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Literature for peptidase S09.001: prolyl oligopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Jia,K., Cheng,B., Huang,L., Xu,J., Liu,F., Liao,X., Liao,K. and Lu,H.
    Activation of prep expression by Tet2 promotes the proliferation of bipotential progenitor cells during liver regeneration
    Development PubMed  Europe PubMed DOI
  2. Peng,H., Guo,Z., Wang,W.L., Yin,D., Zou,S., Asbell,T., Ullman,B.R., Thakar,M., Zhang,F., Hong,S.Y., Rao,A.V.S., Wang,K., Zhang,S., Wu,Z., Li,X., Margolis,S.S., Matsui,W.H., Gocke,C.B., Mao,Y. and Liu,J.O.
    Rapaprotin is Activated by an Endopeptidase to Disassemble 26S Proteasome
    bioRxiv PubMed  Europe PubMed DOI
  3. Van Elzen,R., Waumans,Y., Nath,S., Van der Veken,P., Kerckhoff,S., Van Dijk,E., Morawski,M., Rossner,S., Engelborghs,Y., De Meester,I. and Lambeir,A.M.
    The prolyl oligopeptidase and alpha-synuclein connection revisited
    Biochimie PubMed  Europe PubMed DOI
    4. 2024
  4. Briot,J., Pons,C., Foucher,A., Goudouneche,D., Gaudenzio,N., Donovan,M., Bernard,D., Mechin,M.C. and Simon,M.
    Prolyl Endopeptidase PREP Is Involved in Filaggrinolysis and Cornification
    J Invest Dermatol145, 98-108. PubMed  Europe PubMed DOI
  5. Walczewska-Szewc,K. and Rydzewski,J.
    Structural visualization of inhibitor binding in prolyl oligopeptidase
    Biophys Rev (Melville)5, 032105-032105. PubMed  Europe PubMed DOI
    6. 2023
  6. Kilpelainen,T.P., Patsi,H.T., Svarcbahs,R., Julku,U.H., Etelainen,T.S., Cui,H., Auno,S., Sipari,N., Norrbacka,S., Leino,T.O., Jantti,M., Myohanen,T.T. and Wallen,E.A.A.
    Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease
    J Med Chem66, 7475-7496. PubMed  Europe PubMed DOI
    7. 2022
  7. Baharin,A., Ting,T.Y. and Goh,H.H.
    Post-Proline Cleaving Enzymes (PPCEs): Classification, Structure, Molecular Properties, and Applications
    Plants (Basel)11, PubMed  Europe PubMed DOI  V
  8. Plescia,J., Hedou,D., Pousse,M.E., Labarre,A., Dufresne,C., Mittermaier,A. and Moitessier,N.
    Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-alpha for different indications
    Eur J Med Chem240, 114543-114543. PubMed  Europe PubMed DOI
    9. 2021
  9. Cui,H., Norrbacka,S. and Myohanen,T.T.
    Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy
    Biochem Pharmacol197, 114899-114899. PubMed  Europe PubMed DOI  K
  10. Julku,U.H., Jantti,M., Svarcbahs,R. and Myohanen,T.T.
    Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner
    Int J Mol Sci22, PubMed  Europe PubMed DOI
  11. Kulkarni,A.M., Rampogu,S. and Lee,K.W.
    Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase
    Evid Based Complement Alternat Med2021, 6687572-6687572. PubMed  Europe PubMed DOI
  12. Patsi,H.T., Kilpelainen,T.P., Auno,S., Dillemuth,P.M.J., Arja,K., Lahtela-Kakkonen,M.K., Myohanen,T.T. and Wallen,E.A.A.
    2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors
    ACS Med Chem Lett12, 1578-1584. PubMed  Europe PubMed DOI
  13. Payne,G.A., Sharma,N.S., Lal,C.V., Song,C., Guo,L., Margaroli,C., Viera,L., Kumar,S., Li,J., Bosley,M., Xing,D., Xu,X., Wells,J.M., George,J.F., Tallaj,J.A., Leesar,M., Blalock,J.E. and Gaggar,A.
