Literature for peptidase S01.029: kallikrein-related peptidase 14

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: A Assay, M Mutation, R Splicing, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Brzoza,P., Tyshchenko,M., Kantyka,T., Bielecka,E., Majewski,P., Migaczewski,M., Zabel,B.A. and Cichy,J. Kallikrein 14 activates the chemoattractant protein chemerin in human skin J Biol Chem (2025) 302, 111002-111002. PubMed Europe PubMed DOI

2023

Stuardo-Parada,A., Lopez-Munoz,R., Villarroel-Espindola,F., Figueroa,C.D. and Ehrenfeld,P. Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer Med Oncol (2023) 40, 224-224. PubMed Europe PubMed DOI V

2021

Zani,M.B., Sant'Ana,A.M., Tognato,R.C., Chagas,J.R. and Puzer,L. Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases Front Med (Lausanne) (2021) 8, 777619-777619. PubMed Europe PubMed DOI PMC EPMC V

2020

Gouin,O., Barbieux,C., Leturcq,F., Bonnet des Claustres,M., Petrova,E. and Hovnanian,A. Transgenic kallikrein 14 mice display major hair shaft defects associated with desmoglein 3 and 4 degradation, abnormal epidermal differentiation and Il-36 signature J Invest Dermatol (2020) 140, 1184-1194. PubMed Europe PubMed DOI
Kryza,T., Bock,N., Lovell,S., Rockstroh,A., Lehman,M.L., Lesner,A., Panchadsaram,J., Silva,L.M., Srinivasan,S., Snell,C.E., Williams,E.D., Fazli,L., Gleave,M., Batra,J., Nelson,C., Tate,E.W., Harris,J., Hooper,J.D. and Clements,J.A. The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer Mol Oncol (2020) 14, 105-128. PubMed Europe PubMed DOI

2018

Horn,M., Zbodakova,O., Kasparek,P., Srp,J., Haneckova,R., Hradilek,M., Mares,M. and Sedlacek,R. Profiling system for skin kallikrein proteolysis applied in gene-deficient mouse models Biol Chem (2018) 399, 1085-1089. PubMed Europe PubMed DOI A
Rose,A.M., Krishan,A., Chakarova,C.F., Moya,L., Chambers,S.K., Hollands,M., Illingworth,J.C., Williams,S.M.G., McCabe,H.E., Shah,A.Z., Palmer,C.N.A., Chakravarti,A., Berg,J.N., Batra,J. and Bhattacharya,S.S. MSR1 repeats modulate gene expression and affect risk of breast and prostate cancer Ann Oncol (2018) 29, 1292-1303. PubMed Europe PubMed DOI M
Ulbricht,D., Tindall,C.A., Oertwig,K., Hanke,S., Strater,N. and Heiker,J.T. Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin Biol Chem (2018) 399, 1079-1084. PubMed Europe PubMed DOI

2017

Reid,J.C., Matsika,A., Davies,C.M., He,Y., Broomfield,A., Bennett,N.C., Magdolen,V., Srinivasan,B., Clements,J.A. and Hooper,J.D. Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases Am J Cancer Res (2017) 7, 2257-2274. PubMed Europe PubMed PMC EPMC

2016

Chen,W., Kinsler,V.A., Macmillan,D. and Di,W.L. Tissue kallikrein inhibitors based on the sunflower trypsin inhibitor scaffold - a potential therapeutic intervention for skin diseases PLoS ONE (2016) 11, e0166268-e0166268. PubMed Europe PubMed DOI PMC EPMC
Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P. Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays Mol Cell Proteomics (2016) 15, 2863-2876. PubMed Europe PubMed DOI A
Reid,J.C., Bennett,N.C., Stephens,C.R., Carroll,M.L., Magdolen,V., Clements,J.A. and Hooper,J.D. In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B Biol Chem (2016) 397, 1299-1305. PubMed Europe PubMed DOI

2013

Lundwall,A. Old genes and new genes: The evolution of the kallikrein locus Thromb Haemost (2013) 110, 469-475. PubMed Europe PubMed DOI V
Tan,X., Furio,L., Reboud-Ravaux,M., Villoutreix,B.O., Hovnanian,A. and El Amri,C. 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases Bioorg Med Chem Lett (2013) 23, 4547-4551. PubMed Europe PubMed DOI I

