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Substrates for peptidase M24.028: mitochondrial methionyl aminopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
10 kDa heat shock protein, mitochondrial P26772 1-102 Met1+Ala-peptide P NT - - - Met Ala Gly Gln Ala Hartman et al., 1993
10 kDa heat shock protein, mitochondrial P61604 1-102 Met1+Ala-peptide P NT - - - Met Ala Gly Gln Ala
28S ribosomal protein S6, mitochondrial P82931 1-124 Met1+Pro-peptide P NT - - - Met Pro Arg Tyr Glu Suzuki et al., 2001
3-hydroxyacyl-CoA dehydrogenase type-2 O08756 1-261 Met1+Ala-peptide P NT - - - Met Ala Ala Ala Val
37S ribosomal protein MRP10, mitochondrial O75012 1-95 Met1+Ser-peptide P NT - - - Met Ser Gly Lys Pro Kitakawa et al., 1997
54S ribosomal protein L25, mitochondrial P23369 1-157 Met1+Ser-peptide P NT - - - Met Ser Tyr Lys Gln Kang et al., 1991
54S ribosomal protein L33, mitochondrial P20084 1-86 Met1+Val-peptide P NT - - - Met Val Phe Tyr Lys Grohmann et al., 1991
54S ribosomal protein L39, mitochondrial P36533 1-70 Met1+Val-peptide P NT - - - Met Val Lys Val Lys Grohmann et al., 1991
54S ribosomal protein L8, mitochondrial P22353 1-238 Met1+Thr-peptide P NT - - - Met Thr Val Gly Ile Kitakawa et al., 1990
adenylate kinase 2, mitochondrial P08166 1-234 Met1+Ala-peptide P NT - - - Met Ala Pro Asn Val Frank et al., 1986
adenylate kinase 2, mitochondrial, Isoform 6 P54819-6 1-192 Met1+Met-peptide P NT - - - Met Met Leu Arg Ala
ADP/ATP translocase 1 Q05962 1-298 Met1+Gly-peptide P NT - - - Met Gly Asp Gln Ala
ADP/ATP translocase 1 P12235 1-298 Met1+Gly-peptide P NT - - - Met Gly Asp His Ala
ADP/ATP translocase 1 P02722 1-298 Met1+Ser-peptide P NT - - - Met Ser Asp Gln Ala Aquila et al., 1982
ADP/ATP translocase 2 P05141 1-298 Met1+Thr-peptide P NT - - - Met Thr Asp Ala Ala
ADP/ATP translocase 2 P51881 1-298 Met1+Thr-peptide P NT - - - Met Thr Asp Ala Ala
ADP/ATP translocase 2 Q09073 1-298 Met1+Thr-peptide P NT - - - Met Thr Asp Ala Ala
ADP/ATP translocase 3 P12236 1-298 Met1+Thr-peptide P NT - - - Met Thr Glu Gln Ala
amine oxidase [flavin-containing] B P27338 1-520 Met1+Ser-peptide P NT - - - Met Ser Asn Lys Cys Newton-Vinson et al., 2000
amine oxidase [flavin-containing] B P56560 1-520 Met1+Ser-peptide P NT - - - Met Ser Ser Lys Cys Newton-Vinson et al., 2000
ATP synthase subunit d, mitochondrial P13620 1-161 Met1+Ala-peptide P NT - - - Met Ala Gly Arg Lys Walker et al., 1987
ATP synthase subunit e, mitochondrial P29419 1-71 Met1+Val-peptide P NT - - - Met Val Pro Pro Val Higuti et al., 1992
ATP synthase subunit e, mitochondrial Q00361 1-71 Met1+Val-peptide P NT - - - Met Val Pro Pro Val Walker et al., 1991
ATP synthase subunit e, mitochondrial P81449 1-96 Met1+Ser-peptide P NT - - - Met Ser Thr Val Asn Arnold et al., 1998
ATP synthase subunit epsilon, mitochondrial P05632 1-51 Met1+Val-peptide P NT - - - Met Val Ala Tyr Trp Walker et al., 1991
ATP synthase subunit epsilon, mitochondrial P21306 1-62 Met1+Ser-peptide P NT - - - Met Ser Ala Trp Arg Arselin et al., 1991
ATP synthase subunit epsilon, mitochondrial P29418 1-51 Met1+Val-peptide P NT - - - Met Val Ala Tyr Trp
ATP synthase subunit f, mitochondrial Q28851 1-88 Met1+Ala-peptide P NT - - - Met Ala Ser Val Val Collinson et al., 1994
ATP synthase subunit g, mitochondrial Q28852 1-103 Met1+Ala-peptide P NT - - - Met Ala Glu Phe Val Collinson et al., 1994
ATPase-stabilizing factor 15 kDa protein P16965 1-84 Met1+Thr-peptide P NT - - - Met Thr Arg Thr Asn
carnitine O-palmitoyltransferase 1, liver isoform P32198 1-773 Met1+Ala-peptide P NT - - - Met Ala Glu Ala His Distler et al., 2007
