson,K.W., Christiansen,V.J., Yadav,V.R., Silasi-Mansat,R., Lupu,F., Awasthi,V., Zhang,R.R. and McKee,P.A. \<br\>Suppression of tumor growth in mice by rationally designed pseudopeptide inhibitors of fibroblast activation protein and prolyl oligopeptidase\<br\>Neoplasia (2015) 17, 43-54. PubMed  Europe PubMed DOI  PMC  EPMC  I
  61. Kotev,M., Lecina,D., Tarrago,T., Giralt,E. and Guallar,V. \<br\>Unveiling prolyl oligopeptidase ligand migration by comprehensive computational techniques\<br\>Biophys J (2015) 108, 116-125. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  62. Savolainen,M.H., Yan,X., Myohanen,T.T. and Huttunen,H.J. \<br\>Prolyl oligopeptidase enhances alpha-synuclein dimerization via direct protein-protein interaction\<br\>J Biol Chem (2015) 290, 5117-5126. PubMed  Europe PubMed DOI  I
  63. Schiavini,P., Pottel,J., Moitessier,N. and Auclair,K. \<br\>Metabolic instability of cyanothiazolidine-based prolyl oligopeptidase inhibitors: a structural assignment challenge and potential medicinal chemistry implications\<br\>ChemMedChem (2015) 10, 1174-1183. PubMed  Europe PubMed DOI  I
    64. 2014
  64. Abdul Roda,M., Sadik,M., Gaggar,A., Hardison,M.T., Jablonsky,M.J., Braber,S., Blalock,J.E., Redegeld,F.A., Folkerts,G. and Jackson,P.L. \<br\>Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation\<br\>PLoS ONE (2014) 9, e97594. PubMed  Europe PubMed DOI  PMC  EPMC  I
  65. Dokleja,L., Hannula,M.J. and Myohanen,T.T. \<br\>Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers\<br\>Neurosci Lett (2014) 583, 37-42. PubMed  Europe PubMed DOI  I
  66. Jalkanen,A.J., Leikas,J.V. and Forsberg,M.M. \<br\>KYP-2047 Penetrates mouse brain and effectively inhibits mouse prolyl oligopeptidase\<br\>Basic Clin Pharmacol Toxicol (2014) 114, 460-463. PubMed  Europe PubMed DOI  I
  67. Kallinen,A., Todorov,B., Kallionpaa,R., Back,S., Sarparanta,M., Raki,M., Garcia-Horsman,J.A., Bergstrom,K.A., Wallen,E.A., Mannisto,P.T. and Airaksinen,A.J. \<br\>Synthesis and biological evaluation of novel (123)I-labeled 4-(4-iodophenyl)butanoyl-l-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo\<br\>Eur J Med Chem (2014) 79, 436-445. PubMed  Europe PubMed DOI  L  I
  68. Kaushik,S., Etchebest,C. and Sowdhamini,R. \<br\>Decoding the structural events in substrate-gating mechanism of eukaryotic prolyl oligopeptidase using normal mode analysis and molecular dynamics simulations\<br\>Proteins (2014) 82, 1428-1443. PubMed  Europe PubMed DOI
  69. Kim,J.D., Toda,C., D'Agostino,G., Zeiss,C.J., DiLeone,R.J., Elsworth,J.D., Kibbey,R.G., Chan,O., Harvey,B.K., Richie,C.T., Savolainen,M., Myohannen,T., Jeong,J.K. and Diano,S. \<br\>Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice\<br\>Proc Natl Acad Sci U S A (2014) 111, 11876-11881. PubMed  Europe PubMed DOI  K  I
  70. Safratova,M., Novak,Z., Kulhankova,A., Kunes,J., Hrabinova,M., Jun,D., Macakova,K., Opletal,L. and Cahlikova,L. \<br\>Revised NMR data for 9-O-demethylgalanthine: an alkaloid from Zephyranthes robusta (Amaryllidaceae) and its biological activity\<br\>Nat Prod Commun (2014) 9, 787-788. PubMed  Europe PubMed  I
  71. Savolainen,M.H., Richie,C.T., Harvey,B.K., Mannisto,P.T., Maguire-Zeiss,K.A. and Myohanen,T.T. \<br\>The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse\<br\>Neurobiol Dis (2014) 68, 1-15. PubMed  Europe PubMed DOI  I
  72. Suzuki,K., Sakaguchi,M., Tanaka,S., Yoshimoto,T. and Takaoka,M. \<br\>Prolyl oligopeptidase inhibition-induced growth arrest of human gastric cancer cells\<br\>Biochem Biophys Res Commun (2014) 443, 91-96. PubMed  Europe PubMed DOI  K  I
  73. Takahashi,S., Yoshida,A., Uesugi,S., Hongo,Y., Kimura,K., Matsuoka,K. and Koshino,H. \<br\>Structural revision of kynapcin-12 by total synthesis, and inhibitory activities against prolyl oligopeptidase and cancer cells\<br\>Bioorg Med Chem Lett (2014) 24, 3373-3376. PubMed  Europe PubMed DOI  I
    74. 2013
  74. Adolpho,L.O., Marin,D., Puigpinos,A., Mendieta,L., Tarrago,T., Morel,A.F., Giralt,E. and Dalcol,I.I. \<br\>In vitro evaluation of caffeoyl and cinnamoyl derivatives as potential prolyl oligopeptidase inhibitors\<br\>Planta Med (2013) 79, 1531-1535. PubMed  Europe PubMed DOI  I
  75. Albrecht,A., Rahmoune,H., Leedjarv,K., Knorpp,T., Joos,T., Stocki,P., Guest,P.C. and Bahn,S. \<br\>Development of a novel assay for proprotein converting enzyme activity on a multiplex bead-based array system\<br\>Proteomics (2013) 13, 2976-2979. PubMed  Europe PubMed DOI  A
  76. Christiansen,V.J., Jackson,K.W., Lee,K.N., Downs,T.D. and McKee,P.A. \<br\>Targeting inhibition of fibroblast activation protein-alpha and prolyl oligopeptidase activities on cells common to metastatic tumor microenvironments\<br\>Neoplasia (2013) 15, 348-358. PubMed  Europe PubMed  PMC  EPMC  P
  77. D'Agostino,G., Kim,J.D., Liu,Z.W., Jeong,J.K., Suyama,S., Calignano,A., Gao,X.B., Schwartz,M. and Diano,S. \<br\>Prolyl endopeptidase-deficient mice have reduced synaptic spine density in the CA1 region of the hippocampus, impaired LTP, and spatial learning and memory\<br\>Cereb Cortex (2013) 23, 2007-2014. PubMed  Europe PubMed DOI  K
  78. Lopez,A., Mendieta,L., Prades,R., Royo,S., Tarrago,T. and Giralt,E. \<br\>Peptide POP inhibitors for the treatment of the cognitive symptoms of schizophrenia\<br\>Future Med Chem (2013) 5, 1509-1523. PubMed  Europe PubMed DOI  T
