$VAR1 = undef;

Summary for peptidase M10.007: matrix metallopeptidase-11

Names
MEROPS Name	matrix metallopeptidase-11
Other names	matrix metalloproteinase 11, MMP-11, stromelysin 3

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.007
Holotype	matrix metallopeptidase-11 (Homo sapiens), Uniprot accession P24347 (peptidase unit: 94-274), MERNUM MER0001075
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00160
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (4 cleavages)
Activity status	human: active (Pei & Weiss, 2004) mouse: active (Noel et al., 2000)
Physiology	Role in turnover of extracellular matrix proteins.
Knockout	Accelerated neointima formation after electric injury of the femoral artery has been detected in mice with stromelysin-3 gene inactivation, but the mechanisms by which this enzyme could impair elastin degradation and cellular migration are unknown (Lijnen et al., 1999).
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/MMP11
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/a/a/al/-/-/- (based on 21 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	2	0	1	0	0	1
Pro	4	3	1	1	0	0	1	2
Ala	2	7	6	8	1	1	2	4
Val	2	0	2	0	1	2	0	1
Leu	1	0	2	1	6	2	5	1
Ile	1	1	0	0	2	3	1	2
Met	0	0	1	0	1	0	0	1
Phe	1	0	0	1	4	1	0	0
Tyr	1	1	0	0	3	0	0	1
Trp	0	0	0	0	0	1	0	0
Ser	1	2	1	2	1	1	4	4
Thr	0	1	3	1	1	3	0	0
Cys	1	0	0	1	0	0	0	0
Asn	0	1	0	3	0	0	2	0
Gln	0	1	2	0	0	3	1	0
Asp	1	1	0	0	0	1	2	1
Glu	2	3	1	1	0	3	1	2
Lys	1	0	0	0	0	0	1	0
Arg	0	0	0	0	0	0	0	1
His	2	0	0	2	0	0	1	0