Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P00451

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
19	unknown peptidase	1-2351	P		NT	<%Agarwal et al., 2012[]%>
55	coagulation factor Xa	20-372	P			Nogami et al., 2003
55	plasmin	20-2351	P		NT	Nogami et al., 2007
355	coagulation factor IXa	20-372	P			Nogami et al., 2003
355	coagulation factor Xa	20-372	P			Nogami et al., 2003
355	protein C (activated)	20-372	P			Nogami et al., 2003
355	plasmin	20-2351	P		NT	Nogami et al., 2007
391	coagulation factor Xa	20-2351	P			Nogami et al. 2003
391	thrombin	20-2351	P			Warren et al., 1999
391	plasmin	20-2351	P		NT	Nogami et al., 2007
581	protein C (activated)	20-1332	P			Fay et al., 1991
759	coagulation factor Xa	20-2351	P			Nogami et al. 2003
759	thrombin	20-2351	P	conversion to two-chain form		Warren et al., 1999
759	protein C (activated)	20-1332	P			Fay et al., 1991
759	plasmin	20-2351	P		NT	Nogami et al., 2007
1332	unknown peptidase	1-2351	P		NT	<%Agarwal et al., 2012[]%>
1667	unknown peptidase	1-2351	P		NT	<%Agarwal et al., 2012[]%>
1708	coagulation factor Xa	20-2351	P			Nogami et al. 2003
1708	thrombin	20-2351	P			Warren et al., 1999
1708	plasmin	20-2351	P		NT	Nogami et al., 2007
1740	plasmin	20-2351	P		NT	Nogami et al., 2007