Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 18 |
cathepsin L |
15-27 |
N |
|
MS |
Biniossek et al., 2011 |
| 28 |
meprin beta subunit |
1-543 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 62 |
peptidyl-Lys metallopeptidase |
1-543 |
N |
|
MS |
|
| 63 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 72 |
peptidyl-Lys metallopeptidase |
1-543 |
N |
|
MS |
|
| 73 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 78 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 87 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 91 |
peptidyl-Lys metallopeptidase |
1-543 |
N |
|
MS |
|
| 92 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 95 |
meprin alpha subunit |
1-543 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 95 |
meprin beta subunit |
1-543 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 96 |
meprin beta subunit |
93-109 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 123 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 135 |
peptidyl-Lys metallopeptidase |
1-543 |
N |
|
MS |
|
| 136 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 144 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 153 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 186 |
granzyme B (Homo sapiens-type) |
1-543 |
P |
|
MS |
Bredemeyer et al., 2006 |
| 207 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 222 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 223 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 252 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 272 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 283 |
peptidyl-Lys metallopeptidase |
1-543 |
N |
|
MS |
|
| 300 |
peptidyl-Lys metallopeptidase |
1-543 |
N |
|
MS |
|
| 301 |
lysyl endopeptidase (bacteria) |
1-543 |
N |
|
MS |
|
| 334 |
unknown peptidase |
1-543 |
P |
|
MS |
Van Damme et al., 2005 |
| 351 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 354 |
meprin alpha subunit |
351-364 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 364 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 366 |
lysyl endopeptidase (bacteria) |
1-543 |
N |
|
MS |
|
| 379 |
meprin beta subunit |
1-543 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 406 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 415 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 420 |
matrix metallopeptidase-11 |
1-543 |
N |
|
|
Kleifeld et al., 2010 |
| 429 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 448 |
meprin alpha subunit |
1-543 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 448 |
meprin beta subunit |
1-543 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 452 |
peptidyl-Lys metallopeptidase |
1-543 |
N |
|
MS |
|
| 455 |
meprin alpha subunit |
1-543 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 455 |
meprin beta subunit |
1-543 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 461 |
peptidyl-Lys metallopeptidase |
1-543 |
N |
|
MS |
|
| 505 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 513 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
| 519 |
meprin beta subunit |
516-530 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 523 |
trypsin 1 |
1-543 |
N |
|
MS |
Schilling & Overall, 2008 |
