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Literature for peptidase S01.216: coagulation factor Xa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, A Assay, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Banas,V., Seehra,K., Mahoney,M., Alisio,C., Kyriukha,Y., Weiland,E., Fath,M., Han,Z., Bricker,T., Tartell,M., Whelan,S., Boon,A.C.M. and Janetka,J.W.
    Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1
    Eur J Med Chem (2026) 302, 118385-118385. PubMed  Europe PubMed DOI
  2. Champagne,P.S., Seneci,L., Casewell,N.R. and Fry,B.G.
    Hemostatic hellfire: Rhabdophis helleri (Red-necked Keelback) snake venom pathophysiologically activates Factor VII and Factor X through novel uses of the clotting cofactors calcium, phospholipid, and Factor Va
    Toxicon (2026) 271, 108970-108970. PubMed  Europe PubMed DOI
    3. 2025
  3. Bozhko,A.A. and Panteleev,M.A.
    A mathematical model for activated platelet-dependent activation of coagulation factor X by factor IXa
    Comput Biol Med (2025) 192, 110263-110263. PubMed  Europe PubMed DOI
  4. Iglay,K., Aldridge,M.L., Calcinai,M., Wolford,E. and Ashrani,A.A.
    The global epidemiology of acquired factor X deficiency
    Hematology (2025) 30, 2476254-2476254. PubMed  Europe PubMed DOI  V
  5. Mishima,Y., Okada,H., Butt,A.L., Stewart,K.E., Mazzeffi,M.A. and Tanaka,K.A.
    In vitro procoagulant effects of Gla-domainless factor Xa in factor XI-deficient and factor IX-deficient plasma
    Thromb Res (2025) 247, 109286-109286. PubMed  Europe PubMed DOI
  6. Ustok,F.I. and Huntington,J.A.
    Engineering a membrane-independent human prothrombinase through parsimonious mutation of factor Xa
    J Thromb Haemost (2025) PubMed  Europe PubMed DOI
  7. Ustok,F.I., Faille,A. and Huntington,J.A.
    A 3.3-A cryo-EM structure of an engineered high-affinity human prothrombinase complex
    Blood (2025) PubMed  Europe PubMed DOI
    8. 2024
  8. Al-Horani,R.A.
    Revisiting the effect of cholesteryl sulfate on clotting and fibrinolysis: Inhibition of human thrombin and other human blood proteases
    Heliyon (2024) 10, e28017-e28017. PubMed  Europe PubMed DOI  PMC  EPMC  I
  9. Oda,A., Takeyama,M., Kitazawa,T. and Nogami,K.
    The emicizumab-bridged ternary complex with activated factor IX and factor X evaluated by fluorescence resonance energy transfer
    Thromb Res (2024) 237, 108-111. PubMed  Europe PubMed DOI
  10. Santiago,F., Kaur,A., Bride,S., Monroe,D., Leiderman,K. and Sindi,S.
    A new look at TFPI inhibition of factor X activation
    PLoS Comput Biol (2024) 20, e1012509-e1012509. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Stojanovski,B.M., Mohammed,B.M. and Di Cera,E.
    The Prothrombin-Prothrombinase Interaction
    Subcell Biochem (2024) 104, 409-423. PubMed  Europe PubMed DOI  V
  12. Zhu,B., Lane,M.D., Baller,J.A., Jagtap,P.D., Griffin,T.J. and Seelig,B.
    Comprehensive protease specificity profiling
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2023
  13. Dong,W., Wang,J., Tian,L., Zhang,J., Settles,E.W., Qin,C., Steinken-Kollath,D.R., Itogawa,A.N., Celona,K.R., Yi,J., Bryant,M., Mead,H., Jaramillo,S.A., Lu,H., Li,A., Zumwalt,R.E., Dadwal,S., Feng,P., Yuan,W., Whelan,S.P.J., Keim,P.S., Barker,B.M., Caligiuri,M.A. and Yu,J.
    Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection
    Nat Commun (2023) 14, 1936-1936. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Gackowski,M., Madriwala,B., Studzinska,R. and Koba,M.
