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Literature for peptidase M04.005: pseudolysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Kiefer,A.F., Schutz,C., Englisch,C.N., Kolling,D., Speicher,S., Kany,A.M., Shafiei,R., Wadood,N.A., Aljohmani,A., Wirschem,N., Jumde,R.P., Klein,A., Sikandar,A., Park,Y.M., Krasteva-Christ,G., Yildiz,D., Abdelsamie,A.S., Rox,K., Kohnke,J., Muller,R., Bischoff,M., Haupenthal,J. and Hirsch,A.K.H.
    Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model
    Adv Sci (Weinh)e2411807-e2411807. PubMed  Europe PubMed DOI
  2. Lee,C.S., Li,X.H., Jeon,C.R. and Lee,J.H.
    LasB activation in Pseudomonas aeruginosa: Quorum sensing-mediated release of an auto-activation inhibitor
    J Microbiol63, e2411005-e2411005. PubMed  Europe PubMed DOI
  3. Reichhardt,C., Matwichuk,M.L., Lewerke,L.T., Jacobs,H.M., Yan,J. and Parsek,M.R.
    Non-disruptive matrix turnover is a conserved feature of biofilm aggregate growth in paradigm pathogenic species
    MBioe0393524-e0393524. PubMed  Europe PubMed DOI
    4. 2024
  4. Keim,K., Bhattacharya,M., Crosby,H.A., Jenul,C., Mills,K., Schurr,M. and Horswill,A.
    Polymicrobial interactions between Staphylococcus aureus and Pseudomonas aeruginosa promote biofilm formation and persistence in chronic wound infections
    bioRxiv PubMed  Europe PubMed DOI
  5. Metelkina,O., Konstantinovic,J., Klein,A., Shafiei,R., Fares,M., Alhayek,A., Yahiaoui,S., Elgaher,W.A.M., Haupenthal,J., Titz,A. and Hirsch,A.K.H.
    Dual inhibitors of Pseudomonas aeruginosa virulence factors M04.005 and LasB
    Chem Sci15, 13333-13342. PubMed  Europe PubMed DOI  I
  6. Pei,X.D., Fan,H.L., Jiao,D.Q., Li,F., He,Y.N., Wu,Q.L., Liu,X.L. and Wang,C.H.
    Rational engineering S1' substrate binding pocket to enhance substrate specificity and catalytic activity of thermal-stable keratinase for efficient keratin degradation
    Int J Biol Macromol263, 130688-130688. PubMed  Europe PubMed DOI
  7. Sanchez-Fernandez,R., Sanda-Ares,M., Lamas,N., Cuesta,T., Martinez,J.L., Fernandez-Trillo,P. and Pazos,E.
    Luminescent Ln(III)-Metallopeptide Sensors for Monitoring Pseudomonas aeruginosa Elastase B Activity in Complex Biological Media
    ACS Sens9, 5052-5057. PubMed  Europe PubMed DOI
    8. 2023
  8. Konstantinovic,J., Kany,A.M., Alhayek,A., Abdelsamie,A.S., Sikandar,A., Voos,K., Yao,Y., Andreas,A., Shafiei,R., Loretz,B., Schonauer,E., Bals,R., Brandstetter,H., Hartmann,R.W., Ducho,C., Lehr,C.M., Beisswenger,C., Muller,R., Rox,K., Haupenthal,J. and Hirsch,A.K.H.
    Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections
    ACS Cent Sci9, 2205-2215. PubMed  Europe PubMed DOI
    9. 2022
  9. Camberlein,V., Jezequel,G., Haupenthal,J. and Hirsch,A.K.H.
    The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB
    Antibiotics (Basel)11, PubMed  Europe PubMed DOI  V
  10. Kaya,C., Walter,I., Alhayek,A., Shafiei,R., Jezequel,G., Andreas,A., Konstantinovic,J., Schonauer,E., Sikandar,A., Haupenthal,J., Muller,R., Brandstetter,H., Hartmann,R.W. and Hirsch,A.K.H.
    Structure-Based Design of alpha-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa
    ACS Infect Dis8, 1010-1021. PubMed  Europe PubMed DOI
  11. Shin,Y., Li,X.H., Lee,C.S. and Lee,J.H.
    Mutational analysis on stable expression and LasB inhibition of LasB propeptide in Pseudomonas aeruginosa
    J Microbiol60, 727-734. PubMed  Europe PubMed DOI
    12. 2021
  12. Everett,M.J. and Davies,D.T.
    Pseudomonas aeruginosa elastase (LasB) as a therapeutic target
    Drug Discov Today PubMed  Europe PubMed DOI  V
  13. Leiris,S., Davies,D.T., Sprynski,N., Castandet,J., Beyria,L., Bodnarchuk,M.S., Sutton,J.M., Mullins,T.M.G., Jones,M.W., Forrest,A.K., Pallin,T.D., Karunakar,P., Martha,S.K., Parusharamulu,B., Ramula,R., Kotha,V., Pottabathini,N., Pothukanuri,S., Lemonnier,M. and Everett,M.
    Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors
    ACS Med Chem Lett12, 217-227. PubMed  Europe PubMed DOI  I
  14. Penaloza,H.F., Olonisakin,T.F., Bain,W.G., Qu,Y., van der Geest,R., Zupetic,J., Hulver,M., Xiong,Z., Newstead,M.W., Zou,C., Alder,J.K., Ybe,J.A., Standiford,T.J. and Lee,J.S.
    Thrombospondin-1 Restricts Interleukin-36gamma-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection
    MBio12, PubMed  Europe PubMed DOI
  15. Santajit,S., Kong-Ngoen,T., Chongsa-nguan,M., Boonyuen,U., Pumirat,P., Sookrung,N., Chaicumpa,W. and Indrawattana,N.
    Human Single-Chain Antibodies That Neutralize Elastolytic Activity of Pseudomonas aeruginosa LasB
    Pathogens10, PubMed  Europe PubMed DOI
  16. Scheithauer,L., Thiem,S., Schmelz,S., Dellmann,A., Bussow,K., Brouwer,R.M.H.J., Unal,C.M., Blankenfeldt,W. and Steinert,M.
    Zinc metalloprotease ProA of Legionella pneumophila increases alveolar septal thickness in human lung tissue explants by collagen IV degradation
    Cell Microbiole13313-e13313. PubMed  Europe PubMed DOI
  17. Vermilyea,D.M., Crocker,A.W., Gifford,A.H. and Hogan,D.A.
    Calprotectin-mediated zinc chelation inhibits Pseudomonas aeruginosa protease activity in cystic fibrosis sputum
    J Bacteriol PubMed  Europe PubMed DOI
    18. 2020
  18. Ezawa,T., Saito,R., Suzuki,S., Sugiyama,S., Sylte,I. and Kurita,N.
    Protonation states of central amino acids in a zinc metalloprotease complexed with inhibitor: molecular mechanics optimizations and ab initio molecular orbital calculations
    Biophys Chem261, 106368-106368. PubMed  Europe PubMed DOI  S  I
  19. Fiebig,D., Anderl,A., Al Djaizani,S., Kolmar,H. and Fuchsbauer,H.L.
    Dissecting capture and twisting of aureolysin and pseudolysin: functional amino acids of the Dispase autolysis-inducing protein
    Biochem J477, 2595-2606. PubMed  Europe PubMed DOI
  20. Zhu,F., He,B., Gu,F., Deng,H., Chen,C., Wang,W. and Chen,N.
    Improvement in organic solvent resistance and activity of metalloprotease by directed evolution
