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Literature for peptidase S01.143: tryptase alpha

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, M Mutation, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Broussal,F., Rouzioux,T., Khelifi-Touhami,D., Bachelier,S., Berthier,B., Abbas,A., Choi,S. and Chantran,Y.
    Very Long-Term Stability of Tryptase in Frozen Serum Samples
    Clin Exp Allergy PubMed  Europe PubMed DOI
    2. 2024
  2. Alheraky,A., Wierenga,A.T.J., Simpelaar,A., Hesp,L.B., Minovic,I., Bagheri,N., Roozendaal,C., Span,L.F.R., Oude Elberink,H.N.G., Kema,I.P. and Mulder,A.B.
    Hereditary Alpha Tryptasemia: Validation of a Single-Well Multiplex Digital Droplet PCR Assay in a Cohort of Symptomatic Patients
    Clin Chem70, 425-433. PubMed  Europe PubMed DOI
  3. Ma,Y., Li,B., Zhao,X., Lu,Y., Li,X., Zhang,J., Wang,Y., Zhang,J., Wang,L., Meng,S. and Hao,J.
    Computational modeling of mast cell tryptase family informs selective inhibitor development
    iScience27, 110739-110739. PubMed  Europe PubMed DOI
  4. Michel,M., Giusti,D., Klingebiel,C. and Vitte,J.
    Tryptase in drug-induced anaphylaxis: the need for acute and baseline values
    Curr Opin Allergy Clin Immunol24, 293-299. PubMed  Europe PubMed DOI  V
  5. Monahan,R., Alfaro,E., Ho,H., Otani,I.M. and Tsao,L.R.
    Hereditary alpha tryptasemia presenting as recurrent chemotherapy hypersensitivity reactions
    Ann Allergy Asthma Immunol132, 270-273. PubMed  Europe PubMed DOI
  6. Ribatti,D.
    Tryptase and tumor angiogenesis
    Front Oncol14, 1500482-1500482. PubMed  Europe PubMed DOI  V
  7. Svetina,M., Selb,J., Lyons,J.J., Korosec,P. and Rijavec,M.
    Clinically accessible amplitude-based multiplex ddPCR assay for tryptase genotyping
    Sci Rep14, 2416-2416. PubMed  Europe PubMed DOI
    8. 2023
  8. Lang,A., Kubala,S., Grieco,M.C., Mateja,A., Pongracic,J., Liu,Y., Frischmeyer-Guerrerio,P.A., Kumar,R. and Lyons,J.J.
    Severe food allergy reactions are associated with alpha-tryptase
    J Allergy Clin Immunol152, 933-939. PubMed  Europe PubMed DOI
  9. Marcella,S., Petraroli,A., Cane,L., Ferrara,A.L., Poto,R., Parente,R., Palestra,F., Cristinziano,L., Modestino,L., Galdiero,M.R., Monti,M., Marone,G., Triggiani,M., Varricchi,G. and Loffredo,S.
    Thymic stromal lymphopoietin (TSLP) is a substrate for tryptase in patients with mastocytosis
    Eur J Intern Med117, 111-118. PubMed  Europe PubMed DOI
  10. Michel,M., Klingebiel,C. and Vitte,J.
    Tryptase in type I hypersensitivity
    Ann Allergy Asthma Immunol130, 169-177. PubMed  Europe PubMed DOI
  11. Willows,S.D., Semenchenko,V., Norman,G., Woodside,M.T., Sim,V.L. and Kulka,M.
    Mast Cell Proteases Cleave Prion Proteins and a Recombinant Ig against PrP Can Activate Human Mast Cells
    J Immunol210, 1447-1458. PubMed  Europe PubMed DOI
    12. 2022
  12. Bonadonna,P., Nalin,F. and Olivieri,F.
    Hereditary alpha-tryptasemia
    Curr Opin Allergy Clin Immunol22, 277-282. PubMed  Europe PubMed DOI  V
  13. O'Connell,M.P. and Lyons,J.J.
    Resolving the genetics of human tryptases: implications for health, disease, and clinical use as a biomarker
    Curr Opin Allergy Clin Immunol22, 143-152. PubMed  Europe PubMed DOI  V
    14. 2020
  14. de Almeida,A.D., Silva,I.S., Fernandes-Braga,W., LimaFilho,A.C.M., Florentino,R.O.M., Barra,A., de Oliveira Andrade,L., Leite,M.F., Cassali,G.D. and Klein,A.
