Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P19957

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
22	unknown peptidase	1-117	P	release of a signal peptide	NT	Molhuizen et al., 1993
56	meprin alpha subunit	23-60	N		MS	Becker-Pauly et al., 2011
56	meprin beta subunit	23-117	N		MS	Becker-Pauly et al., 2011
60	cathepsin L	23-117	P	normal turnover		Guyot et al., 2005
60	cathepsin K	23-117	P	normal turnover		Guyot et al., 2005
60	tryptase alpha	23-117	P			Guyot et al., 2005
60	trypsin 1	23-117	P			Guyot et al., 2005
60	plasmin	23-117	P			Guyot et al., 2005
61	meprin alpha subunit	61-117	N		MS	Becker-Pauly et al., 2011
61	meprin beta subunit	23-117	N		MS	Becker-Pauly et al., 2011
62	meprin alpha subunit	61-117	N		MS	Becker-Pauly et al., 2011
62	meprin beta subunit	61-117	N		MS	Becker-Pauly et al., 2011
65	elastase-2	61-117	P			Guyot et al., 2008
69	elastase-2	61-117	P			Guyot et al., 2008
70	meprin alpha subunit	61-117	N		MS	Becker-Pauly et al., 2011
82	gingipain RgpA	61-117	N		MS	Kantyka et al., 2009
84	elastase-2	61-117	P			Guyot et al., 2008
85	pseudolysin	61-117	N			Guyot et al., 2010