Structure for peptidase S09.001: prolyl oligopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1QFS	Sus scrofa	2.00 Å	complex with Z-Pro-prolinal inhibitor
Catalytic residues are shown in ball-and-stick representation: Ser554 in orange, Asp641 in pink and His680 in purple. Bound inhibitor is shown in grey in ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
prolyl oligopeptidase with gsk552	1.56 Å	3DDU	3DDU	3DDU	3DDU	3DDU	3DDU	Haffner et al., 2008
Sus scrofa
mutant form	1.70 Å	1E5T	1E5T	1E5T	1E5T	1E5T	1E5T	Fulop et al., 2000
mutant; complex with N-[(benzyloxy)carbonyl]glycyl-L-proline	1.50 Å	1E8M	1E8M	1E8M	1E8M	1E8M	1E8M	Fulop et al., 2001
mutant; complex with peptide	1.50 Å	1E8N	1E8N	1E8N	1E8N	1E8N	1E8N	Fulop et al., 2001
mature peptidase	1.39 Å	1H2W	1H2W	1H2W	1H2W	1H2W	1H2W	Szeltner et al., 2002
Tyr473Phe mutant	1.49 Å	1H2X	1H2X	1H2X	1H2X	1H2X	1H2X	Szeltner et al., 2002
Tyr473Phe mutant; complex with inhibitor Z-Pro-prolinal	1.78 Å	1H2Y	1H2Y	1H2Y	1H2Y	1H2Y	1H2Y	Szeltner et al., 2002
Ser554Ala mutant; complex with peptide ligand Suc-Gly-Pro	1.65 Å	1H2Z	1H2Z	1H2Z	1H2Z	1H2Z	1H2Z	Szeltner et al., 2002
Asp641Ala mutant; complex with bound peptide ligand Suc-Gly-Pro	1.60 Å	1O6F	1O6F	1O6F	1O6F	1O6F	1O6F	Szeltner et al., 2002
Asp641Asn mutant; complex with bound peptide ligand Suc-Gly-Pro	1.40 Å	1O6G	1O6G	1O6G	1O6G	1O6G	1O6G	Szeltner et al., 2002
mature peptidase	1.40 Å	1QFM	1QFM	1QFM	1QFM	1QFM	1QFM	Fulop et al., 1998
complex with Z-Pro-prolinal inhibitor	2.00 Å	1QFS	1QFS	1QFS	1QFS	1QFS	1QFS	Fulop et al., 1998
prolyl oligopeptidase from porcine brain, s554a mutant with bound peptide ligand gly-phe-arg-pro	2.35 Å	1UOO	1UOO	1UOO	1UOO	1UOO	1UOO	Szeltner et al., 2003
prolyl oligopeptidase from porcine brain, s554a mutant with bound peptide ligand gly-phe-glu-pro	1.85 Å	1UOP	1UOP	1UOP	1UOP	1UOP	1UOP	Szeltner et al., 2003
prolyl oligopeptidase from porcine brain, s554a mutant with bound peptide ligand glu-phe-ser-pro	2.10 Å	1UOQ	1UOQ	1UOQ	1UOQ	1UOQ	1UOQ	Szeltner et al., 2003
Tyr73Cys, Val427Cys and Cys255Thr mutant	2.20 Å	1VZ2	1VZ2	1VZ2	1VZ2	1VZ2	1VZ2	Szeltner et al., 2004
Thr597Cys mutant	1.60 Å	1VZ3	1VZ3	1VZ3	1VZ3	1VZ3	1VZ3	Szeltner et al., 2004
mature peptidase	1.35 Å	2XDW	2XDW	2XDW	2XDW	2XDW	2XDW	Racys et al., 2010
mature peptidase	2.89 Å	3EQ7	3EQ7	3EQ7	3EQ7	3EQ7	3EQ7	Kanai et al., 2008
mature peptidase	2.73 Å	3EQ8	3EQ8	3EQ8	3EQ8	3EQ8	3EQ8	Kanai et al., 2008
mature peptidase	2.47 Å	3EQ9	3EQ9	3EQ9	3EQ9	3EQ9	3EQ9	Kanai et al., 2008
mature peptidase	2.00 Å	4AMY	4AMY	4AMY	4AMY	4AMY	4AMY	Kaszuba et al., 2012
mature peptidase	2.00 Å	4AMZ	4AMZ	4AMZ	4AMZ	4AMZ	4AMZ	Kaszuba et al., 2012
mature peptidase	2.20 Å	4AN0	4AN0	4AN0	4AN0	4AN0	4AN0	Kaszuba et al., 2012
mature peptidase	1.90 Å	4AN1	4AN1	4AN1	4AN1	4AN1	4AN1	Kaszuba et al., 2012
mature peptidase	1.60 Å	4AX4	4AX4	4AX4	4AX4	4AX4	4AX4	Szeltner et al., 2013
mature peptidase	1.70 Å	4BCB	4BCB	4BCB	4BCB	4BCB	4BCB	Van et al., 2012
mature peptidase	1.65 Å	4BCC	4BCC	4BCC	4BCC	4BCC	4BCC	Van et al., 2012
mature peptidase	1.50 Å	4BCD	4BCD	4BCD	4BCD	4BCD	4BCD	Van et al., 2012