    Prolyl Endopeptidase contributes to early neutrophilic inflammation in acute cardiac transplant rejection
    JCI Insight PubMed  Europe PubMed DOI
  14. Simkova,A., Ormsby,T., Sidej,N., Slavetinska,L.P., Brynda,J., Beranova,J., Sacha,P., Majer,P. and Konvalinka,J.
    Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with alpha-ketoamide warheads
    Eur J Med Chem224, 113717-113717. PubMed  Europe PubMed DOI  I
  15. Triposkiadis,F., Starling,R.C., Xanthopoulos,A., Butler,J. and Boudoulas,H.
    Renin-angiotensin-system inhibition in the context of corona virus disease-19: experimental evidence, observational studies, and clinical implications
    Heart Fail Rev26, 381-389. PubMed  Europe PubMed DOI
  16. Zolotov,N.N., Schepetkin,I.A., Voronina,T.A., Pozdnev,V.F., Khlebnikov,A.I., Krylova,I.V. and Quinn,M.T.
    Therapeutic Effect of Novel Cyanopyrrolidine-Based Prolyl Oligopeptidase Inhibitors in Rat Models of Amnesia
    Front Chem9, 780958-780958. PubMed  Europe PubMed DOI  I
    17. 2020
  17. Da'adoosh,B., Kaito,K., Miyashita,K., Sakaguchi,M. and Goldblum,A.
    Computational design of substrate selective inhibition
    PLoS Comput Biol16, e1007713-e1007713. PubMed  Europe PubMed DOI
  18. Dunaevsky,Y.E., Tereshchenkova,V.F., Oppert,B., Belozersky,M.A., Filippova,I.Y. and Elpidina,E.N.
    Human proline specific peptidases: a comprehensive analysis
    Biochim Biophys Acta Gen Subj1864, 129636-129636. PubMed  Europe PubMed DOI  V
  19. He,Z., Long,P., Fang,F., Li,S., Zhang,P. and Chen,Z.
    Diversity of MSDIN family members in amanitin-producing mushrooms and the phylogeny of the MSDIN and prolyl oligopeptidase genes
    BMC Genomics21, 440-440. PubMed  Europe PubMed DOI
  20. Jiang,D.X., Zhang,J.B., Li,M.T., Lin,S.Z., Wang,Y.Q., Chen,Y.W. and Fan,J.G.
    Prolyl endopeptidase gene disruption attenuates high fat diet-induced nonalcoholic fatty liver disease in mice by improving hepatic steatosis and inflammation
    Ann Transl Med8, 218-218. PubMed  Europe PubMed DOI  K
  21. Kilpelainen,T.P., Hellinen,L., Vrijdag,J., Yan,X., Svarcbahs,R., Vellonen,K.S., Lambeir,A.M., Huttunen,H., Urtti,A., Wallen,E.A.A. and Myohanen,T.T.
    The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy
    Biomed Pharmacother128, 110253-110253. PubMed  Europe PubMed DOI  I
  22. Retzl,B., Hellinger,R., Muratspahic,E., Pinto,M.E.F., Bolzani,V.S. and Gruber,C.W.
    Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides
    J Nat Prod PubMed  Europe PubMed DOI
  23. Rostami,J., Jantti,M., Cui,H., Rinne,M.K., Kukkonen,J.P., Falk,A., Erlandsson,A. and Myohanen,T.
    Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells
    Biomed Pharmacother131, 110788-110788. PubMed  Europe PubMed DOI  I
  24. Serfozo,P., Wysocki,J., Gulua,G., Schulze,A., Ye,M., Liu,P., Jin,J., Bader,M., Myohanen,T., Garcia-Horsman,J.A. and Batlle,D.
    Ang II (Angiotensin II) Conversion to angiotensin-(1-7) in the circulation is POP (prolyloligopeptidase)-dependent and ACE2 (angiotensin-converting enzyme 2)-independent
    Hypertension75, 173-182. PubMed  Europe PubMed DOI
  25. Shrivastava,A., Srivastava,S., Malik,R., Alam,M.M., Shaqiquzamman,M. and Akhter,M.
    Identification of novel small molecule non-peptidomimetic inhibitor for prolyl oligopeptidase through in silico and in vitro approaches
    J Biomol Struct Dyn38, 1292-1305. PubMed  Europe PubMed DOI  I
  26. Sobolova,K., Hrabinova,M., Hepnarova,V., Kucera,T., Kobrlova,T., Benkova,M., Janockova,J., Dolezal,R., Prchal,L., Benek,O., Mezeiova,E., Jun,D., Soukup,O. and Korabecny,J.
    Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
    Eur J Med Chem203, 112593-112593. PubMed  Europe PubMed DOI  I
  27. Svarcbahs,R., Jantti,M., Kilpelainen,T., Julku,U.H., Urvas,L., Kivioja,S., Norrbacka,S. and Myohanen,T.T.
    Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A
    Pharmacol Res151, 104558-104558. PubMed  Europe PubMed DOI
    28. 2019
  28. Bandyopadhyay,A.K., Islam,R.N.U., Mitra,D., Banerjee,S. and Goswami,A.
    Analysis of salt-bridges in prolyl oligopeptidase from Pyrococcus furiosus and Homo sapiens
    Bioinformation15, 214-225. PubMed  Europe PubMed DOI
  29. Bracke,A., Van Elzen,R., Van der Veken,P., Augustyns,K., De Meester,I. and Lambeir,A.M.
    The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma
    Clin Chim Acta495, 154-160. PubMed  Europe PubMed DOI  A
  30. Kilpelainen,T.P., Tyni,J.K., Lahtela-Kakkonen,M.K., Etelainen,T.S., Myohanen,T.T. and Wallen,E.A.A.
    Tetrazole as a replacement of the electrophilic group in characteristic prolyl oligopeptidase inhibitors
    ACS Med Chem Lett10, 1635-1640. PubMed  Europe PubMed DOI  I
  31. Kumar,R., Parameswaran,S., Bavi,R., Baek,A., Son,M., Rampogu,S., Park,C., Lee,G., Zeb,A., Parate,S., Rana,R.M. and Lee,K.W.
    Investigation of novel chemical scaffolds targeting prolyl oligopeptidase for neurological therapeutics
    J Mol Graph Model88, 92-103. PubMed  Europe PubMed DOI  I
  32. Maruyama,Y. and Kimura,A.P.
    A molecular mechanism of mouse placental spongiotrophoblast differentiation regulated by prolyl oligopeptidase
    Zygote27, 49-53. PubMed  Europe PubMed DOI  I
  33. Natunen,T.A., Gynther,M., Rostalski,H., Jaako,K. and Jalkanen,A.J.
    Extracellular prolyl oligopeptidase derived from activated microglia is a potential neuroprotection target
    Basic Clin Pharmacol Toxicol124, 40-49. PubMed  Europe PubMed DOI  I
  34. Plescia,J., De Cesco,S., Patrascu,M.B., Kurian,J., Di Trani,J., Dufresne,C., Wahba,A.S., Janmamode,N., Mittermaier,A.K. and Moitessier,N.
    Integrated synthetic, biophysical, and computational investigations of covalent inhibitors of prolyl oligopeptidase and fibroblast activation protein alpha
    J Med Chem62, 7874-7884. PubMed  Europe PubMed DOI  I
  35. Plescia,J., Dufresne,C., Janmamode,N., Wahba,A.S., Mittermaier,A.K. and Moitessier,N.
    Discovery of covalent prolyl oligopeptidase boronic ester inhibitors
    Eur J Med Chem111783-111783. PubMed  Europe PubMed DOI  I
  36. Svarcbahs,R., Julku,U., Kilpelainen,T., Kyyro,M., Jantti,M. and Myohanen,T.T.
    New tricks of prolyl oligopeptidase inhibitors - a common drug therapy for several neurodegenerative diseases
    Biochem Pharmacol161, 113-120. PubMed  Europe PubMed DOI  I
  37. Venditti,M. and Minucci,S.
    Subcellular localization of prolyl endopeptidase during the first wave of rat spermatogenesis and in rat and human sperm
    J Histochem Cytochem67, 229-243. PubMed  Europe PubMed DOI
  38. Xu,P., Bao,R., Zhang,Y., Lu,E., Feng,F., Zhang,L., Li,J., Wang,J., Tan,X., Tang,M., Hu,C., Li,G. and Zhang,C.
    Prolyl oligopeptidase regulates progesterone secretion via the ERK signaling pathway in murine luteal cells
    Mol Reprod Dev86, 714-726. PubMed  Europe PubMed DOI  I
    39. 2018
  39. Becker,B., Nazir,F.H., Brinkmalm,G., Camporesi,E., Kvartsberg,H., Portelius,E., Bostrom,M., Kalm,M., Hoglund,K., Olsson,M., Zetterberg,H. and Blennow,K.
    Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by calpain-1 and prolyl endopeptidase
    Mol Neurodegener13, 47-47. PubMed  Europe PubMed DOI
  40. Di Trani,J.M., De Cesco,S., O'Leary,R., Plescia,J., do Nascimento,C.J., Moitessier,N. and Mittermaier,A.K.
    Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry
    Nat Commun9, 893-893. PubMed  Europe PubMed DOI  I
  41. Fu,P., Sun,W., Lai,J., Shen,Y.H. and Zhang,Z.
    Identification of two isoforms of Pop in the domestic silkworm, Bombyx mori: cloning, characterization and expression analysis
    Gene667, 101-111. PubMed  Europe PubMed DOI  I
  42. Guardiola,S., Prades,R., Mendieta,L., Brouwer,A.J., Streefkerk,J., Nevola,L., Tarrago,T., Liskamp,R.M.J. and Giralt,E.
    Targeted covalent inhibition of prolyl oligopeptidase (POP): discovery of sulfonylfluoride peptidomimetics
    Cell Chem Biol25, 1031-1037. PubMed  Europe PubMed DOI  I
  43. Julku,U.H., Panhelainen,A.E., Tiilikainen,S.E., Svarcbahs,R., Tammimaki,A.E., Piepponen,T.P., Savolainen,M.H. and Myohanen,T.T.
    Prolyl oligopeptidase regulates dopamine transporter phosphorylation in the nigrostriatal pathway of mouse
    Mol Neurobiol55, 470-482. PubMed  Europe PubMed DOI
  44. Manzanares,P., Martinez,R., Garrigues,S., Genoves,S., Ramon,D., Marcos,J.F. and Martorell,P.
    Tryptophan-containing dual neuroprotective peptides: prolyl endopeptidase inhibition and Caenorhabditis elegans protection from beta-amyloid peptide toxicity
    Int J Mol Sci19, DOI  I
  45. Takahashi,S., Kawano,T., Nakajima,N., Suda,Y., Usukhbayar,N., Kimura,K.I. and Koshino,H.
    Synthesis of polyozellin, a prolyl oligopeptidase inhibitor, and its structural revision
    Bioorg Med Chem Lett28, 930-933. PubMed  Europe PubMed DOI  I
  46. Wadhawan,M., Tiwari,S., Sharma,S. and Rathaur,S.
    Identification and characterization of a novel prolyl oligopeptidase in filarial parasite Setaria cervi
    Biochem Biophys Res Commun495, 2235-2241. PubMed  Europe PubMed DOI  I
    47. 2017
  47. Babkova,K., Korabecny,J., Soukup,O., Nepovimova,E., Jun,D. and Kuca,K.
    Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors
    Future Med Chem9, 1015-1038. PubMed  Europe PubMed DOI  I
  48. Guest,P.C., Krishnamurthy,D. and Rahmoune,H.
    Development of an assay for measuring proprotein-conversion activity on a multiplex magnetic bead-based array platform
    Adv Exp Med Biol974, 321-326. PubMed  Europe PubMed DOI  A
  49. Kumar,R., Bavi,R., Jo,M.G., Arulalapperumal,V., Baek,A., Rampogu,S., Kim,M.O. and Lee,K.W.
    New compounds identified through in silico approaches reduce the alpha-synuclein expression by inhibiting prolyl oligopeptidase in vitro
    Sci Rep7, 10827-10827. PubMed  Europe PubMed DOI  I
  50. Lim,P.Y., Tan,L.L., Ow,D.S. and Wong,F.T.
    A propeptide toolbox for secretion optimization of Flavobacterium meningosepticum endopeptidase in Lactococcus lactis
    Microb Cell Fact16, 221-221. PubMed  Europe PubMed DOI  E
  51. Mannisto,P.T. and Garcia-Horsman,J.A.
    Mechanism of action of prolyl oligopeptidase (PREP) in degenerative brain diseases: has peptidase activity only a modulatory role on the interactions of PREP with proteins?
    Front Aging Neurosci9, 27-27. PubMed  Europe PubMed DOI
  52. Prades,R., Munarriz-Cuezva,E., Uriguen,L., Gil-Pisa,I., Gomez,L., Mendieta,L., Royo,S., Giralt,E., Tarrago,T. and Meana,J.J.
