Searches of the MEROPS database
Display Known Cleavages for a Protein
Please enter a UniProt accession (eg P05067):
Sequence P02662
,
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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 15 |
unknown peptidase |
1-214 |
P |
release of a signal peptide |
NT |
Grosclaude et al., 1972 |
| 20 |
oligopeptidase O2 |
16-24 |
P |
|
MS |
Chen et al., 2003 |
| 21 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 24 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 24 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 25 |
Mername-AA083 peptidase |
23-26 |
N |
|
|
Dal Degan et al., 1992 |
| 26 |
Mername-AA083 peptidase |
23-27 |
N |
|
|
Dal Degan et al., 1992 |
| 27 |
Mername-AA083 peptidase |
23-28 |
N |
|
AA |
Dal Degan et al., 1992 |
| 27 |
carboxypeptidase O |
23-28 |
N |
|
AA |
Dal Degan et al., 1992 |
| 28 |
Mername-AA083 peptidase |
23-29 |
N |
|
AA |
Dal Degan et al., 1992 |
| 28 |
carboxypeptidase O |
23-29 |
N |
|
AA |
Dal Degan et al., 1992 |
| 29 |
Mername-AA083 peptidase |
23-30 |
N |
|
|
Dal Degan et al., 1992 |
| 29 |
carboxypeptidase O |
23-30 |
N |
|
|
Dal Degan et al., 1992 |
| 29 |
unknown peptidase |
23-30 |
N |
|
|
Dal Degan et al., 1992 |
| 30 |
Mername-AA083 peptidase |
23-31 |
N |
|
|
Dal Degan et al., 1992 |
| 30 |
carboxypeptidase O |
23-31 |
N |
|
|
Dal Degan et al., 1992 |
| 31 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 31 |
Mername-AA083 peptidase |
23-32 |
N |
|
|
Dal Degan et al., 1992 |
| 31 |
carboxypeptidase O |
23-32 |
N |
|
|
Dal Degan et al., 1992 |
| 32 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 32 |
Mername-AA083 peptidase |
23-33 |
N |
|
AA |
Dal Degan et al., 1992 |
| 32 |
carboxypeptidase O |
23-33 |
N |
|
AA |
Dal Degan et al., 1992 |
| 32 |
archaean signal peptide peptidase 1 |
16-214 |
N |
|
|
Yokoyama & Matsui, 2005 |
| 33 |
Mername-AA083 peptidase |
23-34 |
N |
|
|
Dal Degan et al., 1992 |
| 33 |
carboxypeptidase O |
23-34 |
N |
|
AA |
Dal Degan et al., 1992 |
| 34 |
Mername-AA083 peptidase |
23-35 |
N |
|
AA |
Dal Degan et al., 1992 |
| 34 |
carboxypeptidase O |
23-35 |
N |
|
AA |
Dal Degan et al., 1992 |
| 35 |
Mername-AA083 peptidase |
23-36 |
N |
|
|
Dal Degan et al., 1992 |
| 35 |
carboxypeptidase O |
23-36 |
N |
|
|
Dal Degan et al., 1992 |
| 36 |
Mername-AA083 peptidase |
23-37 |
N |
|
|
Dal Degan et al., 1992 |
| 36 |
carboxypeptidase O |
23-37 |
N |
|
|
Dal Degan et al., 1992 |
| 38 |
chymosin |
16-214 |
P |
normal turnover |
|
Kobayashi, 2004 |
| 38 |
polyporopepsin |
16-214 |
N |
|
|
Kobayashi, 2004 |
| 38 |
phytepsin |
16-214 |
N |
|
|
Pires, 1998 |
| 38 |
Ftsh peptidase (Thermus-type) |
16-214 |
N |
|
|
Asahara et al., 2000 |
| 38 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 38 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 39 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 39 |
carboxypeptidase O |
38-40 |
N |
|
AA |
Dal Degan et al., 1992 |
| 40 |
carboxypeptidase O |
38-41 |
N |
|
|
Dal Degan et al., 1992 |
| 41 |
carboxypeptidase O |
38-42 |
N |
|
|
Dal Degan et al., 1992 |
| 42 |
prolyl oligopeptidase |
16-214 |
P |
|
|
Clare & Swaisgood, 2000 |
| 42 |
carboxypeptidase O |
38-43 |
N |
|
|
Dal Degan et al., 1992 |
| 43 |
Mername-AA083 peptidase |
38-44 |
N |
|
AA |
Dal Degan et al., 1992 |
| 43 |
carboxypeptidase O |
38-44 |
N |
|
AA |
Dal Degan et al., 1992 |
| 44 |
Mername-AA083 peptidase |
38-45 |
N |
|
AA |
Dal Degan et al., 1992 |
| 44 |
carboxypeptidase O |
38-45 |
N |
|
|
Dal Degan et al., 1992 |
| 45 |
Mername-AA083 peptidase |
38-46 |
N |
|
AA |
Dal Degan et al., 1992 |
| 45 |
carboxypeptidase O |
38-46 |
N |
|
AA |
Dal Degan et al., 1992 |
