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Literature for peptidase M04.005: pseudolysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Abdelsamie,A.S., Konstantinovic,J., Kany,A.M., Schutz,C., Kolling,D., Speicher,S., Klein,A., Shafiei,R., Boute,M., Mundry,K., Park,Y.M., Loretz,B., Muller,R., Sallenave,J.M., Lehr,C.M., Koehnke,J., Rox,K., Haupenthal,J. and Hirsch,A.K.H.
    Multiparameter Optimization of Pseudomonas aeruginosa Elastase Inhibitors for Systemic Administration
    J Med Chem (2026) PubMed  Europe PubMed DOI
    2. 2025
  2. Chen,Y., Li,M., Chen,H., Saeed,M., Ni,Z., Guo,Z., Fang,Z. and Feng,Y.
    Directed evolution modification of the keratinase KerD21 and application in feather powder fermented feed
    J Sci Food Agric (2025) PubMed  Europe PubMed DOI
  3. Kiefer,A.F., Schutz,C., Englisch,C.N., Kolling,D., Speicher,S., Kany,A.M., Shafiei,R., Wadood,N.A., Aljohmani,A., Wirschem,N., Jumde,R.P., Klein,A., Sikandar,A., Park,Y.M., Krasteva-Christ,G., Yildiz,D., Abdelsamie,A.S., Rox,K., Kohnke,J., Muller,R., Bischoff,M., Haupenthal,J. and Hirsch,A.K.H.
    Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model
    Adv Sci (Weinh) (2025) , e2411807-e2411807. PubMed  Europe PubMed DOI
  4. Lee,C.S., Li,X.H., Jeon,C.R. and Lee,J.H.
    LasB activation in Pseudomonas aeruginosa: Quorum sensing-mediated release of an auto-activation inhibitor
    J Microbiol (2025) 63, e2411005-e2411005. PubMed  Europe PubMed DOI
  5. Reichhardt,C., Matwichuk,M.L., Lewerke,L.T., Jacobs,H.M., Yan,J. and Parsek,M.R.
    Non-disruptive matrix turnover is a conserved feature of biofilm aggregate growth in paradigm pathogenic species
    MBio (2025) , e0393524-e0393524. PubMed  Europe PubMed DOI
  6. Sandri,A. and Boschi,F.
    Exploring Proteases as Alternative Molecular Targets to Tackle Inflammation in Cystic Fibrosis Respiratory Infections
    Int J Mol Sci (2025) 26 PubMed  Europe PubMed DOI  PMC  EPMC  V
  7. Wauters,M., Van den Bossche,S., Grassi,L., Fernandes Goncalves,M., Van Haver,D., Dufour,S., Devos,S., Meuris,L., Impens,F., Saelens,X. and Crabbe,A.
    Unraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of Pseudomonas aeruginosa in an organotypic 3D lung epithelial cell model
    Virulence (2025) 16, 2581889-2581889. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2024
  8. Keim,K., Bhattacharya,M., Crosby,H.A., Jenul,C., Mills,K., Schurr,M. and Horswill,A.
    Polymicrobial interactions between Staphylococcus aureus and Pseudomonas aeruginosa promote biofilm formation and persistence in chronic wound infections
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  9. Metelkina,O., Konstantinovic,J., Klein,A., Shafiei,R., Fares,M., Alhayek,A., Yahiaoui,S., Elgaher,W.A.M., Haupenthal,J., Titz,A. and Hirsch,A.K.H.
    Dual inhibitors of Pseudomonas aeruginosa virulence factors M04.005 and LasB
    Chem Sci (2024) 15, 13333-13342. PubMed  Europe PubMed DOI  PMC  EPMC  I
  10. Pei,X.D., Fan,H.L., Jiao,D.Q., Li,F., He,Y.N., Wu,Q.L., Liu,X.L. and Wang,C.H.
    Rational engineering S1' substrate binding pocket to enhance substrate specificity and catalytic activity of thermal-stable keratinase for efficient keratin degradation
    Int J Biol Macromol (2024) 263, 130688-130688. PubMed  Europe PubMed DOI
  11. Sanchez-Fernandez,R., Sanda-Ares,M., Lamas,N., Cuesta,T., Martinez,J.L., Fernandez-Trillo,P. and Pazos,E.
    Luminescent Ln(III)-Metallopeptide Sensors for Monitoring Pseudomonas aeruginosa Elastase B Activity in Complex Biological Media
    ACS Sens (2024) 9, 5052-5057. PubMed  Europe PubMed DOI
    12. 2023
  12. Konstantinovic,J., Kany,A.M., Alhayek,A., Abdelsamie,A.S., Sikandar,A., Voos,K., Yao,Y., Andreas,A., Shafiei,R., Loretz,B., Schonauer,E., Bals,R., Brandstetter,H., Hartmann,R.W., Ducho,C., Lehr,C.M., Beisswenger,C., Muller,R., Rox,K., Haupenthal,J. and Hirsch,A.K.H.
    Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections
    ACS Cent Sci (2023) 9, 2205-2215. PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2022
  13. Camberlein,V., Jezequel,G., Haupenthal,J. and Hirsch,A.K.H.
    The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB
    Antibiotics (Basel) (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC  V
  14. Kaya,C., Walter,I., Alhayek,A., Shafiei,R., Jezequel,G., Andreas,A., Konstantinovic,J., Schonauer,E., Sikandar,A., Haupenthal,J., Muller,R., Brandstetter,H., Hartmann,R.W. and Hirsch,A.K.H.
    Structure-Based Design of alpha-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa
    ACS Infect Dis (2022) 8, 1010-1021. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Shin,Y., Li,X.H., Lee,C.S. and Lee,J.H.
    Mutational analysis on stable expression and LasB inhibition of LasB propeptide in Pseudomonas aeruginosa
    J Microbiol (2022) 60, 727-734. PubMed  Europe PubMed DOI
    16. 2021
  16. Everett,M.J. and Davies,D.T.
    Pseudomonas aeruginosa elastase (LasB) as a therapeutic target
    Drug Discov Today (2021) PubMed  Europe PubMed DOI  V
  17. Leiris,S., Davies,D.T., Sprynski,N., Castandet,J., Beyria,L., Bodnarchuk,M.S., Sutton,J.M., Mullins,T.M.G., Jones,M.W., Forrest,A.K., Pallin,T.D., Karunakar,P., Martha,S.K., Parusharamulu,B., Ramula,R., Kotha,V., Pottabathini,N., Pothukanuri,S., Lemonnier,M. and Everett,M.
    Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors
    ACS Med Chem Lett (2021) 12, 217-227. PubMed  Europe PubMed DOI  PMC  EPMC  I
  18. Penaloza,H.F., Olonisakin,T.F., Bain,W.G., Qu,Y., van der Geest,R., Zupetic,J., Hulver,M., Xiong,Z., Newstead,M.W., Zou,C., Alder,J.K., Ybe,J.A., Standiford,T.J. and Lee,J.S.
    Thrombospondin-1 Restricts Interleukin-36gamma-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection
    MBio (2021) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  19. Santajit,S., Kong-Ngoen,T., Chongsa-nguan,M., Boonyuen,U., Pumirat,P., Sookrung,N., Chaicumpa,W. and Indrawattana,N.
    Human Single-Chain Antibodies That Neutralize Elastolytic Activity of Pseudomonas aeruginosa LasB
    Pathogens (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  20. Scheithauer,L., Thiem,S., Schmelz,S., Dellmann,A., Bussow,K., Brouwer,R.M.H.J., Unal,C.M., Blankenfeldt,W. and Steinert,M.