2012

Clements,J.A., Hooper,J.D. and Dong,Y. The human tissue kallikrein and kallikrein-related peptidase family [ISSN:978-0-12-407742-3] (2012) 3, 2747-2756. DOI
de Veer,S.J., Swedberg,J.E., Parker,E.A. and Harris,J.M. Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14 Biol Chem (2012) 393, 331-341. PubMed Europe PubMed DOI P
Eissa,A. and Diamandis,E.P. Kallikrein-related peptidase 14 [ISSN:978-0-12-407742-3] (2012) 3, 2809-2813. DOI
Lose,F., Lawrence,M.G., Srinivasan,S., O'Mara,T., Marquart,L., Chambers,S., Gardiner,R.A., Aitken,J.F., Spurdle,A.B., Batra,J. and Clements,J.A. The kallikrein 14 gene is down-regulated by androgen receptor signalling and harbours genetic variation that is associated with prostate tumour aggressiveness Biol Chem (2012) 393, 403-412. PubMed Europe PubMed DOI

2011

Gratio,V., Loriot,C., Virca,G.D., Oikonomopoulou,K., Walker,F., Diamandis,E.P., Hollenberg,M.D. and Darmoul,D. Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells Am J Pathol (2011) 179, 2625-2636. PubMed Europe PubMed DOI

2009

Angelopoulou,K., Prassas,I. and Yousef,G.M. The canine kallikrein-related peptidase 14: structural characterization, alternative splicing and differential expression in mammary cancer Gene (2009) 446, 68-74. PubMed Europe PubMed DOI

2008

Clements,J.A. Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades? Biol Chem (2008) 389, 1447-1454. PubMed Europe PubMed DOI V
Emami,N. and Diamandis,E.P. Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin J Biol Chem (2008) 283, 3031-3041. PubMed Europe PubMed DOI
Emami,N., Deperthes,D., Malm,J. and Diamandis,E.P. Major role of human KLK14 in seminal clot liquefaction J Biol Chem (2008) 283, 19561-19569. PubMed Europe PubMed DOI
Planque,C., Blechet,C., Ayadi-Kaddour,A., Heuze-Vourc'h,N., Dumont,P., Guyetant,S., Diamandis,E.P., El Mezni,F. and Courty,Y. Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung Biol Chem (2008) 389, 781-786. PubMed Europe PubMed DOI
Yoon,H., Blaber,S.I., Evans,D.M., Trim,J., Juliano,M.A., Scarisbrick,I.A. and Blaber,M. Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis Protein Sci (2008) 17, 1998-2007. PubMed Europe PubMed DOI PMC EPMC

2007

Borgono,C.A., Michael,I.P., Shaw,J.L., Luo,L.Y., Ghosh,M.C., Soosaipillai,A., Grass,L., Katsaros,D. and Diamandis,E.P. Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14 J Biol Chem (2007) 282, 2405-2422. PubMed Europe PubMed DOI
Borgono,C.A., Gavigan,J.A., Alves,J., Bowles,B., Harris,J.L., Sotiropoulou,G. and Diamandis,E.P. Defining the extended substrate specificity of kallikrein 1-related peptidases Biol Chem (2007) 388, 1215-1225. PubMed Europe PubMed DOI P
Deraison,C., Bonnart,C., Lopez,F., Besson,C., Robinson,R., Jayakumar,A., Wagberg,F., Brattsand,M., Hachem,J.P., Leonardsson,G. and Hovnanian,A. LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction Mol Biol Cell (2007) 18, 3607-3619. PubMed Europe PubMed DOI PMC EPMC
Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U. Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis Genomics (2007) 89, 429-438. PubMed Europe PubMed DOI
Rajapakse,S. and Takahashi,T. Expression and enzymatic characterization of recombinant human kallikrein 14 Zoolog Sci (2007) 24, 774-780. PubMed Europe PubMed DOI E P
Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M. Activation profiles and regulatory cascades of the human kallikrein-related peptidases J Biol Chem (2007) 282, 31852-31864. PubMed Europe PubMed DOI V

2006

Felber,L.M., Kundig,C., Borgono,C.A., Chagas,J.R., Tasinato,A., Jichlinski,P., Gygi,C.M., Leisinger,H.J., Diamandis,E.P., Deperthes,D. and Cloutier,S.M. Mutant recombinant serpins as highly specific inhibitors of human kallikrein 14 FEBS J (2006) 273, 2505-2514. PubMed Europe PubMed DOI
Luo,L.Y. and Jiang,W. Inhibition profiles of human tissue kallikreins by serine protease inhibitors Biol Chem (2006) 387, 813-816. PubMed Europe PubMed DOI
Stefansson,K., Brattsand,M., Ny,A., Glas,B. and Egelrud,T. Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum Biol Chem (2006) 387, 761-768. PubMed Europe PubMed DOI

