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CHEBI:3756 - clonazepam
| Formula | C15H10ClN3O3 |
| Net Charge | 0 |
| Average Mass | 315.716 |
| Monoisotopic Mass | 315.04107 |
| SMILES | O=C1CN=C(c2ccccc2Cl)c2cc([N+](=O)[O-])ccc2N1 |
| InChI | InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) |
| InChIKey | DGBIGWXXNGSACT-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| Applications: | GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. anticonvulsant A drug used to prevent seizures or reduce their severity. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| clonazepam (CHEBI:3756) has role anticonvulsant (CHEBI:35623) |
| clonazepam (CHEBI:3756) has role anxiolytic drug (CHEBI:35474) |
| clonazepam (CHEBI:3756) has role GABA modulator (CHEBI:50268) |
| clonazepam (CHEBI:3756) is a 1,4-benzodiazepinone (CHEBI:35500) |
| clonazepam (CHEBI:3756) is a monochlorobenzenes (CHEBI:83403) |
| Incoming Relation(s) |
| clonazepam 3-hemisuccinate (CHEBI:234399) has functional parent clonazepam (CHEBI:3756) |
| IUPAC Name |
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| 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one |
| INNs | Source |
|---|---|
| clonazepamum | ChemIDplus |
| clonazepam | ChemIDplus |
| Synonyms | Source |
|---|---|
| 5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one | ChEMBL |
| 5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one | ChEMBL |
| CLONAZEPAM | ChEMBL |
| 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one | ChemIDplus |
| 5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one | ChemIDplus |
| Citations |
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