EMD-65226
Cryo-EM Structure of GPR158 in Complex with RGS7-Gbeta5 and Nanobody Nb20
EMD-65226
Single-particle4.3 Å
Deposition: 02/07/2025Map released: 22/07/2026
Last modified: 22/07/2026
Sample Organism:
Homo sapiens,
Mus musculus,
Lama glama
Sample: GPR158 complexed with Nb20
Fitted models: 9vos
Deposition Authors: Laboute T
,
Zucca S ,
Sial M,
Sharma M ,
Brunori G,
Singh S ,
Singh A,
Martemyanov K
Sample: GPR158 complexed with Nb20
Fitted models: 9vos
Deposition Authors: Laboute T
,
Zucca S ,
Sial M,
Sharma M ,
Brunori G,
Singh S ,
Singh A,
Martemyanov K
Targeting mGlyR with nanobodies for depression.
Laboute T ,
Zucca S ,
Sial OK,
Sharma M ,
Brunori G,
Singh S ,
Nageswar KV,
Peng H ,
Rader C ,
Becker JA ,
Le Merrer J ,
Singh AK ,
Martemyanov KA
(2026) Nat Commun , 17 , 831 - 831
,
Zucca S ,
Sial OK,
Sharma M ,
Brunori G,
Singh S ,
Nageswar KV,
Peng H ,
Rader C ,
Becker JA ,
Le Merrer J ,
Singh AK ,
Martemyanov KA
(2026) Nat Commun , 17 , 831 - 831
Grant Support:
- National Institutes of Health/National Eye Institute (NIH/NEI): MH105482 (United States)
- National Institutes of Health/National Eye Institute (NIH/NEI): EY034339 (United States)
- Indian Council of Medical Research: Neuro/2022-NCD-I (India)
- Department of Biotechnology (DBT, India): Neuro/2022-NCD-I (India)