  79. Matsubara,S., Maruyama,Y. and Kimura,A.P. \<br\>A 914-bp promoter is sufficient to reproduce the endogenous prolyl oligopeptidase gene localization in the mouse placenta if not subject to position effect\<br\>Gene (2013) 524, 114-123. PubMed  Europe PubMed DOI
  80. Matsuda,T., Sakaguchi,M., Tanaka,S., Yoshimoto,T. and Takaoka,M. \<br\>Prolyl oligopeptidase is a glyceraldehyde-3-phosphate dehydrogenase-binding protein that regulates genotoxic stress-induced cell death\<br\>Int J Biochem Cell Biol (2013) 45, 850-857. PubMed  Europe PubMed DOI  I
  81. Rentzsch,A., Kahlert,V., Jahreis,G., Schlott,B., Schutkowski,M., Malesevic,M. and Fischer,G. \<br\>Identification of prolyl oligopeptidase as a cyclosporine-sensitive protease by screening of mouse liver extracts\<br\>Biol Chem (2013) 394, 1057-1067. PubMed  Europe PubMed DOI  I
  82. Szeltner,Z., Juhasz,T., Szamosi,I., Rea,D., Fulop,V., Modos,K., Juliano,L. and Polgar,L. \<br\>The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity\<br\>Biochim Biophys Acta (2013) 1834, 98-111. PubMed  Europe PubMed DOI
    83. 2012
  83. De Cesco,S., Deslandes,S., Therrien,E., Levan,D., Cueto,M., Schmidt,R., Cantin,L.D., Mittermaier,A., Juillerat-Jeanneret,L. and Moitessier,N. \<br\>Virtual screening and computational optimization for the discovery of covalent prolyl oligopeptidase inhibitors with activity in human cells\<br\>J Med Chem (2012) 55, 6306-6315. PubMed  Europe PubMed DOI  I
  84. Filho,A.G., Morel,A.F., Adolpho,L., Ilha,V., Giralt,E., Tarrago,T. and Dalcol,I.I. \<br\>Inhibitory effect of verbascoside isolated from Buddleja brasiliensis Jacq. ex Spreng on prolyl oligopeptidase activity\<br\>Phytother Res (2012) 26, 1472-1475. PubMed  Europe PubMed DOI  I
  85. Ito,K., Nakajima,Y. and Yoshimoto,T. \<br\>Prolyl oligopeptidase\<br\>[ISSN:978-0-12-407742-3] (2012) 3, 3360-3364. DOI
  86. Jambunathan,K., Watson,D.S., Endsley,A.N., Kodukula,K. and Galande,A.K. \<br\>Comparative analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein alpha\<br\>FEBS Lett (2012) 586, 2507-2512. PubMed  Europe PubMed DOI  P
  87. Kaszuba,K., Rog,T., Danne,R., Canning,P., Fulop,V., Juhasz,T., Szeltner,Z., St Pierre,J.F., Garcia-Horsman,A., Mannisto,P.T., Karttunen,M., Hokkanen,J. and Bunker,A. \<br\>Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase\<br\>Biochimie (2012) 94, 1398-1411. PubMed  Europe PubMed DOI
  88. Khlebnikova,N.N., Krupina,N.A., Kushnareva,E.Yu., Zolotov,N.N. and Kryzhanovskii,G.N. \<br\>Effect of imipramine and prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine on activity of proline-specific peptidases in the brain of rats with experimental anxious-depressive syndrome\<br\>Bull Exp Biol Med (2012) 152, 409-412. PubMed  Europe PubMed DOI  I
  89. Klimaviciusa,L., Jain,R.K., Jaako,K., Van Elzen,R., Gerard,M., Van der Veken,P., Lambeir,A.M. and Zharkovsky,A. \<br\>In situ prolyl oligopeptidase activity assay in neural cell cultures\<br\>J Neurosci Methods (2012) 204, 104-110. PubMed  Europe PubMed DOI  A  I
  90. Van der Veken,P., Fulop,V., Rea,D., Gerard,M., Van Elzen,R., Joossens,J., Cheng,J.D., Baekelandt,V., De Meester,I., Lambeir,A.M. and Augustyns,K. \<br\>P2-Substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy\<br\>J Med Chem (2012) 55, 9856-9867. PubMed  Europe PubMed DOI  I
  91. Wang,M.X., Zhong,C., Cai,Q.F., Liu,G.M., Zhang,L., Hara,K., Su,W.J. and Cao,M.J. \<br\>Study on a prolyl endopeptidase from the skeletal muscle of common carp (Cyprinus carpio)\<br\>Process Biochem (2012) 47, 2211-2218. DOI  I
    92. 2011
  92. Cummins,P.M., Dowling,O. and O'Connor,B.F. \<br\>Ion-exchange chromatography: basic principles and application to the partial purification of soluble mammalian prolyl oligopeptidase\<br\>Methods Mol Biol (2011) 681, 215-228. PubMed  Europe PubMed DOI
  93. Fuhrmann,G. and Leroux,J.C. \<br\>In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract\<br\>Proc Natl Acad Sci U S A (2011) 108, 9032-9037. PubMed  Europe PubMed DOI  U
  94. Lopez,A., Tarrago,T. and Giralt,E. \<br\>Low molecular weight inhibitors of prolyl oligopeptidase: a review of compounds patented from 2003 to 2010\<br\>Expert Opin Ther Pat (2011) 21, 1023-1044. PubMed  Europe PubMed DOI  T  I
  95. Myohanen,T., Tenorio-Laranga,J., Jokinen,B., Vazquez-Sanchez,R., Moreno-Baylach,M., Garcia-Horsman,J. and Mannisto,P. \<br\>Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner\<br\>Br J Pharmacol (2011) 163, 1666-1678. PubMed  Europe PubMed DOI  I
  96. Peltonen,I., Myohanen,T.T. and Mannisto,P.T. \<br\>Association of prolyl oligopeptidase with conventional neurotransmitters in the brain\<br\>CNS Neurol Disord Drug Targets (2011) 10, 311-318. PubMed  Europe PubMed
  97. Penttinen,A., Tenorio-Laranga,J., Siikanen,A., Morawski,M., Rossner,S. and Garcia-Horsman,J.A. \<br\>Prolyl oligopeptidase: a rising star on the stage of neuroinflammation research\<br\>CNS Neurol Disord Drug Targets (2011) 10, 340-348. PubMed  Europe PubMed  V
  98. Rea,D. and Fulop,V. \<br\>Prolyl oligopeptidase structure and dynamics\<br\>CNS Neurol Disord Drug Targets (2011) 10, 306-310. PubMed  Europe PubMed  V
  99. Robic,S., Linscott,K.B., Aseem,M., Humphreys,E.A. and McCartha,S.R. \<br\>Bile acids as modulators of enzyme activity and stability\<br\>Protein J (2011) 30, 539-545. PubMed  Europe PubMed DOI  U
  100. Sakaguchi,M., Matsuda,T., Matsumura,E., Yoshimoto,T. and Takaoka,M. \<br\>Prolyl oligopeptidase participates in cell cycle progression in a human neuroblastoma cell line\<br\>Biochem Biophys Res Commun (2011) 409, 693-698. PubMed  Europe PubMed DOI  I
  101. Tenorio-Laranga,J., Mannisto,P.T. and Garcia-Horsman,J.A. \<br\>Hunting for peptide substrates of prolyl oligopeptidase: classical versus non-classical bioactive peptides\<br\>CNS Neurol Disord Drug Targets (2011) 10, 319-326. PubMed  Europe PubMed
    102. 2010
  102. Agirregoitia,N., Bizet,P., Agirregoitia,E., Boutelet,I., Peralta,L., Vaudry,H. and Jegou,S. \<br\>Prolyl endopeptidase mRNA expression in the central nervous system during rat development\<br\>J Chem Neuroanat (2010) 40, 53-62. PubMed  Europe PubMed DOI
  103. Kichik,N., Tarrago,T. and Giralt,E. \<br\>Simultaneous (19)F NMR screening of prolyl oligopeptidase and dipeptidyl peptidase IV inhibitors\<br\>Chembiochem (2010) 11, 1115-1119. PubMed  Europe PubMed DOI  I
  104. Li,M., Chen,C., Davies,D.R. and Chiu,T.K. \<br\>Induced-fit mechanism for prolyl endopeptidase\<br\>J Biol Chem (2010) 285, 21487-21495. PubMed  Europe PubMed DOI  PMC  EPMC
  105. Lone,A.M., Nolte,W.M., Tinoco,A.D. and Saghatelian,A. \<br\>Peptidomics of the prolyl peptidases\<br\>AAPS J (2010) 12, 483-491. PubMed  Europe PubMed DOI  P
  106. Marques,M.R., Stuker,C., Kichik,N., Tarrago,T., Giralt,E., Morel,A.F. and Dalcol,I.I. \<br\>Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers\<br\>Fitoterapia (2010) 81, 552-556. PubMed  Europe PubMed DOI  I
  107. Matsubara,S., Takahashi,T. and Kimura,A.P. \<br\>Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression\<br\>Gene (2010) 465, 17-29. PubMed  Europe PubMed DOI
  108. Szeltner,Z., Morawski,M., Juhasz,T., Szamosi,I., Liliom,K., Csizmok,V., Tolgyesi,F. and Polgar,L. \<br\>GAP43 shows partial co-localisation but no strong physical interaction with prolyl oligopeptidase\<br\>Biochim Biophys Acta (2010) 1804, 2162-2176. PubMed  Europe PubMed DOI
    109. 2009
  109. Comellas,G., Kaczmarska,Z., Tarrago,T., Teixido,M. and Giralt,E. \<br\>Exploration of the one-bead one-compound methodology for the design of prolyl oligopeptidase substrates\<br\>PLoS ONE (2009) 4, e6222. PubMed  Europe PubMed DOI  PMC  EPMC
  110. Di Daniel,E., Glover,C.P., Grot,E., Chan,M.K., Sanderson,T.H., White,J.H., Ellis,C.L., Gallagher,K.T., Uney,J., Thomas,J., Maycox,P.R. and Mudge,A.W. \<br\>Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity\<br\>Mol Cell Neurosci (2009) 41, 373-382. PubMed  Europe PubMed DOI
  111. Luo,H., Hallen-Adams,H.E. and Walton,J.D. \<br\>Processing of the phalloidin proprotein by prolyl oligopeptidase from the mushroom Conocybe albipes\<br\>J Biol Chem (2009) 284, 18070-18077. PubMed  Europe PubMed DOI  PMC  EPMC
  112. Nolte,W.M., Tagore,D.M., Lane,W.S. and Saghatelian,A. \<br\>Peptidomics of prolyl endopeptidase in the central nervous system\<br\>Biochemistry (2009) 48, 11971-11981. PubMed  Europe PubMed DOI  P
  113. O'Reilly,P.J., Hardison,M.T., Jackson,P.L., Xu,X., Snelgrove,R.J., Gaggar,A., Galin,F.S. and Blalock,J.E. \<br\>Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen\<br\>J Neuroimmunol (2009) 217, 51-54. PubMed  Europe PubMed DOI
  114. Perroud,B., Alvarado,R.J., Espinal,G.M., Morado,A.R., Phinney,B.S. and Warden,C.H. \<br\>In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice\<br\>Mol Brain (2009) 2, 14. PubMed  Europe PubMed DOI  PMC  EPMC  K
  115. Sabido,E., Tarrago,T., Niessen,S., Cravatt,B.F. and Giralt,E. \<br\>Activity-based probes for monitoring postproline protease activity\<br\>Chembiochem (2009) 10, 2361-2366. PubMed  Europe PubMed DOI
  116. Tarrago,T., Martin-Benito,J., Sabido,E., Claasen,B., Madurga,S., Gairi,M., Valpuesta,J.M. and Giralt,E. \<br\>A new side opening on prolyl oligopeptidase revealed by electron microscopy\<br\>FEBS Lett (2009) 583, 3344-3348. PubMed  Europe PubMed DOI  S
  117. Warden,C.H., Fisler,J.S., Espinal,G., Graham,J., Havel,P.J. and Perroud,B. \<br\>Maternal influence of prolyl endopeptidase on fat mass of adult progeny\<br\>Int J Obes (Lond) (2009) 33, 1013-1022. PubMed  Europe PubMed DOI  PMC  EPMC  M
    118. 2008
  118. Ehren,J., Govindarajan,S., Moron,B., Minshull,J. and Khosla,C. \<br\>Protein engineering of improved prolyl endopeptidases for celiac sprue therapy\<br\>Protein Eng Des Sel (2008) 21, 699-707. PubMed  Europe PubMed DOI  PMC  EPMC  U
  119. Haffner,C.D., Diaz,C.J., Miller,A.B., Reid,R.A., Madauss,K.P., Hassell,A., Hanlon,M.H., Porter,D.J., Becherer,J.D. and Carter,L.H. \<br\>Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP)\<br\>Bioorg Med Chem Lett (2008) 18, 4360-4363. PubMed  Europe PubMed DOI  S  I
  120. Szeltner,Z. and Polgar,L. \<br\>Structure, function and biological relevance of prolyl oligopeptidase\<br\>Curr Protein Pept Sci (2008) 9, 96-107. PubMed  Europe PubMed DOI  V
  121. Tarrago,T., Kichik,N., Claasen,B., Prades,R., Teixido,M. and Giralt,E. \<br\>Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor\<br\>Bioorg Med Chem (2008) 16, 7516-7524. PubMed  Europe PubMed DOI  T  I
  122. Tarrago,T., Masdeu,C., Gomez,E., Isambert,N., Lavilla,R. and Giralt,E. \<br\>Benzimidazolium salts as small, nonpeptidic and BBB-permeable human prolyl oligopeptidase inhibitors\<br\>ChemMedChem (2008) 3, 1558-1565. PubMed  Europe PubMed DOI  I
  123. Tenorio-Laranga,J., Venalainen,J.I., Mannisto,P.T. and Garcia-Horsman,J.A. \<br\>Characterization of membrane-bound prolyl endopeptidase from brain\<br\>FEBS J (2008) 275, 4415-4427. PubMed  Europe PubMed DOI
    124. 2007
  124. Cerf-Bensussan,N., Matysiak-Budnik,T., Cellier,C. and Heyman,M. \<br\>Oral proteases: a new approach to managing coeliac disease\<br\>Gut (2007) 56, 157-160. PubMed  Europe PubMed DOI  U
  125. Garcia-Horsman,J.A., Mannisto,P.T. and Venalainen,J.I. \<br\>On the role of prolyl oligopeptidase in health and disease\<br\>Neuropeptides (2007) 41, 1-24. PubMed  Europe PubMed DOI  V
  126. Lee,S.H., Jun,M., Choi,J.Y., Yang,E.J., Hur,J.M., Bae,K., Seong,Y.H., Huh,T.L. and Song,K.S. \<br\>Plant phenolics as prolyl endopeptidase inhibitors\<br\>Arch Pharm Res (2007) 30, 827-833. PubMed  Europe PubMed  I
  127. Mannisto,P.T., Venalainen,J., Jalkanen,A. and Garcia-Horsman,J.A. \<br\>Prolyl oligopeptidase: a potential target for the treatment of cognitive disorders\<br\>Drug News Perspect (2007) 20, 293-305. PubMed  Europe PubMed DOI  T
  128. Tarrago,T., Kichik,N., Segui,J. and Giralt,E. \<br\>The Natural Product Berberine is a Human Prolyl Oligopeptidase Inhibitor\<br\>ChemMedChem (2007) 2, 354-359. PubMed  Europe PubMed DOI  I
  129. Tran,T., Quan,C., Edosada,C.Y., Mayeda,M., Wiesmann,C., Sutherlin,D. and Wolf,B.B. \<br\>Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP\<br\>Bioorg Med Chem Lett (2007) 17, 1438-1442. PubMed  Europe PubMed DOI  I
    130. 2006
  130. [YEAR:4-1-2006]Leprince,J., Cosquer,D., Bellemere,G., Chatenet,D., Tollemer,H., Jegou,S., Tonon,M.C. and Vaudry,H. \<br\>Catabolism of the octadecaneuropeptide ODN by prolyl endopeptidase: identification of an unusual cleavage site\<br\>Peptides (4-1-2006) 27, 1561-1569. PubMed  Europe PubMed DOI  T  I
  131. [YEAR:4-1-2006]Venalainen,J.I., Garcia-Horsman,J.A., Forsberg,M.M., Jalkanen,A., Wallen,E.A., Jarho,E.M., Christiaans,J.A., Gynther,J. and Mannisto,P.T. \<br\>Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors\<br\>Biochem Pharmacol (4-1-2006) 71, 683-692. PubMed  Europe PubMed DOI  T  I
    132. 2005
  132. Brandt,I., De Vriendt,K., Devreese,B., Van Beeumen,J., Van Dongen,W., Augustyns,K., De Meester,I., Scharpe,S. and Lambeir,A.M. \<br\>Search for substrates for prolyl oligopeptidase in porcine brain\<br\>Peptides (2005) 26, 2536-2546. PubMed  Europe PubMed DOI
  133. [YEAR:21-6-2005]Fuxreiter,M., Magyar,C., Juhasz,T., Szeltner,Z., Polgar,L. and Simon,I. \<br\>Flexibility of prolyl oligopeptidase: molecular dynamics and molecular framework analysis of the potential substrate pathways\<br\>Proteins (21-6-2005) 60, 504-512. PubMed  Europe PubMed DOI
  134. [YEAR:25-2-2005]Juhasz,T., Szeltner,Z., Fulop,V. and Polgar,L. \<br\>Unclosed beta-propellers display stable structures: implications for substrate access to the active site of prolyl oligopeptidase\<br\>J Mol Biol (25-2-2005) 346, 907-917. PubMed  Europe PubMed DOI
  135. [YEAR:9-9-2005]Marti,T., Molberg,O., Li,Q., Gray,G.M., Khosla,C. and Sollid,L.M. \<br\>Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization\<br\>J Pharmacol Exp Ther (9-9-2005) 312, 19-26. PubMed  Europe PubMed DOI
    136. 2004
  136. Cavasin,M.A., Rhaleb,N.E., Yang,X.P. and Carretero,O.A. \<br\>Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP\<br\>Hypertension (2004) 43, 1140-1145. PubMed  Europe PubMed DOI  I
  137. [YEAR:25-5-2004]Heinis,C., Alessi,P. and Neri,D. \<br\>Engineering a thermostable human prolyl endopeptidase for antibody-directed enzyme prodrug therapy\<br\>Biochemistry (25-5-2004) 43, 6293-6303. PubMed  Europe PubMed DOI
  138. Ito,K., Kitazono,A.A. and Yoshimoto,T. \<br\>Prolyl oligopeptidase\<br\>[ISSN:0-12-079610-4] (2004) 2, 1897-1900.  V
  139. [YEAR:9-7-2004]Szeltner,Z., Rea,D., Juhasz,T., Renner,V., Fulop,V. and Polgar,L. \<br\>Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding\<br\>J Mol Biol (9-7-2004) 340, 627-637. PubMed  Europe PubMed DOI
  140. [YEAR:15-9-2004]Venalainen,J.I., Juvonen,R.O., Garcia-Horsman,J.A., Wallen,E.A., Christiaans,J.A., Jarho,E.M., Gynther,J. and Mannisto,P.T. \<br\>Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site\<br\>Biochem J (15-9-2004) 382, 1003-1008. PubMed  Europe PubMed DOI  PMC  EPMC  T  I
    141. 2003
  141. Bellemere,G., Morain,P., Vaudry,H. and Jegou,S. \<br\>Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain\<br\>J Neurochem (2003) 84, 919-929. PubMed  Europe PubMed DOI  T  I
  142. [YEAR:5-12-2003]Szeltner,Z., Rea,D., Renner,V., Juliano,L., Fulop,V. and Polgar,L. \<br\>Electrostatic environment at the active site of prolyl oligopeptidase is highly influential during substrate binding\<br\>J Biol Chem (5-12-2003) 278, 48786-48793. PubMed  Europe PubMed DOI
  143. [YEAR:9-10-2003]Wallen,E.A., Christiaans,J.A., Jarho,E.M., Forsberg,M.M., Venalainen,J.I., Mannisto,P.T. and Gynther,J. \<br\>New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides\<br\>J Med Chem (9-10-2003) 46, 4543-4551. PubMed  Europe PubMed DOI  I
    144. 2002
  144. Esumi,Y., Suzuki,Y., Itoh,Y., Uramoto,M., Kimura,K., Goto,M., Yoshihama,M. and Ichikawa,T. \<br\>Propeptin, a new inhibitor of prolyl endopeptidase produced by Microbispora II. Determination of chemical structure\<br\>J Antibiot (Tokyo) (2002) 55, 296-300. PubMed  Europe PubMed  I
