Searches of the MEROPS database
Display Known Cleavages for a Protein
Please enter a UniProt accession (eg P05067):
Sequence P00734
,
Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.
Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 24 |
unknown peptidase |
1-622 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 43 |
lumbrokinase |
44-622 |
N |
|
NT |
Zhao et al., 2007 |
| 198 |
thrombin |
44-622 |
P |
release of an activation peptide |
|
|
| 198 |
lumbrokinase |
44-622 |
N |
|
NT |
Zhao et al., 2007 |
| 201 |
ecarin |
44-622 |
N |
|
|
Kawabata & Iwanaga, 2004 |
| 250 |
vibriolysin |
44-622 |
N |
|
NT |
Chang et al., 2005 |
| 314 |
coagulation factor Xa |
44-622 |
P |
|
|
Brandstetter et al., 1996 |
| 314 |
lumbrokinase |
44-622 |
N |
|
NT |
Zhao et al., 2007 |
| 315 |
vibriolysin |
44-622 |
N |
|
NT |
Chang et al., 2005 |
| 327 |
coagulation factor Xa |
44-622 |
P |
|
|
<%Orcutt et al., 2004[]%> |
| 327 |
thrombin |
44-622 |
P |
|
|
Brown et al., 2004 |
| 327 |
mannan-binding lectin-associated serine peptidase 2 |
44-622 |
P |
|
NT |
Krarup et al., 2007 |
| 327 |
lumbrokinase |
44-622 |
N |
|
NT |
Zhao et al., 2007 |
| 327 |
kallikrein-related peptidase 4 |
1-622 |
P |
|
CS |
Matsumura et al., 2005 |
| 327 |
pseutarin C |
44-622 |
P |
|
|
Rao & Kini, 2002 |
| 363 |
ecarin |
44-622 |
N |
|
|
Kawabata & Iwanaga, 2004 |
| 363 |
multactivase |
44-622 |
N |
|
|
|
| 363 |
aharin |
44-622 |
N |
|
|
Zhang et al., 1998 |
| 363 |
coagulation factor Xa |
44-622 |
P |
|
|
Rosing, 2004 |
| 363 |
thrombin |
44-622 |
P |
conversion to two-chain form |
|
Brown et al., 2004 |
| 363 |
pseutarin C |
44-622 |
P |
|
|
Rao & Kini, 2002 |
| 363 |
unknown peptidase |
44-622 |
N |
|
|
Chan et al., 2002 |
| 436 |
lumbrokinase |
44-622 |
N |
|
NT |
Zhao et al., 2007 |
