EMD-73558

Single-particle
3.1 Å
EMD-73558
3D View Gallery
Deposition: 25/10/2025
Map released: 22/07/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73558

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9yws summary report (pdf.gz) Map-9yws FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human Sec61 complex bound to coibamide A

EMD-73558

Single-particle
3.1 Å
EMD-73558
3D View Gallery
Deposition: 25/10/2025
Map released: 22/07/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Leptolyngbya sp.
Sample: Chimeric (human-yeast) Sec complex bound to coibamide A
Fitted models: 9yws

Deposition Authors: Park E , Wang L
Structure-based design of Sec61 translocon targeting prodrugs minimize off-target toxicity.
Hao Q, Wang L , Pan H, Xiao X, Dong W, Pan W, Sun J, Su W, Fang L, Park E , Yao G
(2026) Cell Chem Biol , 33 , 823 - 836.e21
PUBMED: 42263680
DOI: doi:10.1016/j.chembiol.2026.05.006
ISSN: 2451-9456
Grant Support: