Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P00008

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	mitochondrial methionyl aminopeptidase	1-105	P	release of an initiating methionine	NT	Needleman & Margoliash, 1966
6	trypsin 1	1-105	N			Needleman et al., 1966
9	trypsin 1	1-105	N			Needleman et al., 1966
11	pepsin A	1-105	N			Needleman et al., 1966
11	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
14	trypsin 1	1-105	N			Needleman et al., 1966
22	pepsin A	1-105	N			Needleman et al., 1966
23	pepsin A	1-105	N			Needleman et al., 1966
26	trypsin 1	1-105	N			Needleman et al., 1966
27	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
28	trypsin 1	1-105	N			Needleman et al., 1966
34	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
36	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
37	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
39	trypsin 1	1-105	N			Needleman et al., 1966
40	trypsin 1	1-105	N			Needleman et al., 1966
43	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
47	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
49	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
53	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
54	trypsin 1	1-105	N			Needleman et al., 1966
55	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
56	trypsin 1	1-105	N			Needleman et al., 1966
60	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
65	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
66	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
68	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
69	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
88	trypsin 1	1-105	N			Needleman et al., 1966
92	trypsin 1	1-105	N			Needleman et al., 1966
95	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
98	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
99	chymotrypsin A (cattle-type)	1-105	N			Needleman et al., 1966
100	trypsin 1	1-105	N			Needleman et al., 1966
101	trypsin 1	1-105	N			Needleman et al., 1966