Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P00011

,

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	mitochondrial methionyl aminopeptidase	1-105	P	release of an initiating methionine	NT	McDowall & Smith, 1965
6	trypsin 1	1-105	N			McDowall et al., 1965
9	trypsin 1	1-105	N			McDowall et al., 1965
11	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
14	trypsin 1	1-105	N			McDowall et al., 1965
23	trypsin 1	1-105	N			McDowall et al., 1965
26	trypsin 1	1-105	N			McDowall et al., 1965
27	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
28	trypsin 1	1-105	N			McDowall et al., 1965
34	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
37	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
39	trypsin 1	1-105	N			McDowall et al., 1965
47	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
49	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
54	trypsin 1	1-105	N			McDowall et al., 1965
55	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
56	trypsin 1	1-105	N			McDowall et al., 1965
60	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
66	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
68	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
74	trypsin 1	1-105	N			McDowall et al., 1965
75	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
80	trypsin 1	1-105	N			McDowall et al., 1965
81	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
83	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
87	trypsin 1	1-105	N			McDowall et al., 1965
92	trypsin 1	1-105	N			McDowall et al., 1965
95	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
98	chymotrypsin A (cattle-type)	1-105	N			McDowall et al., 1965
100	trypsin 1	1-105	N			McDowall et al., 1965