    The prolyl oligopeptidase inhibitor IPR19 ameliorates cognitive deficits in mouse models of schizophrenia
    Eur Neuropsychopharmacol27, 180-191. PubMed  Europe PubMed DOI  I
  53. Tsirigotaki,A., Elzen,R.V., Veken,P.V., Lambeir,A.M. and Economou,A.
    Dynamics and ligand-induced conformational changes in human prolyl oligopeptidase analyzed by hydrogen/deuterium exchange mass spectrometry
    Sci Rep7, 2456-2456. PubMed  Europe PubMed DOI
  54. Van Elzen,R., Schoenmakers,E., Brandt,I., Van der Veken,P. and Lambeir,A.M.
    Ligand-induced conformational changes in prolyl oligopeptidase: a kinetic approach
    Protein Eng Des Sel30, 217-224. PubMed  Europe PubMed DOI
  55. Wang,X.D., Jiang,T., Yu,X.W. and Xu,Y.
    Effects of UPR and ERAD pathway on the prolyl endopeptidase production in Pichia pastoris by controlling of nitrogen source
    J Ind Microbiol Biotechnol44, 1053-1063. PubMed  Europe PubMed DOI  E
  56. Zhou,D., Wang,J., He,L.N., Li,B.H., Ding,Y.N., Chen,Y.W. and Fan,J.G.
    Prolyl oligopeptidase attenuates hepatic stellate cell activation through induction of Smad7 and PPAR-gamma
    Exp Ther Med13, 780-786. PubMed  Europe PubMed DOI  I
    57. 2016
  57. Hayes,M., Moen,L.F., Auty,M.A. and Lea,T.E.
    Transport of a prolyl endopeptidase inhibitory peptide across the blood-brain barrier demonstrated using the hCMEC/D3 cell line transcytosis assay
    J Agric Food Chem64, 146-150. PubMed  Europe PubMed DOI  I
  58. Hofling,C., Kulesskaya,N., Jaako,K., Peltonen,I., Mannisto,P.T., Nurmi,A., Vartiainen,N., Morawski,M., Zharkovsky,A., Voikar,V., Rossner,S. and Garcia-Horsman,J.A.
    Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume
    Eur Neuropsychopharmacol26, 1048-1061. PubMed  Europe PubMed DOI  K
  59. Jaako,K., Waniek,A., Parik,K., Klimaviciusa,L., Aonurm-Helm,A., Noortoots,A., Anier,K., Van Elzen,R., Gerard,M., Lambeir,A.M., Rossner,S., Morawski,M. and Zharkovsky,A.
    Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro
    J Cell Sci129, 3792-3802. PubMed  Europe PubMed DOI
  60. Kumar,N., Nakagawa,P., Janic,B., Romero,C.A., Worou,M.E., Monu,S.R., Peterson,E.L., Shaw,J., Valeriote,F., Ongeri,E.M., Niyitegeka,J.M., Rhaleb,N.E. and Carretero,O.A.
    The anti-inflammatory peptide Ac-SDKP is released from thymosin-beta4 by renal meprin-alpha and prolyl oligopeptidase
    Am J Physiol Renal Physiol310, F1026-F1034. PubMed  Europe PubMed DOI
  61. Lopez,A., Vilaseca,M., Madurga,S., Varese,M., Tarrago,T. and Giralt,E.
    Analyzing slowly exchanging protein conformations by ion mobility mass spectrometry: study of the dynamic equilibrium of prolyl oligopeptidase
    J Mass Spectrom51, 504-511. PubMed  Europe PubMed DOI
  62. Mariaule,G., De Cesco,S., Airaghi,F., Kurian,J., Schiavini,P., Rocheleau,S., Huskic,I., Auclair,K., Mittermaier,A. and Moitessier,N.
    3-Oxo-hexahydro-1H-isoindole-4-carboxylic acid as a drug chiral bicyclic scaffold: structure-based design and preparation of conformationally constrained covalent and noncovalent prolyl oligopeptidase inhibitors
    J Med Chem59, 4221-4234. PubMed  Europe PubMed DOI  I
  63. Saidi,M., Kamali,S. and Beaudry,F.
    Characterization of substance P processing in mouse spinal cord S9 fractions using high-resolution quadrupole-orbitrap mass spectrometry
    Neuropeptides59, 47-55. PubMed  Europe PubMed DOI
  64. Svarcbahs,R., Julku,U.H. and Myohanen,T.T.
    Inhibition of prolyl oligopeptidase restores spontaneous motor behavior in the alpha-synuclein virus vector-based Parkinson's disease mouse model by decreasing alpha-synuclein oligomeric species in mouse brain
    J Neurosci36, 12485-12497. PubMed  Europe PubMed DOI  I
    65. 2015
  65. Cahlikova,L., Hulova,L., Hrabinova,M., Chlebek,J., Hostalkova,A., Adamcova,M., Safratova,M., Jun,D., Opletal,L., Locarek,M. and Macakova,K.