    Novel Isosteviol-Based FXa Inhibitors: Molecular Modeling, In Silico Design and Docking Simulation
    Molecules (2023) 28 PubMed  Europe PubMed DOI  PMC  EPMC
  15. Lloyd,J. and Feldman,P.
    Preclinical development and characterization of a human plasma-derived high-purity factor X concentrate for therapeutic use
    Haemophilia (2023) 29, 1394-1409. PubMed  Europe PubMed DOI
  16. Novichikhina,N.P., Shestakov,A.S., Medvedeva,S.M., Lagutina,A.M., Krysin,M.Y., Podoplelova,N.A., Panteleev,M.A., Ilin,I.S., Sulimov,A.V., Tashchilova,A.S., Sulimov,V.B., Geronikaki,A. and Shikhaliev,K.S.
    New Hybrid Tetrahydropyrrolo[3,2,1-ij]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico and Experimental Evaluation
    Molecules (2023) 28 PubMed  Europe PubMed DOI  PMC  EPMC  I
  17. Wagner,N., Shayakhmetov,D.M. and Stewart,P.L.
    Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus
    Viruses (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  18. Wang,H., Poe,A., Martinez Yus,M., Pak,L., Nandakumar,K. and Santhanam,L.
    Lysyl oxidase-like 2 processing by factor Xa modulates its activity and substrate preference
    Commun Biol (2023) 6, 375-375. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Wu,S., Wang,T., Li,J., Zhang,Z., Li,C., Xiao,S., He,J., Wang,X., Hu,Z., Wang,X., Zheng,S., Liang,X., Chen,G., Li,Y., Li,X., Zhan,Y., Zou,Q., Jiang,H., Zheng,Q., Ban,L., Liu,H. and Fang,Y.
    First-in-human trial of SAR107375E, a novel small molecule anticoagulant with dual inhibition of factor Xa and factor IIa
    Expert Opin Investig Drugs (2023) 32, 1085-1094. PubMed  Europe PubMed DOI  I
  20. Yoon,H.J., Kundu,S. and Wu,S.
    Molecular Dynamics Simulation Study of the Selective Inhibition of Coagulation Factor IXa over Factor Xa
    Molecules (2023) 28 PubMed  Europe PubMed DOI  PMC  EPMC
  21. Zhang,Q., Zhang,Z., Chen,W., Zheng,H., Si,D. and Zhang,W.
    Rivaroxaban, a direct inhibitor of coagulation factor Xa, attenuates adverse cardiac remodeling in rats by regulating the PAR-2 and TGF-beta1 signaling pathways
    PeerJ (2023) 11, e16097-e16097. PubMed  Europe PubMed DOI  PMC  EPMC  I
    22. 2022
  22. Fernandez-Bachiller,M.I., Hwang,S., Schembri,M.E., Lindemann,P., Guberman,M., Herziger,S., Specker,E., Matter,H., Will,D.W., Czech,J., Wagner,M., Bauer,A., Schreuder,H., Ritter,K., Urmann,M., Wehner,V., Sun,H. and Nazare,M.
    Probing Factor Xa Protein-Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands
    J Med Chem (2022) 65, 13013-13028. PubMed  Europe PubMed DOI
  23. Gackowski,M., Szewczyk-Golec,K., Madra-Gackowska,K., Pluskota,R. and Koba,M.
    Quantitative Structure-Activity Relationship Analysis of Isosteviol-Related Compounds as Activated Coagulation Factor X (FXa) Inhibitors
    Nutrients (2022) 14 PubMed  Europe PubMed DOI
  24. Modrzycka,S., Kolt,S., Polderdijk,S.G.I., Adams,T.E., Potoczek,S., Huntington,J.A., Kasperkiewicz,P. and Drag,M.
    Parallel imaging of coagulation pathway proteases activated protein C, thrombin, and factor Xa in human plasma
    Chem Sci (2022) 13, 6813-6829. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Payne,J., Batsuli,G., Leavitt,A.D., Mathias,M. and McGuinn,C.E.
    A review of the pharmacokinetics, efficacy and safety of high-purity factor X for the prophylactic treatment of hereditary factor X deficiency
    Haemophilia (2022) 28, 523-531. PubMed  Europe PubMed DOI
  26. Ruben,E.A., Summers,B., Rau,M.J., Fitzpatrick,J.A.J. and Di Cera,E.
    Cryo-EM structure of the prothrombin-prothrombinase complex
    Blood (2022) 139, 3463-3473. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Schroer,K., Alshawabkeh,M., Schellhorn,S., Bronder,K., Zhang,W. and Ehrhardt,A.
    Influence of Heparan Sulfate Proteoglycans and Factor X on species D Human Adenovirus Uptake and Transduction
    Viruses (2022) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  28. Zekri-Nechar,K., Zamorano-Leon,J.J., Reche,C., Giner,M., Lopez-de-Andres,A., Jimenez-Garcia,R., Lopez-Farre,A.J. and Martinez-Martinez,C.H.