  145. Kimura,A., Matsui,H. and Takahashi,T. \<br\>Expression and localization of prolyl oligopeptidase in mouse testis and its possible involvement in sperm motility\<br\>Zoolog Sci (2002) 19, 93-102. PubMed  Europe PubMed DOI  I
  146. Morain,P., Lestage,P., de Nanteuil,G., Jochemsen,R., Robin,J.L., Guez,D. and Boyer,P.A. \<br\>S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies\<br\>CNS Drug Rev (2002) 8, 31-52. PubMed  Europe PubMed  T  I
  147. [YEAR:13-2-2002]Odaka,C., Mizuochi,T., Shirasawa,T., Morain,P. and Checler,F. \<br\>Murine T cells expressing high activity of prolyl endopeptidase are susceptible to activation-induced cell death\<br\>FEBS Lett (13-2-2002) 512, 163-167. PubMed  Europe PubMed DOI  I
  148. Schneider,J.S., Giardiniere,M. and Morain,P. \<br\>Effects of the prolyl endopeptidase inhibitor S 17092 on cognitive deficits in chronic low dose MPTP-treated monkeys\<br\>Neuropsychopharmacology (2002) 26, 176-182. PubMed  Europe PubMed DOI  T  I
  149. Schulz,I., Gerhartz,B., Neubauer,A., Holloschi,A., Heiser,U., Hafner,M. and Demuth,H.U. \<br\>Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition\<br\>Eur J Biochem (2002) 269, 5813-5820. PubMed  Europe PubMed DOI
  150. [YEAR:22-11-2002]Szeltner,Z., Rea,D., Juhasz,T., Renner,V., Mucsi,Z., Orosz,G., Fulop,V. and Polgar,L. \<br\>Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase\<br\>J Biol Chem (22-11-2002) 277, 44597-44605. PubMed  Europe PubMed DOI
  151. [YEAR:8-11-2002]Szeltner,Z., Rea,D., Renner,V., Fulop,V. and Polgar,L. \<br\>Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site\<br\>J Biol Chem (8-11-2002) 277, 42613-42622. PubMed  Europe PubMed DOI
  152. [YEAR:1-8-2002]Venalainen,J.I., Juvonen,R.O., Forsberg,M.M., Garcia-Horsman,A., Poso,A., Wallen,E.A., Gynther,J. and Mannisto,P.T. \<br\>Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819\<br\>Biochem Pharmacol (1-8-2002) 64, 463-471. PubMed  Europe PubMed DOI  I
    153. 2001
  153. [YEAR:12-1-2001]Fulop,V., Szeltner,Z., Renner,V. and Polgar,L. \<br\>Structures of prolyl oligopeptidase substrate/inhibitor complexes. Use of inhibitor binding for titration of the catalytic histidine residue\<br\>J Biol Chem (12-1-2001) 276, 1262-1266. PubMed  Europe PubMed DOI  S  I
  154. Hasebe,T., Hua,J., Someya,A., Morain,P., Checler,F. and Nagaoka,I. \<br\>Involvement of cytosolic prolyl endopeptidase in degradation of p40-phox splice variant protein in myeloid cells\<br\>J Leukoc Biol (2001) 69, 963-968. PubMed  Europe PubMed  I
    155. 2000
  155. Fulop,V., Szeltner,Z. and Polgar,L. \<br\>Catalysis of serine oligopeptidases is controlled by a gating filter mechanism\<br\>EMBO Rep (2000) 1, 277-281. PubMed  Europe PubMed DOI  PMC  EPMC  S
  156. Marighetto,A., Touzani,K., Etchamendy,N., Torrea,C.C., de Nanteuil,G., Guez,D., Jaffard,R. and Morain,P. \<br\>Further evidence for a dissociation between different forms of mnemonic expressions in a mouse model of age-related cognitive decline: effects of tacrine and S 17092, a novel prolyl endopeptidase inhibitor\<br\>Learn Mem (2000) 7, 159-169. PubMed  Europe PubMed DOI  PMC  EPMC  I
  157. Morain,P., Robin,J.L., de Nanteuil,G., Jochemsen,R., Heidet,V. and Guez,D. \<br\>Pharmacodynamic and pharmacokinetic profile of S 17092, a new orally active prolyl endopeptidase inhibitor, in elderly healthy volunteers. A phase I study\<br\>Br J Clin Pharmacol (2000) 50, 350-359. PubMed  Europe PubMed DOI  PMC  EPMC  I
  158. [YEAR:15-6-2000]Stockel-Maschek,A., Mrestani-Klaus,C., Stiebitz,B., Demuth,H. and Neubert,K. \<br\>Thioxo amino acid pyrrolidides and thiazolidides: new inhibitors of proline specific peptidases\<br\>Biochim Biophys Acta (15-6-2000) 1479, 15-31. PubMed  Europe PubMed DOI  I
  159. [YEAR:19-5-2000]Szeltner,Z., Renner,V. and Polgar,L. \<br\>The noncatalytic beta-propeller domain of prolyl oligopeptidase enhances the catalytic capability of the peptidase domain\<br\>J Biol Chem (19-5-2000) 275, 15000-15005. PubMed  Europe PubMed DOI
  160. Szeltner,Z., Renner,V. and Polgar,L. \<br\>Substrate- and pH-dependent contribution of oxyanion binding site to the catalysis of prolyl oligopeptidase, a paradigm of the serine oligopeptidase family\<br\>Protein Sci (2000) 9, 353-360. PubMed  Europe PubMed DOI  PMC  EPMC  I
    161. 1999
  161. Amin,A., Li,Y. and Finkelstein,R. \<br\>Identification of a Drosophila prolyl endopeptidase and analysis of its expression\<br\>DNA Cell Biol (1999) 18, 605-610. PubMed  Europe PubMed DOI
  162. [YEAR:21-4-1999]Barelli,H., Petit,A., Hirsch,E., Wilk,S., de Nanteuil,G., Morain,P. and Checler,F. \<br\>S 17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase\<br\>Biochem Biophys Res Commun (21-4-1999) 257, 657-661. PubMed  Europe PubMed DOI  I
  163. Feher,M., Kanai,K., Hermecz,I., Lopata,A. and Novak,I. \<br\>A 3D-QSAR analysis of prolyl endopeptidase inhibitors\<br\>Quant Struct -Act Relatsh (1999) 18, 456-463. DOI  S  I
  164. [YEAR:15-2-1999]Shinoda,M., Miyazaki,A. and Toide,K. \<br\>Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and on cholinergic and peptidergic neurons in rats with ibotenate-induced lesions of the nucleus basalis magnocellularis\<br\>Behav Brain Res (15-2-1999) 99, 17-25. PubMed  Europe PubMed DOI  I