    Zinc metalloprotease ProA of Legionella pneumophila increases alveolar septal thickness in human lung tissue explants by collagen IV degradation
    Cell Microbiol (2021) , e13313-e13313. PubMed  Europe PubMed DOI
  21. Vermilyea,D.M., Crocker,A.W., Gifford,A.H. and Hogan,D.A.
    Calprotectin-mediated zinc chelation inhibits Pseudomonas aeruginosa protease activity in cystic fibrosis sputum
    J Bacteriol (2021) PubMed  Europe PubMed DOI
    22. 2020
  22. Ezawa,T., Saito,R., Suzuki,S., Sugiyama,S., Sylte,I. and Kurita,N.
    Protonation states of central amino acids in a zinc metalloprotease complexed with inhibitor: molecular mechanics optimizations and ab initio molecular orbital calculations
    Biophys Chem (2020) 261, 106368-106368. PubMed  Europe PubMed DOI  S  I
  23. Fiebig,D., Anderl,A., Al Djaizani,S., Kolmar,H. and Fuchsbauer,H.L.
    Dissecting capture and twisting of aureolysin and pseudolysin: functional amino acids of the Dispase autolysis-inducing protein
    Biochem J (2020) 477, 2595-2606. PubMed  Europe PubMed DOI
  24. Zhu,F., He,B., Gu,F., Deng,H., Chen,C., Wang,W. and Chen,N.
    Improvement in organic solvent resistance and activity of metalloprotease by directed evolution
    J Biotechnol (2020) 309, 68-74. PubMed  Europe PubMed DOI
    25. 2019
  25. Eisenhardt,M., Schlupp,P., Hofer,F., Schmidts,T., Hoffmann,D., Czermak,P., Poppel,A.K., Vilcinskas,A. and Runkel,F.
    The therapeutic potential of the insect metalloproteinase inhibitor against infections caused by Pseudomonas aeruginosa
    J Pharm Pharmacol (2019) 71, 316-328. PubMed  Europe PubMed DOI
  26. Ma,L., Zhou,L., Lin,J., Ji,J., Wang,Y., Jiang,H., Shen,X. and Lu,Z.
    Manipulation of the silkworm immune system by a metalloprotease from the pathogenic bacterium Pseudomonas aeruginosa
    Dev Comp Immunol (2019) 90, 176-185. PubMed  Europe PubMed DOI
  27. Said,Z.S.A.M., Arifi,F.A.M., Salleh,A.B., Rahman,R.N.Z.R.A., Leow,A.T.C., Latip,W. and Ali,M.S.M.
    Unravelling protein-organic solvent interaction of organic solvent tolerant elastase from Pseudomonas aeruginosa strain K crystal structure
    Int J Biol Macromol (2019) 127, 575-584. PubMed  Europe PubMed DOI  S
    28. 2018
  28. Kany,A.M., Sikandar,A., Yahiaoui,S., Haupenthal,J., Walter,I., Empting,M., Kohnke,J. and Hartmann,R.W.
    Tackling Pseudomonas aeruginosa virulence by a hydroxamic acid-based LasB inhibitor
    ACS Chem Biol (2018) 13, 2449-2455. PubMed  Europe PubMed DOI  I
  29. Kany,A.M., Sikandar,A., Haupenthal,J., Yahiaoui,S., Maurer,C.K., Proschak,E., Kohnke,J. and Hartmann,R.W.
    Binding mode characterization and early in vivo evaluation of fragment-like thiols as inhibitors of the virulence factor LasB from Pseudomonas aeruginosa
    ACS Infect Dis (2018) 4, 988-997. PubMed  Europe PubMed DOI  I
  30. Saint-Criq,V., Villeret,B., Bastaert,F., Kheir,S., Hatton,A., Cazes,A., Xing,Z., Sermet-Gaudelus,I., Garcia-Verdugo,I., Edelman,A. and Sallenave,J.M.
    Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator-IL-6-antimicrobial-repair pathway
    Thorax (2018) 73, 49-61. PubMed  Europe PubMed DOI
  31. Saraiva,R.G., Fang,J., Kang,S., Anglero-Rodriguez,Y.I., Dong,Y. and Dimopoulos,G.
    Aminopeptidase secreted by Chromobacterium sp. Panama inhibits dengue virus infection by degrading the E protein
    PLoS Negl Trop Dis (2018) 12, e0006443-e0006443. PubMed  Europe PubMed DOI
  32. Zhu,F., Jiang,T., Wu,B. and He,B.
    Enhancement of Z-aspartame synthesis by rational engineering of metalloprotease
    Food Chem (2018) 253, 30-36. PubMed  Europe PubMed DOI
    33. 2017
  33. Ara,A., Kadoya,R., Ishimura,H., Shimamura,K., Sylte,I. and Kurita,N.
    Specific interactions between zinc metalloproteinase and its inhibitors: Ab initio fragment molecular orbital calculations
    J Mol Graph Model (2017) 75, 277-286. PubMed  Europe PubMed DOI  I
  34. Kareem,S.M., Al-Kadmy,I.M.S., Al-Kaabi,M.H., Aziz,S.N. and Ahmad,M.
    Acinetobacter baumannii virulence is enhanced by the combined presence of virulence factors genes phospholipase C (plcN) and elastase (lasB)
    Microb Pathog (2017) 110, 568-572. PubMed  Europe PubMed DOI
    35. 2016
  35. Sjoli,S., Nuti,E., Camodeca,C., Bilto,I., Rossello,A., Winberg,J.O., Sylte,I. and Adekoya,O.A.
    Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors
    Eur J Med Chem (2016) 108, 141-153. PubMed  Europe PubMed DOI  I
  36. Szamosvari,D., Reichle,V.F., Jureschi,M. and Bottcher,T.
    Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa
    Chem Commun (Camb) (2016) 52, 13440-13443. PubMed  Europe PubMed DOI  I
  37. van der Plas,M.J., Bhongir,R.K., Kjellstrom,S., Siller,H., Kasetty,G., Morgelin,M. and Schmidtchen,A.
    Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
    Nat Commun (2016) 7, 11567-11567. PubMed  Europe PubMed DOI
  38. Zhu,F., Liu,F., Wu,B. and He,B.
    Efficient extracellular expression of metalloprotease for Z-aspartame synthesis
    J Agric Food Chem (2016) 64, 9631-9638. PubMed  Europe PubMed DOI
    39. 2015
  39. Adekoya,O.A., Sjoli,S., Wuxiuer,Y., Bilto,I., Marques,S.M., Santos,M.A., Nuti,E., Cercignani,G., Rossello,A., Winberg,J.-O. and Sylte,I.
    Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors
    Eur J Med Chem (2015) 89, 340-348. PubMed  Europe PubMed DOI  I
  40. Bian,F., Yue,S., Peng,Z., Zhang,X., Chen,G., Yu,J., Xuan,N. and Bi,Y.
    A comprehensive alanine-scanning mutagenesis study reveals roles for salt bridges in the structure and activity of Pseudomonas aeruginosa elastase
    PLoS ONE (2015) 10, e0121108-e0121108. PubMed  Europe PubMed DOI  PMC  EPMC  S
  41. Casilag,F., Lorenz,A., Krueger,J., Klawonn,F., Weiss,S. and Haussler,S.
    The LasB elastase of Pseudomonas aeruginosa acts in concert with alkaline protease AprA to prevent flagellin-mediated immune recognition
    Infect Immun (2015) 84, 162-171. PubMed  Europe PubMed DOI
  42. Odunuga,O.O., Adekoya,O.A. and Sylte,I.
    High-level expression of pseudolysin, the extracellular elastase of Pseudomonas aeruginosa, in Escherichia coli and its purification