    A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice
    Inflamm Res PubMed  Europe PubMed DOI
  15. de Almeida,A.D., Silva,I.S., Fernandes-Braga,W., LimaFilho,A.C.M., Florentino,R.M., Barra,A., de Oliveira Andrade,L., Leite,M.F., Cassali,G.D. and Klein,A.
    Correction to: A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice
    Inflamm Res69, 1071-1071. PubMed  Europe PubMed DOI
  16. Garland,J., Ondruschka,B., Da Broi,U., Palmiere,C., Glenn,C., Morrow,P., Kesha,K., Stables,S. and Tse,R.
    Differences Between Central and Peripheral Postmortem Tryptase Levels
    Am J Forensic Med Pathol PubMed  Europe PubMed DOI
  17. Joossen,C., Baan,A., Moreno-Cinos,C., Joossens,J., Cools,N., Lanckacker,E., Moons,L., Lemmens,K., Lambeir,A.M., Fransen,E., Delputte,P., Caljon,G., Van der Veken,P., Maes,L., De Meester,I., Kiekens,F., Augustyns,K. and Cos,P.
    A novel serine protease inhibitor as potential treatment for dry eye syndrome and ocular inflammation
    Sci Rep10, 17268-17268. PubMed  Europe PubMed DOI  I
  18. Lyons,J.J., Chovanec,J., O'Connell,M.P., Liu,Y., Selb,J., Zanotti,R., Bai,Y., Kim,J., DiMaggio,T., Schwartz,L.B., Komarow,H.D., Rijavec,M., Carter,M.C., Milner,J.D., Bonadonna,P., Metcalfe,D.D. and Korosec,P.
    Heritable risk for severe anaphylaxis associated with increased alpha-tryptase-encoding germline copy number at TPSAB1
    J Allergy Clin Immunol PubMed  Europe PubMed DOI
    19. 2019
  19. Le,Q.T., Lyons,J.J., Naranjo,A.N., Olivera,A., Lazarus,R.A., Metcalfe,D.D., Milner,J.D. and Schwartz,L.B.
    Impact of naturally forming human alpha/beta-tryptase heterotetramers in the pathogenesis of hereditary alpha-tryptasemia
    J Exp Med216, 2348-2361. PubMed  Europe PubMed DOI
  20. Maun,H.R., Jackman,J.K., Choy,D.F., Loyet,K.M., Staton,T.L., Jia,G., Dressen,A., Hackney,J.A., Bremer,M., Walters,B.T., Vij,R., Chen,X., Trivedi,N.N., Morando,A., Lipari,M.T., Franke,Y., Wu,X., Zhang,J., Liu,J., Wu,P., Chang,D., Orozco,L.D., Christensen,E., Wong,M., Corpuz,R., Hang,J.Q., Lutman,J., Sukumaran,S., Wu,Y., Ubhayakar,S., Liang,X., Schwartz,L.B., Babina,M., Woodruff,P.G., Fahy,J.V., Ahuja,R., Caughey,G.H., Kusi,A., Dennis,M.S., Eigenbrot,C., Kirchhofer,D., Austin,C.D., Wu,L.C., Koerber,J.T., Lee,W.P., Yaspan,B.L., Alatsis,K.R., Arron,J.R., Lazarus,R.A. and Yi,T.
    An allosteric anti-tryptase antibody for the treatment of mast cell-mediated severe asthma
    Cell179, 417-431. PubMed  Europe PubMed DOI
  21. Mohajeri,M., Kovanen,P.T., Bianconi,V., Pirro,M., Cicero,A.F.G. and Sahebkar,A.
    Mast cell tryptase - marker and maker of cardiovascular diseases
    Pharmacol Ther199, 91-110. PubMed  Europe PubMed DOI
  22. Shim,J.K., Kennedy,R.H., Weatherly,L.M., Abovian,A.V., Hashmi,H.N., Rajaei,A. and Gosse,J.A.
    Searching for tryptase in the RBL-2H3 mast cell model: preparation for comparative mast cell toxicology studies with zebrafish
    J Appl Toxicol39, 473-484. PubMed  Europe PubMed DOI
    23. 2018
  23. Atiakshin,D., Buchwalow,I., Samoilova,V. and Tiemann,M.
    Tryptase as a polyfunctional component of mast cells
    Histochem Cell Biol149, 461-477. PubMed  Europe PubMed DOI
    24. 2017
  24. Denadai-Souza,A., Ribeiro,C.M., Rolland,C., Thouard,A., Deraison,C., Scavone,C., Gonzalez-Dunia,D., Vergnolle,N. and Avellar,M.C.W.
    Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study
    Arthritis Res Ther19, 124-124. PubMed  Europe PubMed DOI  I
  25. Grujic,M., Paivandy,A., Gustafson,A.M., Thomsen,A.R., Ohrvik,H. and Pejler,G.
    The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung
    Oncotarget8, 25066-25079. PubMed  Europe PubMed DOI
  26. Melo,F.R., Wallerman,O., Paivandy,A., Calounova,G., Gustafson,A.M., Sabari,B.R., Zabucchi,G., Allis,C.D. and Pejler,G.
    Tryptase-catalyzed core histone truncation: a novel epigenetic regulatory mechanism in mast cells
    J Allergy Clin Immunol140, 474-485. PubMed  Europe PubMed DOI
  27. Ni,W.W., Cao,M.D., Huang,W., Meng,L. and Wei,J.F.
    Tryptase inhibitors: a patent review
    Expert Opin Ther Pat27, 919-928. PubMed  Europe PubMed DOI  I
    28. 2016
  28. Guo,X., Zhai,L., Xue,R., Shi,J., Zeng,Q. and Gao,C.
    Mast cell tryptase contributes to pancreatic cancer growth through promoting angiogenesis via activation of angiopoietin-1
    Int J Mol Sci17, PubMed  Europe PubMed DOI
    29. 2015
  29. Ribatti,D. and Ranieri,G.
    Tryptase, a novel angiogenic factor stored in mast cell granules
    Exp Cell Res332, 157-162. PubMed  Europe PubMed DOI
  30. Vasquez Velasquez,C., Roman,A.D., Lan,N.T., Huy,N.T., Mercado,E.S., Espino,F.E., Perez,M.L., Huong,V.T., Thuy,T.T., Tham,V.D., Nga,C.T., Ha,T.T., Bilar,J.M., Bajaro,J.D., Baello,B.Q., Kikuchi,M., Yasunami,M., Morita,K., Watanabe,N., Karbwang,J. and Hirayama,K.
    Alpha tryptase allele of tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines
    Hum Immunol76, 318-323. PubMed  Europe PubMed DOI  M
  31. Vitte,J.
    Human mast cell tryptase in biology and medicine
    Mol Immunol63, 18-24. PubMed  Europe PubMed DOI
    32. 2014
  32. Abdelmotelb,A.M., Rose-Zerilli,M.J., Barton,S.J., Holgate,S.T., Walls,A.F. and Holloway,J.W.
    Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma
    Clin Exp Allergy44, 822-830. PubMed  Europe PubMed DOI  M
  33. Le,Q.T., Lotfi-Emran,S., Min,H.K. and Schwartz,L.B.
    A simple, sensitive and safe method to determine the human alpha/beta-tryptase genotype
    PLoS ONE9, e114944-e114944. PubMed  Europe PubMed DOI  M
  34. Melo,F.R., Vita,F., Berent-Maoz,B., Levi-Schaffer,F., Zabucchi,G. and Pejler,G.
    Proteolytic histone modification by mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease
    J Biol Chem289, 7682-7690. PubMed  Europe PubMed DOI
    35. 2013
  35. Zhi,X., Xu,C., Zhang,H., Tian,D., Li,X., Ning,Y. and Yin,L.
    Tryptase promotes atherosclerotic plaque haemorrhage in ApoE-/- Mice
    PLoS ONE8, e60960-e60960. PubMed  Europe PubMed DOI
    36. 2012
  36. Prieto-Garcia,A., Zheng,D., Adachi,R., Xing,W., Lane,W.S., Chung,K., Anderson,P., Hansbro,P.M., Castells,M. and Stevens,R.L.
