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Literature for peptidase S01.029: kallikrein-related peptidase 14

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, M Mutation, R Splicing, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Brzoza,P., Tyshchenko,M., Kantyka,T., Bielecka,E., Majewski,P., Migaczewski,M., Zabel,B.A. and Cichy,J.
    Kallikrein 14 activates the chemoattractant protein chemerin in human skin
    J Biol Chem (2025) 302, 111002-111002. PubMed  Europe PubMed DOI
    2. 2023
  2. Stuardo-Parada,A., Lopez-Munoz,R., Villarroel-Espindola,F., Figueroa,C.D. and Ehrenfeld,P.
    Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer
    Med Oncol (2023) 40, 224-224. PubMed  Europe PubMed DOI  V
    3. 2021
  3. Zani,M.B., Sant'Ana,A.M., Tognato,R.C., Chagas,J.R. and Puzer,L.
    Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases
    Front Med (Lausanne) (2021) 8, 777619-777619. PubMed  Europe PubMed DOI  PMC  EPMC  V
    4. 2020
  4. Gouin,O., Barbieux,C., Leturcq,F., Bonnet des Claustres,M., Petrova,E. and Hovnanian,A.
    Transgenic kallikrein 14 mice display major hair shaft defects associated with desmoglein 3 and 4 degradation, abnormal epidermal differentiation and Il-36 signature
    J Invest Dermatol (2020) 140, 1184-1194. PubMed  Europe PubMed DOI
  5. Kryza,T., Bock,N., Lovell,S., Rockstroh,A., Lehman,M.L., Lesner,A., Panchadsaram,J., Silva,L.M., Srinivasan,S., Snell,C.E., Williams,E.D., Fazli,L., Gleave,M., Batra,J., Nelson,C., Tate,E.W., Harris,J., Hooper,J.D. and Clements,J.A.
    The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer
    Mol Oncol (2020) 14, 105-128. PubMed  Europe PubMed DOI
    6. 2018
  6. Horn,M., Zbodakova,O., Kasparek,P., Srp,J., Haneckova,R., Hradilek,M., Mares,M. and Sedlacek,R.
    Profiling system for skin kallikrein proteolysis applied in gene-deficient mouse models
    Biol Chem (2018) 399, 1085-1089. PubMed  Europe PubMed DOI  A
  7. Rose,A.M., Krishan,A., Chakarova,C.F., Moya,L., Chambers,S.K., Hollands,M., Illingworth,J.C., Williams,S.M.G., McCabe,H.E., Shah,A.Z., Palmer,C.N.A., Chakravarti,A., Berg,J.N., Batra,J. and Bhattacharya,S.S.
    MSR1 repeats modulate gene expression and affect risk of breast and prostate cancer
    Ann Oncol (2018) 29, 1292-1303. PubMed  Europe PubMed DOI  M
  8. Ulbricht,D., Tindall,C.A., Oertwig,K., Hanke,S., Strater,N. and Heiker,J.T.
    Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin
    Biol Chem (2018) 399, 1079-1084. PubMed  Europe PubMed DOI
    9. 2017
  9. Reid,J.C., Matsika,A., Davies,C.M., He,Y., Broomfield,A., Bennett,N.C., Magdolen,V., Srinivasan,B., Clements,J.A. and Hooper,J.D.
    Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases
    Am J Cancer Res (2017) 7, 2257-2274. PubMed  Europe PubMed  PMC  EPMC
    10. 2016
  10. Chen,W., Kinsler,V.A., Macmillan,D. and Di,W.L.
    Tissue kallikrein inhibitors based on the sunflower trypsin inhibitor scaffold - a potential therapeutic intervention for skin diseases
    PLoS ONE (2016) 11, e0166268-e0166268. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P.
    Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays
    Mol Cell Proteomics (2016) 15, 2863-2876. PubMed  Europe PubMed DOI  A
  12. Reid,J.C., Bennett,N.C., Stephens,C.R., Carroll,M.L., Magdolen,V., Clements,J.A. and Hooper,J.D.
    In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B
    Biol Chem (2016) 397, 1299-1305. PubMed  Europe PubMed DOI
    13. 2013
  13. Lundwall,A.
    Old genes and new genes: The evolution of the kallikrein locus
    Thromb Haemost (2013) 110, 469-475. PubMed  Europe PubMed DOI  V
  14. Tan,X., Furio,L., Reboud-Ravaux,M., Villoutreix,B.O., Hovnanian,A. and El Amri,C.
    1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases
    Bioorg Med Chem Lett (2013) 23, 4547-4551. PubMed  Europe PubMed DOI  I
    15. 2012
  15. Clements,J.A., Hooper,J.D. and Dong,Y.
    The human tissue kallikrein and kallikrein-related peptidase family
    [ISSN:978-0-12-407742-3] (2012) 3, 2747-2756. DOI
  16. de Veer,S.J., Swedberg,J.E., Parker,E.A. and Harris,J.M.
    Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14
    Biol Chem (2012) 393, 331-341. PubMed  Europe PubMed DOI  P
  17. Eissa,A. and Diamandis,E.P.
    Kallikrein-related peptidase 14
    [ISSN:978-0-12-407742-3] (2012) 3, 2809-2813. DOI
  18. Lose,F., Lawrence,M.G., Srinivasan,S., O'Mara,T., Marquart,L., Chambers,S., Gardiner,R.A., Aitken,J.F., Spurdle,A.B., Batra,J. and Clements,J.A.
    The kallikrein 14 gene is down-regulated by androgen receptor signalling and harbours genetic variation that is associated with prostate tumour aggressiveness
    Biol Chem (2012) 393, 403-412. PubMed  Europe PubMed DOI
    19. 2011
  19. Gratio,V., Loriot,C., Virca,G.D., Oikonomopoulou,K., Walker,F., Diamandis,E.P., Hollenberg,M.D. and Darmoul,D.
    Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells
    Am J Pathol (2011) 179, 2625-2636. PubMed  Europe PubMed DOI
    20. 2009
  20. Angelopoulou,K., Prassas,I. and Yousef,G.M.
    The canine kallikrein-related peptidase 14: structural characterization, alternative splicing and differential expression in mammary cancer
    Gene (2009) 446, 68-74. PubMed  Europe PubMed DOI
    21. 2008
  21. Clements,J.A.
    Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?
    Biol Chem (2008) 389, 1447-1454. PubMed  Europe PubMed DOI  V
  22. Emami,N. and Diamandis,E.P.
    Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin
    J Biol Chem (2008) 283, 3031-3041. PubMed  Europe PubMed DOI
  23. Emami,N., Deperthes,D., Malm,J. and Diamandis,E.P.
    Major role of human KLK14 in seminal clot liquefaction
    J Biol Chem (2008) 283, 19561-19569. PubMed  Europe PubMed DOI
  24. Planque,C., Blechet,C., Ayadi-Kaddour,A., Heuze-Vourc'h,N., Dumont,P., Guyetant,S., Diamandis,E.P., El Mezni,F. and Courty,Y.
    Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung
    Biol Chem (2008) 389, 781-786. PubMed  Europe PubMed DOI
  25. Yoon,H., Blaber,S.I., Evans,D.M., Trim,J., Juliano,M.A., Scarisbrick,I.A. and Blaber,M.
    Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis
    Protein Sci (2008) 17, 1998-2007. PubMed  Europe PubMed DOI  PMC  EPMC
    26. 2007
  26. Borgono,C.A., Michael,I.P., Shaw,J.L., Luo,L.Y., Ghosh,M.C., Soosaipillai,A., Grass,L., Katsaros,D. and Diamandis,E.P.
    Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14
    J Biol Chem (2007) 282, 2405-2422. PubMed  Europe PubMed DOI
  27. Borgono,C.A., Gavigan,J.A., Alves,J., Bowles,B., Harris,J.L., Sotiropoulou,G. and Diamandis,E.P.
    Defining the extended substrate specificity of kallikrein 1-related peptidases
    Biol Chem (2007) 388, 1215-1225. PubMed  Europe PubMed DOI  P
  28. Deraison,C., Bonnart,C., Lopez,F., Besson,C., Robinson,R., Jayakumar,A., Wagberg,F., Brattsand,M., Hachem,J.P., Leonardsson,G. and Hovnanian,A.
    LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction
    Mol Biol Cell (2007) 18, 3607-3619. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U.
    Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis
    Genomics (2007) 89, 429-438. PubMed  Europe PubMed DOI
  30. Rajapakse,S. and Takahashi,T.
    Expression and enzymatic characterization of recombinant human kallikrein 14
    Zoolog Sci (2007) 24, 774-780. PubMed  Europe PubMed DOI  E  P
  31. Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M.
    Activation profiles and regulatory cascades of the human kallikrein-related peptidases
    J Biol Chem (2007) 282, 31852-31864. PubMed  Europe PubMed DOI  V
    32. 2006
  32. Felber,L.M., Kundig,C., Borgono,C.A., Chagas,J.R., Tasinato,A., Jichlinski,P., Gygi,C.M., Leisinger,H.J., Diamandis,E.P., Deperthes,D. and Cloutier,S.M.