cytochrome b-c1 complex subunit 10 P37299 1-77 Met1+Ala-peptide P NT - - - Met Ala Tyr Thr Ser Geier et al., 1992
cytochrome b-c1 complex subunit 7 P00129 1-111 Met1+Ala-peptide P NT - - - Met Ala Gly Arg Pro Wakabayashi et al., 1985
cytochrome b-c1 complex subunit 8 O14949 1-82 Met1+Gly-peptide P NT - - - Met Gly Arg Glu Phe Schaegger et al., 1995
cytochrome b-c1 complex subunit 8 P13271 1-82 Met1+Gly-peptide P NT - - - Met Gly Arg Gln Phe Usui et al., 1990
cytochrome b-c1 complex subunit 9 Q9UDW1 1-63 Met1+Ala-peptide P NT - - - Met Ala Ala Ala Thr Schaegger et al., 1995
cytochrome b-c1 complex subunit 9 P22289 1-66 Met1+Ser-peptide P NT - - - Met Ser Phe Ser Ser Phillips et al., 1990
cytochrome b-c1 complex subunit 9 P00130 1-64 Met1+Val-peptide P NT - - - Met Val Ala Pro Thr Schaegger et al., 1983
cytochrome C P12831 1-108 Met1+Gly-peptide P NT - - - Met Gly Val Pro Ala Inoue et al., 1986
cytochrome C P67881 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Ile Glu Chan & Margoliash, 1966
cytochrome C P99998 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Margoliash & Fitch, 1968
cytochrome C P99999 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Matsubara & Smith, 1963
cytochrome C P68517 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Bahl & Smith, 1965
cytochrome C P68518 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Ambler & Daniel, 1991
cytochrome C P68519 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Ambler & Daniel, 1991
cytochrome C P62894 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Nakashima et al., 1966
cytochrome C P62895 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Stewart & Margoliash, 1965
cytochrome C P21665 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Ambler & Daniel, 1991
cytochrome C P68097 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Walasek & Margoliash, 1977
cytochrome C P68098 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Niece et al., 1977
cytochrome C P68099 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Sokolovsky & Moldovan, 1972
cytochrome C P00002 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Rothfus & Smith, 1965
cytochrome C P00003 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Shelnutt et al., 1981
cytochrome C P00004 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Margoliash et al., 1961
cytochrome C P00007 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Thompson et al., 1978
cytochrome C P00008 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Needleman & Margoliash, 1966
cytochrome C P00011 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu McDowall & Smith, 1965
cytochrome C P00012 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Augusteyn et al., 1972
cytochrome C P00013 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Strydom et al., 1972
cytochrome C P00014 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Nolan & Margoliash, 1966
cytochrome C P00017 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Ile Glu
cytochrome C P00018 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Ile Glu Augusteyn 1973
cytochrome C P00019 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Ile Glu Howard et al., 1974
cytochrome C P00020 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu
cytochrome C P00021 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Ile Glu
cytochrome C P00022 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Chan et al., 1966
cytochrome C P00025 1-104 Met1+Gly-peptide P NT - - - Met Gly Asp Val Ala Nakayama et al., 1971
cytochrome C P00027 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Goldstone & Smith, 1967
cytochrome C P00028 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Nolan et al., 1973
cytochrome C P00029 1-104 Met1+Gly-peptide P NT - - - Met Gly Gln Val Glu Lyddiatt & Boulter, 1976
cytochrome C P00031 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Lyddiatt & Boulter, 1976
cytochrome C P00035 1-108 Met1+Gly-peptide P NT - - - Met Gly Val Pro Ala
cytochrome C P00037 1-108 Met1+Gly-peptide P NT - - - Met Gly Val Pro Ala Chan & Margoliash, 1966
cytochrome C P00038 1-108 Met1+Gly-peptide P NT - - - Met Gly Ile Pro Ala Inoue et al., 1985
cytochrome C P00039 1-108 Met1+Gly-peptide P NT - - - Met Gly Val Pro Ala Chan 1970
cytochrome C P00040 1-108 Met1+Gly-peptide P NT - - - Met Gly Val Pro Gln Lyddiatt & Boulter, 1977
cytochrome C P00043 1-110 Met1+Pro-peptide P NT - - - Met Pro Ala Pro Tyr Sugeno et al., 1971
cytochrome C P00046 1-109 Met1+Pro-peptide P NT - - - Met Pro Tyr Ala Pro Simon-Becam et al., 1978
cytochrome C P00048 1-108 Met1+Gly-peptide P NT - - - Met Gly Phe Ser Ala Lederer & Simon, 1974
cytochrome C P00077 1-113 Met1+Pro-peptide P NT - - - Met Pro Pro Lys Ala Smith & Pettigrew, 1980
cytochrome C P00078 1-114 Met1+Pro-peptide P NT - - - Met Pro Pro Lys Ala Hill & Pettigrew, 1975
cytochrome C P68100 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Goldstone & Smith, 1966
cytochrome C P81280 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Barber et al., 1993
cytochrome C P19974 1-111 Met1+Ser-peptide P NT - - - Met Ser Asp Ile Pro Vanfleteren et al., 1990
cytochrome C iso-1 P00044 1-109 Met1+Thr-peptide P NT - - - Met Thr Glu Phe Lys Narita & Titani, 1969
cytochrome C oxidase copper chaperone Q12287 1-69 Met1+Thr-peptide P NT - - - Met Thr Glu Thr Asp Beers et al., 1997
cytochrome C oxidase polypeptide 6, mitochondrial P26310 1-93 Met1+Ser-peptide P NT - - - Met Ser Thr Gly Asn Rizzuto et al., 1991
cytochrome C oxidase polypeptide VIb Q01519 1-83 Met1+Ala-peptide P NT - - - Met Ala Asp Gln Glu Taanman & Capaldi, 1992
cytochrome C oxidase polypeptide VIc-1 P11950 1-76 Met1+Ser-peptide P NT - - - Met Ser Ser Gly Ala Schaegger et al., 1995
cytochrome C oxidase polypeptide VIc-2 P11951 1-76 Met1+Ser-peptide P NT - - - Met Ser Ser Gly Ala Schaegger et al., 1995
cytochrome C oxidase subunit 3 P05505 1-261 Met1+Thr-peptide P NT - - - Met Thr His Gln Thr Schaegger et al., 1995
cytochrome C oxidase subunit 7 P10174 1-60 Met1+Ala-peptide P NT - - - Met Ala Asn Lys Val Power et al., 1986
cytochrome C oxidase subunit 7A P07255 1-59 Met1+Thr-peptide P NT - - - Met Thr Ile Ala Pro Power et al., 1986
cytochrome C oxidase subunit 7e P20609 1-53 Met1+Ser-peptide P NT - - - Met Ser His Ala Leu Capaldi et al., 1990
cytochrome C oxidase subunit 7s P20610 1-55 Met1+Thr-peptide P NT - - - Met Thr His Ala Leu Capaldi et al., 1990
cytochrome C oxidase subunit VIb isoform 1 P00429 1-86 Met1+Ala-peptide P NT - - - Met Ala Glu Asp Ile Tanaka et al., 1981
cytochrome C type-1 P92504 1-112 Met1+Pro-peptide P NT - - - Met Pro Glu Ile Pro Takamiya et al., 1996
cytochrome C, somatic P62897 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Carlson et al., 1977
cytochrome C, somatic P62898 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Val Glu Carlson et al., 1977
cytochrome C, testis-specific P00015 1-105 Met1+Gly-peptide P NT - - - Met Gly Asp Ala Glu Hennig 1975
cytochrome C-2 P84029 1-108 Met1+Gly-peptide P NT - - - Met Gly Val Pro Ala Inoue et al., 1986
