Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 31 |
kallikrein-related peptidase 4 |
1-86 |
P |
|
CS |
Matsumura et al., 2005 |
| 31 |
unknown peptidase |
1-2477 |
P |
release of a signal peptide |
NT |
Garcia-Pardo et al., 1983 |
| 44 |
matrix metallopeptidase-8 |
32-2386 |
P |
|
NT |
Doucet & Overall, 2010 |
| 44 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 47 |
matrix metallopeptidase-8 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 47 |
matrix metallopeptidase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 68 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 73 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 208 |
matrix metallopeptidase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 211 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 239 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 240 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 286 |
chymase (Homo sapiens-type) |
32-2386 |
P |
|
|
Andersson et al., 2008 |
| 290 |
staphopain B |
32-2386 |
N |
|
|
Massimi et al., 2002 |
| 290 |
kallikrein-related peptidase 14 |
32-2386 |
P |
|
|
Borgoņo et al., 2007 |
| 290 |
kallikrein-related peptidase 2 |
32-2386 |
P |
|
|
Deperthes et al., 1996 |
| 290 |
kallikrein-related peptidase 8 |
32-2386 |
N |
|
|
Shimizu et al., 1998 |
| 291 |
matrix metallopeptidase-8 |
32-2386 |
P |
|
NT |
Doucet & Overall, 2010 |
| 291 |
matrix metallopeptidase-2 |
32-2386 |
P |
|
NT |
Doucet & Overall, 2010 |
| 292 |
ADAM8 peptidase |
32-2386 |
P |
|
NT |
Zack et al., 2009 |
| 294 |
meprin alpha subunit |
32-2386 |
P |
|
|
Kruse et al., 2004 |
| 294 |
kallikrein-related peptidase 3 |
32-2386 |
P |
|
|
Deperthes et al., 1996 |
| 465 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 480 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 558 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 606 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 613 |
matrix metallopeptidase-8 |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 613 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 613 |
matrix metallopeptidase-3 |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 613 |
matrix metallopeptidase-12 |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 626 |
unknown peptidase |
1-2386 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 627 |
matrix metallopeptidase-8 |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 627 |
matrix metallopeptidase-3 |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 627 |
matrix metallopeptidase-12 |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 629 |
matrix metallopeptidase-2 |
32-2386 |
P |
|
NT |
Doucet & Overall, 2010 |
| 629 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 629 |
matrix metallopeptidase-3 |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 629 |
matrix metallopeptidase-12 |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 631 |
legumain, animal-type |
32-2386 |
P |
|
NT |
Morita et al., 2007 |
| 635 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 667 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 702 |
unknown peptidase |
1-2386 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 709 |
meprin alpha subunit |
32-2386 |
P |
|
|
Kruse et al., 2004 |
| 720 |
matrix metallopeptidase-8 |
32-2386 |
P |
|
NT |
Doucet & Overall, 2010 |
| 720 |
matrix metallopeptidase-2 |
32-2386 |
P |
|
NT |
Doucet & Overall, 2010 |
| 720 |
matrix metallopeptidase-3 |
32-2386 |
P |
normal turnover |
|
Wilhelm et al., 1993 |
| 721 |
meprin beta subunit |
32-2386 |
P |
|
|
Kruse et al., 2004 |
| 721 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 722 |
unknown peptidase |
1-2386 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 738 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 773 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 881 |
kallikrein-related peptidase 3 |
32-2386 |
P |
|
|
Deperthes et al., 1996 |
| 903 |
meprin beta subunit |
32-2386 |
P |
|
|
Kruse et al., 2004 |
| 903 |
kallikrein-related peptidase 14 |
32-2386 |
P |
|
|
Borgoņo et al., 2007 |
| 903 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 911 |
trypsin 1 |
32-2386 |
P |
conversion to two-chain form |
MS |
Pinto et al., 2007 |
| 925 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 958 |
trypsin 1 |
32-2386 |
P |
normal turnover |
MS |
Pinto et al., 2007 |
| 1040 |
trypsin 1 |
32-2386 |
P |
normal turnover |
MS |
Pinto et al., 2007 |
| 1054 |
trypsin 1 |
32-2386 |
P |
normal turnover |
MS |
Pinto et al., 2007 |
| 1101 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1105 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1166 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1170 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1171 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1179 |
matrix metallopeptidase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1179 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1181 |
matrix metallopeptidase-8 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1181 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1181 |
matrix metallopeptidase-12 |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 1186 |
matrix metallopeptidase-8 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1207 |
matrix metallopeptidase-12 |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 1247 |
matrix metallopeptidase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1248 |
kallikrein-related peptidase 3 |
32-2386 |
P |
|
|
Deperthes et al., 1996 |
| 1249 |
matrix metallopeptidase-8 |
32-2386 |
P |
|
NT |
Doucet & Overall, 2010 |
| 1249 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1258 |
matrix metallopeptidase-8 |
32-2386 |
P |
|
NT |
Doucet & Overall, 2010 |
| 1259 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1457 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1460 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1462 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1479 |
trypsin 1 |
32-2386 |
P |
normal turnover |
MS |
Pinto et al., 2007 |
| 1539 |
trypsin 1 |
32-2386 |
P |
normal turnover |
MS |
Pinto et al., 2007 |
| 1547 |
matrix metallopeptidase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1547 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1625 |
matrix metallopeptidase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1736 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1761 |
lysyl endopeptidase (bacteria) |
1-2386 |
N |
|
MS |
|
| 1766 |
trypsin 1 |
32-2386 |
P |
normal turnover |
MS |
Pinto et al., 2007 |
| 1787 |
trypsin 1 |
32-2386 |
P |
normal turnover |
MS |
Pinto et al., 2007 |
| 1808 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1809 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1835 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1866 |
trypsin 1 |
32-2386 |
P |
normal turnover |
MS |
Pinto et al., 2007 |
| 1870 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1895 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1897 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1899 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1929 |
kallikrein-related peptidase 13 |
32-2386 |
P |
|
CS |
Borgoņo et al., 2007 |
| 1930 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 1950 |
trypsin 1 |
32-2386 |
P |
normal turnover |
MS |
Pinto et al., 2007 |
| 1961 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2022 |
ADAMTS5 peptidase |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 2044 |
ADAMTS5 peptidase |
32-2386 |
P |
|
|
Zhen et al., 2008 |
| 2050 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2052 |
chymase (Homo sapiens-type) |
32-2386 |
P |
|
|
Andersson et al., 2008 |
| 2059 |
kallikrein-related peptidase 2 |
32-2386 |
P |
|
|
Deperthes et al., 1996 |
| 2070 |
kallikrein-related peptidase 14 |
32-2386 |
P |
|
|
Borgoņo et al., 2007 |
| 2134 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2147 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2169 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2197 |
matrix metallopeptidase-8 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2197 |
matrix metallopeptidase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2197 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2212 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2213 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2214 |
matrix metallopeptidase-2 |
32-2386 |
P |
|
NT |
Doucet & Overall, 2010 |
| 2214 |
matrix metallopeptidase-9 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2227 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2230 |
matrix metallopeptidase-8 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2231 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2232 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2233 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2236 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2256 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2316 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
| 2345 |
elastase-2 |
32-2386 |
P |
|
MS |
Doucet & Overall, 2010 |