    Isoquinoline alkaloids as prolyl oligopeptidase inhibitors
    Fitoterapia103, 192-196. PubMed  Europe PubMed DOI  I
  66. Fajtova,P., Stefanic,S., Hradilek,M., Dvorak,J., Vondrasek,J., Jilkova,A., Ulrychova,L., McKerrow,J.H., Caffrey,C.R., Mares,M. and Horn,M.
    Prolyl oligopeptidase from the blood fluke Schistosoma mansoni: from functional analysis to anti-schistosomal inhibitors
    PLoS Negl Trop Dis9, e0003827-e0003827. PubMed  Europe PubMed DOI
  67. Hellinger,R., Koehbach,J., Puigpinos,A., Clark,R.J., Tarrago,T., Giralt,E. and Gruber,C.W.
    Inhibition of human prolyl oligopeptidase activity by the cyclotide psysol 2 isolated from Psychotria solitudinum
    J Nat Prod78, 1073-1082. PubMed  Europe PubMed DOI  I
  68. Ikuma,Y., Hochigai,H., Kimura,H., Nunami,N., Kobayashi,T., Uchiyama,K., Umezome,T., Sakurai,Y., Sawada,N., Tadano,J., Sugaru,E., Ono,M., Hirose,Y. and Nakahira,H.
    Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors: use of a carboxylate prodrug to improve bioavailability
    Bioorg Med Chem23, 779-790. PubMed  Europe PubMed DOI  I
  69. Jackson,K.W., Christiansen,V.J., Yadav,V.R., Silasi-Mansat,R., Lupu,F., Awasthi,V., Zhang,R.R. and McKee,P.A.
    Suppression of tumor growth in mice by rationally designed pseudopeptide inhibitors of fibroblast activation protein and prolyl oligopeptidase
    Neoplasia17, 43-54. PubMed  Europe PubMed DOI  I
  70. Kotev,M., Lecina,D., Tarrago,T., Giralt,E. and Guallar,V.
    Unveiling prolyl oligopeptidase ligand migration by comprehensive computational techniques
    Biophys J108, 116-125. PubMed  Europe PubMed DOI  S  I
  71. Savolainen,M.H., Yan,X., Myohanen,T.T. and Huttunen,H.J.
    Prolyl oligopeptidase enhances alpha-synuclein dimerization via direct protein-protein interaction
    J Biol Chem290, 5117-5126. PubMed  Europe PubMed DOI  I
  72. Schiavini,P., Pottel,J., Moitessier,N. and Auclair,K.
    Metabolic instability of cyanothiazolidine-based prolyl oligopeptidase inhibitors: a structural assignment challenge and potential medicinal chemistry implications
    ChemMedChem10, 1174-1183. PubMed  Europe PubMed DOI  I
    73. 2014
  73. Abdul Roda,M., Sadik,M., Gaggar,A., Hardison,M.T., Jablonsky,M.J., Braber,S., Blalock,J.E., Redegeld,F.A., Folkerts,G. and Jackson,P.L.
    Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation
    PLoS ONE9, e97594-e97594. PubMed  Europe PubMed DOI  I
  74. Dokleja,L., Hannula,M.J. and Myohanen,T.T.
    Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers
    Neurosci Lett583, 37-42. PubMed  Europe PubMed DOI  I
  75. Jalkanen,A.J., Leikas,J.V. and Forsberg,M.M.
    KYP-2047 Penetrates mouse brain and effectively inhibits mouse prolyl oligopeptidase
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  76. Kallinen,A., Todorov,B., Kallionpaa,R., Back,S., Sarparanta,M., Raki,M., Garcia-Horsman,J.A., Bergstrom,K.A., Wallen,E.A., Mannisto,P.T. and Airaksinen,A.J.
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