Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P69905

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-142	P		NT	<%Agarwal et al., 2012[]%>
2	falcipain-2	2-142	N	normal turnover		Subramanian et al., 2009
2	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
3	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover	MS	Lowther et al., 2009
3	falcipain-2	2-142	N	normal turnover		Subramanian et al., 2009
3	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
4	falcipain-2	2-142	N			Subramanian et al., 2009
4	falcipain-3	2-142	N			Subramanian et al., 2009
6	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
7	falcipain-2	2-142	N			Subramanian et al., 2009
8	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
8	falcipain-2	2-142	N			Subramanian et al., 2009
9	necepsin-1	1-142	N		NT	Williamson et al., 2003
9	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
10	legumain, animal-type	2-142	P		NT	Sojka et al., 2007
11	falcipain-2	2-142	N			Subramanian et al., 2009
12	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
12	falcipain-2	2-142	N	normal turnover		Subramanian et al., 2009
12	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
12	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
13	necepsin-1	2-142	N	normal turnover		Williamson et al., 2003
13	cathepsin B-like peptidase, nematode	2-142	P		MS	Ranjit et al., 2009
14	necepsin-1	1-142	N		NT	Williamson et al., 2003
14	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
15	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
16	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
16	falcipain-2	2-142	N			Subramanian et al., 2009
18	falcipain-2	2-142	N			Subramanian et al., 2009
19	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
19	falcipain-2	2-142	N	normal turnover		Subramanian et al., 2009
19	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
20	falcipain-3	2-142	N			Subramanian et al., 2009
20	MEP peptidase (nematode)	2-142	N		MS	Ranjit et al., 2009
21	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
23	necepsin-2	1-142	N		MS	Ranjit et al., 2009
23	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
25	necepsin-1	1-142	N		NT	Williamson et al., 2003
26	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
27	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
27	falcipain-2	2-142	N			Subramanian et al., 2009
28	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
28	falcipain-2	2-142	N			Subramanian et al., 2009
29	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
29	falcipain-2	2-142	N			Subramanian et al., 2009
29	falcipain-3	2-142	N			Subramanian et al., 2009
30	cathepsin D	2-142	N	normal turnover		Brindley et al., 2001
30	necepsin-1	1-142	N		NT	Williamson et al., 2003
30	cathepsin B-like peptidase, nematode	2-142	P		MS	Ranjit et al., 2009
31	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
31	falcipain-2	2-142	N			Subramanian et al., 2009
31	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
32	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
32	falcipain-2	2-142	N			Subramanian et al., 2009
32	falcipain-3	2-142	N			Subramanian et al., 2009
33	falcipain-2	2-142	N			Subramanian et al., 2009
34	cathepsin D	2-142	N	normal turnover		Brindley et al., 2001
34	plasmepsin-1	2-142	N	pathological turnover		Berry & Goldberg, 2004
34	plasmepsin-2	2-142	N	pathological turnover		Berry & Goldberg, 2004
34	plasmepsin-4	2-142	N			Wyatt & Berry, 2002
34	necepsin-2	1-142	N		MS	Ranjit et al., 2009
34	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
34	falcipain-2	2-142	N			Subramanian et al., 2009
35	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover	MS	Lowther et al., 2009
35	falcipain-2	2-142	N			Subramanian et al., 2009
35	falcipain-3	2-142	N			Subramanian et al., 2009
36	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
36	falcipain-2	2-142	N			Subramanian et al., 2009
36	falcipain-3	2-142	N			Subramanian et al., 2009
37	cathepsin D	2-142	N	normal turnover		Brindley et al., 2001
37	falcipain-2	2-142	N			Subramanian et al., 2009
37	falcipain-3	2-142	N			Subramanian et al., 2009
37	cathepsin B-like peptidase, nematode	2-142	P		MS	Ranjit et al., 2009
38	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
39	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
40	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
40	falcipain-2	2-142	N	normal turnover		Subramanian et al., 2009
40	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
40	CPG70 carboxypeptidase (Porphyromonas gingivalis)	33-41	N			Chen et al., 2002
41	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
41	falcipain-2	2-142	N	normal turnover		Subramanian et al., 2009
41	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
42	necepsin-2	2-142	N	normal turnover	MS	Ranjit et al., 2009
42	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
42	falcipain-2	2-142	N			Subramanian et al., 2009
42	falcilysin	2-142	N			Eggleson et al., 1999
43	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
43	falcipain-2	2-142	N			Subramanian et al., 2009
43	falcipain-3	2-142	N			Subramanian et al., 2009
45	falcipain-2	2-142	N			Subramanian et al., 2009
46	necepsin-1	1-142	N		NT	Williamson et al., 2003
46	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
47	plasmepsin-1	2-142	P		NT	Gluzman et al., 1994
