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Literature for peptidase S01.143: tryptase alpha

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, M Mutation, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Broussal,F., Rouzioux,T., Khelifi-Touhami,D., Bachelier,S., Berthier,B., Abbas,A., Choi,S. and Chantran,Y.<br>Very Long-Term Stability of Tryptase in Frozen Serum Samples<br>Clin Exp Allergy (2025) PubMed  Europe PubMed DOI
  2. Fialho,M.F.P., Tonello,R., Brum,E.S., Becker,G., Bunnett,N.W. and Oliveira,S.M.<br>Critical role of the mast cell/tryptase/PAR2 axis in anastrozole-induced pain<br>Br J Pharmacol (2025) PubMed  Europe PubMed DOI
  3. Pano,F., Bub,L., Parrine,D., Paivandy,A., Olsson,A.K., Pejler,G. and Rabelo Melo,F.<br>Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells<br>Cell Death Discov (2025) 11, 485-485. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2024
  4. Alheraky,A., Wierenga,A.T.J., Simpelaar,A., Hesp,L.B., Minovic,I., Bagheri,N., Roozendaal,C., Span,L.F.R., Oude Elberink,H.N.G., Kema,I.P. and Mulder,A.B.<br>Hereditary Alpha Tryptasemia: Validation of a Single-Well Multiplex Digital Droplet PCR Assay in a Cohort of Symptomatic Patients<br>Clin Chem (2024) 70, 425-433. PubMed  Europe PubMed DOI
  5. Ma,Y., Li,B., Zhao,X., Lu,Y., Li,X., Zhang,J., Wang,Y., Zhang,J., Wang,L., Meng,S. and Hao,J.<br>Computational modeling of mast cell tryptase family informs selective inhibitor development<br>iScience (2024) 27, 110739-110739. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Michel,M., Giusti,D., Klingebiel,C. and Vitte,J.<br>Tryptase in drug-induced anaphylaxis: the need for acute and baseline values<br>Curr Opin Allergy Clin Immunol (2024) 24, 293-299. PubMed  Europe PubMed DOI  V
  7. Monahan,R., Alfaro,E., Ho,H., Otani,I.M. and Tsao,L.R.<br>Hereditary alpha tryptasemia presenting as recurrent chemotherapy hypersensitivity reactions<br>Ann Allergy Asthma Immunol (2024) 132, 270-273. PubMed  Europe PubMed DOI
  8. Ribatti,D.<br>Tryptase and tumor angiogenesis<br>Front Oncol (2024) 14, 1500482-1500482. PubMed  Europe PubMed DOI  PMC  EPMC  V
  9. Svetina,M., Selb,J., Lyons,J.J., Korosec,P. and Rijavec,M.<br>Clinically accessible amplitude-based multiplex ddPCR assay for tryptase genotyping<br>Sci Rep (2024) 14, 2416-2416. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2023
  10. Lang,A., Kubala,S., Grieco,M.C., Mateja,A., Pongracic,J., Liu,Y., Frischmeyer-Guerrerio,P.A., Kumar,R. and Lyons,J.J.<br>Severe food allergy reactions are associated with alpha-tryptase<br>J Allergy Clin Immunol (2023) 152, 933-939. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Marcella,S., Petraroli,A., Cane,L., Ferrara,A.L., Poto,R., Parente,R., Palestra,F., Cristinziano,L., Modestino,L., Galdiero,M.R., Monti,M., Marone,G., Triggiani,M., Varricchi,G. and Loffredo,S.<br>Thymic stromal lymphopoietin (TSLP) is a substrate for tryptase in patients with mastocytosis<br>Eur J Intern Med (2023) 117, 111-118. PubMed  Europe PubMed DOI
  12. Michel,M., Klingebiel,C. and Vitte,J.<br>Tryptase in type I hypersensitivity<br>Ann Allergy Asthma Immunol (2023) 130, 169-177. PubMed  Europe PubMed DOI
