Substrates for peptidase A01.023: plasmepsin-2

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ala-Leu-Gly-Arg-Thr-Phe-Nph-Ser-Phe-Pro-Thr			Ala-Leu-Gly-Arg-Thr-Phe+Nph-Ser-Phe-Pro-Thr	S		Gly	Arg	Thr	Phe	Nph	Ser	Phe	Pro	Hill et al., 1994
Dabcyl-GABA-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-GABA-5-(2-aminoethylaminio)-1-naphthalene-sulfonic acid			Dabcyl-GABA-Glu-Arg-Met-Phe+Leu-Ser-Phe-Pro-GABA-EDANS	S		Glu	Arg	Met	Phe	Leu	Ser	Phe	Pro	Berry & Goldberg, 2004
hemoglobin subunit alpha	P69905	2-142	peptide-Phe33+Leu-peptide	N		Glu	Arg	Met	Phe	Leu	Ser	Phe	Pro	Berry & Goldberg, 2004	15902
Hemoglobin subunit alpha	P69905	2-142	Peptide-Thr109+Leu-Peptide	P	NT	Leu	Leu	Val	Thr	Leu	Ala	Ala	His	Gluzman et al., 1994
Hemoglobin subunit alpha	P69905	2-142	Peptide-Leu137+Thr-Peptide	P	NT	Ser	Thr	Val	Leu	Thr	Ser	Lys	Tyr	Gluzman et al., 1994
Hemoglobin subunit beta	P68871	2-147	Peptide-Leu33+Val-Peptide	P	MS	Gly	Arg	Leu	Leu	Val	Val	Tyr	Pro	Gluzman et al., 1994
Lys-Glu-Phe-Ala-Phe-Nph-Ala-Leu-Lys			Lys-Glu-Phe-Ala-Phe+Nph-Ala-Leu-Lys	S		Glu	Phe	Ala	Phe	Nph	Ala	Leu	Lys	Martins et al., 2006
Lys-Glu-Phe-Asn-Phe-Nph-Ala-Leu-Lys			Lys-Glu-Phe-Asn-Phe+Nph-Ala-Leu-Lys	S		Glu	Phe	Asn	Phe	Nph	Ala	Leu	Lys	Martins et al., 2006
Lys-Glu-Phe-Val-Phe-Nph-Ala-Leu-Lys			Lys-Glu-Phe-Val-Phe+Nph-Ala-Leu-Lys	S		Glu	Phe	Val	Phe	Nph	Ala	Leu	Lys	Berry & Goldberg, 2004
Lys-Pro-Ile-Val-Phe-Nph-Arg-Leu			Lys-Pro-Ile-Val-Phe+Nph-Arg-Leu	S		Pro	Ile	Val	Phe	Nph	Arg	Leu	-	Berry & Goldberg, 2004
plasmepsin-2 precursor	P46925	1-453	peptide-Gly124+Ser-peptide	P	NT	Asn	Tyr	Leu	Gly	Ser	Ser	Asn	Asp	Drew et al., 2008
Spectrin alpha chain, erythrocyte	P02549	1-2419	Peptide-Phe988+Gln-Peptide	N	MS	Leu	Tyr	Asp	Phe	Gln	Ala	Arg	Ser	Le Bonniec et al., 1999
Spectrin alpha chain, erythrocyte	P02549	1-2419	Peptide-Leu1006+Leu-Peptide	N	MS	Val	Leu	Thr	Leu	Leu	Ser	Ser	Ile	Le Bonniec et al., 1999
Spectrin alpha chain, erythrocyte	P02549	1-2419	Peptide-Leu1007+Ser-Peptide	N	MS	Leu	Thr	Leu	Leu	Ser	Ser	Ile	Asn	Le Bonniec et al., 1999
Spectrin alpha chain, erythrocyte	P02549	1-2419	Peptide-Tyr1030+Val-Peptide	N	MS	Pro	Ala	Val	Tyr	Val	Arg	Arg	Leu	Le Bonniec et al., 1999