Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P00743

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
23	unknown peptidase	1-492	P		NT	<%Agarwal et al., 2012[]%>
40	unknown peptidase	1-492	P		NT	<%Agarwal et al., 2012[]%>
180	unknown peptidase	1-492	P		NT	<%Agarwal et al., 2012[]%>
182	unknown peptidase	1-492	P		NT	<%Agarwal et al., 2012[]%>
233	coagulation factor IXa	24-492	N
233	coagulation factor VIIa	24-492	N
371	coagulation factor Xa	41-180; 183-492	P			Brandstetter et al., 1996
475	unknown peptidase	1-492	P		NT	<%Agarwal et al., 2012[]%>