Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph B

Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph A

PhuZ Tubulin Filament from phage Goslar

PhuZ Tubulin from phage Goslar (locally refined monomer)

structure of MCT2-embigin complex

Structure of the flotillin complex

structure of MCT2-embigin-AR-C155858 complex

Consensus map of KATP channel in complex with centipede toxin SpTx1

The capsid structure of Mink Enteritis Virus

Complex structure of 2014-422 spike RBD bound to human DPP4

Complex structure of GX2012 spike RBD bound to human DPP4

C. thermocellum UvrA in complex with unmodified DNA and AMPPNP (ATP-bound conformation 1)

C. thermocellum UvrA in complex with unmodified DNA and AMPPNP (ATP-bound conformation 2)

C. thermocellum UvrA in complex with unmodified DNA and AMPPNP (basal conformation)

C. thermocellum UvrA (basal conformation)

C. thermocellum UvrA in complex with DNA with a fluorescein modification (basal conformation)

C. thermocellum UvrA in complex with DNA with a fluorescein modification and AMPPNP (ATP-bound conformation 1)

C. thermocellum UvrA in complex with DNA with an abasic site (basal conformation)

C. thermocellum UvrA in complex with DNA with an abasic site and AMPPNP (ATP-bound conformation 2)

C. thermocellum UvrA in complex with DNA with an abasic site and AMPPNP (ATP-bound conformation 1)

C. thermocellum UvrA in complex with AMPPNP (basal conformation)

C. thermocellum UvrA in complex with DNA with a fluorescein modification and ADP (basal conformation)

C. thermocellum UvrA (K647A) in complex with DNA with a fluorescein modification (basal conformation)

C. thermocellum UvrA (K39A) in complex with DNA with a fluorescein modification and AMPPNP (basal conformation)

C. thermocellum UvrA-UvrB in complex with DNA with a fluorescein modification and AMPPNP (composite map)

FZD7 in complex with negative allosteric modulator C407

a5b3 GABAAR bound to Etomidate, GABA, and Mb25 in a desensitized state in saposin nanodiscs

a5b3 GABAA Receptor bound to GABA and Mb25 in desensitized state in detergent micelles

70S P. gingivalis ribosome W83 strain consensus map

a5b3 GABAA Receptor in 1 a5 to 4 b3 stoichiometry in desensitized state

Docedameric RuvBL1/RuvBL2

a5b3 GABAAR bound to GABA and Mb25 in a desensitized state in saposin nanodiscs after long GABA treatment

Early Expressome Consensus Refinement

Early Expressome Composite Map of TEC and 30S IC

E. coli 30S IC containing mRNA, IF1 and IF3

E. coli 30S IC containing mRNA, initiator tRNA, IF1 and IF2

Early Expressome RNAP/TEC body

Hexamer Msp1 from S.cerevisiae (with a catalytic dead mutation) in complex with an unknown peptide substrate

Core filament of the spirochete periplasmic flagella of Leptospira biflexa

core filament of the spirochete periplasmic flagella of Leptospira biflexa wild type

core filament of the spirochete periplasmic flagella of Leptospira biflexa deleted fcpB strain

Octamer Msp1 from S.cerevisiae(with a catalytic dead mutation) in complex with an unknown peptide substrate

core filament of the spirochete periplasmic flagella of Leptospira biflexa from the flaA2-complemented stain

Straight and symmetrical filament of the spirochete periplasmic flagella of Leptospira biflexa

core filament of the spirochete periplasmic flagella of Leptospira biflexa from the deleted fcpB_CL13 strain

Sheathed filament of the spirochete periplasmic flagella of Leptospira biflexa from the deleted fcpB_CL13 strain

Straight and symmetrical filament of the spirochete periplasmic flagella of Leptospira biflexa deleted fcpB strain

Heptamer Msp1 from S.cerevisiae(with a catalytic dead mutation) in complex with an unknown peptide substrate

Enterovirus B 75

sheathed filament of the spirochete periplasmic flagella of Leptospira biflexa wild type

sheathed filament of the spirochete periplasmic flagella of Leptospira biflexa from the flaA2-complemented stain