    Mutant recombinant serpins as highly specific inhibitors of human kallikrein 14
    FEBS J (2006) 273, 2505-2514. PubMed  Europe PubMed DOI
  33. Luo,L.Y. and Jiang,W.
    Inhibition profiles of human tissue kallikreins by serine protease inhibitors
    Biol Chem (2006) 387, 813-816. PubMed  Europe PubMed DOI
  34. Stefansson,K., Brattsand,M., Ny,A., Glas,B. and Egelrud,T.
    Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum
    Biol Chem (2006) 387, 761-768. PubMed  Europe PubMed DOI
    35. 2005
  35. Brattsand,M., Stefansson,K., Lundh,C., Haasum,Y. and Egelrud,T.
    A proteolytic cascade of kallikreins in the stratum corneum
    J Invest Dermatol (2005) 124, 198-203. PubMed  Europe PubMed DOI
  36. Felber,L.M., Borgono,C.A., Cloutier,S.M., Kundig,C., Kishi,T., Ribeiro Chagas,J., Jichlinski,P., Gygi,C.M., Leisinger,H.J., Diamandis,E.P. and Deperthes,D.
    Enzymatic profiling of human kallikrein 14 using phage-display substrate technology
    Biol Chem (2005) 386, 291-298. PubMed  Europe PubMed DOI  P
  37. [YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P.
    A survey of alternative transcripts of human tissue kallikrein genes
    Biochim Biophys Acta (25-5-2005) 1755, 1-14. PubMed  Europe PubMed DOI  R
    38. 2004
  38. Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y.
    The tissue kallikrein gene cluster
    [ISSN:0-12-079610-4] (2004) 2, 1569-1577.  V
    39. 2003
  39. [YEAR:15-12-2003]Borgono,C.A., Grass,L., Soosaipillai,A., Yousef,G.M., Petraki,C.D., Howarth,D.H., Fracchioli,S., Katsaros,D. and Diamandis,E.P.
    Human kallikrein 14: a new potential biomarker for ovarian and breast cancer
    Cancer Res (15-12-2003) 63, 9032-9041. PubMed  Europe PubMed
  40. Yousef,G.M., Fracchioli,S., Scorilas,A., Borgono,C.A., Iskander,L., Puopolo,M., Massobrio,M., Diamandis,E.P. and Katsaros,D.
    Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer
    Am J Clin Pathol (2003) 119, 346-355. PubMed  Europe PubMed
  41. [YEAR:1-5-2003]Yousef,G.M., Polymeris,M.E., Yacoub,G.M., Scorilas,A., Soosaipillai,A., Popalis,C., Fracchioli,S., Katsaros,D. and Diamandis,E.P.
    Parallel overexpression of seven kallikrein genes in ovarian cancer
    Cancer Res (1-5-2003) 63, 2223-2227. PubMed  Europe PubMed
  42. [YEAR:1-9-2003]Yousef,G.M., Stephan,C., Scorilas,A., Ellatif,M.A., Jung,K., Kristiansen,G., Jung,M., Polymeris,M.E. and Diamandis,E.P.
    Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues
    Prostate (1-9-2003) 56, 287-292. PubMed  Europe PubMed DOI
    43. 2002
  43. [YEAR:18-11-2002]Yousef,G.M., Borgono,C.A., Scorilas,A., Ponzone,R., Biglia,N., Iskander,L., Polymeris,M.E., Roagna,R., Sismondi,P. and Diamandis,E.P.
    Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis
    Br J Cancer (18-11-2002) 87, 1287-1293. PubMed  Europe PubMed DOI  PMC  EPMC
    44. 2001
  44. Clements,J., Hooper,J., Dong,Y. and Harvey,T.
    The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions
    Biol Chem (2001) 382, 5-14. PubMed  Europe PubMed DOI  V
  45. [YEAR:1-4-2001]Hooper,J.D., Bui,L.T., Rae,F.K., Harvey,T.J., Myers,S.A., Ashworth,L.K. and Clements,J.A.
    Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle
    Genomics (1-4-2001) 73, 117-122. PubMed  Europe PubMed DOI
  46. [YEAR:15-4-2001]Yousef,G.M., Magklara,A., Chang,A., Jung,K., Katsaros,D. and Diamandis,E.P.
    Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies
    Cancer Res (15-4-2001) 61, 3425-3431. PubMed  Europe PubMed
    47. 2000
  47. Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.
    The new human kallikrein gene family: implications in carcinogenesis
    Trends Endocrinol Metab (2000) 11, 54-60. PubMed  Europe PubMed DOI
    48. 1994
  48. [YEAR:15-7-1994]Southard-Smith,M., Pierce,J.C. and Macdonald,R.J.
    Physical mapping of the rat tissue kallikrein family in two gene clusters by analysis of P1 bacteriophage clones
    Genomics (15-7-1994) 22, 404-417. PubMed  Europe PubMed DOI
    49. 1992
  49. Berg,T., Bradshaw,R.A., Carretero,O.A., Chao,J., Chao,L., Clements,J.A., Fahnestock,M., Fritz,H., Gauthier,F. and Macdonald,R.J.
    A common nomenclature for members of the tissue (glandular) kallikrein gene families
    Agents Actions Suppl (1992) 38, 19-25. PubMed  Europe PubMed DOI

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