    J Biotechnol309, 68-74. PubMed  Europe PubMed DOI
    21. 2019
  21. Eisenhardt,M., Schlupp,P., Hofer,F., Schmidts,T., Hoffmann,D., Czermak,P., Poppel,A.K., Vilcinskas,A. and Runkel,F.
    The therapeutic potential of the insect metalloproteinase inhibitor against infections caused by Pseudomonas aeruginosa
    J Pharm Pharmacol71, 316-328. PubMed  Europe PubMed DOI
  22. Ma,L., Zhou,L., Lin,J., Ji,J., Wang,Y., Jiang,H., Shen,X. and Lu,Z.
    Manipulation of the silkworm immune system by a metalloprotease from the pathogenic bacterium Pseudomonas aeruginosa
    Dev Comp Immunol90, 176-185. PubMed  Europe PubMed DOI
  23. Said,Z.S.A.M., Arifi,F.A.M., Salleh,A.B., Rahman,R.N.Z.R.A., Leow,A.T.C., Latip,W. and Ali,M.S.M.
    Unravelling protein-organic solvent interaction of organic solvent tolerant elastase from Pseudomonas aeruginosa strain K crystal structure
    Int J Biol Macromol127, 575-584. PubMed  Europe PubMed DOI  S
    24. 2018
  24. Kany,A.M., Sikandar,A., Yahiaoui,S., Haupenthal,J., Walter,I., Empting,M., Kohnke,J. and Hartmann,R.W.
    Tackling Pseudomonas aeruginosa virulence by a hydroxamic acid-based LasB inhibitor
    ACS Chem Biol13, 2449-2455. PubMed  Europe PubMed DOI  I
  25. Kany,A.M., Sikandar,A., Haupenthal,J., Yahiaoui,S., Maurer,C.K., Proschak,E., Kohnke,J. and Hartmann,R.W.
    Binding mode characterization and early in vivo evaluation of fragment-like thiols as inhibitors of the virulence factor LasB from Pseudomonas aeruginosa
    ACS Infect Dis4, 988-997. PubMed  Europe PubMed DOI  I
  26. Saint-Criq,V., Villeret,B., Bastaert,F., Kheir,S., Hatton,A., Cazes,A., Xing,Z., Sermet-Gaudelus,I., Garcia-Verdugo,I., Edelman,A. and Sallenave,J.M.
    Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator-IL-6-antimicrobial-repair pathway
    Thorax73, 49-61. PubMed  Europe PubMed DOI
  27. Saraiva,R.G., Fang,J., Kang,S., Anglero-Rodriguez,Y.I., Dong,Y. and Dimopoulos,G.
    Aminopeptidase secreted by Chromobacterium sp. Panama inhibits dengue virus infection by degrading the E protein
    PLoS Negl Trop Dis12, e0006443-e0006443. PubMed  Europe PubMed DOI
  28. Zhu,F., Jiang,T., Wu,B. and He,B.
    Enhancement of Z-aspartame synthesis by rational engineering of metalloprotease
    Food Chem253, 30-36. PubMed  Europe PubMed DOI
    29. 2017
  29. Ara,A., Kadoya,R., Ishimura,H., Shimamura,K., Sylte,I. and Kurita,N.
    Specific interactions between zinc metalloproteinase and its inhibitors: Ab initio fragment molecular orbital calculations
    J Mol Graph Model75, 277-286. PubMed  Europe PubMed DOI  I
  30. Kareem,S.M., Al-Kadmy,I.M.S., Al-Kaabi,M.H., Aziz,S.N. and Ahmad,M.
    Acinetobacter baumannii virulence is enhanced by the combined presence of virulence factors genes phospholipase C (plcN) and elastase (lasB)
    Microb Pathog110, 568-572. PubMed  Europe PubMed DOI
    31. 2016
  31. Sjoli,S., Nuti,E., Camodeca,C., Bilto,I., Rossello,A., Winberg,J.O., Sylte,I. and Adekoya,O.A.
    Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors
    Eur J Med Chem108, 141-153. PubMed  Europe PubMed DOI  I
  32. Szamosvari,D., Reichle,V.F., Jureschi,M. and Bottcher,T.
    Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa
    Chem Commun (Camb)52, 13440-13443. PubMed  Europe PubMed DOI  I
  33. van der Plas,M.J., Bhongir,R.K., Kjellstrom,S., Siller,H., Kasetty,G., Morgelin,M. and Schmidtchen,A.
    Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
    Nat Commun7, 11567-11567. PubMed  Europe PubMed DOI
  34. Zhu,F., Liu,F., Wu,B. and He,B.
    Efficient extracellular expression of metalloprotease for Z-aspartame synthesis
    J Agric Food Chem64, 9631-9638. PubMed  Europe PubMed DOI
    35. 2015
  35. Adekoya,O.A., Sjoli,S., Wuxiuer,Y., Bilto,I., Marques,S.M., Santos,M.A., Nuti,E., Cercignani,G., Rossello,A., Winberg,J.-O. and Sylte,I.
    Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors
    Eur J Med Chem89, 340-348. PubMed  Europe PubMed DOI  I
  36. Bian,F., Yue,S., Peng,Z., Zhang,X., Chen,G., Yu,J., Xuan,N. and Bi,Y.
    A comprehensive alanine-scanning mutagenesis study reveals roles for salt bridges in the structure and activity of Pseudomonas aeruginosa elastase
    PLoS ONE10, e0121108-e0121108. PubMed  Europe PubMed DOI  S
  37. Casilag,F., Lorenz,A., Krueger,J., Klawonn,F., Weiss,S. and Haussler,S.
    The LasB elastase of Pseudomonas aeruginosa acts in concert with alkaline protease AprA to prevent flagellin-mediated immune recognition
    Infect Immun84, 162-171. PubMed  Europe PubMed DOI
  38. Odunuga,O.O., Adekoya,O.A. and Sylte,I.
    High-level expression of pseudolysin, the extracellular elastase of Pseudomonas aeruginosa, in Escherichia coli and its purification
    Protein Expr Purif113, 79-84. PubMed  Europe PubMed DOI  E
  39. Wei,G., Tian,N., Valery,A.C., Zhong,Y., Schuppan,D. and Helmerhorst,E.J.
    Identification of pseudolysin (lasB) as an aciduric gluten-degrading enzyme with high therapeutic potential for celiac disease
    Am J Gastroenterol110, 899-908. PubMed  Europe PubMed DOI
  40. Yang,J., Zhao,H.L., Ran,L.Y., Li,C.Y., Zhang,X.Y., Su,H.N., Shi,M., Zhou,B.C., Chen,X.L. and Zhang,Y.Z.
    Mechanistic insights into elastin degradation by pseudolysin, the major virulence factor of the opportunistic pathogen Pseudomonas aeruginosa
    Sci Rep5, 9936- PubMed  Europe PubMed DOI
  41. Zhu,F., Zhuang,Y. and He,B.
    [Cloning and expression of protease PT121 from Pseudomonas aeruginosa and application in peptide synthesis]
    Wei Sheng Wu Xue Bao55, 67-72. PubMed  Europe PubMed
    42. 2014
  42. Golovkine,G., Faudry,E., Bouillot,S., Voulhoux,R., Attree,I. and Huber,P.
    VE-Cadherin cleavage by LasB protease from Pseudomonas aeruginosa facilitates type III secretion system toxicity in endothelial cells
    PLoS Pathog10, e1003939-e1003939. PubMed  Europe PubMed DOI
  43. Han,M., Wang,X., Ding,H., Jin,M., Yu,L., Wang,J. and Yu,X.
    The role of N-glycosylation sites in the activity, stability, and expression of the recombinant elastase expressed by Pichia pastoris
    Enzyme Microb Technol54, 32-37. PubMed  Europe PubMed DOI  E
  44. Han,M., Wang,W., Jiang,G., Wang,X., Liu,X., Cao,H., Tao,Y. and Yu,X.
    Enhanced expression of recombinant elastase in Pichia pastoris through addition of N-glycosylation sites to the propeptide