A2AR-BRIL in complex with ZM241385

A2AR-BRIL + ZM241385 + PGD2

Negative stain EM map of EBV glycoprotein gH/gL in complex with glycoprotein gp42 and FAB ATX-42-1.1 partially open conformation

Negative stain EM map of EBV glycoprotein gH/gL in complex with glycoprotein gp42 and FAB ATX-42-2 closed conformation

Negative stain EM map of EBV glycoprotein gH/gL in complex with glycoprotein gp42 and HLA-DR1 Beta chain

Negative Stain EM map of EBV glycoprotein gp350 in complex with ATX-350-2 FAB

Negative Stain EM map of EBV glycoprotein gp350 in complex with 72A1 FAB

Negative Stain EM map of EBV glycoprotein gp350 in complex with ATX-350-1 FAB

Negative Stain EM map of EBV glycoprotein gp350 in complex with ATX-350-1 FAB and 72A1 FAB

Ribosome with accommodated A-site tRNA, Structure V

Vacant ribosome with P-site tRNA, substate 1, Structure Ia

Structure of a LGR dimer from Caenorhabditis elegans in apo state

Negative stain EM map of EBV glycoprotein gH/gL in complex with glycoprotein gp42 and FAB ATX-42-2 Open conformation

Globular domain of monkeypox virus OPG153 (A28) in complex with antibodies 08E11 and 12I12

Globular domain of monkeypox virus OPG153 (A28) bound to antibody 02M12

Negative stain EM map of EBV glycoprotein gH/gL in complex with glycoprotein gp42 and FAB ATX-42-1.1 open conformation

Hamster Scap/Insig-2 complex with cholesterol and bound Fab4G10

Hamster Scap with bound Fab4G10

Hamster Scap/Insig-2 complex L1-L7 domain/Fab4G10 focused map

Hamster Scap L1-L7 domain/Fab4G10 focused map

Cryo-EM structure of MERS-CoV nsp10-nsp14 (E191A) in complex with T20P14-G RNA

Cryo-EM structure of MERS-CoV nsp10-nsp14 (E191A) in complex with T20P14-A RNA

Cryo-EM structure of MERS-CoV nsp10-nsp14 (E191A) in complex with T20P14-U RNA

Cryo-EM structure of MERS-CoV nsp10-nsp14 (E191A) in complex with T20P15 RNA, dimeric form

Cryo-EM structure of MERS-CoV nsp10-nsp14 (E191A) in complex with T20P15 RNA, monomeric form

In situ HHT and CHX treated human P state 80S ribosome

In situ HHT and CHX treated human eEF1A-A/T-P-Z state 80S ribosome

In situ HHT and CHX treated human P-Z state 80S ribosome

Structure of E. Coli DNA protection during starvation protein (DPS) from single particle cryoEM