    Mast cell restricted mouse and human tryptase.heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen
    J Biol Chem287, 7834-7844. PubMed  Europe PubMed DOI
  37. Trivedi,N.N. and Caughey,G.H.
    Human alpha-, beta- and delta-tryptases
    [ISSN:978-0-12-407742-3]3, 2683-2693. DOI
    38. 2011
  38. Le,Q.T., Min,H.K., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B.
    Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C
    J Immunol186, 7136-7143. PubMed  Europe PubMed DOI
    39. 2010
  39. Pejler,G., Ronnberg,E., Waern,I. and Wernersson,S.
    Mast cell proteases: multifaceted regulators of inflammatory disease
    Blood115, 4981-4990. PubMed  Europe PubMed DOI  V
  40. Reimer,J.M., Samollow,P.B. and Hellman,L.
    High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution
    Immunogenetics62, 369-382. PubMed  Europe PubMed DOI
  41. Trivedi,N.N. and Caughey,G.H.
    Mast cell peptidases: chameleons of innate immunity and host defense
    Am J Respir Cell Mol Biol42, 257-267. PubMed  Europe PubMed DOI
  42. Yeong,P., Ning,Y., Xu,Y., Li,X. and Yin,L.
    Tryptase promotes human monocyte-derived macrophage foam cell formation by suppressing LXRalpha activation
    Biochim Biophys Acta1801, 567-576. PubMed  Europe PubMed DOI  I
    43. 2009
  43. Trivedi,N.N., Tamraz,B., Chu,C., Kwok,P.Y. and Caughey,G.H.
    Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations
    J Allergy Clin Immunol124, 1099-1105. PubMed  Europe PubMed DOI  M
    44. 2008
  44. Costanzo,M.J., Yabut,S.C., Zhang,H.C., White,K.B., de Garavilla,L., Wang,Y., Minor,L.K., Tounge,B.A., Barnakov,A.N., Lewandowski,F., Milligan,C., Spurlino,J.C., Abraham,W.M., Boswell-Smith,V., Page,C.P. and Maryanoff,B.E.
    Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives
    Bioorg Med Chem Lett18, 2114-2121. PubMed  Europe PubMed DOI  S  I
  45. Costanzo,M.J., Yabut,S.C., Zhang,H.C., White,K.B., Wang,Y., Minor,L.K., Tounge,B.A., Barnakov,A.N., Lewandowski,F., Milligan,C., Spurlino,J.C. and Maryanoff,B.E.
    Potent, nonpeptide inhibitors of human mast cell tryptase. 2. Investigation of the carboxamide portion of spirocyclic piperidine amides
    Lett Drug Des Discov5, 116-121. DOI  I
    46. 2007
  46. Akin,C., Soto,D., Brittain,E., Chhabra,A., Schwartz,L.B., Caughey,G.H. and Metcalfe,D.D.
    Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels
    Clin Immunol123, 268-271. PubMed  Europe PubMed DOI
  47. McNeil,H.P., Adachi,R. and Stevens,R.L.
    Mast cell-restricted tryptases: structure and function in inflammation and pathogen defense
    J Biol Chem282, 20785-20789. PubMed  Europe PubMed DOI  V
  48. Trivedi,N.N., Tong,Q., Raman,K., Bhagwandin,V.J. and Caughey,G.H.
    Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates
    J Immunol179, 6072-6079. PubMed  Europe PubMed
    49. 2006
  49. Caughey,G.H.
    Tryptase genetics and anaphylaxis
    J Allergy Clin Immunol117, 1411-1414. PubMed  Europe PubMed DOI
  50. [YEAR:28-12-2006]Rohr,K.B., Selwood,T., Marquardt,U., Huber,R., Schechter,N.M., Bode,W. and Than,M.E.
    X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha - >beta-tryptase transition
    J Mol Biol357, 195-209. PubMed  Europe PubMed DOI  S  I
  51. Yoshida,N., Isozaki,Y., Takagi,T., Takenaka,S., Uchikawa,R., Arizono,N., Yoshikawa,T. and Okanoue,T.
    Anti-tryptase therapy in inflammatory bowel disease
    Aliment Pharmacol Ther24 Suppl 4, 249-255. DOI  V
    52. 2005
  52. Asano-Kato,N., Fukagawa,K., Okada,N., Dogru,M., Tsubota,K. and Fujishima,H.
    Tryptase increases proliferative activity of human conjunctival fibroblasts through protease-activated receptor-2
    Invest Ophthalmol Vis Sci46, 4622-4626. PubMed  Europe PubMed DOI
  53. [YEAR:2-6-2005]Hopkins,C.R., Czekaj,M., Kaye,S.S., Gao,Z., Pribish,J., Pauls,H., Liang,G., Sides,K., Cramer,D., Cairns,J., Luo,Y., Lim,H.K., Vaz,R., Rebello,S., Maignan,S., Dupuy,A., Mathieu,M. and Levell,J.
    Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase
    Bioorg Med Chem Lett15, 2734-2737. PubMed  Europe PubMed DOI  I
  54. Namazi,M.R.
    Possible molecular mechanisms to account for the involvement of tryptase in the pathogenesis of psoriasis
    Autoimmunity38, 449-452. PubMed  Europe PubMed DOI
  55. [YEAR:20-4-2005]Nishio,H. and Suzuki,K.
    Three cases of suspected hyperthermia with remarkable elevation of serum mast cell tryptase
    Forensic Sci Int149, 51-55. PubMed  Europe PubMed DOI
  56. [YEAR:1-4-2005]Wong,T., Groutas,C.S., Mohan,S., Lai,Z., Alliston,K.R., Vu,N., Schechter,N.M. and Groutas,W.C.
    1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase
    Arch Biochem Biophys436, 1-7. PubMed  Europe PubMed DOI  I
    57. 2004
  57. Caughey,G.H.
    Tryptases
    [ISSN:0-12-079610-4]2, 1535-1543.  V
  58. Fiorucci,L. and Ascoli,F.
    Mast cell tryptase, a still enigmatic enzyme
    Cell Mol Life Sci61, 1278-1295. PubMed  Europe PubMed DOI
  59. [YEAR:1-8-2004]Hallgren,J., Backstrom,S., Estrada,S., Thuveson,M. and Pejler,G.
    Histidines are critical for heparin-dependent activation of mast cell tryptase
    J Immunol173, 1868-1875. PubMed  Europe PubMed
  60. [YEAR:4-10-2004]Hopkins,C., Neuenschwander,K., Scotese,A., Jackson,S., Nieduzak,T., Pauls,H., Liang,G., Sides,K., Cramer,D., Cairns,J., Maignan,S. and Mathieu,M.
    Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation
    Bioorg Med Chem Lett14, 4819-4823. PubMed  Europe PubMed DOI  I
  61. [YEAR:19-1-2004]Zhao,G., Bolton,S.A., Kwon,C., Hartl,K.S., Seiler,S.M., Slusarchyk,W.A., Sutton,J.C. and Bisacchi,G.S.
    Synthesis of potent and selective 2-azepanone inhibitors of human tryptase
    Bioorg Med Chem Lett14, 309-312. PubMed  Europe PubMed DOI  I
    62. 2003
  62. [YEAR:28-8-2003]Costanzo,M.J., Yabut,S.C., Almond,H.R., Jr., Andrade-Gordon,P., Corcoran,T.W., de Garavilla,L., Kauffman,J.A., Abraham,W.M., Recacha,R., Chattopadhyay,D. and Maryanoff,B.E.
    Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone
    J Med Chem46, 3865-3876. PubMed  Europe PubMed DOI  I
  63. Mori,S., Itoh,Y., Shinohata,R., Sendo,T., Oishi,R. and Nishibori,M.
    Nafamostat mesilate is an extremely potent inhibitor of human tryptase
    J Pharmacol Sci92, 420-423. PubMed  Europe PubMed  I
  64. Peng,Q., McEuen,A.R., Benyon,R.C. and Walls,A.F.
    The heterogeneity of mast cell tryptase from human lung and skin. Differences in size, charge and substrate affinity
    Eur J Biochem270, 270-283. PubMed  Europe PubMed DOI
    65. 2002
  65. Lee,M., Sommerhoff,C.P., von Eckardstein,A., Zettl,F., Fritz,H. and Kovanen,P.T.
    Mast cell tryptase degrades HDL and blocks its function as an acceptor of cellular cholesterol
    Arterioscler Thromb Vasc Biol22, 2086-2091. PubMed  Europe PubMed DOI
  66. [YEAR:16-8-2002]Marquardt,U., Zettl,F., Huber,R., Bode,W. and Sommerhoff,C.
    The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region
    J Mol Biol321, 491-502. PubMed  Europe PubMed DOI  S
  67. [YEAR:15-2-2002]Oh,S.W., Pae,C.I., Lee,D.K., Jones,F., Chiang,G.K., Kim,H.O., Moon,S.H., Cao,B., Ogbu,C., Jeong,K.W., Kozu,G., Nakanishi,H., Kahn,M., Chi,E.Y. and Henderson,W.R., Jr.
