Substrates for peptidase S01.306: kallikrein-related peptidase 13

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
A disintegrin and metalloproteinase with thrombospondin motifs 3	O15072	250-1205	peptide-Arg574+Thr-peptide	P	CS	Val	Arg	Phe	Arg	Thr	Arg	Gln	Cys	Borgoño et al., 2007
Ac-Tyr-Ala-Ala-Arg-NHMec			Ac-Tyr-Ala-Ala-Arg+NHMec	S		Tyr	Ala	Ala	Arg	AMC	-	-	-	Borgoño et al., 2007
Ac-Tyr-Ala-Ala-Lys-NHMec			Ac-Tyr-Ala-Ala-Lys+NHMec	S		Tyr	Ala	Ala	Lys	AMC	-	-	-	Borgoño et al., 2007
Cadherin-16	O75309	19-829	peptide-Arg513+Leu-peptide	P	CS	Val	Arg	Leu	Arg	Leu	Cys	Lys	Asn	Borgoño et al., 2007
Collagen alpha-1(VII) chain	Q02388	17-2944	peptide-Arg295+Gly-peptide	P	CS	Val	Arg	Leu	Arg	Gly	Leu	Arg	Pro	Borgoño et al., 2007
Fibronectin	P02751	32-2386	peptide-Arg1929+Ile-peptide	P	CS	Pro	Arg	Ala	Arg	Ile	Thr	Gly	Tyr	Borgoño et al., 2007
Interleukin-1 beta precursor	P10749	1-269	peptide-Leu113+Leu-peptide	P	NT	Asp	Asp	Asn	Leu	Leu	Val	Cys	Asp	Yao et al., 2006
Kallikrein-1 precursor	P06870	19-262	peptide-Arg24+Ile-peptide	P	NT	Ile	Gln	Ser	Arg	Ile	Val	Gly	Gly	Yoon et al., 2007
Kallikrein-11 precursor	Q9UBX7	51-282	Glu-Thr-Arg53+Ile-peptide	P	NT	-	Glu	Thr	Arg	Ile	Ile	Lys	Gly	Yoon et al., 2007
Kallikrein-12 precursor	Q9UKR0	18-248	Ala-Thr-Pro-Lys21+Ile-peptide	P	NT	Ala	Thr	Pro	Lys	Ile	Phe	Asn	Gly	Yoon et al., 2007
Kallikrein-2 precursor	P20151	19-261	peptide-Arg24+Ile-peptide	P	NT	Ile	Gln	Ser	Arg	Ile	Val	Gly	Gly	Yoon et al., 2007
Kallikrein-5 precursor	Q9Y337	23-293	peptide-Arg66+Ile-peptide	P	NT	Ser	Ser	Ser	Arg	Ile	Ile	Asn	Gly	Yoon et al., 2007
Kallikrein-6 precursor	Q92876	17-244	peptide-Lys21+Leu-peptide	P	NT	Glu	Gln	Asn	Lys	Leu	Val	His	Gly	Yoon et al., 2007
Kallikrein-9 precursor	Q9UKQ9	16-250	peptide-Arg22+Ala-peptide	P	NT	Ala	Asp	Thr	Arg	Ala	Ile	Gly	Ala	Yoon et al., 2007
kallikrein-related peptidase 13	Q9UKR3	17-277	peptide-Arg114+Ser-peptide	P		Glu	Tyr	Arg	Arg	Ser	Pro	Thr	His	Sotiropoulou et al., 2003	20439
Laminin subunit alpha-5	O15230	36-3695	peptide-Arg262+Phe-peptide	P	CS	Val	Arg	Leu	Arg	Phe	Leu	Arg	Thr	Borgoño et al., 2007
Neurotrypsin	P56730	21-875	peptide-Arg173+Gly-peptide	P	CS	Val	Arg	Leu	Arg	Gly	Gly	Lys	Asn	Borgoño et al., 2007
Prostate-specific antigen precursor	P07288	18-261	peptide-Arg24+Ile-peptide	P	NT	Ile	Leu	Ser	Arg	Ile	Val	Gly	Gly	Yoon et al., 2007
Somatotropin	P01241	27-217	Peptide-Arg160+Thr-Peptide	P	NT	Gly	Ser	Pro	Arg	Thr	Gly	Gln	Ile	Komatsu et al., 2007
Thyroglobulin	P01266	20-2768	peptide-Arg296+Cys-peptide	P	CS	Gly	Arg	Phe	Arg	Cys	Pro	Thr	Lys	Borgoño et al., 2007
Urokinase-type plasminogen activator	P00749	21-431	peptide-Arg243+Leu-peptide	P	CS	Gly	Arg	Ser	Arg	Leu	Asn	Ser	Asn	Borgoño et al., 2007