In situ HHT and CHX treated human eEF1A-A/T-P state 80S ribosome

In situ HHT and CHX treated A-P state 80S ribosome

In situ HHT and CHX treated A-P-Z state 80S ribosome

In situ human P-E state 80S ribosome

In situ human P-Z state 80S ribosome

In situ human A-P state 80S ribosome

In situ human A-P-Z state 80S ribosome

In situ human hibernating class2 80S ribosome

In situ human A-P-E state 80S ribosome

In situ human Hibernating class5 80S ribosome

In situ human AT-P-Z state ribosome

In situ human Hibernating class3 80S ribosome

In situ human Hibernating class4 80S ribosome

In situ human Post-eEF1A-A/T-P-Z state 80S ribosome

In situ human Post-eEF1A-AT-P state 80S ribosome

In situ human unrotated hibernating without CCDC124 state 80S ribosome

In situ human eEF1A-A/T-P-E state 80S ribosome

In situ human A/P-P/E state 80S ribosome

In situ human unrotated hibernating with CCDC124 state 80S ribosome

In situ human 60S ribosome with EIF6

In situ human 60S ribosome

In situ human P state 80S ribosome

N4 Empty Particle C6 Tail

In situ human Hibernating class1 (rotate3) without E tRNA state 80S ribosome

In situ human Hibernating rotate3 with Z site tRNA state 80S ribosome

In situ human Hibernating rotate 3 with E-site tRNA state 80S ribosome

N4 Full Virion Portal

Native intermediate synaptic vesicle tether, likely Munc13

C. thermocellum UvrA-UvrB in complex with DNA with a fluorescein modification and AMPPNP: consensus map

C. thermocellum UvrA-UvrB in complex with DNA with a fluorescein modification and AMPPNP: focused map

Short (SNARE complex dependent) synaptic vesicle tether

Structure of the Chaetomium thermophilum Pmt4 homodimer (C2 symmetry)

Structure of the Chaetomium thermophilum Pmt4 homodimer (C1 symmetry)

Structure of human 1918 influenza A polymerase heterotrimer in complex with 1918 NEP.

Yeast 80S with nascent chain in complex with Ssb1-ADP in the S1 state

influx carrier substrate bound form

Structure of apo AsfvPrimPol with dodecamer

Structure of human 1918 influenza A polymerase heterotrimer in complex with WSN NEP.

influx carrier apo form

Structure of Full-Length AsfvPrimPol with polyT DNA

structure of bundle-shaped PBS with both long rod and (ApcA2B3ApcD) trimer

human CTPS1 with 2CTP and DON

Structure of the energy converting methyltransferase (Mtr) of Methanosarcina mazei in complex with a novel protein binder

Structure of the energy converting methyltransferase (Mtr) of Methanosarcina mazei in complex with a novel protein binder

Structure of the energy converting methyltransferase (Mtr) of Methanosarcina mazei in complex with a novel protein binder

Structure of the energy converting methyltransferase (Mtr) of Methanosarcina mazei in complex with a novel protein binder

Subtomogram averaging of HTLV-1 Gag capsid from immature particles

HTLV-1 Gag capsid from immature particles

Microtubules in presence of Ndc80 and Ska, non-Ndc80 microtubule-bound molecules

Ndc80-decorated microtubule

Ndc80-decorated microtubule

Oligomer of the human Ndc80 complex decorating a microtubule

Helical structure of KomBCMUT in complex with dITP and NAD

Cryo-EM structure of CD73 in complex with antibody Sym024

Focused-Refinement Cryo-EM Map of the RAZR-ZFD Domain within the In Vitro Reconstituted RAZR.Gp77 Complex

Cryo-EM Structure of Gp77 within the In Vitro Reconstituted RAZR:GP77 Complex

Cryo-EM structure of the Fta RNAP complex

Cryo-EM Map of the Copurified Ring-Activated Zinc-Finger RNase (RAZR, H154A) in Complex with Phage Protein Gp77

Cryo-EM map of the in vitro reconstituted RAZR:GP77 complex with AlphaFold-predicted models fitted into the density.

In situ human eEF1A-A/T-P state 80S ribosome

In situ human post eEF1A-A/T-P-E state 80S ribosome

In situ human eEF2-A/P-P/E state 80S ribosome

Cryo-EM structure of the dCas12f-gRNA complex

Cryo-EM structure of the dCas12f-gRNA-dsDNA complex (full R-Loop)

Cryo-EM structure of the dCas12f-gRNA-DNA complex (partial R-Loop)

Cryo-EM structure of the RNA-guided transcription complex

RECQL5 and RNA polymerase II map U

Pol II-DSIF-SPT6-PAF1c-TFIIS-IWS1-ELOF1-LEDGF-nucleosome CDC73 local map J

Cryo-EM structure of active human green cone opsin in complex with chimeric G protein (miniGist)

Pol II-DSIF-SPT6-PAF1c-TFIIS-IWS1-ELOF1-LEDGF-nucleosome RPB5 local map I

Structure of the bacteriophage T4 portal-neck-tail complex

Pol II-DSIF-SPT6-PAF1c-TFIIS-IWS1-ELOF1-LEDGF-nucleosome non-template DNA local map H