    Tryptase inhibition blocks airway inflammation in a mouse asthma model
    J Immunol168, 1992-2000. PubMed  Europe PubMed
  68. [YEAR:31-5-2002]Qian,X., Zheng,B., Burke,B., Saindane,M.T. and Kronenthal,D.R.
    A stereoselective synthesis of BMS-262084, an azetidinone-based tryptase inhibitor
    J Org Chem67, 3595-3600. PubMed  Europe PubMed DOI  I
  69. [YEAR:12-3-2002]Selwood,T., Wang,Z.M., McCaslin,D.R. and Schechter,N.M.
    Diverse stability and catalytic properties of human tryptase alpha and beta isoforms are mediated by residue differences at the S1 pocket
    Biochemistry41, 3329-3340. PubMed  Europe PubMed DOI
  70. [YEAR:4-11-2002]Slusarchyk,W.A., Bolton,S.A., Hartl,K.S., Huang,M.H., Jacobs,G., Meng,W., Ogletree,M.L., Pi,Z., Schumacher,W.A., Seiler,S.M., Sutton,J.C., Treuner,U., Zahler,R., Zhao,G. and Bisacchi,G.S.
    Synthesis of potent and highly selective inhibitors of human tryptase
    Bioorg Med Chem Lett12, 3235-3238. PubMed  Europe PubMed DOI  I
  71. Soto,D., Malmsten,C., Blount,J.L., Muilenburg,D.J. and Caughey,G.H.
    Genetic deficiency of human mast cell alpha-tryptase
    Clin Exp Allergy32, 1000-1006. PubMed  Europe PubMed DOI  K
  72. [YEAR:4-11-2002]Sutton,J.C., Bolton,S.A., Hartl,K.S., Huang,M.H., Jacobs,G., Meng,W., Ogletree,M.L., Pi,Z., Schumacher,W.A., Seiler,S.M., Slusarchyk,W.A., Treuner,U., Zahler,R., Zhao,G. and Bisacchi,G.S.
    Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors
    Bioorg Med Chem Lett12, 3229-3233. PubMed  Europe PubMed DOI  I
    73. 2001
  73. Brown,J.K., Jones,C.A., Rooney,L.A. and Caughey,G.H.
    Mast cell tryptase activates extracellular-regulated kinases (p44/p42) in airway smooth-muscle cells: importance of proteolytic events, time course, and role in mediating mitogenesis
    Am J Respir Cell Mol Biol24, 146-154. PubMed  Europe PubMed DOI
  74. [YEAR:19-6-2001]Hallgren,J., Estrada,S., Karlson,U., Alving,K. and Pejler,G.
    Heparin antagonists are potent inhibitors of mast cell tryptase
    Biochemistry40, 7342-7349. PubMed  Europe PubMed
  75. [YEAR:15-11-2001]Sommerhoff,C.P.
    Mast cell tryptases and airway remodeling
    Am J Respir Crit Care Med164, S52-S58. PubMed  Europe PubMed DOI
    76. 2000
  76. [YEAR:16-10-2000]Rice,K.D., Gangloff,A.R., Kuo,E.Y., Dener,J.M., Wang,V.R., Lum,R., Newcomb,W.S., Havel,C., Putnam,D., Cregar,L., Wong,M. and Warne,R.L.
    Dibasic inhibitors of human mast cell tryptase. Part 1: Synthesis and optimization of a novel class of inhibitors
    Bioorg Med Chem Lett10, 2357-2360. PubMed  Europe PubMed DOI  I
  77. [YEAR:16-10-2000]Rice,K.D., Wang,V.R., Gangloff,A.R., Kuo,E.Y., Dener,J.M., Newcomb,W.S., Young,W.B., Putnam,D., Cregar,L., Wong,M. and Simpson,P.J.
    Dibasic inhibitors of human mast cell tryptase. Part 2: structure-activity relationships and requirements for potent activity
    Bioorg Med Chem Lett10, 2361-2366. PubMed  Europe PubMed DOI  I
  78. Sakaguchi,M., Takai,S., Jin,D., Yamada,M. and Miyazaki,M.
    Characteristics of monkey tryptase purified from cheek pouch vascular tissues
    Jpn J Pharmacol84, 375-380. PubMed  Europe PubMed DOI
    79. 1999
  79. Chan,H., Elrod,K.C., Numerof,R.P., Sideris,S. and Clark,J.M.
    Expression and characterization of recombinant mast cell tryptase
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