47	necepsin-2	1-142	N		MS	Ranjit et al., 2009
48	necepsin-1	1-142	N		NT	Williamson et al., 2003
48	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
48	falcipain-2	2-142	N	normal turnover		Subramanian et al., 2009
48	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
49	necepsin-2	1-142	N		MS	Ranjit et al., 2009
49	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
49	falcipain-2	2-142	N			Subramanian et al., 2009
49	falcipain-3	2-142	N			Subramanian et al., 2009
50	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
50	falcipain-2	2-142	N			Subramanian et al., 2009
50	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
50	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
52	falcipain-3	2-142	N			Subramanian et al., 2009
53	necepsin-1	1-142	N		NT	Williamson et al., 2003
53	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
54	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
54	falcipain-3	2-142	N			Subramanian et al., 2009
54	MEP peptidase (nematode)	2-142	N		MS	Ranjit et al., 2009
55	falcipain-3	2-142	N			Subramanian et al., 2009
56	necepsin-1	1-142	N		NT	Williamson et al., 2003
56	falcipain-2	2-142	N			Subramanian et al., 2009
56	falcipain-3	2-142	N			Subramanian et al., 2009
56	CPG70 carboxypeptidase (Porphyromonas gingivalis)	42-57	N			Chen et al., 2002
57	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
57	falcipain-2	2-142	N			Subramanian et al., 2009
57	falcipain-3	2-142	N			Subramanian et al., 2009
57	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
59	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
59	falcipain-2	2-142	N			Subramanian et al., 2009
59	falcipain-3	2-142	N			Subramanian et al., 2009
60	necepsin-1	1-142	N		NT	Williamson et al., 2003
60	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
63	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
64	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
64	falcipain-2	2-142	N			Subramanian et al., 2009
64	falcipain-3	2-142	N			Subramanian et al., 2009
64	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
67	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
68	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
68	falcipain-2	2-142	N	normal turnover		Subramanian et al., 2009
68	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
68	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
69	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
69	falcipain-2	2-142	N	normal turnover		Subramanian et al., 2009
69	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
69	legumain, animal-type	2-142	P		NT	Sojka et al., 2007
69	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
70	necepsin-2	1-142	N		MS	Ranjit et al., 2009
70	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
71	falcipain-2	2-142	N			Subramanian et al., 2009
71	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
72	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
72	falcipain-2	2-142	N			Subramanian et al., 2009
72	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
72	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
75	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
75	falcilysin	2-142	N			Eggleson et al., 1999
76	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
76	falcipain-2	2-142	N			Subramanian et al., 2009
77	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
78	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
79	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
79	falcipain-2	2-142	N			Subramanian et al., 2009
79	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
80	falcipain-2	2-142	N			Subramanian et al., 2009
80	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
81	necepsin-2	1-142	N		MS	Ranjit et al., 2009
81	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
82	necepsin-2	1-142	N		MS	Ranjit et al., 2009
82	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
82	falcipain-2	2-142	N	normal turnover		Subramanian et al., 2009
82	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
83	necepsin-2	1-142	N		MS	Ranjit et al., 2009
83	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
83	falcipain-2	2-142	N			Subramanian et al., 2009
83	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
84	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
84	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
85	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
85	falcipain-2	2-142	N	normal turnover		Subramanian et al., 2009
85	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
85	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
87	necepsin-2	1-142	N		MS	Ranjit et al., 2009
88	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
88	falcipain-2	2-142	N			Subramanian et al., 2009
89	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
89	falcipain-2	2-142	N			Subramanian et al., 2009
90	CPG70 carboxypeptidase (Porphyromonas gingivalis)	62-91	N			Chen et al., 2002
91	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
91	falcilysin	2-142	N			Eggleson et al., 1999
92	necepsin-1	1-142	N		NT	Williamson et al., 2003
92	falcipain-2	2-142	N			Subramanian et al., 2009
92	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
93	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