| 46 |
Mername-AA083 peptidase |
38-47 |
N |
|
AA |
Dal Degan et al., 1992 |
| 46 |
carboxypeptidase O |
38-47 |
N |
|
|
Dal Degan et al., 1992 |
| 46 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 47 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 47 |
Mername-AA083 peptidase |
38-48 |
N |
|
AA |
Dal Degan et al., 1992 |
| 47 |
carboxypeptidase O |
38-48 |
N |
|
AA |
Dal Degan et al., 1992 |
| 48 |
Mername-AA083 peptidase |
38-49 |
N |
|
AA |
Dal Degan et al., 1992 |
| 48 |
carboxypeptidase O |
38-49 |
N |
|
AA |
Dal Degan et al., 1992 |
| 50 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 56 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 64 |
carboxypeptidase O |
58-65 |
N |
|
AA |
Dal Degan et al., 1992 |
| 65 |
carboxypeptidase O |
58-66 |
N |
|
|
Dal Degan et al., 1992 |
| 66 |
carboxypeptidase O |
58-67 |
N |
|
|
Dal Degan et al., 1992 |
| 67 |
carboxypeptidase O |
58-68 |
N |
|
AA |
Dal Degan et al., 1992 |
| 68 |
Mername-AA083 peptidase |
58-69 |
N |
|
AA |
Dal Degan et al., 1992 |
| 68 |
carboxypeptidase O |
58-69 |
N |
|
|
Dal Degan et al., 1992 |
| 69 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 69 |
Mername-AA083 peptidase |
58-70 |
N |
|
AA |
Dal Degan et al., 1992 |
| 69 |
carboxypeptidase O |
58-70 |
N |
|
|
Dal Degan et al., 1992 |
| 70 |
Mername-AA083 peptidase |
58-71 |
N |
|
AA |
Dal Degan et al., 1992 |
| 70 |
carboxypeptidase O |
58-71 |
N |
|
|
Dal Degan et al., 1992 |
| 71 |
Mername-AA083 peptidase |
58-72 |
N |
|
AA |
Dal Degan et al., 1992 |
| 71 |
carboxypeptidase O |
58-72 |
N |
|
|
Dal Degan et al., 1992 |
| 72 |
Mername-AA083 peptidase |
58-73 |
N |
|
AA |
Dal Degan et al., 1992 |
| 72 |
carboxypeptidase O |
58-73 |
N |
|
AA |
Dal Degan et al., 1992 |
| 73 |
trypsin 1 |
16-214 |
P |
normal turnover |
NT |
Clare & Swaisgood, 2000 |
| 75 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 88 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 89 |
legumain, animal-type |
16-214 |
N |
|
NT |
Dando et al., 1999 |
| 89 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 94 |
trypsin 1 |
16-214 |
P |
release of a bioactive peptide |
NT |
Clare & Swaisgood, 2000 |
| 104 |
pepsin A |
16-214 |
P |
normal turnover |
NT |
Clare & Swaisgood, 2000 |
| 107 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 110 |
Ftsh peptidase (Thermus-type) |
16-214 |
N |
|
|
Asahara et al., 2000 |
| 111 |
pepsin A |
16-214 |
P |
normal turnover |
NT |
Clare & Swaisgood, 2000 |
| 113 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 114 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 118 |
polyporopepsin |
16-214 |
N |
|
|
Kobayashi, 2004 |
| 119 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 120 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 124 |
archaean signal peptide peptidase 1 |
16-214 |
N |
|
NT |
Yokoyama & Matsui, 2005 |
| 129 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 130 |
carboxypeptidase O |
119-131 |
N |
|
|
Dal Degan et al., 1992 |
| 131 |
carboxypeptidase O |
119-132 |
N |
|
|
Dal Degan et al., 1992 |
| 132 |
Mername-AA083 peptidase |
119-133 |
N |
|
AA |
Dal Degan et al., 1992 |
| 132 |
carboxypeptidase O |
119-133 |
N |
|
AA |
Dal Degan et al., 1992 |
| 133 |
Mername-AA083 peptidase |
119-134 |
N |
|
AA |
Dal Degan et al., 1992 |
| 133 |
carboxypeptidase O |
119-134 |
N |
|
|
Dal Degan et al., 1992 |
| 135 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 136 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 144 |
Ftsh peptidase (Thermus-type) |
16-214 |
N |
|
|
Asahara et al., 2000 |
| 145 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 146 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 155 |
