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Literature for peptidase M04.005: pseudolysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Abdelsamie,A.S., Konstantinovic,J., Kany,A.M., Schutz,C., Kolling,D., Speicher,S., Klein,A., Shafiei,R., Boute,M., Mundry,K., Park,Y.M., Loretz,B., Muller,R., Sallenave,J.M., Lehr,C.M., Koehnke,J., Rox,K., Haupenthal,J. and Hirsch,A.K.H.<br>Multiparameter Optimization of Pseudomonas aeruginosa Elastase Inhibitors for Systemic Administration<br>J Med Chem (2026) PubMed  Europe PubMed DOI
    2. 2025
  2. Chen,Y., Li,M., Chen,H., Saeed,M., Ni,Z., Guo,Z., Fang,Z. and Feng,Y.<br>Directed evolution modification of the keratinase KerD21 and application in feather powder fermented feed<br>J Sci Food Agric (2025) PubMed  Europe PubMed DOI
  3. Kiefer,A.F., Schutz,C., Englisch,C.N., Kolling,D., Speicher,S., Kany,A.M., Shafiei,R., Wadood,N.A., Aljohmani,A., Wirschem,N., Jumde,R.P., Klein,A., Sikandar,A., Park,Y.M., Krasteva-Christ,G., Yildiz,D., Abdelsamie,A.S., Rox,K., Kohnke,J., Muller,R., Bischoff,M., Haupenthal,J. and Hirsch,A.K.H.<br>Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model<br>Adv Sci (Weinh) (2025) , e2411807-e2411807. PubMed  Europe PubMed DOI
  4. Lee,C.S., Li,X.H., Jeon,C.R. and Lee,J.H.<br>LasB activation in Pseudomonas aeruginosa: Quorum sensing-mediated release of an auto-activation inhibitor<br>J Microbiol (2025) 63, e2411005-e2411005. PubMed  Europe PubMed DOI
  5. Reichhardt,C., Matwichuk,M.L., Lewerke,L.T., Jacobs,H.M., Yan,J. and Parsek,M.R.<br>Non-disruptive matrix turnover is a conserved feature of biofilm aggregate growth in paradigm pathogenic species<br>MBio (2025) , e0393524-e0393524. PubMed  Europe PubMed DOI
  6. Sandri,A. and Boschi,F.<br>Exploring Proteases as Alternative Molecular Targets to Tackle Inflammation in Cystic Fibrosis Respiratory Infections<br>Int J Mol Sci (2025) 26 PubMed  Europe PubMed DOI  PMC  EPMC  V
  7. Wauters,M., Van den Bossche,S., Grassi,L., Fernandes Goncalves,M., Van Haver,D., Dufour,S., Devos,S., Meuris,L., Impens,F., Saelens,X. and Crabbe,A.<br>Unraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of Pseudomonas aeruginosa in an organotypic 3D lung epithelial cell model<br>Virulence (2025) 16, 2581889-2581889. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2024
  8. Keim,K., Bhattacharya,M., Crosby,H.A., Jenul,C., Mills,K., Schurr,M. and Horswill,A.<br>Polymicrobial interactions between Staphylococcus aureus and Pseudomonas aeruginosa promote biofilm formation and persistence in chronic wound infections<br>bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  9. Metelkina,O., Konstantinovic,J., Klein,A., Shafiei,R., Fares,M., Alhayek,A., Yahiaoui,S., Elgaher,W.A.M., Haupenthal,J., Titz,A. and Hirsch,A.K.H.<br>Dual inhibitors of Pseudomonas aeruginosa virulence factors M04.005 and LasB<br>Chem Sci (2024) 15, 13333-13342. PubMed  Europe PubMed DOI  PMC  EPMC  I
  10. Pei,X.D., Fan,H.L., Jiao,D.Q., Li,F., He,Y.N., Wu,Q.L., Liu,X.L. and Wang,C.H.<br>Rational engineering S1' substrate binding pocket to enhance substrate specificity and catalytic activity of thermal-stable keratinase for efficient keratin degradation<br>Int J Biol Macromol (2024) 263, 130688-130688. PubMed  Europe PubMed DOI
  11. Sanchez-Fernandez,R., Sanda-Ares,M., Lamas,N., Cuesta,T., Martinez,J.L., Fernandez-Trillo,P. and Pazos,E.<br>Luminescent Ln(III)-Metallopeptide Sensors for Monitoring Pseudomonas aeruginosa Elastase B Activity in Complex Biological Media<br>ACS Sens (2024) 9, 5052-5057. PubMed  Europe PubMed DOI
    12. 2023