    Biotechnol Lett36, 2467-2471. PubMed  Europe PubMed DOI  E
  45. Jovic,S., Shikhagaie,M., Morgelin,M., Kjellstrom,S., Erjefalt,J., Olin,A.I., Frick,I.M. and Egesten,A.
    Expression of MIG/CXCL9 in cystic fibrosis and modulation of its activities by elastase of Pseudomonas aeruginosa
    J Innate Immun6, 846-859. PubMed  Europe PubMed DOI
  46. Kessler,E. and Safrin,M.
    Elastinolytic and proteolytic enzymes
    Methods Mol Biol1149, 135-169. PubMed  Europe PubMed DOI  V
  47. Nomura,K., Obata,K., Keira,T., Miyata,R., Hirakawa,S., Takano,K., Kohno,T., Sawada,N., Himi,T. and Kojima,T.
    Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells
    Respir Res15, 21-21. PubMed  Europe PubMed DOI
  48. Simard,M., Hill,L.A., Underhill,C.M., Keller,B.O., Villanueva,I., Hancock,R.E. and Hammond,G.L.
    Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin
    Endocrinology155, 2900-2908. PubMed  Europe PubMed DOI
  49. Yu,H., He,X., Xie,W., Xiong,J., Sheng,H., Guo,S., Huang,C., Zhang,D. and Zhang,K.
    Elastase LasB of Pseudomonas aeruginosa promotes biofilm formation partly through rhamnolipid-mediated regulation
    Can J Microbiol60, 227-235. PubMed  Europe PubMed DOI
    50. 2013
  50. Ali,M.S., Said,Z.S., Rahman,R.N., Chor,A.L., Basri,M. and Salleh,A.B.
    Capillary-seeding crystallization and preliminary crystallographic analysis of a solvent-tolerant elastase from Pseudomonas aeruginosa strain K
    Int J Mol Sci14, 17608-17617. PubMed  Europe PubMed DOI
  51. Fullagar,J.L., Garner,A.L., Struss,A.K., Day,J.A., Martin,D.P., Yu,J., Cai,X., Janda,K.D. and Cohen,S.M.
    Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase
    Chem Commun (Camb)49, 3197-3199. PubMed  Europe PubMed DOI  I
  52. Han,M., Ding,H., Wang,J., Jin,M. and Yu,X.
    Expression of the lasB gene encoding an organic solvent-stable elastase in Pichia pastoris and potential applications of the recombinant enzymes in peptide synthesis
    Biochem Eng J77, 154-160. DOI  E
  53. Jaouadi,B., Zarai Jaouadi,N., Rekik,H., Naili,B., Beji,A., Dhouib,A. and Bejar,S.
    Biochemical and molecular characterization of Pseudomonas aeruginosa CTM50182 organic solvent-stable elastase
    Int J Biol Macromol60, 165-177. PubMed  Europe PubMed DOI
  54. Raftari,M., Ghafourian,S., Sadeghifard,N. and Abu Bakar,F.
    Cloning and overexpression of extracellular elastase from Pseudomonas aeruginosa
    Eur J Inflamm11, 55-60.  E
  55. Xu,J., Sun,H., He,X., Bai,Z. and He,B.
    Highly efficient synthesis of endomorphin-2 under thermodynamic control catalyzed by organic solvent stable proteases with in situ product removal
    Bioresour Technol129, 663-666. PubMed  Europe PubMed DOI
    56. 2012
  56. Carson,L., Cathcart,G.R., Ceri,H., Walker,B. and Gilmore,B.F.
    Comparison of the binding specificity of two bacterial metalloproteases, LasB of Pseudomonas aeruginosa and ZapA of Proteus mirabilis, using N-alpha mercaptoamide template-based inhibitor analogues
    Biochem Biophys Res Commun422, 316-320. PubMed  Europe PubMed DOI  I
  57. Kessler,E. and Ohman,D.E.
    Pseudolysin
    [ISSN:978-0-12-407744-7]3, 582-592. DOI
  58. Lousa,D., Baptista,A.M. and Soares,C.M.
    Analyzing the molecular basis of enzyme stability in ethanol/water mixtures using molecular dynamics simulations
    J Chem Inf Model52, 465-473. PubMed  Europe PubMed DOI
  59. Takenaka,S., Hano,S., Cheng,M., Yoshida,K. and Aoki,K.
    Organic solvent-tolerant elastase efficiently hydrolyzes insoluble, cross-linked, protein fiber of eggshell membranes
    Biotechnol Lett34, 949-955. PubMed  Europe PubMed DOI
    60. 2011
  60. Beaufort,N., Corvazier,E., Hervieu,A., Choqueux,C., Dussiot,M., Louedec,L., Cady,A., de Bentzmann,S., Michel,J.B. and Pidard,D.
