Substrates for peptidase A01.059: plasmepsin-4

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Dabcyl-GABA-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-GABA-5-(2-aminoethylaminio)-1-naphthalene-sulfonic acid Dabcyl-GABA-Glu-Arg-Met-Phe+Leu-Ser-Phe-Pro-GABA-EDANS S Glu Arg Met Phe Leu Ser Phe Pro
hemoglobin subunit alpha P69905 2-142 peptide-Phe33+Leu-peptide N Glu Arg Met Phe Leu Ser Phe Pro Wyatt & Berry, 2002 15943
Lys-Glu-Phe-Ala-Phe-Nph-Ala-Leu-Lys Lys-Glu-Phe-Ala-Phe+Nph-Ala-Leu-Lys S Glu Phe Ala Phe Nph Ala Leu Lys Martins et al., 2006
Lys-Glu-Phe-Asn-Phe-Nph-Ala-Leu-Lys Lys-Glu-Phe-Asn-Phe+Nph-Ala-Leu-Lys S Glu Phe Asn Phe Nph Ala Leu Lys Martins et al., 2006
Lys-Glu-Phe-Val-Phe-Nph-Ala-Leu-Lys Lys-Glu-Phe-Val-Phe+Nph-Ala-Leu-Lys S Glu Phe Val Phe Nph Ala Leu Lys Martins et al., 2006
Lys-Pro-Ile-Val-Phe-Nph-Arg-Leu Lys-Pro-Ile-Val-Phe+Nph-Arg-Leu S Pro Ile Val Phe Nph Arg Leu - Martins et al., 2006
plasmepsin 4 Q17SB3 1-448 peptide-Phe109+Phe-peptide P NT Ser Phe Lys Phe Phe Lys Ser Gly Wyatt & Berry, 2002
plasmepsin 4 Q17SB3 1-448 peptide-Phe110+Lys-peptide P NT Phe Lys Phe Phe Lys Ser Gly Tyr Wyatt & Berry, 2002