  12. Konstantinovic,J., Kany,A.M., Alhayek,A., Abdelsamie,A.S., Sikandar,A., Voos,K., Yao,Y., Andreas,A., Shafiei,R., Loretz,B., Schonauer,E., Bals,R., Brandstetter,H., Hartmann,R.W., Ducho,C., Lehr,C.M., Beisswenger,C., Muller,R., Rox,K., Haupenthal,J. and Hirsch,A.K.H.<br>Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections<br>ACS Cent Sci (2023) 9, 2205-2215. PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2022
  13. Camberlein,V., Jezequel,G., Haupenthal,J. and Hirsch,A.K.H.<br>The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB<br>Antibiotics (Basel) (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC  V
  14. Kaya,C., Walter,I., Alhayek,A., Shafiei,R., Jezequel,G., Andreas,A., Konstantinovic,J., Schonauer,E., Sikandar,A., Haupenthal,J., Muller,R., Brandstetter,H., Hartmann,R.W. and Hirsch,A.K.H.<br>Structure-Based Design of alpha-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa<br>ACS Infect Dis (2022) 8, 1010-1021. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Shin,Y., Li,X.H., Lee,C.S. and Lee,J.H.<br>Mutational analysis on stable expression and LasB inhibition of LasB propeptide in Pseudomonas aeruginosa<br>J Microbiol (2022) 60, 727-734. PubMed  Europe PubMed DOI
    16. 2021
  16. Everett,M.J. and Davies,D.T.<br>Pseudomonas aeruginosa elastase (LasB) as a therapeutic target<br>Drug Discov Today (2021) PubMed  Europe PubMed DOI  V
  17. Leiris,S., Davies,D.T., Sprynski,N., Castandet,J., Beyria,L., Bodnarchuk,M.S., Sutton,J.M., Mullins,T.M.G., Jones,M.W., Forrest,A.K., Pallin,T.D., Karunakar,P., Martha,S.K., Parusharamulu,B., Ramula,R., Kotha,V., Pottabathini,N., Pothukanuri,S., Lemonnier,M. and Everett,M.<br>Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors<br>ACS Med Chem Lett (2021) 12, 217-227. PubMed  Europe PubMed DOI  PMC  EPMC  I
  18. Penaloza,H.F., Olonisakin,T.F., Bain,W.G., Qu,Y., van der Geest,R., Zupetic,J., Hulver,M., Xiong,Z., Newstead,M.W., Zou,C., Alder,J.K., Ybe,J.A., Standiford,T.J. and Lee,J.S.<br>Thrombospondin-1 Restricts Interleukin-36gamma-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection<br>MBio (2021) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  19. Santajit,S., Kong-Ngoen,T., Chongsa-nguan,M., Boonyuen,U., Pumirat,P., Sookrung,N., Chaicumpa,W. and Indrawattana,N.<br>Human Single-Chain Antibodies That Neutralize Elastolytic Activity of Pseudomonas aeruginosa LasB<br>Pathogens (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  20. Scheithauer,L., Thiem,S., Schmelz,S., Dellmann,A., Bussow,K., Brouwer,R.M.H.J., Unal,C.M., Blankenfeldt,W. and Steinert,M.<br>Zinc metalloprotease ProA of Legionella pneumophila increases alveolar septal thickness in human lung tissue explants by collagen IV degradation<br>Cell Microbiol (2021) , e13313-e13313. PubMed  Europe PubMed DOI
  21. Vermilyea,D.M., Crocker,A.W., Gifford,A.H. and Hogan,D.A.<br>Calprotectin-mediated zinc chelation inhibits Pseudomonas aeruginosa protease activity in cystic fibrosis sputum<br>J Bacteriol (2021) PubMed  Europe PubMed DOI
    22. 2020
  22. Ezawa,T., Saito,R., Suzuki,S., Sugiyama,S., Sylte,I. and Kurita,N.<br>Protonation states of central amino acids in a zinc metalloprotease complexed with inhibitor: molecular mechanics optimizations and ab initio molecular orbital calculations<br>Biophys Chem (2020) 261, 106368-106368. PubMed  Europe PubMed DOI  S  I
  23. Fiebig,D., Anderl,A., Al Djaizani,S., Kolmar,H. and Fuchsbauer,H.L.<br>Dissecting capture and twisting of aureolysin and pseudolysin: functional amino acids of the Dispase autolysis-inducing protein<br>Biochem J (2020) 477, 2595-2606. PubMed  Europe PubMed DOI
