Substrates for peptidase A01.022: plasmepsin-1

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Dabcyl-GABA-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-GABA-5-(2-aminoethylaminio)-1-naphthalene-sulfonic acid			Dabcyl-GABA-Glu-Arg-Met-Phe+Leu-Ser-Phe-Pro-GABA-EDANS	S		Glu	Arg	Met	Phe	Leu	Ser	Phe	Pro	Berry & Goldberg, 2004
hemoglobin subunit alpha	P69905	2-142	peptide-Phe34+Leu-peptide	N		Glu	Arg	Met	Phe	Leu	Ser	Phe	Pro	Berry & Goldberg, 2004	15901
Hemoglobin subunit alpha	P69905	2-142	Peptide-Phe47+Asp-Peptide	P	NT	Phe	Pro	His	Phe	Asp	Leu	Ser	His	Gluzman et al., 1994
Hemoglobin subunit alpha	P69905	2-142	Peptide-Phe99+Lys-Peptide	P	MS	Pro	Val	Asn	Phe	Lys	Leu	Leu	Ser	Gluzman et al., 1994
Hemoglobin subunit beta	P68871	2-147	Peptide-Leu32+Leu-Peptide	P	NT	Leu	Gly	Arg	Leu	Leu	Val	Val	Tyr	Gluzman et al., 1994
Hemoglobin subunit beta	P68871	2-147	Peptide-Phe42+Phe-Peptide	P	NT	Thr	Gln	Arg	Phe	Phe	Glu	Ser	Phe	Gluzman et al., 1994
Hemoglobin subunit beta	P68871	2-147	Peptide-Ala130+Tyr-Peptide	P	NT	Val	Gln	Ala	Ala	Tyr	Gln	Lys	Val	Gluzman et al., 1994
Leu-Glu-Arg-Ile-Phe-NPh-Ser-Phe			Leu-Glu-Arg-Ile-Phe+Nph-Ser-Phe	S		Glu	Arg	Ile	Phe	NPh	Ser	Phe	-	Liu et al., 2009
Lys-Glu-Leu-Val-Phe-NPh-Ala-Leu-Lys			Lys-Glu-Leu-Val-Phe+Nph-Ala-Leu-Lys	S		Glu	Leu	Val	Phe	NPh	Ala	Leu	Lys	Liu et al., 2009
Lys-Glu-Phe-Ala-Phe-Nph-Ala-Leu-Lys			Lys-Glu-Phe-Ala-Phe+Nph-Ala-Leu-Lys	S		Glu	Phe	Ala	Phe	Nph	Ala	Leu	Lys	Martins et al., 2006
Lys-Glu-Phe-Asn-Phe-Nph-Ala-Leu-Lys			Lys-Glu-Phe-Asn-Phe+Nph-Ala-Leu-Lys	S		Glu	Phe	Asn	Phe	Nph	Ala	Leu	Lys	Martins et al., 2006
plasmepsin-1 precursor	P39898	1-452	Peptide-Leu116-Thr-Peptide	P	NT	Lys	Thr	Gly	Leu	Thr	Gln	Lys	Pro	Liu et al., 2009
plasmepsin-1 precursor	P39898	1-452	Peptide-Phe111-Phe-Peptide	P	NT	Ser	Leu	Lys	Phe	Phe	Lys	Thr	Gly	Liu et al., 2009