    Spike Protein Subunits of SARS-CoV-2 Alter Mitochondrial Metabolism in Human Pulmonary Microvascular Endothelial Cells: Involvement of Factor Xa
    Dis Markers (2022) 2022, 1118195-1118195. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Zhang,Z.L., Chen,C., Qu,S.Y., Ding,Q. and Xu,Q.
    Unexpected Dynamic Binding May Rescue the Binding Affinity of Rivaroxaban in a Mutant of Coagulation Factor X
    Front Mol Biosci (2022) 9, 877170-877170. PubMed  Europe PubMed DOI  PMC  EPMC  I
    30. 2021
  30. Ebert,M., Raquet,E., Schweisgut,S., Schmidt,P.M. and Weimer,T.
    Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent
    Blood Cells Mol Dis (2021) 89, 102570-102570. PubMed  Europe PubMed DOI
  31. Fischer,A., Sellner,M., Mitusinska,K., Bzowka,M., Lill,M.A., Gora,A. and Smiesko,M.
    Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  32. Ichinose,A., Osaki,T. and Souri,M.
    Autoimmune Coagulation Factor X Deficiency as a Rare Acquired Hemorrhagic Disorder: A Literature Review
    Thromb Haemost (2021) PubMed  Europe PubMed DOI
  33. Jackson,C.M.
    Structure and function of factor X: properties, activation, and activity in prothrombinase. A retrospective in a historical context
    J Thromb Thrombolysis (2021) PubMed  Europe PubMed DOI
  34. Kundu,S. and Wu,S.
    A Structure Based Study of Selective Inhibition of Factor IXa over Factor Xa
    Molecules (2021) 26 PubMed  Europe PubMed DOI  PMC  EPMC
  35. Paul,D. and Morrissey,J.H.
    Stoichiometric analysis reveals a unique phosphatidylserine binding site in coagulation factor X
    J Thromb Haemost (2021) PubMed  Europe PubMed DOI
  36. Ruf,W.
    Roles of factor Xa beyond coagulation
    J Thromb Thrombolysis (2021) PubMed  Europe PubMed DOI
    37. 2020
  37. Al-Horani,R.A.
    Potential Therapeutic Roles for Direct Factor Xa Inhibitors in Coronavirus Infections
    Am J Cardiovasc Drugs (2020) 20, 525-533. PubMed  Europe PubMed DOI  PMC  EPMC  V
  38. Basavaraj,M.G. and Krishnaswamy,S.
    Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex
    J Biol Chem (2020) PubMed  Europe PubMed DOI
  39. de Laat-Kremers,R.M.W., Yan,Q., Ninivaggi,M., de Maat,M. and de Laat,B.
    Deciphering the coagulation profile through the dynamics of thrombin activity
    Sci Rep (2020) 10, 12544-12544. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Dorgalaleh,A., Baghaipour,M.R., Tabibian,S., Ghazizadeh,F., Dabbagh,A., Bahoush,G., Jazebi,M., Bahraini,M., Fazeli,A., Baghaipour,N. and Yousefi,F.
    Gastrointestinal bleeding in a newborn infant with congenital factor X deficiency and COVID-19-A common clinical feature between a rare disorder and a new, common infection
    Int J Lab Hematol (2020) PubMed  Europe PubMed DOI  PMC  EPMC
  41. Frydman,G.H., Streiff,M.B., Connors,J.M. and Piazza,G.
    The Potential Role of Coagulation Factor Xa in the Pathophysiology of COVID-19: A Role for Anticoagulants as Multimodal Therapeutic Agents
    TH Open (2020) 4, e288-e288. PubMed  Europe PubMed DOI  PMC  EPMC  V
  42. Papadaki,S., Sidiropoulou,S., Moschonas,I.C. and Tselepis,A.D.
    Factor Xa and thrombin induce endothelial progenitor cell activation. The effect of direct oral anticoagulants
    Platelets (2020) , 1-8. PubMed  Europe PubMed DOI  I
  43. Ruf,W. and Graf,C.
    Coagulation signaling and cancer immunotherapy
    Thromb Res (2020) 191 Suppl 1, S106-S106. PubMed  Europe PubMed DOI
  44. Shima,M.
    Bispecific Antibodies and Advances in Non-Gene Therapy Options in Hemophilia
    Res Pract Thromb Haemost (2020) 4, 446-454. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Stallone,G., Pontrelli,P., Rascio,F., Castellano,G., Gesualdo,L. and Grandaliano,G.
