$VAR1 = undef;

Summary for peptidase S01.143: tryptase alpha

Names
MEROPS Name	tryptase alpha
Other names	tryptase alpha 1 (Homo sapiens), TPSAB1 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.143
Holotype	tryptase alpha (Homo sapiens), Uniprot accession P15157 (peptidase unit: 31-274), MERNUM MER0000135
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00278
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.59
Enzymology	BRENDA database
Proteolytic events	CutDB database (11 cleavages)
Physiology	Has potential to cleave a variety of extracellular proteins of biomedical importance.
Pharmaceutical relevance	Regarded as a drug target for asthma and antigen-induced bronchoconstriction (Slusarchyk et al., 2002; Sutton et al., 2002).
Other databases	PANTHER	http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR24256:SF149
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/KR-/-/-/- (based on 23 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	2	2	0	1	0	3	2
Pro	3	0	3	0	0	1	2	1
Ala	2	1	0	0	2	0	1	1
Val	0	1	2	0	1	0	0	1
Leu	2	3	2	0	0	3	2	1
Ile	0	1	0	0	1	1	1	0
Met	1	0	0	0	0	1	1	0
Phe	1	2	1	0	0	1	0	1
Tyr	0	1	0	0	2	1	0	0
Trp	0	0	0	0	0	0	0	0
Ser	2	0	2	0	2	0	1	1
Thr	1	0	0	0	0	0	0	2
Cys	0	0	0	0	0	0	0	0
Asn	0	1	1	0	1	0	2	1
Gln	0	2	0	0	1	3	0	0
Asp	1	1	4	0	1	2	0	1
Glu	0	0	1	0	0	1	2	1
Lys	1	2	1	13	3	0	0	0
Arg	3	2	1	10	0	1	0	1
His	0	1	0	0	0	0	0	1

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
TPSAB1	16p13.3		ENSG00000172236	7176	TPS1	191080