  165. [YEAR:14-5-1999]Shishido,Y., Furushiro,M., Tanabe,S., Shibata,S., Hashimoto,S. and Yokokura,T. \<br\>Effects of prolyl endopeptidase inhibitors and neuropeptides on delayed neuronal death in rats\<br\>Eur J Pharmacol (14-5-1999) 372, 135-142. PubMed  Europe PubMed DOI  I
  166. Umemura,K., Kondo,K., Ikeda,Y., Nishimoto,M., Hiraga,Y., Yoshida,Y. and Nakashima,M. \<br\>Pharmacokinetics and safety of Z-321, a novel specific orally active prolyl endopeptidase inhibitor, in healthy male volunteers\<br\>J Clin Pharmacol (1999) 39, 462-470. PubMed  Europe PubMed  I
  167. [YEAR:17-5-1999]Williams,R.S., Eames,M., Ryves,W.J., Viggars,J. and Harwood,A.J. \<br\>Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate\<br\>EMBO J (17-5-1999) 18, 2734-2745. PubMed  Europe PubMed DOI  PMC  EPMC
  168. Yoshida,K., Inaba,K., Ohtake,H. and Morisawa,M. \<br\>Purification and characterization of prolyl endopeptidase from the Pacific herring, Clupea pallasi, and its role in the activation of sperm motility\<br\>Dev Growth Differ (1999) 41, 217-225. PubMed  Europe PubMed DOI  I
    169. 1998
  169. [YEAR:24-7-1998]Fulop,V., Bocskei,Z. and Polgar,L. \<br\>Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis\<br\>Cell (24-7-1998) 94, 161-170. PubMed  Europe PubMed DOI  S
  170. Ishino,T., Ohtsuki,S., Homma,K. and Natori,S. \<br\>cDNA cloning of mouse prolyl endopeptidase and its involvement in DNA synthesis by Swiss 3T3 cells\<br\>J Biochem (1998) 123, 540-545. PubMed  Europe PubMed
  171. [YEAR:1-10-1998]Kabashima,T., Fujii,M., Meng,Y., Ito,K. and Yoshimoto,T. \<br\>Prolyl endopeptidase from Sphingomonas capsulata: Isolation and characterization of the enzyme and nucleotide sequence of the gene\<br\>Arch Biochem Biophys (1-10-1998) 358, 141-148. PubMed  Europe PubMed DOI
  172. Miyazaki,A., Toide,K., Sasaki,Y., Ichitani,Y. and Iwasaki,T. \<br\>Effect of a prolyl endopeptidase inhibitor, JTP-4819, on radial maze performance in hippocampal-lesioned rats\<br\>Pharmacol Biochem Behav (1998) 59, 361-368. PubMed  Europe PubMed DOI  I
  173. Toide,K., Shinoda,M. and Miyazaki,A. \<br\>A novel prolyl endopeptidase inhibitor, JTP-4819 - its behavioral and neurochemical properties for the treatment of Alzheimer's disease\<br\>Rev Neurosci (1998) 9, 17-29. PubMed  Europe PubMed  I
    174. 1997
  174. [YEAR:15-11-1997]Goossens,F., Vanhoof,G., De Meester,I., Augustyns,K., Borloo,M., Tourwe,D., Haemers,A. and Scharpe,S. \<br\>Development and evaluation of peptide-based prolyl oligopeptidase inhibitors - introduction of N-benzyloxycarbonyl-prolyl-3-fluoropyrrolidine as a lead in inhibitor design\<br\>Eur J Biochem (15-11-1997) 250, 177-183. PubMed  Europe PubMed  I
  175. Kahyaoglu,A., Haghjoo,K., Guo,F., Jordan,F., Kettner,C., Felfoldi,F. and Polgar,L. \<br\>Low barrier hydrogen bond is absent in the catalytic triads in the ground state but is present in a transition-state complex in the prolyl oligopeptidase family of serine proteases\<br\>J Biol Chem (1997) 272, 25547-25554. PubMed  Europe PubMed DOI  I
  176. Kahyaoglu,A., Haghjoo,K., Kraicsovits,F., Jordan,F. and Polgar,L. \<br\>Benzyloxycarbonylprolylprolinal, a transition-state analogue for prolyl oligopeptidase, forms a tetrahedral adduct with catalytic serine, not a reactive cysteine\<br\>Biochem J (1997) 322, 839-843. PubMed  Europe PubMed  PMC  EPMC  I
  177. [YEAR:27-6-1997]Shinoda,M., Toide,K., Ohsawa,I. and Kohsaka,S. \<br\>Specific inhibitor for prolyl endopeptidase suppresses the generation of amyloid beta protein in NG108-15 cells\<br\>Biochem Biophys Res Commun (27-6-1997) 235, 641-645. PubMed  Europe PubMed DOI  I
  178. Toide,K., Shinoda,M., Fujiwara,T. and Iwamoto,Y. \<br\>Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and central cholinergic neurons in aged rats\<br\>Pharmacol Biochem Behav (1997) 56, 427-434. PubMed  Europe PubMed DOI  I
  179. Toide,K., Shinoda,M., Iwamoto,Y., Fujiwara,T., Okamiya,K. and Uemura,A. \<br\>A novel prolyl endopeptidase inhibitor, JTP-4819, with potential for treating Alzheimer's disease\<br\>Behav Brain Res (1997) 83, 147-151. PubMed  Europe PubMed DOI  T  I
    180. 1996
  180. Li,J., Wilk,E. and Wilk,S. \<br\>Inhibition of prolyl oligopeptidase by Fmoc-aminoacylpyrrolidine-2-nitriles\<br\>J Neurochem (1996) 66, 2105-2112. PubMed  Europe PubMed  I
  181. [YEAR:7-6-1996]Portevin,B., Benoist,A., Remond,G., Herve,Y., Vincent,M., Lepagnol,J. and de Nanteuil,G. \<br\>New prolyl endopeptidase inhibitors: in vitro and in vivo activities of azabicyclo[2.2.2]octane, azabicyclo[2.2.1]heptane, and perhydroindole derivatives\<br\>J Med Chem (7-6-1996) 39, 2379-2391. PubMed  Europe PubMed DOI  T  I
  182. [YEAR:3-6-1996]Shinoda,M., Matsuo,A. and Toide,K. \<br\>Pharmacological studies of a novel prolyl endopeptidase inhibitor, JTP-4819, in rats with middle cerebral artery occlusion\<br\>Eur J Pharmacol (3-6-1996) 305, 31-38. PubMed  Europe PubMed DOI  I
  183. Toide,K., Fujiwara,T., Iwamoto,Y., Shinoda,M., Okamiya,K. and Kato,T. \<br\>Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain\<br\>Naunyn Schmiedebergs Arch Pharmacol (1996) 353, 355-362. PubMed  Europe PubMed DOI  I
  184. Tsuda,M., Muraoka,Y., Nagai,M., Aoyagi,T. and Takeuchi,T. \<br\>Poststatin, a new inhibitor of prolyl endopeptidase. VII. N-Cycloalkylamide analogues\<br\>J Antibiot (Tokyo) (1996) 49, 909-920. PubMed  Europe PubMed  I