  13. Willows,S.D., Semenchenko,V., Norman,G., Woodside,M.T., Sim,V.L. and Kulka,M.<br>Mast Cell Proteases Cleave Prion Proteins and a Recombinant Ig against PrP Can Activate Human Mast Cells<br>J Immunol (2023) 210, 1447-1458. PubMed  Europe PubMed DOI
    14. 2022
  14. Bonadonna,P., Nalin,F. and Olivieri,F.<br>Hereditary alpha-tryptasemia<br>Curr Opin Allergy Clin Immunol (2022) 22, 277-282. PubMed  Europe PubMed DOI  V
  15. O'Connell,M.P. and Lyons,J.J.<br>Resolving the genetics of human tryptases: implications for health, disease, and clinical use as a biomarker<br>Curr Opin Allergy Clin Immunol (2022) 22, 143-152. PubMed  Europe PubMed DOI  V
    16. 2020
  16. de Almeida,A.D., Silva,I.S., Fernandes-Braga,W., LimaFilho,A.C.M., Florentino,R.O.M., Barra,A., de Oliveira Andrade,L., Leite,M.F., Cassali,G.D. and Klein,A.<br>A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice<br>Inflamm Res (2020) PubMed  Europe PubMed DOI
  17. de Almeida,A.D., Silva,I.S., Fernandes-Braga,W., LimaFilho,A.C.M., Florentino,R.M., Barra,A., de Oliveira Andrade,L., Leite,M.F., Cassali,G.D. and Klein,A.<br>Correction to: A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice<br>Inflamm Res (2020) 69, 1071-1071. PubMed  Europe PubMed DOI
  18. Garland,J., Ondruschka,B., Da Broi,U., Palmiere,C., Glenn,C., Morrow,P., Kesha,K., Stables,S. and Tse,R.<br>Differences Between Central and Peripheral Postmortem Tryptase Levels<br>Am J Forensic Med Pathol (2020) PubMed  Europe PubMed DOI
  19. Joossen,C., Baan,A., Moreno-Cinos,C., Joossens,J., Cools,N., Lanckacker,E., Moons,L., Lemmens,K., Lambeir,A.M., Fransen,E., Delputte,P., Caljon,G., Van der Veken,P., Maes,L., De Meester,I., Kiekens,F., Augustyns,K. and Cos,P.<br>A novel serine protease inhibitor as potential treatment for dry eye syndrome and ocular inflammation<br>Sci Rep (2020) 10, 17268-17268. PubMed  Europe PubMed DOI  PMC  EPMC  I
  20. Lyons,J.J., Chovanec,J., O'Connell,M.P., Liu,Y., Selb,J., Zanotti,R., Bai,Y., Kim,J., DiMaggio,T., Schwartz,L.B., Komarow,H.D., Rijavec,M., Carter,M.C., Milner,J.D., Bonadonna,P., Metcalfe,D.D. and Korosec,P.<br>Heritable risk for severe anaphylaxis associated with increased alpha-tryptase-encoding germline copy number at TPSAB1<br>J Allergy Clin Immunol (2020) PubMed  Europe PubMed DOI
    21. 2019
  21. Le,Q.T., Lyons,J.J., Naranjo,A.N., Olivera,A., Lazarus,R.A., Metcalfe,D.D., Milner,J.D. and Schwartz,L.B.<br>Impact of naturally forming human alpha/beta-tryptase heterotetramers in the pathogenesis of hereditary alpha-tryptasemia<br>J Exp Med (2019) 216, 2348-2361. PubMed  Europe PubMed DOI
  22. Maun,H.R., Jackman,J.K., Choy,D.F., Loyet,K.M., Staton,T.L., Jia,G., Dressen,A., Hackney,J.A., Bremer,M., Walters,B.T., Vij,R., Chen,X., Trivedi,N.N., Morando,A., Lipari,M.T., Franke,Y., Wu,X., Zhang,J., Liu,J., Wu,P., Chang,D., Orozco,L.D., Christensen,E., Wong,M., Corpuz,R., Hang,J.Q., Lutman,J., Sukumaran,S., Wu,Y., Ubhayakar,S., Liang,X., Schwartz,L.B., Babina,M., Woodruff,P.G., Fahy,J.V., Ahuja,R., Caughey,G.H., Kusi,A., Dennis,M.S., Eigenbrot,C., Kirchhofer,D., Austin,C.D., Wu,L.C., Koerber,J.T., Lee,W.P., Yaspan,B.L., Alatsis,K.R., Arron,J.R., Lazarus,R.A. and Yi,T.<br>An allosteric anti-tryptase antibody for the treatment of mast cell-mediated severe asthma<br>Cell (2019) 179, 417-431. PubMed  Europe PubMed DOI
  23. Mohajeri,M., Kovanen,P.T., Bianconi,V., Pirro,M., Cicero,A.F.G. and Sahebkar,A.<br>Mast cell tryptase - marker and maker of cardiovascular diseases<br>Pharmacol Ther (2019) 199, 91-110. PubMed  Europe PubMed DOI
  24. Shim,J.K., Kennedy,R.H., Weatherly,L.M., Abovian,A.V., Hashmi,H.N., Rajaei,A. and Gosse,J.A.<br>Searching for tryptase in the RBL-2H3 mast cell model: preparation for comparative mast cell toxicology studies with zebrafish<br>J Appl Toxicol (2019) 39, 473-484. PubMed  Europe PubMed DOI
    25. 2018
  25. Atiakshin,D., Buchwalow,I., Samoilova,V. and Tiemann,M.<br>Tryptase as a polyfunctional component of mast cells<br>Histochem Cell Biol (2018) 149, 461-477. PubMed  Europe PubMed DOI
    26. 2017
  26. Denadai-Souza,A., Ribeiro,C.M., Rolland,C., Thouard,A., Deraison,C., Scavone,C., Gonzalez-Dunia,D., Vergnolle,N. and Avellar,M.C.W.<br>Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study<br>Arthritis Res Ther (2017) 19, 124-124. PubMed  Europe PubMed DOI  PMC  EPMC  I
  27. Grujic,M., Paivandy,A., Gustafson,A.M., Thomsen,A.R., Ohrvik,H. and Pejler,G.<br>The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung<br>Oncotarget (2017) 8, 25066-25079. PubMed  Europe PubMed DOI
  28. Melo,F.R., Wallerman,O., Paivandy,A., Calounova,G., Gustafson,A.M., Sabari,B.R., Zabucchi,G., Allis,C.D. and Pejler,G.<br>Tryptase-catalyzed core histone truncation: a novel epigenetic regulatory mechanism in mast cells<br>J Allergy Clin Immunol (2017) 140, 474-485. PubMed  Europe PubMed DOI
  29. Ni,W.W., Cao,M.D., Huang,W., Meng,L. and Wei,J.F.<br>Tryptase inhibitors: a patent review<br>Expert Opin Ther Pat (2017) 27, 919-928. PubMed  Europe PubMed DOI  I
    30. 2016
  30. Guo,X., Zhai,L., Xue,R., Shi,J., Zeng,Q. and Gao,C.<br>Mast cell tryptase contributes to pancreatic cancer growth through promoting angiogenesis via activation of angiopoietin-1<br>Int J Mol Sci (2016) 17 PubMed  Europe PubMed DOI
    31. 2015
  31. Ribatti,D. and Ranieri,G.<br>Tryptase, a novel angiogenic factor stored in mast cell granules<br>Exp Cell Res (2015) 332, 157-162. PubMed  Europe PubMed DOI
  32. Vasquez Velasquez,C., Roman,A.D., Lan,N.T., Huy,N.T., Mercado,E.S., Espino,F.E., Perez,M.L., Huong,V.T., Thuy,T.T., Tham,V.D., Nga,C.T., Ha,T.T., Bilar,J.M., Bajaro,J.D., Baello,B.Q., Kikuchi,M., Yasunami,M., Morita,K., Watanabe,N., Karbwang,J. and Hirayama,K.<br>Alpha tryptase allele of tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines<br>Hum Immunol (2015) 76, 318-323. PubMed  Europe PubMed DOI  M
  33. Vitte,J.<br>Human mast cell tryptase in biology and medicine<br>Mol Immunol (2015) 63, 18-24. PubMed  Europe PubMed DOI
    34. 2014
  34. Abdelmotelb,A.M., Rose-Zerilli,M.J., Barton,S.J., Holgate,S.T., Walls,A.F. and Holloway,J.W.<br>Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma<br>Clin Exp Allergy (2014) 44, 822-830. PubMed  Europe PubMed DOI  M
  35. Le,Q.T., Lotfi-Emran,S., Min,H.K. and Schwartz,L.B.<br>A simple, sensitive and safe method to determine the human alpha/beta-tryptase genotype<br>PLoS ONE (2014) 9, e114944-e114944. PubMed  Europe PubMed DOI  M
  36. Melo,F.R., Vita,F., Berent-Maoz,B., Levi-Schaffer,F., Zabucchi,G. and Pejler,G.<br>Proteolytic histone modification by mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease<br>J Biol Chem (2014) 289, 7682-7690. PubMed  Europe PubMed DOI
    37. 2013
  37. Zhi,X., Xu,C., Zhang,H., Tian,D., Li,X., Ning,Y. and Yin,L.<br>Tryptase promotes atherosclerotic plaque haemorrhage in ApoE-/- Mice<br>PLoS ONE (2013) 8, e60960-e60960. PubMed  Europe PubMed DOI
    38. 2012
  38. Prieto-Garcia,A., Zheng,D., Adachi,R., Xing,W., Lane,W.S., Chung,K., Anderson,P., Hansbro,P.M., Castells,M. and Stevens,R.L.<br>Mast cell restricted mouse and human tryptase.heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen<br>J Biol Chem (2012) 287, 7834-7844. PubMed  Europe PubMed DOI
  39. Trivedi,N.N. and Caughey,G.H.<br>Human alpha-, beta- and delta-tryptases<br>[ISSN:978-0-12-407742-3] (2012) 3, 2683-2693. DOI
    40. 2011
  40. Le,Q.T., Min,H.K., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B.<br>Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C<br>J Immunol (2011) 186, 7136-7143. PubMed  Europe PubMed DOI
    41. 2010
  41. Pejler,G., Ronnberg,E., Waern,I. and Wernersson,S.<br>Mast cell proteases: multifaceted regulators of inflammatory disease<br>Blood (2010) 115, 4981-4990. PubMed  Europe PubMed DOI  V
  42. Reimer,J.M., Samollow,P.B. and Hellman,L.<br>High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution<br>Immunogenetics (2010) 62, 369-382. PubMed  Europe PubMed DOI
  43. Trivedi,N.N. and Caughey,G.H.<br>Mast cell peptidases: chameleons of innate immunity and host defense<br>Am J Respir Cell Mol Biol (2010) 42, 257-267. PubMed  Europe PubMed DOI
  44. Yeong,P., Ning,Y., Xu,Y., Li,X. and Yin,L.<br>Tryptase promotes human monocyte-derived macrophage foam cell formation by suppressing LXRalpha activation<br>Biochim Biophys Acta (2010) 1801, 567-576. PubMed  Europe PubMed DOI  I
    45. 2009
  45. Trivedi,N.N., Tamraz,B., Chu,C., Kwok,P.Y. and Caughey,G.H.<br>Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations<br>J Allergy Clin Immunol (2009) 124, 1099-1105. PubMed  Europe PubMed DOI  M
    46. 2008
  46. Costanzo,M.J., Yabut,S.C., Zhang,H.C., White,K.B., de Garavilla,L., Wang,Y., Minor,L.K., Tounge,B.A., Barnakov,A.N., Lewandowski,F., Milligan,C., Spurlino,J.C., Abraham,W.M., Boswell-Smith,V., Page,C.P. and Maryanoff,B.E.<br>Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives<br>Bioorg Med Chem Lett (2008) 18, 2114-2121. PubMed  Europe PubMed DOI  S  I
  47. Costanzo,M.J., Yabut,S.C., Zhang,H.C., White,K.B., Wang,Y., Minor,L.K., Tounge,B.A., Barnakov,A.N., Lewandowski,F., Milligan,C., Spurlino,J.C. and Maryanoff,B.E.<br>Potent, nonpeptide inhibitors of human mast cell tryptase. 2. Investigation of the carboxamide portion of spirocyclic piperidine amides<br>Lett Drug Des Discov (2008) 5, 116-121. DOI  I
    48. 2007
  48. Akin,C., Soto,D., Brittain,E., Chhabra,A., Schwartz,L.B., Caughey,G.H. and Metcalfe,D.D.<br>Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels<br>Clin Immunol (2007) 123, 268-271. PubMed  Europe PubMed DOI  PMC  EPMC
  49. McNeil,H.P., Adachi,R. and Stevens,R.L.<br>Mast cell-restricted tryptases: structure and function in inflammation and pathogen defense<br>J Biol Chem (2007) 282, 20785-20789. PubMed  Europe PubMed DOI  V
  50. Trivedi,N.N., Tong,Q., Raman,K., Bhagwandin,V.J. and Caughey,G.H.<br>Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates<br>J Immunol (2007) 179, 6072-6079. PubMed  Europe PubMed  PMC  EPMC
    51. 2006
  51. Caughey,G.H.<br>Tryptase genetics and anaphylaxis<br>J Allergy Clin Immunol (2006) 117, 1411-1414. PubMed  Europe PubMed DOI  PMC  EPMC
  52. [YEAR:28-12-2006]Rohr,K.B., Selwood,T., Marquardt,U., Huber,R., Schechter,N.M., Bode,W. and Than,M.E.<br>X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha - >beta-tryptase transition<br>J Mol Biol (28-12-2006) 357, 195-209. PubMed  Europe PubMed DOI  S  I
  53. Yoshida,N., Isozaki,Y., Takagi,T., Takenaka,S., Uchikawa,R., Arizono,N., Yoshikawa,T. and Okanoue,T.<br>Anti-tryptase therapy in inflammatory bowel disease<br>Aliment Pharmacol Ther (2006) 24 Suppl 4, 249-255. DOI  V
    54. 2005
  54. Asano-Kato,N., Fukagawa,K., Okada,N., Dogru,M., Tsubota,K. and Fujishima,H.<br>Tryptase increases proliferative activity of human conjunctival fibroblasts through protease-activated receptor-2<br>Invest Ophthalmol Vis Sci (2005) 46, 4622-4626. PubMed  Europe PubMed DOI
  55. [YEAR:2-6-2005]Hopkins,C.R., Czekaj,M., Kaye,S.S., Gao,Z., Pribish,J., Pauls,H., Liang,G., Sides,K., Cramer,D., Cairns,J., Luo,Y., Lim,H.K., Vaz,R., Rebello,S., Maignan,S., Dupuy,A., Mathieu,M. and Levell,J.<br>Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase<br>Bioorg Med Chem Lett (2-6-2005) 15, 2734-2737. PubMed  Europe PubMed DOI  I
  56. Namazi,M.R.<br>Possible molecular mechanisms to account for the involvement of tryptase in the pathogenesis of psoriasis<br>Autoimmunity (2005) 38, 449-452. PubMed  Europe PubMed DOI
  57. [YEAR:20-4-2005]Nishio,H. and Suzuki,K.<br>Three cases of suspected hyperthermia with remarkable elevation of serum mast cell tryptase<br>Forensic Sci Int (20-4-2005) 149, 51-55. PubMed  Europe PubMed DOI
  58. [YEAR:1-4-2005]Wong,T., Groutas,C.S., Mohan,S., Lai,Z., Alliston,K.R., Vu,N., Schechter,N.M. and Groutas,W.C.<br>1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase<br>Arch Biochem Biophys (1-4-2005) 436, 1-7. PubMed  Europe PubMed DOI  I
    59. 2004
  59. Caughey,G.H.<br>Tryptases<br>[ISSN:0-12-079610-4] (2004) 2, 1535-1543.  V
  60. Fiorucci,L. and Ascoli,F.<br>Mast cell tryptase, a still enigmatic enzyme<br>Cell Mol Life Sci (2004) 61, 1278-1295. PubMed  Europe PubMed DOI
  61. [YEAR:1-8-2004]Hallgren,J., Backstrom,S., Estrada,S., Thuveson,M. and Pejler,G.<br>Histidines are critical for heparin-dependent activation of mast cell tryptase<br>J Immunol (1-8-2004) 173, 1868-1875. PubMed  Europe PubMed
  62. [YEAR:4-10-2004]Hopkins,C., Neuenschwander,K., Scotese,A., Jackson,S., Nieduzak,T., Pauls,H., Liang,G., Sides,K., Cramer,D., Cairns,J., Maignan,S. and Mathieu,M.<br>Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation<br>Bioorg Med Chem Lett (4-10-2004) 14, 4819-4823. PubMed  Europe PubMed DOI  I
  63. [YEAR:19-1-2004]Zhao,G., Bolton,S.A., Kwon,C., Hartl,K.S., Seiler,S.M., Slusarchyk,W.A., Sutton,J.C. and Bisacchi,G.S.<br>Synthesis of potent and selective 2-azepanone inhibitors of human tryptase<br>Bioorg Med Chem Lett (19-1-2004) 14, 309-312. PubMed  Europe PubMed DOI  I
    64. 2003
  64. [YEAR:28-8-2003]Costanzo,M.J., Yabut,S.C., Almond,H.R., Jr., Andrade-Gordon,P., Corcoran,T.W., de Garavilla,L., Kauffman,J.A., Abraham,W.M., Recacha,R., Chattopadhyay,D. and Maryanoff,B.E.<br>Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone<br>J Med Chem (28-8-2003) 46, 3865-3876. PubMed  Europe PubMed DOI  I
  65. Mori,S., Itoh,Y., Shinohata,R., Sendo,T., Oishi,R. and Nishibori,M.<br>Nafamostat mesilate is an extremely potent inhibitor of human tryptase<br>J Pharmacol Sci (2003) 92, 420-423. PubMed  Europe PubMed  I
  66. Peng,Q., McEuen,A.R., Benyon,R.C. and Walls,A.F.<br>The heterogeneity of mast cell tryptase from human lung and skin. Differences in size, charge and substrate affinity<br>Eur J Biochem (2003) 270, 270-283. PubMed  Europe PubMed DOI
    67. 2002
  67. Lee,M., Sommerhoff,C.P., von Eckardstein,A., Zettl,F., Fritz,H. and Kovanen,P.T.<br>Mast cell tryptase degrades HDL and blocks its function as an acceptor of cellular cholesterol<br>Arterioscler Thromb Vasc Biol (2002) 22, 2086-2091. PubMed  Europe PubMed DOI
  68. [YEAR:16-8-2002]Marquardt,U., Zettl,F., Huber,R., Bode,W. and Sommerhoff,C.<br>The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region<br>J Mol Biol (16-8-2002) 321, 491-502. PubMed  Europe PubMed DOI  S
  69. [YEAR:15-2-2002]Oh,S.W., Pae,C.I., Lee,D.K., Jones,F., Chiang,G.K., Kim,H.O., Moon,S.H., Cao,B., Ogbu,C., Jeong,K.W., Kozu,G., Nakanishi,H., Kahn,M., Chi,E.Y. and Henderson,W.R., Jr.<br>Tryptase inhibition blocks airway inflammation in a mouse asthma model<br>J Immunol (15-2-2002) 168, 1992-2000. PubMed  Europe PubMed
  70. [YEAR:31-5-2002]Qian,X., Zheng,B., Burke,B., Saindane,M.T. and Kronenthal,D.R.<br>A stereoselective synthesis of BMS-262084, an azetidinone-based tryptase inhibitor<br>J Org Chem (31-5-2002) 67, 3595-3600. PubMed  Europe PubMed DOI  I
  71. [YEAR:12-3-2002]Selwood,T., Wang,Z.M., McCaslin,D.R. and Schechter,N.M.<br>Diverse stability and catalytic properties of human tryptase alpha and beta isoforms are mediated by residue differences at the S1 pocket<br>Biochemistry (12-3-2002) 41, 3329-3340. PubMed  Europe PubMed DOI
  72. [YEAR:4-11-2002]Slusarchyk,W.A., Bolton,S.A., Hartl,K.S., Huang,M.H., Jacobs,G., Meng,W., Ogletree,M.L., Pi,Z., Schumacher,W.A., Seiler,S.M., Sutton,J.C., Treuner,U., Zahler,R., Zhao,G. and Bisacchi,G.S.<br>Synthesis of potent and highly selective inhibitors of human tryptase<br>Bioorg Med Chem Lett (4-11-2002) 12, 3235-3238. PubMed  Europe PubMed DOI  I
  73. Soto,D., Malmsten,C., Blount,J.L., Muilenburg,D.J. and Caughey,G.H.<br>Genetic deficiency of human mast cell alpha-tryptase<br>Clin Exp Allergy (2002) 32, 1000-1006. PubMed  Europe PubMed DOI  K
  74. [YEAR:4-11-2002]Sutton,J.C., Bolton,S.A., Hartl,K.S., Huang,M.H., Jacobs,G., Meng,W., Ogletree,M.L., Pi,Z., Schumacher,W.A., Seiler,S.M., Slusarchyk,W.A., Treuner,U., Zahler,R., Zhao,G. and Bisacchi,G.S.<br>Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors<br>Bioorg Med Chem Lett (4-11-2002) 12, 3229-3233. PubMed  Europe PubMed DOI  I
    75. 2001
  75. Brown,J.K., Jones,C.A., Rooney,L.A. and Caughey,G.H.<br>Mast cell tryptase activates extracellular-regulated kinases (p44/p42) in airway smooth-muscle cells: importance of proteolytic events, time course, and role in mediating mitogenesis<br>Am J Respir Cell Mol Biol (2001) 24, 146-154. PubMed  Europe PubMed DOI
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