93	falcipain-2	2-142	N			Subramanian et al., 2009
93	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
93	cathepsin B-like peptidase, nematode	2-142	P		MS	Ranjit et al., 2009
95	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
97	necepsin-1	1-142	N		NT	Williamson et al., 2003
97	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
98	necepsin-2	1-142	N		MS	Ranjit et al., 2009
98	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
98	legumain, animal-type	2-142	P		NT	Sojka et al., 2007
99	plasmepsin-1	2-142	P		MS	Gluzman et al., 1994
99	necepsin-2	1-142	N		MS	Ranjit et al., 2009
99	CPG70 carboxypeptidase (Porphyromonas gingivalis)	92-100	N			Chen et al., 2002
100	necepsin-2	1-142	N		MS	Ranjit et al., 2009
100	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
100	falcipain-2	2-142	N			Subramanian et al., 2009
100	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
101	necepsin-2	1-142	N		MS	Ranjit et al., 2009
101	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
101	falcipain-2	2-142	N			Subramanian et al., 2009
102	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
102	falcipain-2	2-142	N			Subramanian et al., 2009
102	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
103	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
104	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
104	falcipain-3	2-142	N			Subramanian et al., 2009
105	falcipain-3	2-142	N			Subramanian et al., 2009
106	cathepsin D	2-142	N	normal turnover		Brindley et al., 2001
106	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
107	necepsin-1	1-142	N		NT	Williamson et al., 2003
107	falcipain-2	2-142	N			Subramanian et al., 2009
109	cathepsin D	2-142	N	normal turnover		Brindley et al., 2001
109	plasmepsin-2	2-142	P		NT	Gluzman et al., 1994
109	necepsin-1	1-142	N		NT	Williamson et al., 2003
109	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
109	falcipain-3	2-142	N			Subramanian et al., 2009
110	cathepsin D	2-142	N	normal turnover		Brindley et al., 2001
110	necepsin-2	1-142	N		MS	Ranjit et al., 2009
110	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
110	falcipain-2	2-142	N			Subramanian et al., 2009
110	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
111	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
111	falcipain-2	2-142	N			Subramanian et al., 2009
111	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
112	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
113	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
114	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
114	falcipain-2	2-142	N			Subramanian et al., 2009
115	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
115	falcipain-3	2-142	N			Subramanian et al., 2009
116	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
117	falcipain-2	2-142	N			Subramanian et al., 2009
117	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
118	necepsin-2	1-142	N		MS	Ranjit et al., 2009
118	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
118	falcipain-2	2-142	N			Subramanian et al., 2009
118	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
119	necepsin-2	1-142	N		MS	Ranjit et al., 2009
119	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
120	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
121	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
122	necepsin-1	1-142	N		NT	Williamson et al., 2003
122	falcipain-2	2-142	N			Subramanian et al., 2009
123	necepsin-2	1-142	N		MS	Ranjit et al., 2009
123	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
123	falcipain-2	2-142	N			Subramanian et al., 2009
123	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
124	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
125	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
125	MEP peptidase (nematode)	2-142	P		MS	Ranjit et al., 2009
126	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
127	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
127	falcipain-2	2-142	N	normal turnover		Subramanian et al., 2009
127	falcipain-3	2-142	N	normal turnover		Subramanian et al., 2009
127	CPG70 carboxypeptidase (Porphyromonas gingivalis)	101-128	N			Chen et al., 2002
129	cathepsin D	2-142	N	normal turnover		Brindley et al., 2001
129	necepsin-2	1-142	N		MS	Ranjit et al., 2009
130	necepsin-2	1-142	N		MS	Ranjit et al., 2009
130	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
131	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
131	falcipain-2	2-142	N			Subramanian et al., 2009
131	falcipain-3	2-142	N			Subramanian et al., 2009
132	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
134	cathepsin D	2-142	N	normal turnover		Brindley et al., 2001
134	necepsin-1	1-142	N		NT	Williamson et al., 2003
135	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
137	plasmepsin-2	2-142	P		NT	Gluzman et al., 1994
137	falcipain-2	2-142	N			Subramanian et al., 2009
137	falcipain-3	2-142	N			Subramanian et al., 2009
138	falcipain-2	2-142	N			Subramanian et al., 2009
138	falcipain-3	2-142	N			Subramanian et al., 2009
139	falcipain-2	2-142	N			Subramanian et al., 2009
139	falcipain-3	2-142	N			Subramanian et al., 2009
140	cathepsin L1 (Fasciola sp.)	2-142	N	normal turnover		Lowther et al., 2009
141	carboxypeptidase N	2-142	P			Michel et al., 1996
141	carboxypeptidase M	2-142	P			Michel et al., 1996