    Protein Expr Purif (2015) 113, 79-84. PubMed  Europe PubMed DOI  E
  43. Wei,G., Tian,N., Valery,A.C., Zhong,Y., Schuppan,D. and Helmerhorst,E.J.
    Identification of pseudolysin (lasB) as an aciduric gluten-degrading enzyme with high therapeutic potential for celiac disease
    Am J Gastroenterol (2015) 110, 899-908. PubMed  Europe PubMed DOI
  44. Yang,J., Zhao,H.L., Ran,L.Y., Li,C.Y., Zhang,X.Y., Su,H.N., Shi,M., Zhou,B.C., Chen,X.L. and Zhang,Y.Z.
    Mechanistic insights into elastin degradation by pseudolysin, the major virulence factor of the opportunistic pathogen Pseudomonas aeruginosa
    Sci Rep (2015) 5, 9936- PubMed  Europe PubMed DOI
  45. Zhu,F., Zhuang,Y. and He,B.
    [Cloning and expression of protease PT121 from Pseudomonas aeruginosa and application in peptide synthesis]
    Wei Sheng Wu Xue Bao (2015) 55, 67-72. PubMed  Europe PubMed
    46. 2014
  46. Golovkine,G., Faudry,E., Bouillot,S., Voulhoux,R., Attree,I. and Huber,P.
    VE-Cadherin cleavage by LasB protease from Pseudomonas aeruginosa facilitates type III secretion system toxicity in endothelial cells
    PLoS Pathog (2014) 10, e1003939-e1003939. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Han,M., Wang,X., Ding,H., Jin,M., Yu,L., Wang,J. and Yu,X.
    The role of N-glycosylation sites in the activity, stability, and expression of the recombinant elastase expressed by Pichia pastoris
    Enzyme Microb Technol (2014) 54, 32-37. PubMed  Europe PubMed DOI  E
  48. Han,M., Wang,W., Jiang,G., Wang,X., Liu,X., Cao,H., Tao,Y. and Yu,X.
    Enhanced expression of recombinant elastase in Pichia pastoris through addition of N-glycosylation sites to the propeptide
    Biotechnol Lett (2014) 36, 2467-2471. PubMed  Europe PubMed DOI  E
  49. Jovic,S., Shikhagaie,M., Morgelin,M., Kjellstrom,S., Erjefalt,J., Olin,A.I., Frick,I.M. and Egesten,A.
    Expression of MIG/CXCL9 in cystic fibrosis and modulation of its activities by elastase of Pseudomonas aeruginosa
    J Innate Immun (2014) 6, 846-859. PubMed  Europe PubMed DOI
  50. Kessler,E. and Safrin,M.
    Elastinolytic and proteolytic enzymes
    Methods Mol Biol (2014) 1149, 135-169. PubMed  Europe PubMed DOI  V
  51. Nomura,K., Obata,K., Keira,T., Miyata,R., Hirakawa,S., Takano,K., Kohno,T., Sawada,N., Himi,T. and Kojima,T.
    Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells
    Respir Res (2014) 15, 21-21. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Simard,M., Hill,L.A., Underhill,C.M., Keller,B.O., Villanueva,I., Hancock,R.E. and Hammond,G.L.
    Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin
    Endocrinology (2014) 155, 2900-2908. PubMed  Europe PubMed DOI
  53. Yu,H., He,X., Xie,W., Xiong,J., Sheng,H., Guo,S., Huang,C., Zhang,D. and Zhang,K.
    Elastase LasB of Pseudomonas aeruginosa promotes biofilm formation partly through rhamnolipid-mediated regulation
    Can J Microbiol (2014) 60, 227-235. PubMed  Europe PubMed DOI
    54. 2013
  54. Ali,M.S., Said,Z.S., Rahman,R.N., Chor,A.L., Basri,M. and Salleh,A.B.
    Capillary-seeding crystallization and preliminary crystallographic analysis of a solvent-tolerant elastase from Pseudomonas aeruginosa strain K
