Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P61604

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	mitochondrial methionyl aminopeptidase	1-102	P	release of an initiating methionine	NT
18	cathepsin S	16-28	N		MS	Biniossek et al., 2011
19	cathepsin L	16-28	N		MS	Biniossek et al., 2011
19	cathepsin S	16-28	N		MS	Biniossek et al., 2011
27	peptidyl-Lys metallopeptidase	1-102	N		MS
35	peptidyl-Lys metallopeptidase	1-102	N		MS
43	meprin beta subunit	40-54	N		MS	Becker-Pauly et al., 2011
50	cathepsin S	41-66	N		MS	Biniossek et al., 2011
64	matrix metallopeptidase-2	59-75	N		MS	Schilling & Overall, 2008
75	glutamyl endopeptidase I	2-102	N		MS	Schilling & Overall, 2008
83	meprin alpha subunit	2-102	N		MS	Becker-Pauly et al., 2011
83	meprin beta subunit	2-102	N		MS	Becker-Pauly et al., 2011
83	chymotrypsin A (cattle-type)	2-102	N		MS	Schilling & Overall, 2008
88	HIV-1 retropepsin	2-102	N		MS	Schilling & Overall, 2008
99	trypsin 1	2-102	N		MS	Schilling & Overall, 2008