Pol II-DSIF-SPT6-PAF1c-TFIIS-IWS1-ELOF1-LEDGF-nucleosome CTR9+WDR61 local map K

Pol II-DSIF-SPT6-PAF1c-TFIIS-IWS1-ELOF1-LEDGF-nucleosome CTR9 TPR local map L

Pol II-DSIF-SPT6-PAF1c-TFIIS-IWS1-ELOF1-LEDGF-nucleosome PAF1+LEO1 local map M

Pol II-DSIF-SPT6-PAF1c-TFIIS-IWS1-ELOF1-LEDGF-nucleosome LEO1 C-terminus map N

Pol II-DSIF-SPT6-PAF1c-TFIIS-IWS1-ELOF1-LEDGF-nucleosome SPT6 local map O

Subtomogram average of influenza hemagglutinin (A/Puerto Rico/8/1934)

Mycobacterium smegmatis 70S ribosome with small molecule drug MK-7762

Cryo-EM structure of human PLD3 bound to ssDNA (poly(T))

Cryo-EM structure of PLD3 bound to ssDNA (poly(A))

CryoEM structure of cyclised H-pilus (D69N)

Cryo-EM structure of human PLD4 apo form

CryoEM structure of cyclised H-pilus (D69R)

CryoEM structure of cyclised H-pilus (D69A)

Cryo-EM structure of human PLD4 bound to ssDNA (poly(T))

Cryo-EM structure of human PLD3 apo form

CryoEM structure of cyclised H-pilus (D69G)

Apo class from combined 0, 10, 20, 30 mM ATP datastes

Putative ATP-bound class from combined 10, 20, 30 mM ATP datasets

Constricted-pore class from combined 0, 10, 20, 30 mM ATP datasets

Dilated-pore class from combined 0, 10, 20, 30 mM ATP datasets

Hexameric RVFV GnGc-Fab140 complex

Cryo-EM structure of SARS-CoV-2 KP.2 spike RBD in complex with ACE2

The cryo-EM structure of the native PMEL fibril lamella

Cryo-EM structure of a designed AAV2-based vector

Cryo-EM structure of P1X1 in complex with BTFA

Cryo-EM structure of SARS-CoV-2 KP.2 spike in complex with ACE2

Block based reconstruction of RVFV GnGc-Fab140 complex

Human pannexin 1 channel with 10 mM ATP

Human pannexin 1 channel with 30 mM ATP

Cardiac lambda-6 light chain amyloid AL-224L single protofilament

Human pannexin 1 channel with 1mM mefloquine

Human pannexin 1 channel with 0 mM ATP

Human pannexin 1 channel W74A mutant with 10mM ATP

Yeast 80S with nascent chain in complex with Ssb1-ADP in the S2 state

Human pannexin 1 channel from combined 0, 10, 20, 30 mM ATP datasets

Human pannexin 1 channel with 20 mM ATP

Cryo-EM reconstruction of human PI3KC3-C2, focused map 1/2

Cryo-EM reconstruction of human PI3KC3-C2, focused map 2/2

Cryo-EM composite map of human PI3KC3-C2

Cryo-EM reconstruction of PI3KC3-C2 in complex with Rubicon Middle Region of C terminus, focused map 2/2

Cryo-EM reconstruction of PI3KC3-C2 in complex with Rubicon Middle Region of C terminus, composite map

Cryo-EM reconstruction of PI3KC3-C2 in complex with Rubicon Middle Region of C terminus, focused map 1/2

Cryo-EM structure of human PI3KC3-C2 in complex with Rubicon Middle Region of C terminus

Cryo-EM structure of human PI3KC3-C2

In situ human 80S ribosome (consensus map)

In situ human 80S ribosome (focused on 60S)

In situ human 80S consensus ribosome with EBP1

In situ human 80S ribosome (Focused on 40S head)

In situ human 80S ribosome (Focused on 40S body)

In situ human 80S ribosome (composite map)

Cryo-EM map of ASFV DNA polymerase in apo state 2

Co-transcriptional histone H3K36 methylation complex containing RNA polymerase II elongation complex, Set2, and the upstream nucleosome. (temp115, type A)

Co-transcriptional histone H3K36 methylation complex containing RNA polymerase II elongation complex, Set2, and the upstream nucleosome. (temp115, type B)

Co-transcriptional histone H3K36 methylation complex containing RNA polymerase II elongation complex, Set2, and the upstream nucleosome. (temp130, type B)

Co-transcriptional histone H3K36 methylation complex containing RNA polymerase II elongation complex, Set2, and the upstream nucleosome. (temp130, type A)

The complex structure of 0086-0043 and NET determined with Cryo-EM.