    Int J Mol Sci (2013) 14, 17608-17617. PubMed  Europe PubMed DOI
  55. Fullagar,J.L., Garner,A.L., Struss,A.K., Day,J.A., Martin,D.P., Yu,J., Cai,X., Janda,K.D. and Cohen,S.M.
    Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase
    Chem Commun (Camb) (2013) 49, 3197-3199. PubMed  Europe PubMed DOI  I
  56. Han,M., Ding,H., Wang,J., Jin,M. and Yu,X.
    Expression of the lasB gene encoding an organic solvent-stable elastase in Pichia pastoris and potential applications of the recombinant enzymes in peptide synthesis
    Biochem Eng J (2013) 77, 154-160. DOI  E
  57. Jaouadi,B., Zarai Jaouadi,N., Rekik,H., Naili,B., Beji,A., Dhouib,A. and Bejar,S.
    Biochemical and molecular characterization of Pseudomonas aeruginosa CTM50182 organic solvent-stable elastase
    Int J Biol Macromol (2013) 60, 165-177. PubMed  Europe PubMed DOI
  58. Raftari,M., Ghafourian,S., Sadeghifard,N. and Abu Bakar,F.
    Cloning and overexpression of extracellular elastase from Pseudomonas aeruginosa
    Eur J Inflamm (2013) 11, 55-60.  E
  59. Xu,J., Sun,H., He,X., Bai,Z. and He,B.
    Highly efficient synthesis of endomorphin-2 under thermodynamic control catalyzed by organic solvent stable proteases with in situ product removal
    Bioresour Technol (2013) 129, 663-666. PubMed  Europe PubMed DOI
    60. 2012
  60. Carson,L., Cathcart,G.R., Ceri,H., Walker,B. and Gilmore,B.F.
    Comparison of the binding specificity of two bacterial metalloproteases, LasB of Pseudomonas aeruginosa and ZapA of Proteus mirabilis, using N-alpha mercaptoamide template-based inhibitor analogues
    Biochem Biophys Res Commun (2012) 422, 316-320. PubMed  Europe PubMed DOI  I
  61. Kessler,E. and Ohman,D.E.
    Pseudolysin
    [ISSN:978-0-12-407744-7] (2012) 3, 582-592. DOI
  62. Lousa,D., Baptista,A.M. and Soares,C.M.
    Analyzing the molecular basis of enzyme stability in ethanol/water mixtures using molecular dynamics simulations
    J Chem Inf Model (2012) 52, 465-473. PubMed  Europe PubMed DOI
  63. Takenaka,S., Hano,S., Cheng,M., Yoshida,K. and Aoki,K.
    Organic solvent-tolerant elastase efficiently hydrolyzes insoluble, cross-linked, protein fiber of eggshell membranes
    Biotechnol Lett (2012) 34, 949-955. PubMed  Europe PubMed DOI
    64. 2011
  64. Beaufort,N., Corvazier,E., Hervieu,A., Choqueux,C., Dussiot,M., Louedec,L., Cady,A., de Bentzmann,S., Michel,J.B. and Pidard,D.
    The thermolysin-like metalloproteinase and virulence factor LasB from pathogenic Pseudomonas aeruginosa induces anoikis of human vascular cells
    Cell Microbiol (2011) 13, 1149-1167. PubMed  Europe PubMed DOI
  65. Cathcart,G.R., Quinn,D., Greer,B., Harriott,P., Lynas,J.F., Gilmore,B.F. and Walker,B.
    Novel inhibitors of the Pseudomonas aeruginosa virulence factor LasB: a potential therapeutic approach for the attenuation of virulence mechanisms in pseudomonal infection
    Antimicrob Agents Chemother (2011) 55, 2670-2678. PubMed  Europe PubMed DOI  I
  66. Kuang,Z., Hao,Y., Walling,B.E., Jeffries,J.L., Ohman,D.E. and Lau,G.W.
    Pseudomonas aeruginosa elastase provides an escape from phagocytosis by degrading the pulmonary surfactant protein-A
    PLoS ONE (2011) 6, e27091-e27091. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Pandeeti,E.V., Pitchika,G.K., Jotshi,J., Nilegaonkar,S.S., Kanekar,P.P. and Siddavattam,D.
