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CHEBI:31912 - nimetazepam
| Formula | C16H13N3O3 |
| Net Charge | 0 |
| Average Mass | 295.298 |
| Monoisotopic Mass | 295.09569 |
| SMILES | CN1C(=O)CN=C(c2ccccc2)c2cc([N+](=O)[O-])ccc21 |
| InChI | InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 |
| InChIKey | GWUSZQUVEVMBPI-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| Applications: | GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. antispasmodic drug A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder. sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. anticonvulsant A drug used to prevent seizures or reduce their severity. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| nimetazepam (CHEBI:31912) has functional parent nitrazepam (CHEBI:7581) |
| nimetazepam (CHEBI:31912) has role anticonvulsant (CHEBI:35623) |
| nimetazepam (CHEBI:31912) has role antispasmodic drug (CHEBI:53784) |
| nimetazepam (CHEBI:31912) has role GABA modulator (CHEBI:50268) |
| nimetazepam (CHEBI:31912) has role sedative (CHEBI:35717) |
| nimetazepam (CHEBI:31912) is a C-nitro compound (CHEBI:35716) |
| nimetazepam (CHEBI:31912) is a 1,4-benzodiazepinone (CHEBI:35500) |
| IUPAC Name |
|---|
| 1-methyl-7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one |
| INNs | Source |
|---|---|
| nimetazepam | WHO MedNet |
| nimetazepam | WHO MedNet |
| nimétazépam | WHO MedNet |
| nimetazepamum | WHO MedNet |
| Synonyms | Source |
|---|---|
| 1,3-dihydro-1-methyl-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one | NIST Chemistry WebBook |
| 1-methyl-5-phenyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one | NIST Chemistry WebBook |
| 1-methyl-7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one | NIST Chemistry WebBook |
| 1-methylnitrazepam | NIST Chemistry WebBook |
| methylnitrazepam | NIST Chemistry WebBook |
| Ro 5-3453 | NIST Chemistry WebBook |
| Brand Names | Source |
|---|---|
| Dormalon | ChEBI |
| Erimin | KEGG DRUG |
| Citations |
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