The complex structure of Y510-9709 and NET determined with Cryo-EM

Co-transcriptional histone H3K36 methylation complex containing RNA polymerase II elongation complex, Set2, and the upstream nucleosome. (temp115, FACT-hexamer)

Full-length GluA4 with TARP gamma 2 (composite map)

consensus map of Neddylated CUL5-ARIH2-L3A2-1 bound to ASB9-EloB/C-CKB

Structure of the Complement classical and lectin pathway C3 convertase

Consensus Map of Neddylated CUL5 C-terminal region-RBX2-ARIH2~L3A2-1~Ub

Structure of the Complement classical and lectin pathway proconvertase, C4b2

Cerebellar GluAx/A4 TMD with four TARPs (focused refinement)

GluA4 LBD-TMD with TARP gamma 2 (focused refinement)

Structure of the Complement classical and lectin pathway C3 convertase in complex with substrate C3

Focus refined map of Neddylated CUL5 C-terminal region-RBX2-ARIH2~L3A2-1~Ub

Cerebellar GluA2/4 NTD heterophilic tetramer interface (focused refinement)

GluA4 with TARP gamma2 (consensus refinement)

GluA4 N-terminal domain bound to nanobody NB74 (focused refinement)

Cerebellar GluA1/4 TMD with TARP gamma 7 (focused refinement)

Structure of Neddylated CUL5 C-terminal region-RBX2-ARIH2~L3A2-1~Ub

Structure of the Complement classical and lectin pathway proconvertase, C4b2

Focus refined map of Neddylated CUL5-ARIH2-L3A2-1 bound to ASB9-EloB/C-CKB, focus refined on ARIH2-L3A2-1

Cryo-EM map of focus refined ASB9-Elob/C-CKB bound to Nedd8-CUL5-RBX2-ARIH2-L3A2-1

Structure of RBR E2 variant binding to CUL5-RBX2 bound ARIH2

P116 from Mycoplasma pneumoniae in complex with mild growth suppressor monoclonal antibody

Structure of an Engineered Sodium/Iodide Symporter (PF-NIS)

C. elegans PEZO-1 Isoform G

cryoEM structure of the human OGA-L Catalytic Dimer

cryoEM structure of the B-chain of the human OGA-L Catalytic Dimer

cryoEM structure of the human OGA-L Dimer

cryoEM structure of the A-chain of the human OGA-L Catalytic Dimer

cryoEM structure of the human OGA-L Catalytic Dimer, extra A-chain density

Low-resolution electron density map of C. elegans PEZO-1 Isoform L

C. elegans PEZO-1 Isoform K

Zebrafish ovum lysosomal peptide:N-glycanase

Structure of C. elegans piezo channel

Prefusion structure of GX2012 spike glycoprotein

Prefusion structure of 2014-422 spike glycoprotein

Structure of C. elegans piezo channel isoform k

Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity

Structure of the wild-type ABCC2 in Arabidopsis thaliana in the apo state

Cryo-EM Structure of the BLOC-3-RAB9A complex

Cryo-EM structure of amyloid peptide-silk block protein fibril, Type 2

Structure of ABCC2(E1404Q) in Arabidopsis thaliana in the apo state

Structure of ABCC2(E1404Q) in Arabidopsis thaliana in the DNP-GS bound state

Structure of ABCC2(E1404Q) monomer in Arabidopsis thaliana in the DNP-GS bound state

Structure of ABCC2(E1404Q) in Arabidopsis thaliana in the ATP bound state

Structure of the wild-type ABCC2 dimer in Arabidopsis thaliana in the apo state