    Enzymatic depilation of animal hide: identification of elastase (LasB) from Pseudomonas aeruginosa MCM B-327 as a depilating protease
    PLoS ONE (2011) 6, e16742-e16742. PubMed  Europe PubMed DOI  PMC  EPMC
  68. Sharma,R., Murty,N.A. and Gupta,R.
    Molecular characterization of N-terminal pro-sequence of keratinase Ker P from Pseudomonas aeruginosa: identification of region with chaperone activity
    Appl Biochem Biotechnol (2011) 165, 892-901. PubMed  Europe PubMed DOI
    69. 2010
  69. Beaufort,N., Seweryn,P., de Bentzmann,S., Tang,A., Kellermann,J., Grebenchtchikov,N., Schmitt,M., Sommerhoff,C.P., Pidard,D. and Magdolen,V.
    Activation of human pro-urokinase by unrelated proteases secreted by Pseudomonas aeruginosa
    Biochem J (2010) 428, 473-482. PubMed  Europe PubMed DOI
  70. Guyot,N., Bergsson,G., Butler,M.W., Greene,C.M., Weldon,S., Kessler,E., Levine,R.L., O'Neill,S.J., Taggart,C.C. and McElvaney,N.G.
    Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases
    Biol Chem (2010) 391, 705-716. PubMed  Europe PubMed DOI  P
  71. Ogino,H., Tsuchiyama,S., Yasuda,M. and Doukyu,N.
    Enhancement of the aspartame precursor synthetic activity of an organic solvent-stable protease
    Protein Eng Des Sel (2010) 23, 147-152. PubMed  Europe PubMed DOI
  72. Sharma,R. and Gupta,R.
    Extracellular expression of keratinase Ker P from Pseudomonas aeruginosa in E. coli
    Biotechnol Lett (2010) 32, 1863-1868. PubMed  Europe PubMed DOI
  73. Tang,X.Y., Wu,B., Ying,H.J. and He,B.F.
    Biochemical properties and potential applications of a solvent-stable protease from the high-yield protease producer Pseudomonas aeruginosa PT121
    Appl Biochem Biotechnol (2010) 160, 1017-1031. PubMed  Europe PubMed DOI
    74. 2009
  74. Cathcart,G.R., Gilmore,B.F., Greer,B., Harriott,P. and Walker,B.
    Inhibitor profiling of the Pseudomonas aeruginosa virulence factor LasB using N-alpha mercaptoamide template-based inhibitors
    Bioorg Med Chem Lett (2009) 19, 6230-6232. PubMed  Europe PubMed DOI  I
  75. Lin,X., Xu,W., Huang,K., Mei,X., Liang,Z., Li,Z., Guo,J. and Luo,Y.
    Cloning, expression and characterization of recombinant elastase from Pseudomonas aeruginosa in Picha pastoris
    Protein Expr Purif (2009) 63, 69-74. PubMed  Europe PubMed DOI  E
  76. Mun,J.J., Tam,C., Kowbel,D., Hawgood,S., Barnett,M.J., Evans,D.J. and Fleiszig,S.M.
    Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model
    Infect Immun (2009) 77, 2392-2398. PubMed  Europe PubMed DOI  PMC  EPMC
    77. 2008
  77. Gupta,A., Ray,S., Kapoor,S. and Khare,S.K.
    Solvent-stable Pseudomonas aeruginosa PseA protease gene: identification, molecular characterization, phylogenetic and bioinformatic analysis to study reasons for solvent stability
    J Mol Microbiol Biotechnol (2008) 15, 234-243. PubMed  Europe PubMed DOI
    78. 2007
  78. Elston,C., Wallach,J. and Saulnier,J.
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