cytochrome C-2 P84030 1-108 Met1+Gly-peptide P NT - - - Met Gly Val Pro Ala Fernandez-Sousa et al., 1975
electron transfer flavoprotein subunit beta Q9DCW4 1-255 Met1+Ala-peptide P NT - - - Met Ala Glu Leu Arg
glutathione S-transferase kappa 1 P24473 1-226 Met1+Gly-peptide P NT - - - Met Gly Pro Ala Pro Harris et al., 1991
GTP:AMP phosphotransferase mitochondrial P08760 1-227 Met1+Gly-peptide P NT - - - Met Gly Ala Ser Ala Tomasselli et al., 1986
HCLS1-associated protein X-1 O00165 1-279 Met1+Ser-peptide P NT - - - Met Ser Leu Phe Asp
mitochondrial 2-oxoglutarate/malate carrier protein Q02978 1-314 Met1+Ala-peptide P NT - - - Met Ala Ala Thr Ala
mitochondrial brown fat uncoupling protein 1 P04575 1-307 Met1+Val-peptide P NT - - - Met Val Asn Pro Thr Aquila et al., 1985
mitochondrial import inner membrane translocase subunit TIM14 Q96DA6 1-116 Met1+Ala-peptide P NT - - - Met Ala Ser Thr Val
mitochondrial import receptor subunit TOM22 P49334 1-152 Met1+Val-peptide P NT - - - Met Val Glu Leu Thr Hoenlinger et al., 1995
mitochondrial import receptor subunit TOM22 homolog Q9NS69 1-142 Met1+Ala-peptide P NT - - - Met Ala Ala Ala Val
mitochondrial import receptor subunit TOM7 P53507 1-60 Met1+Ser-peptide P NT - - - Met Ser Phe Leu Pro Hoenlinger et al., 1996
mitochondrial inner membrane peptidase 1 P28627 1-190 Met1+Thr-peptide P NT - - - Met Thr Val Gly Thr Schneider et al., 1994
mitochondrial outer membrane protein porin 1 P04840 1-283 Met1+Ser-peptide P NT - - - Met Ser Pro Pro Val
mitochondrial replication protein MTF1 P14908 1-341 Met1+Ser-peptide P NT - - - Met Ser Val Pro Ile Jang & Jaehning, 1991
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Q86Y39 1-228 Met1+Ala-peptide P NT - - - Met Ala Pro Lys Val Gevaert et al., 2003
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 P23935 1-116 Met1+Ala-peptide P NT - - - Met Ala Gly Leu Leu Masui et al., 1991
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 P42029 1-172 Met1+Pro-peptide P NT - - - Met Pro Gly Ile Val Dupuis et al., 1991
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 P51970 1-172 Met1+Pro-peptide P NT - - - Met Pro Gly Ile Val Sarto et al., 1997
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Q9Y6M9 1-179 Met1+Ala-peptide P NT - - - Met Ala Phe Leu Ala
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Q02379 1-106 Met1+Pro-peptide P NT - - - Met Pro Phe Phe Asp Walker et al., 1992
NADH-ubiquinone oxidoreductase 14.8 kDa subunit P42114 1-124 Met1+Pro-peptide P NT - - - Met Pro Ile Thr Pro Azevedo et al., 1994
NADH-ubiquinone oxidoreductase 9.5 kDa subunit P42117 1-82 Met1+Ser-peptide P NT - - - Met Ser Gly Thr Ile Heinrich et al., 1992
ras-related protein Rab-32 Q13637 1-225 Met1+Ala-peptide P NT - - - Met Ala Gly Gly Gly
sideroflexin-1 Q9H9B4 1-322 Met1+Ser-peptide P NT - - - Met Ser Gly Glu Leu
thiosulfate sulfurtransferase P00586 1-297 Met1+Val-peptide P NT - - - Met Val His Gln Val Russell et al., 1978
thiosulfate sulfurtransferase Q16762 1-297 Met1+Val-peptide P NT - - - Met Val His Gln Val Gevaert et al., 2003
Up-regulated during skeletal muscle growth protein 5 Q3ZBI7 1-58 Met1+Ala-peptide P NT - - - Met Ala Gly Pro Glu Carroll et al., 2006
vitamin D3 hydroxylase-associated protein Q90578 1-464 Met1+Thr-peptide P NT - - - Met Thr Leu Glu Arg Burgos-Trinidad et al., 1992
voltage-dependent anion-selective channel Q94920 1-282 Met1+Ala-peptide P NT - - - Met Ala Pro Pro Ser Messina et al., 1996
voltage-dependent anion-selective channel protein 1 P21796 1-283 Met1+Ala-peptide P NT - - - Met Ala Val Pro Pro

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