Structure for peptidase S01.143: tryptase alpha

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
2F9P Homo sapiens 2.30 Å Asp216Gly mutant; complex with leupeptin
Catalytic residues are shown in ball-and-stick representation: His74 in purple, Asp121 in pink and Ser224 in orange. Bound inhibitor is shown in grey in ball-and-stick representation.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Homo sapiens
tetramer 2.20 Å 1LTO 1LTO 1LTO 1LTO 1LTO 1LTO Marquardt et al., 2002
Lys192Gln, Asp216Gly double mutant; complex with leupeptin 1.60 Å 2F9N 2F9N 2F9N 2F9N 2F9N 2F9N Rohr et al., 2006
Asp216Gly mutant 2.10 Å 2F9O 2F9O 2F9O 2F9O 2F9O 2F9O Rohr et al., 2006
Asp216Gly mutant; complex with leupeptin 2.30 Å 2F9P 2F9P 2F9P 2F9P 2F9P 2F9P Rohr et al., 2006