  24. Zhu,F., He,B., Gu,F., Deng,H., Chen,C., Wang,W. and Chen,N.<br>Improvement in organic solvent resistance and activity of metalloprotease by directed evolution<br>J Biotechnol (2020) 309, 68-74. PubMed  Europe PubMed DOI
    25. 2019
  25. Eisenhardt,M., Schlupp,P., Hofer,F., Schmidts,T., Hoffmann,D., Czermak,P., Poppel,A.K., Vilcinskas,A. and Runkel,F.<br>The therapeutic potential of the insect metalloproteinase inhibitor against infections caused by Pseudomonas aeruginosa<br>J Pharm Pharmacol (2019) 71, 316-328. PubMed  Europe PubMed DOI
  26. Ma,L., Zhou,L., Lin,J., Ji,J., Wang,Y., Jiang,H., Shen,X. and Lu,Z.<br>Manipulation of the silkworm immune system by a metalloprotease from the pathogenic bacterium Pseudomonas aeruginosa<br>Dev Comp Immunol (2019) 90, 176-185. PubMed  Europe PubMed DOI
  27. Said,Z.S.A.M., Arifi,F.A.M., Salleh,A.B., Rahman,R.N.Z.R.A., Leow,A.T.C., Latip,W. and Ali,M.S.M.<br>Unravelling protein-organic solvent interaction of organic solvent tolerant elastase from Pseudomonas aeruginosa strain K crystal structure<br>Int J Biol Macromol (2019) 127, 575-584. PubMed  Europe PubMed DOI  S
    28. 2018
  28. Kany,A.M., Sikandar,A., Yahiaoui,S., Haupenthal,J., Walter,I., Empting,M., Kohnke,J. and Hartmann,R.W.<br>Tackling Pseudomonas aeruginosa virulence by a hydroxamic acid-based LasB inhibitor<br>ACS Chem Biol (2018) 13, 2449-2455. PubMed  Europe PubMed DOI  I
  29. Kany,A.M., Sikandar,A., Haupenthal,J., Yahiaoui,S., Maurer,C.K., Proschak,E., Kohnke,J. and Hartmann,R.W.<br>Binding mode characterization and early in vivo evaluation of fragment-like thiols as inhibitors of the virulence factor LasB from Pseudomonas aeruginosa<br>ACS Infect Dis (2018) 4, 988-997. PubMed  Europe PubMed DOI  I
  30. Saint-Criq,V., Villeret,B., Bastaert,F., Kheir,S., Hatton,A., Cazes,A., Xing,Z., Sermet-Gaudelus,I., Garcia-Verdugo,I., Edelman,A. and Sallenave,J.M.<br>Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator-IL-6-antimicrobial-repair pathway<br>Thorax (2018) 73, 49-61. PubMed  Europe PubMed DOI
  31. Saraiva,R.G., Fang,J., Kang,S., Anglero-Rodriguez,Y.I., Dong,Y. and Dimopoulos,G.<br>Aminopeptidase secreted by Chromobacterium sp. Panama inhibits dengue virus infection by degrading the E protein<br>PLoS Negl Trop Dis (2018) 12, e0006443-e0006443. PubMed  Europe PubMed DOI
  32. Zhu,F., Jiang,T., Wu,B. and He,B.<br>Enhancement of Z-aspartame synthesis by rational engineering of metalloprotease<br>Food Chem (2018) 253, 30-36. PubMed  Europe PubMed DOI
    33. 2017
  33. Ara,A., Kadoya,R., Ishimura,H., Shimamura,K., Sylte,I. and Kurita,N.<br>Specific interactions between zinc metalloproteinase and its inhibitors: Ab initio fragment molecular orbital calculations<br>J Mol Graph Model (2017) 75, 277-286. PubMed  Europe PubMed DOI  I
  34. Kareem,S.M., Al-Kadmy,I.M.S., Al-Kaabi,M.H., Aziz,S.N. and Ahmad,M.<br>Acinetobacter baumannii virulence is enhanced by the combined presence of virulence factors genes phospholipase C (plcN) and elastase (lasB)<br>Microb Pathog (2017) 110, 568-572. PubMed  Europe PubMed DOI
    35. 2016
  35. Sjoli,S., Nuti,E., Camodeca,C., Bilto,I., Rossello,A., Winberg,J.O., Sylte,I. and Adekoya,O.A.<br>Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors<br>Eur J Med Chem (2016) 108, 141-153. PubMed  Europe PubMed DOI  I
  36. Szamosvari,D., Reichle,V.F., Jureschi,M. and Bottcher,T.<br>Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa<br>Chem Commun (Camb) (2016) 52, 13440-13443. PubMed  Europe PubMed DOI  I
  37. van der Plas,M.J., Bhongir,R.K., Kjellstrom,S., Siller,H., