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Peptidase

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Substrates for peptidase A01.053: necepsin-1

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
hemoglobin subunit alpha P69905 2-142 peptide-Ala13+Trp-peptide N Val Lys Ala Ala Trp Gly Lys Val Williamson et al., 2003 15946
hemoglobin subunit alpha P69905 2-142 peptide-Asp47+Leu-peptide N Pro His Phe Asp Leu Ser His Gly Williamson et al., 2003 15947
hemoglobin subunit alpha P60529 1-141 peptide-Gly51+Ser-peptide N Leu Ser Pro Gly Ser Ala Gln Val Williamson et al., 2003 15944
hemoglobin subunit alpha P60529 1-141 peptide-Val93+Asp-peptide N Lys Leu Arg Val Asp Pro Val Asn Williamson et al., 2003 15945
hemoglobin subunit alpha P60529 1-141 peptide-Val1+Leu-peptide N MS - - - Val Leu Ser Pro Ala Williamson et al., 2004 24566
hemoglobin subunit alpha P60529 1-141 peptide-Ala5+Asp-peptide N MS Leu Ser Pro Ala Asp Lys Thr Asn Williamson et al., 2004 24567
hemoglobin subunit alpha P60529 1-141 peptide-Lys11+Ser-peptide N MS Thr Asn Ile Lys Ser Thr Trp Asp Williamson et al., 2004 24568
hemoglobin subunit alpha P60529 1-141 peptide-Trp14+Asp-peptide N MS Lys Ser Thr Trp Asp Lys Ile Gly Williamson et al., 2004 24569
hemoglobin subunit alpha P60529 1-141 peptide-Asp23+Tyr-peptide N MS His Ala Gly Asp Tyr Gly Gly Glu Williamson et al., 2004 24570
hemoglobin subunit alpha P60529 1-141 peptide-Glu27+Ala-peptide N MS Tyr Gly Gly Glu Ala Leu Asp Arg Williamson et al., 2004 24571
hemoglobin subunit alpha P60529 1-141 peptide-Leu29+Asp-peptide N MS Gly Glu Ala Leu Asp Arg Thr Phe Williamson et al., 2004 24572
hemoglobin subunit alpha P60529 1-141 peptide-Asp30+Arg-peptide N MS Glu Ala Leu Asp Arg Thr Phe Gln Williamson et al., 2004 24573
hemoglobin subunit alpha P60529 1-141 peptide-Arg31+Thr-peptide N MS Ala Leu Asp Arg Thr Phe Gln Ser Williamson et al., 2004 24574
hemoglobin subunit alpha P60529 1-141 peptide-Phe33+Gln-peptide N MS Asp Arg Thr Phe Gln Ser Phe Pro Williamson et al., 2004 24575
hemoglobin subunit alpha P60529 1-141 peptide-Gln34+Ser-peptide N MS Arg Thr Phe Gln Ser Phe Pro Thr Williamson et al., 2004 24576
hemoglobin subunit alpha P60529 1-141 peptide-Phe36+Pro-peptide N MS Phe Gln Ser Phe Pro Thr Thr Lys Williamson et al., 2004 24577
hemoglobin subunit alpha P60529 1-141 peptide-Lys40+Thr-peptide N MS Pro Thr Thr Lys Thr Tyr Phe Pro Williamson et al., 2004 24578
hemoglobin subunit alpha P60529 1-141 peptide-Phe43+Pro-peptide N MS Lys Thr Tyr Phe Pro His Phe Asp Williamson et al., 2004 24579
hemoglobin subunit alpha P60529 1-141 peptide-His58+Gly-peptide N MS Val Lys Ala His Gly Lys Lys Val Williamson et al., 2004 24583
hemoglobin subunit alpha P60529 1-141 peptide-Leu48+Ser-peptide N MS His Phe Asp Leu Ser Pro Gly Ser Williamson et al., 2004 24581
hemoglobin subunit alpha P60529 1-141 peptide-Lys56+Ala-peptide N MS Ala Gln Val Lys Ala His Gly Lys Williamson et al., 2004 24582
hemoglobin subunit alpha P60529 1-141 peptide-Ala69+Val-peptide N MS Leu Thr Thr Ala Val Ala His Leu Williamson et al., 2004 24584
hemoglobin subunit alpha P60529 1-141 peptide-Val70+Ala-peptide N MS Thr Thr Ala Val Ala His Leu Asp Williamson et al., 2004 24585
hemoglobin subunit alpha P60529 1-141 peptide-Leu76+Pro-peptide N MS Leu Asp Asp Leu Pro Gly Ala Leu Williamson et al., 2004 24586
hemoglobin subunit alpha P60529 1-141 peptide-Gly78+Ala-peptide N MS Asp Leu Pro Gly Ala Leu Ser Ala Williamson et al., 2004 24587
hemoglobin subunit alpha P60529 1-141 peptide-Leu83+Ser-peptide N MS Leu Ser Ala Leu Ser Asp Leu His Williamson et al., 2004 24588
hemoglobin subunit alpha P60529 1-141 peptide-Leu86+His-peptide N MS Leu Ser Asp Leu His Ala Tyr Lys Williamson et al., 2004 24589
hemoglobin subunit alpha P60529 1-141 peptide-Ala88+Tyr-peptide N MS Asp Leu His Ala Tyr Lys Leu Arg Williamson et al., 2004 24590
hemoglobin subunit alpha P60529 1-141 peptide-Leu91+Arg-peptide N MS Ala Tyr Lys Leu Arg Val Asp Pro Williamson et al., 2004 24591
hemoglobin subunit alpha P60529 1-141 peptide-Val96+Asn-peptide N MS Val Asp Pro Val Asn Phe Lys Leu Williamson et al., 2004 24592
hemoglobin subunit alpha P60529 1-141 peptide-Val107+Thr-peptide N MS Cys Leu Leu Val Thr Leu Ala Cys Williamson et al., 2004 24593
hemoglobin subunit alpha P60529 1-141 peptide-Pro114+Thr-peptide N MS Cys His His Pro Thr Glu Phe Thr Williamson et al., 2004 24594
hemoglobin subunit alpha P60529 1-141 peptide-Val121+His-peptide N MS Thr Pro Ala Val His Ala Ser Leu Williamson et al., 2004 24595
hemoglobin subunit alpha P60529 1-141 peptide-Phe128+Phe-peptide N MS Leu Asp Lys Phe Phe Ala Ala Val Williamson et al., 2004 24597
hemoglobin subunit alpha P60529 1-141 peptide-Phe129+Ala-peptide N MS Asp Lys Phe Phe Ala Ala Val Ser Williamson et al., 2004 24598
hemoglobin subunit alpha P60529 1-141 peptide-Ala131+Val-peptide N MS Phe Phe Ala Ala Val Ser Thr Val Williamson et al., 2004 24599
hemoglobin subunit alpha P60529 1-141 peptide-Leu136+Thr-peptide N MS Ser Thr Val Leu Thr Ser Lys Tyr Williamson et al., 2004 24600
hemoglobin subunit alpha P60529 1-141 peptide-Phe46+Asp-peptide N MS Phe Pro His Phe Asp Leu Ser Pro Williamson et al., 2004
hemoglobin subunit alpha P60529 1-141 peptide-Gly51+Ser-peptide N MS Leu Ser Pro Gly Ser Ala Gln Val Williamson et al., 2004
hemoglobin subunit alpha P60529 1-141 peptide-Ala82+Leu-peptide N MS Ala Leu Ser Ala Leu Ser Asp Leu Williamson et al., 2004
hemoglobin subunit alpha P60529 1-141 peptide-Phe98+Lys-peptide N MS Pro Val Asn Phe Lys Leu Leu Ser Williamson et al., 2004
hemoglobin subunit alpha P60529 1-141 peptide-His122+Ala-peptide N MS Pro Ala Val His Ala Ser Leu Asp Williamson et al., 2004
hemoglobin subunit alpha P60529 1-141 peptide-Val55+Lys-peptide N NT Ser Ala Gln Val Lys Ala His Gly Williamson et al., 2003
hemoglobin subunit alpha P60529 1-141 peptide-Val93+Asp-peptide N NT Lys Leu Arg Val Asp Pro Val Asn Williamson et al., 2003
hemoglobin subunit alpha P60529 1-141 peptide-Ser133+Thr-peptide N NT Ala Ala Val Ser Thr Val Leu Thr Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Thr9+Asn-peptide N NT Ala Asp Lys Thr Asn Val Lys Ala Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Ala14+Trp-peptide N NT Val Lys Ala Ala Trp Gly Lys Val Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Tyr25+Gly-peptide N NT Ala Gly Glu Tyr Gly Ala Glu Ala Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Leu30+Glu-peptide N NT Ala Glu Ala Leu Glu Arg Met Phe Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-His46+Phe-peptide N NT Tyr Phe Pro His Phe Asp Leu Ser Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Asp48+Leu-peptide N NT Pro His Phe Asp Leu Ser His Gly Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Ser53+Ala-peptide N NT Ser His Gly Ser Ala Gln Val Lys Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Val56+Lys-peptide N NT Ser Ala Gln Val Lys Gly His Gly Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Gly60+Lys-peptide N NT Lys Gly His Gly Lys Lys Val Ala Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Leu92+Arg-peptide N NT Ala His Lys Leu Arg Val Asp Pro Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Val97+Asn-peptide N NT Val Asp Pro Val Asn Phe Lys Leu Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Leu107+Val-peptide N NT His Cys Leu Leu Val Thr Leu Ala Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Thr109+Leu-peptide N NT Leu Leu Val Thr Leu Ala Ala His Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Val122+His-peptide N NT Thr Pro Ala Val His Ala Ser Leu Williamson et al., 2003
hemoglobin subunit alpha P69905 1-142 peptide-Ser134+Thr-peptide N NT Ala Ser Val Ser Thr Val Leu Thr Williamson et al., 2003
hemoglobin subunit beta P68871 2-147 peptide-Trp37+Thr-peptide N MS Val Tyr Pro Trp Thr Gln Arg Phe Williamson et al., 2003 15949
hemoglobin subunit beta P60524 1-146 peptide-Gly136+Val-peptide N MS Val Val Ala Gly Val Ala Asn Ala Williamson et al., 2003 15948
hemoglobin subunit beta P60524 1-146 peptide-Val24+Asp-peptide N MS Lys Val Asn Val Asp Glu Val Gly Williamson et al., 2004 24684
hemoglobin subunit beta P60524 1-146 peptide-Ala5+Glu-peptide N MS His Leu Thr Ala Glu Glu Lys Ser Williamson et al., 2004 24673
hemoglobin subunit beta P60524 1-146 peptide-Ser9+Leu-peptide N MS Glu Glu Lys Ser Leu Val Ser Gly Williamson et al., 2004 24674
hemoglobin subunit beta P60524 1-146 peptide-Leu10+Val-peptide N MS Glu Lys Ser Leu Val Ser Gly Leu Williamson et al., 2004 24675
hemoglobin subunit beta P60524 1-146 peptide-Val11+Ser-peptide N MS Lys Ser Leu Val Ser Gly Leu Trp Williamson et al., 2004 24676
hemoglobin subunit beta P60524 1-146 peptide-Leu14+Trp-peptide N MS Val Ser Gly Leu Trp Gly Lys Val Williamson et al., 2004 24677
hemoglobin subunit beta P60524 1-146 peptide-Gly16+Lys-peptide N MS Gly Leu Trp Gly Lys Val Asn Val Williamson et al., 2004 24683
hemoglobin subunit beta P60524 1-146 peptide-Glu22+Val-peptide N MS Asn Val Asp Glu Val Gly Gly Glu Williamson et al., 2004 24686
hemoglobin subunit beta P60524 1-146 peptide-Gly25+Glu-peptide N MS Glu Val Gly Gly Glu Ala Leu Gly Williamson et al., 2004 24688
hemoglobin subunit beta P60524 1-146 peptide-Ala27+Leu-peptide N MS Gly Gly Glu Ala Leu Gly Arg Leu Williamson et al., 2004 24691
hemoglobin subunit beta P60524 1-146 peptide-Leu28+Gly-peptide N MS Gly Glu Ala Leu Gly Arg Leu Leu Williamson et al., 2004
hemoglobin subunit beta P60524 1-146 peptide-Leu31+Leu-peptide N MS Leu Gly Arg Leu Leu Ile Val Tyr Williamson et al., 2004 24740
hemoglobin subunit beta P60524 1-146 peptide-Leu32+Ile-peptide N MS Gly Arg Leu Leu Ile Val Tyr Pro Williamson et al., 2004 24742
hemoglobin subunit beta P60524 1-146 peptide-Phe41+Phe-peptide N MS Thr Gln Arg Phe Phe Asp Ser Phe Williamson et al., 2004
hemoglobin subunit beta P60524 1-146 peptide-Phe45+Gly-peptide N MS Phe Asp Ser Phe Gly Asp Leu Ser Williamson et al., 2004 24744
hemoglobin subunit beta P60524 1-146 peptide-Thr50+Pro-peptide N MS Asp Leu Ser Thr Pro Asp Ala Val Williamson et al., 2004 24747
hemoglobin subunit beta P60524 1-146 peptide-Asp52+Ala-peptide N MS Ser Thr Pro Asp Ala Val Met Ser Williamson et al., 2004 24749
hemoglobin subunit beta P60524 1-146 peptide-Asn57+Ala-peptide N MS Val Met Ser Asn Ala Lys Val Lys Williamson et al., 2004 24753
hemoglobin subunit beta P60524 1-146 peptide-Ala58+Lys-peptide N MS Met Ser Asn Ala Lys Val Lys Ala Williamson et al., 2004 24751
hemoglobin subunit beta P60524 1-146 peptide-Lys65+Lys-peptide N MS Ala His Gly Lys Lys Val Leu Asn Williamson et al., 2004 24755
hemoglobin subunit beta P60524 1-146 peptide-Leu68+Asn-peptide N MS Lys Lys Val Leu Asn Ser Phe Ser Williamson et al., 2004 24758
hemoglobin subunit beta P60524 1-146 peptide-Ser72+Asp-peptide N MS Asn Ser Phe Ser Asp Gly Leu Lys Williamson et al., 2004 24760
hemoglobin subunit beta P60524 1-146 peptide-Leu78+Asp-peptide N MS Leu Lys Asn Leu Asp Asn Leu Lys Williamson et al., 2004 24762
hemoglobin subunit beta P60524 1-146 peptide-Asp79+Asn-peptide N MS Lys Asn Leu Asp Asn Leu Lys Gly Williamson et al., 2004 24764
hemoglobin subunit beta P60524 1-146 peptide-Asn80+Leu-peptide N MS Asn Leu Asp Asn Leu Lys Gly Thr Williamson et al., 2004 24766
hemoglobin subunit beta P60524 1-146 peptide-Leu81+Lys-peptide N MS Leu Asp Asn Leu Lys Gly Thr Phe Williamson et al., 2004 24768
hemoglobin subunit beta P60524 1-146 peptide-Gly83+Thr-peptide N MS Asn Leu Lys Gly Thr Phe Ala Lys Williamson et al., 2004 24770
hemoglobin subunit beta P60524 1-146 peptide-Ala86+Lys-peptide N MS Gly Thr Phe Ala Lys Leu Ser Glu Williamson et al., 2004
hemoglobin subunit beta P60524 1-146 peptide-Leu88+Ser-peptide N MS Phe Ala Lys Leu Ser Glu Leu His Williamson et al., 2004 24774
hemoglobin subunit beta P60524 1-146 peptide-Asn102+Phe-peptide N MS Asp Pro Glu Asn Phe Lys Leu Leu Williamson et al., 2004 24776
hemoglobin subunit beta P60524 1-146 peptide-Phe103+Lys-peptide N MS Pro Glu Asn Phe Lys Leu Leu Gly Williamson et al., 2004 24778
hemoglobin subunit beta P60524 1-146 peptide-Leu106+Gly-peptide N MS Phe Lys Leu Leu Gly Asn Val Leu Williamson et al., 2004 24780
hemoglobin subunit beta P60524 1-146 peptide-Asn108+Val-peptide N MS Leu Leu Gly Asn Val Leu Val Cys Williamson et al., 2004 24782
hemoglobin subunit beta P60524 1-146 peptide-Cys112+Val-peptide N MS Val Leu Val Cys Val Leu Ala His Williamson et al., 2004
hemoglobin subunit beta P60524 1-146 peptide-His117+Phe-peptide N MS Leu Ala His His Phe Gly Lys Glu Williamson et al., 2004 24786
hemoglobin subunit beta P60524 1-146 peptide-Glu121+Phe-peptide N MS Phe Gly Lys Glu Phe Thr Pro Gln Williamson et al., 2004 24788
hemoglobin subunit beta P60524 1-146 peptide-Gln125+Val-peptide N MS Phe Thr Pro Gln Val Gln Ala Ala Williamson et al., 2004 24790
hemoglobin subunit beta P60524 1-146 peptide-Gln127+Ala-peptide N MS Pro Gln Val Gln Ala Ala Tyr Gln Williamson et al., 2004 24792
hemoglobin subunit beta P60524 1-146 peptide-Ala129+Tyr-peptide N MS Val Gln Ala Ala Tyr Gln Lys Val Williamson et al., 2004
hemoglobin subunit beta P60524 1-146 peptide-Val134+Ala-peptide N MS Gln Lys Val Val Ala Gly Val Ala Williamson et al., 2004 24794
hemoglobin subunit beta P60524 1-146 peptide-Ala140+Leu-peptide N MS Val Ala Asn Ala Leu Ala His Lys Williamson et al., 2004 24796
hemoglobin subunit beta P60524 1-146 peptide-Ala142+His-peptide N MS Asn Ala Leu Ala His Lys Tyr His Williamson et al., 2004
hemoglobin subunit beta P60524 1-146 peptide-Phe86+Ala-peptide N MS Lys Gly Thr Phe Ala Lys Leu Ser Williamson et al., 2004 24772
hemoglobin subunit beta P60524 1-146 peptide-Leu110+Val-peptide N MS Gly Asn Val Leu Val Cys Val Leu Williamson et al., 2004 24784
hemoglobin subunit beta P60524 1-146 peptide-Thr4+Ala-peptide N NT Val His Leu Thr Ala Glu Glu Lys Williamson et al., 2003
hemoglobin subunit beta P60524 1-146 peptide-Lys8+Ser-peptide N NT Ala Glu Glu Lys Ser Leu Val Ser Williamson et al., 2003
hemoglobin subunit beta P60524 1-146 peptide-Phe42+Asp-peptide N NT Gln Arg Phe Phe Asp Ser Phe Gly Williamson et al., 2003
hemoglobin subunit beta P60524 1-146 peptide-Ala53+Val-peptide N NT Thr Pro Asp Ala Val Met Ser Asn Williamson et al., 2003
hemoglobin subunit beta P60524 1-146 peptide-Gly64+Lys-peptide N NT Lys Ala His Gly Lys Lys Val Leu Williamson et al., 2003
hemoglobin subunit beta P60524 1-146 peptide-His92+Cys-peptide N NT Ser Glu Leu His Cys Asp Lys Leu Williamson et al., 2003
hemoglobin subunit beta P60524 1-146 peptide-Asp94+Lys-peptide N NT Leu His Cys Asp Lys Leu His Val Williamson et al., 2003
hemoglobin subunit beta P60524 1-146 peptide-Asn139+Ala-peptide N NT Gly Val Ala Asn Ala Leu Ala His Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Glu8+Lys-peptide N NT Thr Pro Glu Glu Lys Ser Ala Val Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Gly26+Glu-peptide N NT Glu Val Gly Gly Glu Ala Leu Gly Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Gly30+Arg-peptide N NT Glu Ala Leu Gly Arg Leu Leu Val Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Tyr36+Pro-peptide N NT Leu Val Val Tyr Pro Trp Thr Gln Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Trp38+Thr-peptide N NT Val Tyr Pro Trp Thr Gln Arg Phe Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Phe46+Gly-peptide N NT Phe Glu Ser Phe Gly Asp Leu Ser Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Asp53+Ala-peptide N NT Ser Thr Pro Asp Ala Val Met Gly Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Gly57+Asn-peptide N NT Ala Val Met Gly Asn Pro Lys Val Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Phe72+Ser-peptide N NT Leu Gly Ala Phe Ser Asp Gly Leu Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Gly75+Leu-peptide N NT Phe Ser Asp Gly Leu Ala His Leu Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Thr85+Phe-peptide N NT Leu Lys Gly Thr Phe Ala Thr Leu Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-His93+Cys-peptide N NT Ser Glu Leu His Cys Asp Lys Leu Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Arg105+Leu-peptide N NT Glu Asn Phe Arg Leu Leu Gly Asn Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Leu111+Val-peptide N NT Gly Asn Val Leu Val Cys Val Leu Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Gly120+Lys-peptide N NT His His Phe Gly Lys Glu Phe Thr Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Phe123+Thr-peptide N NT Gly Lys Glu Phe Thr Pro Pro Val Williamson et al., 2003 24546
hemoglobin subunit beta P68871 1-147 peptide-Ala129+Ala-peptide N NT Pro Val Gln Ala Ala Tyr Gln Lys Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Ala141+Leu-peptide N NT Val Ala Asn Ala Leu Ala His Lys Williamson et al., 2003
hemoglobin subunit beta P68871 1-147 peptide-Lys145+Tyr-His N NT Leu Ala His Lys Tyr His - - Williamson et al., 2003

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