  185. Tsuda,M., Muraoka,Y., Nagai,M., Aoyagi,T. and Takeuchi,T. \<br\>Poststatin, a new inhibitor of prolyl endopeptidase. VIII. Endopeptidase inhibitory activity of non-peptidyl poststatin analogues\<br\>J Antibiot (Tokyo) (1996) 49, 1022-1030. PubMed  Europe PubMed  I
  186. Tsuda,M., Muraoka,Y., Nagai,M., Takeuchi,T. and Aoyagi,T. \<br\>Poststatin, a new inhibitor of prolyl endopeptidase. IV. The chemical synthesis of poststatin\<br\>J Antibiot (Tokyo) (1996) 49, 287-291. PubMed  Europe PubMed  I
  187. Tsuda,M., Muraoka,Y., Nagai,M., Aoyagi,T. and Takeuchi,T. \<br\>Poststatin, a new inhibitor of prolyl endopeptidase. III. Optical resolution of 3-amino-2-hydroxyvaleric acid and absolute configuration of poststatin\<br\>J Antibiot (Tokyo) (1996) 49, 281-286. PubMed  Europe PubMed  I
    188. 1995
  188. Borloo,M., Augustyns,K., Belyaev,A., De Meester,I., Lambeir,A.M., Goossens,F., Bollaert,W., Rajan,P., Scharpe,S. and Haemers,A. \<br\>Synthesis and evaluation of azaproline peptides as potential inhibitors of dipeptidyl peptidase IV and prolyl oligopeptidase\<br\>Lett Pept Sci (1995) 2, 198-202. DOI  I
  189. Goossens,F., De Meester,I., Vanhoof,G., Hendriks,D., Vriend,G. and Scharpe,S. \<br\>The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha/beta hydrolase fold family\<br\>Eur J Biochem (1995) 233, 432-441. PubMed  Europe PubMed
  190. Shinoda,M., Okamiya,K. and Toide,K. \<br\>Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on thyrotropin-releasing hormone-like immunoreactivity in the cerebral cortex and hippocampus of aged rats\<br\>Jpn J Pharmacol (1995) 69, 273-276. PubMed  Europe PubMed  I
  191. Toide,K., Iwamoto,Y., Fujiwara,T. and Abe,H. \<br\>JTP-4819: a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer\<br\>J Pharmacol Exp Ther (1995) 274, 1370-1378. PubMed  Europe PubMed  I
  192. Toide,K., Okamiya,K., Iwamoto,Y. and Kato,T. \<br\>Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on prolyl endopeptidase activity and substance P- and arginine-vasopressin-like immunoreactivity in the brains of aged rats\<br\>J Neurochem (1995) 65, 234-240. PubMed  Europe PubMed  I
    193. 1994
  193. Makinen,P.L., Makinen,K.K. and Syed,S.A. \<br\>An endo-acting proline-specific oligopeptidase from Treponema denticola ATCC 35405: evidence of hydrolysis of human bioactive peptides\<br\>Infect Immun (1994) 62, 4938-4947. PubMed  Europe PubMed  PMC  EPMC  P
  194. Polgar,L. \<br\>Prolyl oligopeptidases\<br\>Methods Enzymol (1994) 244, 188-200. PubMed  Europe PubMed DOI  V
  195. Salers,P. \<br\>Evidence for the presence of prolyl oligopeptidase and its endogenous inhibitor in neonatal rat pancreatic beta-cells\<br\>Regul Pept (1994) 50, 235-245. PubMed  Europe PubMed DOI
  196. Tanaka,Y., Niwa,S., Nishioka,H., Yamanaka,T., Torizuka,M., Yoshinaga,K., Kobayashi,N., Ikeda,Y. and Arai,H. \<br\>New potent prolyl endopeptidase inhibitors: synthesis and structure-activity relationships of indan and tetralin derivatives and their analogues\<br\>J Med Chem (1994) 37, 2071-2078. PubMed  Europe PubMed DOI  I
  197. Vanhoof,G., Goossens,F., Hendriks,L., De Meester,I., Hendriks,D., Vriend,G., Van Broeckhoven,C. and Scharpe,S. \<br\>Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase\<br\>Gene (1994) 149, 363-366. PubMed  Europe PubMed DOI
    198. 1993
  198. Diefenthal,T., Dargatz,H., Witte,V., Reipen,G. and Svendsen,I. \<br\>Cloning of proline-specific endopeptidase gene from Flavobacterium meningosepticum: Expression in Escherichia coli and purification of the heterologous protein\<br\>Appl Microbiol Biotechnol (1993) 40, 90-97. PubMed  Europe PubMed
  199. Kanatani,A., Yoshimoto,T., Kitazono,A., Kokubo,T. and Tsuru,D. \<br\>Prolyl endopeptidase from Aeromonas hydrophila: cloning, sequencing, and expression of the enzyme gene, and characterization of the expressed enzyme\<br\>J Biochem (1993) 113, 790-796. PubMed  Europe PubMed
  200. Polgar,L., Kollt,E. and Hollosi,M. \<br\>Prolyl oligopeptidase catalysis. Reactions with thiono substrates reveal substrate-induced conformational change to be the rate-limiting step\<br\>FEBS Lett (1993) 322, 227-230. PubMed  Europe PubMed DOI
    201. 1992
  201. Barrett,A.J. and Rawlings,N.D. \<br\>Oligopeptidases, and the emergence of the prolyl oligopeptidase family\<br\>Biol Chem Hoppe Seyler (1992) 373, 353-360. PubMed  Europe PubMed
  202. Chevallier,S., Goeltz,P., Thibault,P., Banville,D. and Gagnon,J. \<br\>Characterization of a prolyl endopeptidase from Flavobacterium meningosepticum. Complete sequence and localization of the active-site serine\<br\>J Biol Chem (1992) 267, 8192-8199. PubMed  Europe PubMed
  203. Kamei,H., Ueki,T., Obi,Y., Fukagawa,Y. and Oki,T. \<br\>Protective effect of eurystatins A and B, new prolyl endopeptidase inhibitors, on scopolamine-induced amnesia in rats\<br\>Jpn J Pharmacol (1992) 60, 377-380. PubMed  Europe PubMed  I
  204. Medeiros,M.S., Iazigi,N., Camargo,A.C. and Oliveira,E.B. \<br\>Distribution and properties of endo-oligopeptidases A and B in the human neuroendocrine system\<br\>J Endocrinol (1992) 135, 579-588. PubMed  Europe PubMed
  205. Polgar,L. \<br\>Structural relationship between lipases and peptidases of the prolyl oligopeptidase family\<br\>FEBS Lett (1992) 311, 281-284. PubMed  Europe PubMed DOI