    Coagulation and Fibrinolysis in Kidney Graft Rejection
    Front Immunol (2020) 11, 1807-1807. PubMed  Europe PubMed DOI  PMC  EPMC  V
  46. Zhang,X., Chen,K., Wang,G., Zhang,C., Zhao,B., Liu,X., Qin,X. and Yang,L.
    Molecular mechanism of a novel Ser362Asn mutation causing inherited FX deficiency in a Chinese family
    Int J Hematol (2020) 112, 8-16. PubMed  Europe PubMed DOI  M
  47. Zimowski,K.L., McGuinn,C.E., Abajas,Y.L., Schultz,C.L., Kaicker,S. and Batsuli,G.
    Use of plasma-derived factor X concentrate in neonates and infants with congenital factor X deficiency
    J Thromb Haemost (2020) 18, 2551-2556. PubMed  Europe PubMed DOI
    48. 2019
  48. Abache,T., Fontayne,A., Grenier,D., Jacque,E., Longue,A., Dezetter,A.S., Souilliart,B., Chevreux,G., Bataille,D., Chtourou,S. and Plantier,J.L.
    A mutated factor X activatable by thrombin corrects bleedings in vivo in a rabbit model of antibody-induced hemophilia A
    Haematologica (2019) 105, 2335-2340. PubMed  Europe PubMed DOI
  49. Ferrarese,M., Pignani,S., Lombardi,S., Balestra,D., Bernardi,F., Pinotti,M. and Branchini,A.
    The carboxyl-terminal region of human coagulation factor X as a natural linker for fusion strategies
    Thromb Res (2019) 173, 4-11. PubMed  Europe PubMed DOI  E
  50. Ferrarese,M., Baroni,M., Della Valle,P., Spiga,I., Poloniato,A., D'Angelo,A., Pinotti,M., Bernardi,F. and Branchini,A.
    Missense changes in the catalytic domain of coagulation factor X account for minimal function preventing a perinatal lethal condition
    Haemophilia (2019) 25, 685-692. PubMed  Europe PubMed DOI  M
  51. Girard,T.J., Lasky,N.M., Grunz,K. and Broze GJ Jr
    Suppressing protein Z-dependent inhibition of factor Xa improves coagulation in hemophilia A
    J Thromb Haemost (2019) 17, 149-156. PubMed  Europe PubMed DOI
  52. Girolami,A., de Paoletti,D.N.G., Nenkies,M.L., Ferrari,S. and Guglielmone,H.
    Factor X deficiency due to a compound heterozygosis between a new mutation (Gla72Asp) in exon 2 and an already known one (Gly154Arg) in exon 5: factor X Mar del Plata1)
    Cardiovasc Hematol Disord Drug Targets (2019) 19, 169-173. PubMed  Europe PubMed DOI  M
  53. Ilin,I., Lipets,E., Sulimov,A., Kutov,D., Shikhaliev,K., Potapov,A., Krysin,M., Zubkov,F., Sapronova,L., Ataullakhanov,F. and Sulimov,V.
    New factor Xa inhibitors based on 1,2,3,4-tetrahydroquinoline developed by molecular modelling
    J Mol Graph Model (2019) 89, 215-224. PubMed  Europe PubMed DOI  I
  54. Li,F., Chen,C., Qu,S.Y., Zhao,M.Z., Xie,X., Wu,X., Li,L., Wang,X., Ding,Q., Xu,Q., Wei,D.Q. and Wu,W.
    The disulfide bond between Cys22 and Cys27 in the protease domain modulate clotting activity of coagulation factor X
    Thromb Haemost (2019) 119, 871-881. PubMed  Europe PubMed DOI
  55. Mitchell,M., Gattens,M., Kavakli,K., Liesner,R., Payne,J., Norton,M. and Austin,S.
    Genotype analysis and identification of novel mutations in a multicentre cohort of patients with hereditary factor X deficiency
    Blood Coagul Fibrinolysis (2019) 30, 34-41. PubMed  Europe PubMed DOI  M
  56. Muczynski,V., Verhenne,S., Casari,C., Cherel,G., Panicot-Dubois,L., Gueguen,P., Trossaert,M., Dubois,C., Lenting,P.J., Denis,C.V. and Christophe,O.D.