carboxypeptidase O |
151-156 |
N |
|
AA |
Dal Degan et al., 1992 |
| 156 |
carboxypeptidase O |
151-157 |
N |
|
|
Dal Degan et al., 1992 |
| 157 |
Ftsh peptidase (Thermus-type) |
16-214 |
N |
|
|
Asahara et al., 2000 |
| 157 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 157 |
Mername-AA083 peptidase |
151-158 |
N |
|
AA |
Dal Degan et al., 1992 |
| 157 |
carboxypeptidase O |
151-158 |
N |
|
|
Dal Degan et al., 1992 |
| 157 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 158 |
Ftsh peptidase (Thermus-type) |
16-214 |
N |
|
|
Asahara et al., 2000 |
| 158 |
Mername-AA083 peptidase |
151-159 |
N |
|
|
Dal Degan et al., 1992 |
| 158 |
carboxypeptidase O |
151-159 |
N |
|
|
Dal Degan et al., 1992 |
| 159 |
Mername-AA083 peptidase |
151-160 |
N |
|
AA |
Dal Degan et al., 1992 |
| 159 |
carboxypeptidase O |
151-160 |
N |
|
|
Dal Degan et al., 1992 |
| 160 |
phytepsin |
16-214 |
N |
|
|
Pires, 1998 |
| 160 |
Mername-AA083 peptidase |
151-161 |
N |
|
AA |
Dal Degan et al., 1992 |
| 160 |
carboxypeptidase O |
151-161 |
N |
|
|
Dal Degan et al., 1992 |
| 161 |
Mername-AA083 peptidase |
151-162 |
N |
|
AA |
Dal Degan et al., 1992 |
| 161 |
carboxypeptidase O |
151-162 |
N |
|
|
Dal Degan et al., 1992 |
| 162 |
Mername-AA083 peptidase |
151-163 |
N |
|
AA |
Dal Degan et al., 1992 |
| 162 |
carboxypeptidase O |
151-163 |
N |
|
AA |
Dal Degan et al., 1992 |
| 163 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 163 |
Mername-AA083 peptidase |
151-164 |
N |
|
AA |
Dal Degan et al., 1992 |
| 163 |
carboxypeptidase O |
151-164 |
N |
|
AA |
Dal Degan et al., 1992 |
| 163 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 164 |
Ftsh peptidase (Thermus-type) |
16-214 |
N |
|
|
Asahara et al., 2000 |
| 164 |
Mername-AA083 peptidase |
151-165 |
N |
|
|
Dal Degan et al., 1992 |
| 164 |
carboxypeptidase O |
151-165 |
N |
|
|
Dal Degan et al., 1992 |
| 165 |
phytepsin |
16-214 |
N |
|
|
Pires, 1998 |
| 165 |
Ftsh peptidase (Thermus-type) |
16-214 |
N |
|
|
Asahara et al., 2000 |
| 165 |
Mername-AA083 peptidase |
151-166 |
N |
|
AA |
Dal Degan et al., 1992 |
| 165 |
carboxypeptidase O |
151-166 |
N |
|
AA |
Dal Degan et al., 1992 |
| 169 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 171 |
Ftsh peptidase (Thermus-type) |
16-214 |
N |
|
|
Asahara et al., 2000 |
| 171 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 172 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 176 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 176 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 179 |
phytepsin |
16-214 |
N |
|
|
Pires, 1998 |
| 180 |
Ftsh peptidase (Thermus-type) |
16-214 |
N |
|
|
Asahara et al., 2000 |
| 183 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 184 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 184 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 201 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 205 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 205 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 207 |
lactocepin-3 |
16-214 |
P |
|
NT |
Reid et al., 1999 |
| 208 |
CP790 peptidase (Lactobacillus helveticus CP790) |
16-214 |
P |
|
NT |
Yamamoto et al., 1993 |
| 211 |
Mername-AA083 peptidase |
209-212 |
N |
|
AA |
Dal Degan et al., 1992 |
| 211 |
carboxypeptidase O |
209-212 |
N |
|
AA |
Dal Degan et al., 1992 |
| 212 |
Mername-AA083 peptidase |
209-213 |
N |
|
AA |
Dal Degan et al., 1992 |
| 212 |
carboxypeptidase O |
209-213 |
N |
|
AA |
Dal Degan et al., 1992 |
| 213 |
Mername-AA083 peptidase |
209-214 |
N |
|
AA |
Dal Degan et al., 1992 |
| 213 |
carboxypeptidase O |
209-214 |
N |
|
AA |
Dal Degan et al., 1992 |
