Substrates for peptidase M16.011: falcilysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
acyl carrier protein	O77077	17-40	peptide-Lys32+Lys-peptide	P	Ile	Leu	Lys	Lys	Lys	Arg	Ser	Asn	Ponpuak et al., 2007
acyl carrier protein	O77077	17-40	peptide-Lys33+Arg-peptide	P	Leu	Lys	Lys	Lys	Arg	Ser	Asn	Gln	Ponpuak et al., 2007
acyl carrier protein	O77077	17-40	peptide-Leu27+Gln-peptide	P	Gly	Val	Ser	Leu	Gln	Ile	Leu	Lys	Ponpuak et al., 2007
hemoglobin subunit alpha	P69905	2-142	peptide-Thr41+Tyr-peptide	N	Thr	Thr	Lys	Thr	Tyr	Phe	Pro	His	Eggleson et al., 1999	17049
hemoglobin subunit alpha	P69905	2-142	peptide-Asp74+Asp-peptide	N	Ala	His	Val	Asp	Asp	Met	Pro	Asn	Eggleson et al., 1999	17047
hemoglobin subunit alpha	P69905	2-142	peptide-Lys90+Leu-peptide	N	His	Ala	His	Lys	Leu	Arg	Val	Asp	Eggleson et al., 1999	17048
hemoglobin subunit beta	P68871	2-147	peptide-Asp73+Gly-peptide	N	Ala	Phe	Ser	Asp	Gly	Leu	Ala	His	Eggleson et al., 1999	17052
hemoglobin subunit beta	P68871	2-147	peptide-Leu78+Asp-peptide	N	Leu	Ala	His	Leu	Asp	Asn	Leu	Lys	Eggleson et al., 1999	17053
hemoglobin subunit beta	P68871	2-147	peptide-Lys132+Val-peptide	N	Ala	Tyr	Gln	Lys	Val	Val	Ala	Gly	Eggleson et al., 1999	17054
Hemoglobin subunit delta	P02042	2-147	peptide-Arg41+Phe-peptide	N	Trp	Thr	Gln	Arg	Phe	Phe	Glu	Ser	Eggleson et al., 1999	17051