EMD-71555

Single-particle
2.6 Å
EMD-71555
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Deposition: 01/07/2025
Map released: 22/07/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71555
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9pea summary report (pdf.gz) Map and 9pea FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of full-length human TRPV1 in complex with analgesic MSP20

EMD-71555

Single-particle
2.6 Å
EMD-71555
3D View Gallery
Deposition: 01/07/2025
Map released: 22/07/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: full-length human TRPV1 in complex with MSP20
Fitted models: 9pea

Deposition Authors: Neuberger A, Talyzina IA, Romeo I, Aiello F, Maramai S, Alcaro S, Artese A, Brizzi A, Sobolevsky AI
Design, synthesis and structural mechanism of action of TRPV1 agonist MSP20 with long-lasting analgesic effect.
Neuberger A, Romeo I, Aiello F, Alekseev A, Maramai S, Pessina F, Vagaggini C, Poggialini F, Dreassi E, Frosini M, Schiano Moriello A, De Petrocellis L, Morace AM, Belardo C, Perrone M, Bonsale R, Luongo L, Maione S, Talyzina IA, Alcaro S, Artese A, Brizzi A, Sobolevsky AI
(2026) Nat Commun
PUBMED: 42409805
DOI: doi:10.1038/s41467-026-74972-3
ISSN: 2041-1723