Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P00004

,

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	mitochondrial methionyl aminopeptidase	1-105	P	release of an initiating methionine	NT	Margoliash et al., 1961
9	syncephapepsin	2-105	N			Ho et al., 1998
11	pepsin A	2-105	N			Hamuro et al., 2008
14	syncephapepsin	2-105	N			Ho et al., 1998
19	syncephapepsin	2-105	N			Ho et al., 1998
22	pepsin A	2-105	N			Hamuro et al., 2008
22	peptidyl-Lys metallopeptidase	2-105	P			Takio, 2004
26	syncephapepsin	2-105	N			Ho et al., 1998
36	syncephapepsin	2-105	N			Ho et al., 1998
37	pepsin A	2-105	N			Hamuro et al., 2008
47	pepsin A	2-105	N			Hamuro et al., 2008
48	pepsin A	2-105	N			Hamuro et al., 2008
51	syncephapepsin	2-105	N			Ho et al., 1998
63	syncephapepsin	2-105	N			Ho et al., 1998
65	pepsin A	2-105	N			Hamuro et al., 2008
66	pepsin A	2-105	N			Hamuro et al., 2008
67	pepsin A	2-105	N			Hamuro et al., 2008
68	pepsin A	2-105	N			Hamuro et al., 2008
68	syncephapepsin	2-105	N			Ho et al., 1998
80	syncephapepsin	2-105	N			Ho et al., 1998
81	pepsin A	2-105	N			Hamuro et al., 2008
83	pepsin A	2-105	N			Hamuro et al., 2008
87	syncephapepsin	2-105	N			Ho et al., 1998
95	pepsin A	2-105	N			Hamuro et al., 2008
95	syncephapepsin	2-105	N			Ho et al., 1998
97	pepsin A	2-105	N			Hamuro et al., 2008
100	syncephapepsin	2-105	N			Ho et al., 1998