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CHEBI:31413 - clobazam
| Formula | C16H13ClN2O2 |
| Net Charge | 0 |
| Average Mass | 300.745 |
| Monoisotopic Mass | 300.06656 |
| SMILES | CN1C(=O)CC(=O)N(c2ccccc2)c2cc(Cl)ccc21 |
| InChI | InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3 |
| InChIKey | CXOXHMZGEKVPMT-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| Applications: | anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. anticonvulsant A drug used to prevent seizures or reduce their severity. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| clobazam (CHEBI:31413) has role anticonvulsant (CHEBI:35623) |
| clobazam (CHEBI:31413) has role anxiolytic drug (CHEBI:35474) |
| clobazam (CHEBI:31413) has role GABA modulator (CHEBI:50268) |
| clobazam (CHEBI:31413) is a 1,4-benzodiazepinone (CHEBI:35500) |
| clobazam (CHEBI:31413) is a organochlorine compound (CHEBI:36683) |
| IUPAC Name |
|---|
| 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione |
| INNs | Source |
|---|---|
| clobazamum | ChemIDplus |
| clobazam | ChemIDplus |
| Synonyms | Source |
|---|---|
| 7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione | ChEMBL |
| CLOBAZAM | ChEMBL |
| 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Reaxys:758410 | Reaxys |
| CAS:22316-47-8 | KEGG DRUG |
| CAS:22316-47-8 | NIST Chemistry WebBook |
| CAS:22316-47-8 | ChemIDplus |
| Citations |
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