Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P12259

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
28	unknown peptidase	1-2224	P		NT	<%Agarwal et al., 2012[]%>
334	unknown peptidase	1-2224	P		NT	<%Agarwal et al., 2012[]%>
335	protein C (activated)	29-2224	P			<%Kalafatis et al., 1995[]%>
369	elastase-2	29-2224	P	normal turnover		Samis et al., 1997
534	protein C (activated)	29-2224	P			<%Kalafatis et al., 1995[]%>
536	elastase-2	29-2224	P	normal turnover		Samis et al., 1997
706	elastase-2	29-2224	N		-	Camire et al., 1998
707	coagulation factor VIIa	29-2224	P			Safa et al., 1999
707	protein C (activated)	29-2224	P			<%Kalafatis et al., 1995[]%>
725	najalysin	29-2224	N			Camire et al., 1998
736	elastase-2	29-2224	P			Camire et al., 1998
737	coagulation factor VIIa	29-2224	P			Safa et al., 1999
737	coagulation factor Xa	29-2224	P			Thorelli et al., 1997
737	thrombin	29-2224	P	conversion to two-chain form		Safa et al., 1999
847	elastase-2	29-2224	P			Camire et al., 1998
1022	protein C (activated)	29-2224	P			Kalafatis et al., 1994
1046	coagulation factor VIIa	29-2224	P			Safa et al., 1999
1046	coagulation factor Xa	29-2224	P			Thorelli et al., 1997
1046	thrombin	29-2224	P			Safa et al., 1999
1059	cathepsin G	29-2224	P			Camire et al., 1998
1220	coagulation factor VIIa	29-2224	P			Safa et al., 1999
1475	cathepsin G	29-2224	P			Camire et al., 1998
1512	elastase-2	29-2224	P			Camire et al., 1998
1546	cathepsin G	29-2224	P			Camire et al., 1998
1573	factor V activator (Daboia russellii)	29-2224	N			Markland & Swenson, 2004
1573	coagulation factor Xa	29-2224	P			Thorelli et al., 1997
1573	thrombin	29-2224	P	release of an activation peptide		<%Kalafatis et al., 1995[]%>
1793	coagulation factor Xa	29-2224	P			Thorelli et al., 1997
1795	elastase-2	29-2224	P	normal turnover		Samis et al., 1997
2018	mast cell peptidase 4 (Rattus)	2015-2020	N		CS	Karlson et al., 2002