  206. [YEAR:1-5-1992]Stone,S.R., Rennex,D., Wikstrom,P., Shaw,E. and Hofsteenge,J. \<br\>Peptidyldiazomethanes. A novel mechanism of interaction with prolyl endopeptidase\<br\>Biochem J (1-5-1992) 283, 871-876. PubMed  Europe PubMed  PMC  EPMC  I
    207. 1991
  207. Aoyagi,T., Nagai,M., Ogawa,K., Kojima,F., Okada,M., Ikeda,T., Hamada,M. and Takeuchi,T. \<br\>Poststatin, a new inhibitor of prolyl endopeptidase, produced by Streptomyces viridochromogenes MH534-30F3. I. Taxonomy, production, isolation, physico-chemical properties and biological activities\<br\>J Antibiot (Tokyo) (1991) 44, 949-955. PubMed  Europe PubMed  I
  208. Atack,J.R., Suman-Chauhan,N., Dawson,G. and Kulagowski,J.J. \<br\>In vitro and in vivo inhibition of prolyl endopeptidase\<br\>Eur J Pharmacol (1991) 205, 157-163. PubMed  Europe PubMed  I
  209. Kalwant,S. and Porter,A.G. \<br\>Purification and characterization of human brain prolyl endopeptidase\<br\>Biochem J (1991) 276, 237-244. PubMed  Europe PubMed  PMC  EPMC
  210. Rennex,D., Hemmings,B.A., Hofsteenge,J. and Stone,S.R. \<br\>cDNA cloning of porcine brain prolyl endopeptidase and identification of the active-site seryl residue\<br\>Biochemistry (1991) 30, 2195-2203. PubMed  Europe PubMed  I
  211. Stone,S.R., Rennex,D., Wikstrom,P., Shaw,E. and Hofsteenge,J. \<br\>Inactivation of prolyl endopeptidase by a peptidylchloromethane. Kinetics of inactivation and identification of sites of modification\<br\>Biochem J (1991) 276, 837-840. PubMed  Europe PubMed  PMC  EPMC  I
  212. Takkinen,K., Peranen,J. and Kaariainen,L. \<br\>Proteolytic processing of Semliki Forest virus-specific non-structural polyprotein\<br\>J Gen Virol (1991) 72, 1627-1633. PubMed  Europe PubMed
    213. 1988
  213. Heins,J., Welker,P., Schonlein,C., Born,I., Hartrodt,B., Neubert,K., Tsuru,D. and Barth,A. \<br\>Mechanism of proline-specific proteinases: (I) Substrate specificity of dipeptidyl peptidase IV from pig kidney and proline-specific endopeptidase from Flavobacterium meningosepticum\<br\>Biochim Biophys Acta (1988) 954, 161-169. PubMed  Europe PubMed  P
  214. Moriyama,A., Nakanishi,M. and Sasaki,M. \<br\>Porcine muscle prolyl endopeptidase and its endogenous substrates\<br\>J Biochem (1988) 104, 112-117. PubMed  Europe PubMed
    215. 1987
  215. Yoshimoto,T., Abdus Sattar,A.K.M., Hirose,W. and Tsuru,D. \<br\>Studies on prolyl endopeptidase from carrot (Daucus carota): purification and enzymatic properties\<br\>Biochim Biophys Acta (1987) 916, 29-37.
    216. 1986
  216. Friedman,T.C. and Wilk,S. \<br\>Delineation of a particulate thyrotropin-releasing hormone-degrading enzyme in rat brain by the use of specific inhibitors of prolyl endopeptidase and pyroglutamyl peptide hydrolase\<br\>J Neurochem (1986) 46, 1231-1239. PubMed  Europe PubMed  I
  217. Knisatschek,H. and Bauer,K. \<br\>Specific inhibition of post proline cleaving enzyme by benzyloxycarbonyl-Gly-Pro-diazomethyl ketone\<br\>Biochem Biophys Res Commun (1986) 134, 888-894. PubMed  Europe PubMed  I
  218. Nomura,K. \<br\>Specificity of prolyl endopeptidase\<br\>FEBS Lett (1986) 209, 235-237. PubMed  Europe PubMed  P
    219. 1985
  219. Yoshimoto,T., Kawahara,K., Matsubara,F., Kado,K. and Tsuru,D. \<br\>Comparison of inhibitory effects of prolinal-containing peptide derivatives on prolyl endopeptidases from bovine brain and Flavobacterium\<br\>J Biochem (1985) 98, 975-979. PubMed  Europe PubMed  I
    220. 1984
  220. Friedman,T.C., Orlowski,M. and Wilk,S. \<br\>Prolyl endopeptidase: inhibition in vivo by N-benzyloxycarbonyl-prolyl-prolinal\<br\>J Neurochem (1984) 42, 237-241. PubMed  Europe PubMed  I
    221. 1983
  221. Camargo,A.C., Caldo,H. and Emson,P.C. \<br\>Degradation of neurotensin by rabbit brain endo-oligopeptidase A and endo-oligopeptidase B (proline-endopeptidase)\<br\>Biochem Biophys Res Commun (1983) 116, 1151-1159. PubMed  Europe PubMed
  222. Moriyama,A. and Sasaki,M. \<br\>Porcine liver succinyltrialanine p-nitroanilide hydrolytic enzyme. Its purification and characterization as a post-proline cleaving enzyme\<br\>J Biochem (1983) 94, 1387-1397. PubMed  Europe PubMed
  223. Wilk,S. and Orlowski,M. \<br\>Inhibition of rabbit brain prolyl endopeptidase by N-benzyloxycarbonyl-prolyl-prolinal, a transition state aldehyde inhibitor\<br\>J Neurochem (1983) 41, 69-75. PubMed  Europe PubMed  I
    224. 1982
  224. Greene,L.J., Spadaro,A.C., Martins,A.R., Perussi De Jesus,W.D. and Camargo,A.C. \<br\>Brain endo-oligopeptidase B: a post-proline cleaving enzyme that inactivates angiotensin I and II\<br\>Hypertension (1982) 4, 178-184. PubMed  Europe PubMed
  225. Yoshimoto,T., Tsukumo,K., Takatsuka,N. and Tsuru,D. \<br\>An inhibitor for post-proline cleaving enzyme; distribution and partial purification from porcine pancreas\<br\>J Pharmacobiodyn (1982) 5, 734-740. PubMed  Europe PubMed
    226. 1980
  226. Andrews,P.C., Hines,C.M. and Dixon,J.E. \<br\>Characterization of proline endopeptidase from rat brain\<br\>Biochemistry (1980) 19, 5494-5500. PubMed  Europe PubMed
    227. 1977
  227. Yoshimoto,T. and Walter,R. \<br\>Post-proline dipeptidyl aminopeptidase (dipeptidyl aminopeptidase IV) from lamb kidney. Purification and some enzymatic properties\<br\>Biochim Biophys Acta (1977) 485, 391-401. PubMed  Europe PubMed

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