    The thermolysin-like metalloproteinase and virulence factor LasB from pathogenic Pseudomonas aeruginosa induces anoikis of human vascular cells
    Cell Microbiol13, 1149-1167. PubMed  Europe PubMed DOI
  61. Cathcart,G.R., Quinn,D., Greer,B., Harriott,P., Lynas,J.F., Gilmore,B.F. and Walker,B.
    Novel inhibitors of the Pseudomonas aeruginosa virulence factor LasB: a potential therapeutic approach for the attenuation of virulence mechanisms in pseudomonal infection
    Antimicrob Agents Chemother55, 2670-2678. PubMed  Europe PubMed DOI  I
  62. Kuang,Z., Hao,Y., Walling,B.E., Jeffries,J.L., Ohman,D.E. and Lau,G.W.
    Pseudomonas aeruginosa elastase provides an escape from phagocytosis by degrading the pulmonary surfactant protein-A
    PLoS ONE6, e27091-e27091. PubMed  Europe PubMed DOI
  63. Pandeeti,E.V., Pitchika,G.K., Jotshi,J., Nilegaonkar,S.S., Kanekar,P.P. and Siddavattam,D.
    Enzymatic depilation of animal hide: identification of elastase (LasB) from Pseudomonas aeruginosa MCM B-327 as a depilating protease
    PLoS ONE6, e16742-e16742. PubMed  Europe PubMed DOI
  64. Sharma,R., Murty,N.A. and Gupta,R.
    Molecular characterization of N-terminal pro-sequence of keratinase Ker P from Pseudomonas aeruginosa: identification of region with chaperone activity
    Appl Biochem Biotechnol165, 892-901. PubMed  Europe PubMed DOI
    65. 2010
  65. Beaufort,N., Seweryn,P., de Bentzmann,S., Tang,A., Kellermann,J., Grebenchtchikov,N., Schmitt,M., Sommerhoff,C.P., Pidard,D. and Magdolen,V.
    Activation of human pro-urokinase by unrelated proteases secreted by Pseudomonas aeruginosa
    Biochem J428, 473-482. PubMed  Europe PubMed DOI
  66. Guyot,N., Bergsson,G., Butler,M.W., Greene,C.M., Weldon,S., Kessler,E., Levine,R.L., O'Neill,S.J., Taggart,C.C. and McElvaney,N.G.
    Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases
    Biol Chem391, 705-716. PubMed  Europe PubMed DOI  P
  67. Ogino,H., Tsuchiyama,S., Yasuda,M. and Doukyu,N.
    Enhancement of the aspartame precursor synthetic activity of an organic solvent-stable protease
    Protein Eng Des Sel23, 147-152. PubMed  Europe PubMed DOI
  68. Sharma,R. and Gupta,R.
    Extracellular expression of keratinase Ker P from Pseudomonas aeruginosa in E. coli
    Biotechnol Lett32, 1863-1868. PubMed  Europe PubMed DOI
  69. Tang,X.Y., Wu,B., Ying,H.J. and He,B.F.
    Biochemical properties and potential applications of a solvent-stable protease from the high-yield protease producer Pseudomonas aeruginosa PT121
