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CHEBI:35500 - 1,4-benzodiazepinone

ChEBI IDCHEBI:35500
ChEBI Name1,4-benzodiazepinone
Stars
Last Modified2 June 2025
SubmitterKirill Degtyarenko
Roles Classification
Biological Role:
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
Application:
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
ChEBI Ontology
Outgoing Relation(s)
1,4-benzodiazepinone (CHEBI:35500) is a benzodiazepine (CHEBI:22720)
Incoming Relation(s)
(S)-4'-methoxycyclopeptine (CHEBI:193537) is a 1,4-benzodiazepinone (CHEBI:35500)
(Z)-4'-methoxydehydrocyclopeptine (CHEBI:193538) is a 1,4-benzodiazepinone (CHEBI:35500)
2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-3-carboxylic acid (CHEBI:85617) is a 1,4-benzodiazepinone (CHEBI:35500)
5-(2-chlorophenyl)-7-(dihydroxyamino)-1,3-dihydro-1,4-benzodiazepin-2-one (CHEBI:143343) is a 1,4-benzodiazepinone (CHEBI:35500)
cinolazepam (CHEBI:59514) is a 1,4-benzodiazepinone (CHEBI:35500)
clobazam (CHEBI:31413) is a 1,4-benzodiazepinone (CHEBI:35500)
clonazepam (CHEBI:3756) is a 1,4-benzodiazepinone (CHEBI:35500)
clonazepam 3-hemisuccinate (CHEBI:234399) is a 1,4-benzodiazepinone (CHEBI:35500)
clorazepic acid (CHEBI:3761) is a 1,4-benzodiazepinone (CHEBI:35500)
compound E (CHEBI:101713) is a 1,4-benzodiazepinone (CHEBI:35500)
cyclopeptine (CHEBI:71320) is a 1,4-benzodiazepinone (CHEBI:35500)
dehydrocyclopeptine (CHEBI:71322) is a 1,4-benzodiazepinone (CHEBI:35500)
devazepide (CHEBI:4460) is a 1,4-benzodiazepinone (CHEBI:35500)
diazepam (CHEBI:49575) is a 1,4-benzodiazepinone (CHEBI:35500)
didesethylflurazepam (CHEBI:143439) is a 1,4-benzodiazepinone (CHEBI:35500)
fludiazepam (CHEBI:31618) is a 1,4-benzodiazepinone (CHEBI:35500)
flunitrazepam (CHEBI:31622) is a 1,4-benzodiazepinone (CHEBI:35500)
flurazepam (CHEBI:5128) is a 1,4-benzodiazepinone (CHEBI:35500)
hydroxyethylflurazepam (CHEBI:143437) is a 1,4-benzodiazepinone (CHEBI:35500)
lormetazepam (CHEBI:52993) is a 1,4-benzodiazepinone (CHEBI:35500)
nimetazepam (CHEBI:31912) is a 1,4-benzodiazepinone (CHEBI:35500)
nitrazepam (CHEBI:7581) is a 1,4-benzodiazepinone (CHEBI:35500)
nordazepam (CHEBI:111762) is a 1,4-benzodiazepinone (CHEBI:35500)
oxazepam (CHEBI:7823) is a 1,4-benzodiazepinone (CHEBI:35500)
Ro 5-3335 (CHEBI:131785) is a 1,4-benzodiazepinone (CHEBI:35500)
Synonym  Source
1,4-benzodiazepinonesChEBI