    A thrombin-activatable factor X variant corrects hemostasis in a mouse model for hemophilia A
    Thromb Haemost (2019) 119, 1981-1993. PubMed  Europe PubMed DOI  U
  57. Othman,T., Abdelkarim,A., Huynh,K., Uche,A. and Lee,J.
    Inherited moderate factor X deficiency presenting as cardiac tamponade
    Case Rep Hematol (2019) 2019, 9657516-9657516. PubMed  Europe PubMed DOI  PMC  EPMC  M
  58. Qu,S.Y., Xu,Q., Wu,W., Li,F., Li,C.D., Huang,R., Ding,Q. and Wei,D.Q.
    An unexpected dynamic binding mode between coagulation factor X and rivaroxaban reveals importance of flexibility in drug binding
    Chem Biol Drug Des (2019) 94, 1664-1671. PubMed  Europe PubMed DOI  I
  59. van Dievoet,M.A., Jacquemin,M., Van Calsteren,K. and Peerlinck,K.
    A rare presentation of homozygous factor X deficiency in a pregnant patient: a case report and review of the literature
    Haemophilia (2019) 25, e57-e57. PubMed  Europe PubMed DOI  M
    60. 2018
  60. Arita,K., Niimi,H., Yamagishi,N., Ueno,T., Kitajima,I. and Sugiyama,T.
    Factor X heterozygous mutation in a patient with potential risk of bleeding: a case report
    Medicine (Baltimore) (2018) 97, e10950-e10950. PubMed  Europe PubMed DOI  M
  61. Augustsson,C., Svensson,A., Kjaer,B., Chao,T.Y., Wenjuan,X., Krogh,B.O., Breinholt,J., Clausen,J.T., Hilden,I., Petersen,H.H. and Petersen,L.C.
    Factor Xa and VIIa inhibition by tissue factor pathway Inhibitor is prevented by a monoclonal antibody to its Kunitz-1 domain
    J Thromb Haemost (2018) 16, 893-904. PubMed  Europe PubMed DOI
  62. Girolami,A., Cosi,E., Santarossa,C., Ferrari,S., Girolami,B. and Lombardi,A.M.
    Factor X Friuli coagulation disorder: almost 50 years later
    Clin Appl Thromb Hemost (2018) 24, 33-40. PubMed  Europe PubMed DOI  M
  63. Gunaratne,R., Kumar,S., Frederiksen,J.W., Stayrook,S., Lohrmann,J.L., Perry,K., Bompiani,K.M., Chabata,C.V., Thalji,N.K., Ho,M.D., Arepally,G., Camire,R.M., Krishnaswamy,S. and Sullenger,B.A.
    Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass
    Nat Biotechnol (2018) 36, 606-613. PubMed  Europe PubMed DOI  PMC  EPMC
  64. Horinaka,S., Sugawara,R., Yonezawa,Y. and Ishimitsu,T.
    Factor Xa inhibition by rivaroxaban in the trough steady state can significantly reduce thrombin generation
    Br J Clin Pharmacol (2018) 84, 79-87. PubMed  Europe PubMed DOI  I
  65. Hu,X., Xiao,Y., Yu,C., Zuo,Y., Yang,W., Wang,X., Gu,B. and Li,J.
    Characterization of a novel selective factor Xa inhibitor, DJT06001, which reduces thrombus formation with low risk of bleeding
    Eur J Pharmacol (2018) 825, 85-91. PubMed  Europe PubMed DOI  I
  66. Jourdi,G., Gouin-Thibault,I., Siguret,V., Gandrille,S., Gaussem,P. and Le Bonniec,B.
    FXa-alpha2-Macroglobulin complex neutralizes direct oral anticoagulants targeting FXa in vitro and in vivo
    Thromb Haemost (2018) 118, 1535-1544. PubMed  Europe PubMed DOI  U
  67. Kanade,G.D., Pingale,K.D. and Karpe,Y.A.
    Activities of thrombin and factor Xa are essential for replication of hepatitis E virus and are possibly implicated in the ORF1 polyprotein processing
    J Virol (2018) 92, e01853-17-e01853-17. PubMed  Europe PubMed DOI
  68. Lu,G., Pine,P., Leeds,J.M., DeGuzman,F., Pratikhya,P., Lin,J., Malinowski,J., Hollenbach,S.J., Curnutte,J.T. and Conley,P.B.
    Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model
    PLoS ONE (2018) 13, e0195122-e0195122. PubMed  Europe PubMed DOI  I
  69. Ramesh,K., Lama,D., Tan,K.W., Nguyen,V.S., Chew,F.T., Verma,C.S. and Mok,Y.K.
    Homologous lympho-epithelial Kazal-type inhibitor domains delay blood coagulation by inhibiting factor X and XI with differential specificity
    Structure (2018) 26, 1178-1186. PubMed  Europe PubMed DOI
  70. Shinozawa,E., Nakayama,M. and Imura,Y.
    TAK-442, a direct factor Xa inhibitor, inhibits monocyte chemoattractant protein 1 production in endothelial cells via involvement of protease-activated receptor 1
    Front Pharmacol (2018) 9, 1431-1431. PubMed  Europe PubMed DOI  PMC  EPMC  I
    71. 2017
  71. Hack,K., Renzi,F., Hess,E., Lauber,F., Douxfils,J., Dogne,J.M. and Cornelis,G.R.
    Inactivation of human coagulation factor X by a protease of the pathogen Capnocytophaga canimorsus
    J Thromb Haemost (2017) 15, 487-499. PubMed  Europe PubMed DOI
  72. Hu,Z., Liu,Y., Huarng,M.C., Menegatti,M., Reyon,D., Rost,M.S., Norris,Z.G., Richter,C.E., Stapleton,A.N., Chi,N.C., Peyvandi,F., Joung,J.K. and Shavit,J.A.
    Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway
    Blood (2017) 130, 666-676. PubMed  Europe PubMed DOI
  73. Jaegle,M., Steinmetzer,T. and Rademann,J.
    Protein-templated formation of an inhibitor of the blood coagulation factor Xa through a background-free amidation reaction
    Angew Chem Int Ed Engl (2017) 56, 3718-3722. PubMed  Europe PubMed DOI  I
  74. Kovalenko,T.A., Panteleev,M.A. and Sveshnikova,A.N.
    Substrate delivery mechanism and the role of membrane curvature in factor X activation by extrinsic tenase
    J Theor Biol (2017) 435, 125-133. PubMed  Europe PubMed DOI
  75. Lagos,C.F., Segovia,G.F., Nunez-Navarro,N., Faundez,M.A. and Zacconi,F.C.
    Novel FXa inhibitor identification through integration of ligand- and structure-based approaches
    Molecules (2017) 22 PubMed  Europe PubMed DOI  I
  76. Lenting,P.J., Denis,C.V. and Christophe,O.D.
    Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII?
    Blood (2017) 130, 2463-2468. PubMed  Europe PubMed DOI
  77. Thalji,N.K. and Camire,R.M.
    Rendering factor Xa zymogen-like as a therapeutic strategy to treat bleeding
    Curr Opin Hematol (2017) 24, 453-459. PubMed  Europe PubMed DOI  U
    78. 2016
  78. Arian,D., Harenberg,J. and Kramer,R.
    A chromogenic and fluorogenic peptide substrate for the highly sensitive detection of proteases in biological matrices
    J Med Chem (2016) 59, 7576-7583. PubMed  Europe PubMed DOI  A
  79. Camire,R.M.
    Bioengineering factor Xa to treat bleeding
    Thromb Res (2016) 141 Suppl 2, S31-S33. PubMed  Europe PubMed DOI  E  U
  80. Escobar,M.A., Auerswald,G., Austin,S., Huang,J.N., Norton,M. and Millar,C.M.
    Experience of a new high-purity factor X concentrate in subjects with hereditary factor X deficiency undergoing surgery
    Haemophilia (2016) 22, 713-720. PubMed  Europe PubMed DOI  U
  81. Girish,V.M. and Kini,R.M.
    Exactin: a specific inhibitor of factor X activation by extrinsic tenase complex from the venom of Hemachatus haemachatus
    Sci Rep (2016) 6, 32036-32036. PubMed  Europe PubMed DOI  PMC  EPMC
  82. Girolami,A., Molina,M.A., Galletti,M.L., Ferrari,S., Sambado,L. and Guglielmone,H.
    A family with factor X deficiency from Argentina: a compound heterozygosis because of the combination of a new mutation (Gln138Arg) with an already known one (Glu350Lys)
    Blood Coagul Fibrinolysis (2016) 27, 732-736. PubMed  Europe PubMed DOI  M
  83. Peraramelli,S., Thomassen,S., Heinzmann,A., Hackeng,T.M., Hartmann,R., Scheiflinger,F., Dockal,M. and Rosing,J.
    Role of exosite binding modulators in the inhibition of FXa by TFPI
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