    Appl Biochem Biotechnol160, 1017-1031. PubMed  Europe PubMed DOI
    70. 2009
  70. Cathcart,G.R., Gilmore,B.F., Greer,B., Harriott,P. and Walker,B.
    Inhibitor profiling of the Pseudomonas aeruginosa virulence factor LasB using N-alpha mercaptoamide template-based inhibitors
    Bioorg Med Chem Lett19, 6230-6232. PubMed  Europe PubMed DOI  I
  71. Lin,X., Xu,W., Huang,K., Mei,X., Liang,Z., Li,Z., Guo,J. and Luo,Y.
    Cloning, expression and characterization of recombinant elastase from Pseudomonas aeruginosa in Picha pastoris
    Protein Expr Purif63, 69-74. PubMed  Europe PubMed DOI  E
  72. Mun,J.J., Tam,C., Kowbel,D., Hawgood,S., Barnett,M.J., Evans,D.J. and Fleiszig,S.M.
    Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model
    Infect Immun77, 2392-2398. PubMed  Europe PubMed DOI
    73. 2008
  73. Gupta,A., Ray,S., Kapoor,S. and Khare,S.K.
    Solvent-stable Pseudomonas aeruginosa PseA protease gene: identification, molecular characterization, phylogenetic and bioinformatic analysis to study reasons for solvent stability
    J Mol Microbiol Biotechnol15, 234-243. PubMed  Europe PubMed DOI
    74. 2007
  74. Elston,C., Wallach,J. and Saulnier,J.
    New continuous and specific fluorometric assays for Pseudomonas aeruginosa elastase and LasA protease
    Anal Biochem368, 87-94. PubMed  Europe PubMed DOI  A
  75. Leduc,D., Beaufort,N., de Bentzmann,S., Rousselle,J.C., Namane,A., Chignard,M. and Pidard,D.
    The Pseudomonas aeruginosa LasB metalloproteinase regulates the human urokinase-type plasminogen activator receptor through domain-specific endoproteolysis
    Infect Immun75, 3848-3858. PubMed  Europe PubMed DOI  P
  76. Ogino,H., Uchiho,T., Doukyu,N., Yasuda,M., Ishimi,K. and Ishikawa,H.
    Effect of exchange of amino acid residues of the surface region of the PST-01 protease on its organic solvent-stability
    Biochem Biophys Res Commun358, 1028-1033. PubMed  Europe PubMed DOI
  77. Thibodeaux,B.A., Caballero,A.R., Marquart,M.E., Tommassen,J. and O'Callaghan,R.J.
    Corneal virulence of Pseudomonas aeruginosa elastase B and alkaline protease produced by Pseudomonas putida
    Curr Eye Res32, 373-386. PubMed  Europe PubMed DOI
  78. Tsuchiyama,S., Doukyu,N., Yasuda,M., Ishimi,K. and Ogino,H.
    Peptide synthesis of aspartame precursor using organic-solvent-stable PST-01 protease in monophasic aqueous-organic solvent systems
    Biotechnol Prog23, 820-823. PubMed  Europe PubMed DOI
    79. 2005
  79. [YEAR:10-2-2005]Dulon,S., Leduc,D., Cottrell,G.S., D'Alayer,J., Hansen,K.K., Bunnett,N.W., Hollenberg,M.D., Pidard,D. and Chignard,M.
    Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells
    Am J Respir Cell Mol Biol32, 411-419. PubMed  Europe PubMed DOI
    80. 2004
  80. [YEAR:3-5-2004]Alcorn,J.F. and Wright,J.R.
    Degradation of pulmonary surfactant protein D by Pseudomonas aeruginosa elastase abrogates innate immune function
    J Biol Chem279, 30871-30879. PubMed  Europe PubMed DOI
  81. [YEAR:5-5-2004]Bobe,I.M., Abdelmoez,W., Ogino,H., Yasuda,M., Ishimi,K. and Ishikawa,H.
    Kinetics and mechanism of a reaction catalyzed by PST-01 protease from Pseudomonas aeruginosa PST-01
    Biotechnol Bioeng86, 365-373. PubMed  Europe PubMed DOI
  82. Kessler,E. and Ohman,D.E.
    Pseudolysin
    [ISSN:0-12-079610-4]2, 401-409.  V
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