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CHEBI:52993 - lormetazepam

ChEBI IDCHEBI:52993
ChEBI Namelormetazepam
Stars
DefinitionA 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorophenyl group at the 5-position and a chloro substituent at the 7-position.
Secondary ChEBI IDsCHEBI:31782, CHEBI:52992
Last Modified22 February 2017
SubmitterSteve
DownloadsMolfile
FormulaC16H12Cl2N2O2
Net Charge0
Average Mass335.190
Monoisotopic Mass334.02758
SMILESCN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21
InChIInChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3
InChIKeyFJIKWRGCXUCUIG-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
Applications:
sedative  A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
ChEBI Ontology
Outgoing Relation(s)
lormetazepam (CHEBI:52993) has role sedative (CHEBI:35717)
lormetazepam (CHEBI:52993) is a 1,4-benzodiazepinone (CHEBI:35500)
lormetazepam (CHEBI:52993) is a organochlorine compound (CHEBI:36683)
IUPAC Name 
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
INN  Source
lormetazepamumChemIDplus
Synonyms  Source
LormetazepamKEGG DRUG
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-oneChemIDplus
MethyllorazepamChemIDplus
N-MethyllorazepamChemIDplus
LorazepamDrugBank
(±)-LorazepamDrugBank
Brand Name  Source
Loramet (TN)KEGG DRUG
Manual XrefsDatabases
D01657KEGG DRUG
DB00186DrugBank
BE621819Patent
US3296249Patent
LormetazepamWikipedia
HMDB0041919HMDB
1608DrugCentral
Registry NumbersSources
Reaxys:759821Reaxys
Beilstein:759821Beilstein
CAS:848-75-9ChemIDplus
CAS:848-75-9KEGG DRUG
CAS:848-75-9NIST Chemistry WebBook
Citations