2005

Brattsand,M., Stefansson,K., Lundh,C., Haasum,Y. and Egelrud,T. A proteolytic cascade of kallikreins in the stratum corneum J Invest Dermatol (2005) 124, 198-203. PubMed Europe PubMed DOI
Felber,L.M., Borgono,C.A., Cloutier,S.M., Kundig,C., Kishi,T., Ribeiro Chagas,J., Jichlinski,P., Gygi,C.M., Leisinger,H.J., Diamandis,E.P. and Deperthes,D. Enzymatic profiling of human kallikrein 14 using phage-display substrate technology Biol Chem (2005) 386, 291-298. PubMed Europe PubMed DOI P
[YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P. A survey of alternative transcripts of human tissue kallikrein genes Biochim Biophys Acta (25-5-2005) 1755, 1-14. PubMed Europe PubMed DOI R

2004

Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y. The tissue kallikrein gene cluster [ISSN:0-12-079610-4] (2004) 2, 1569-1577. V

2003

[YEAR:15-12-2003]Borgono,C.A., Grass,L., Soosaipillai,A., Yousef,G.M., Petraki,C.D., Howarth,D.H., Fracchioli,S., Katsaros,D. and Diamandis,E.P. Human kallikrein 14: a new potential biomarker for ovarian and breast cancer Cancer Res (15-12-2003) 63, 9032-9041. PubMed Europe PubMed
Yousef,G.M., Fracchioli,S., Scorilas,A., Borgono,C.A., Iskander,L., Puopolo,M., Massobrio,M., Diamandis,E.P. and Katsaros,D. Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer Am J Clin Pathol (2003) 119, 346-355. PubMed Europe PubMed
[YEAR:1-5-2003]Yousef,G.M., Polymeris,M.E., Yacoub,G.M., Scorilas,A., Soosaipillai,A., Popalis,C., Fracchioli,S., Katsaros,D. and Diamandis,E.P. Parallel overexpression of seven kallikrein genes in ovarian cancer Cancer Res (1-5-2003) 63, 2223-2227. PubMed Europe PubMed
[YEAR:1-9-2003]Yousef,G.M., Stephan,C., Scorilas,A., Ellatif,M.A., Jung,K., Kristiansen,G., Jung,M., Polymeris,M.E. and Diamandis,E.P. Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues Prostate (1-9-2003) 56, 287-292. PubMed Europe PubMed DOI

2002

[YEAR:18-11-2002]Yousef,G.M., Borgono,C.A., Scorilas,A., Ponzone,R., Biglia,N., Iskander,L., Polymeris,M.E., Roagna,R., Sismondi,P. and Diamandis,E.P. Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis Br J Cancer (18-11-2002) 87, 1287-1293. PubMed Europe PubMed DOI PMC EPMC

2001

Clements,J., Hooper,J., Dong,Y. and Harvey,T. The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions Biol Chem (2001) 382, 5-14. PubMed Europe PubMed DOI V
[YEAR:1-4-2001]Hooper,J.D., Bui,L.T., Rae,F.K., Harvey,T.J., Myers,S.A., Ashworth,L.K. and Clements,J.A. Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle Genomics (1-4-2001) 73, 117-122. PubMed Europe PubMed DOI
[YEAR:15-4-2001]Yousef,G.M., Magklara,A., Chang,A., Jung,K., Katsaros,D. and Diamandis,E.P. Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies Cancer Res (15-4-2001) 61, 3425-3431. PubMed Europe PubMed

2000

Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V. The new human kallikrein gene family: implications in carcinogenesis Trends Endocrinol Metab (2000) 11, 54-60. PubMed Europe PubMed DOI

1994

[YEAR:15-7-1994]Southard-Smith,M., Pierce,J.C. and Macdonald,R.J. Physical mapping of the rat tissue kallikrein family in two gene clusters by analysis of P1 bacteriophage clones Genomics (15-7-1994) 22, 404-417. PubMed Europe PubMed DOI

1992

Berg,T., Bradshaw,R.A., Carretero,O.A., Chao,J., Chao,L., Clements,J.A., Fahnestock,M., Fritz,H., Gauthier,F. and Macdonald,R.J. A common nomenclature for members of the tissue (glandular) kallikrein gene families Agents Actions Suppl (1992) 38, 19-25. PubMed Europe PubMed DOI