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CHEBI:111762 - nordazepam
| Formula | C15H11ClN2O |
| Net Charge | 0 |
| Average Mass | 270.719 |
| Monoisotopic Mass | 270.05599 |
| SMILES | O=C1CN=C(c2ccccc2)c2cc(Cl)ccc2N1 |
| InChI | InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19) |
| InChIKey | AKPLHCDWDRPJGD-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Homo sapiens (ncbitaxon:9606) | - | DOI (10.1038/nbt.2488) |
| Roles Classification |
|---|
| Biological Roles: | GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| Applications: | GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. anticonvulsant A drug used to prevent seizures or reduce their severity. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| nordazepam (CHEBI:111762) has role anticonvulsant (CHEBI:35623) |
| nordazepam (CHEBI:111762) has role anxiolytic drug (CHEBI:35474) |
| nordazepam (CHEBI:111762) has role GABA modulator (CHEBI:50268) |
| nordazepam (CHEBI:111762) has role human metabolite (CHEBI:77746) |
| nordazepam (CHEBI:111762) has role sedative (CHEBI:35717) |
| nordazepam (CHEBI:111762) is a 1,4-benzodiazepinone (CHEBI:35500) |
| nordazepam (CHEBI:111762) is a organochlorine compound (CHEBI:36683) |
| IUPAC Name |
|---|
| 7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one |
| INNs | Source |
|---|---|
| nordazepamum | ChemIDplus |
| nordazepam | ChemIDplus |
| Synonyms | Source |
|---|---|
| Desmethyldiazepam | KEGG COMPOUND |
| 7-Chloro-1,3-dihydro-5-phenyl-(2H)-1,4-benzodiazepin-2-one | KEGG COMPOUND |
| N-Desmethyldiazepam | ChemIDplus |
| Desmethyldiazepam | ChemIDplus |
| Norprazepam | ChemIDplus |
| N-Demethyldiazepam | ChemIDplus |
| Citations |
|---|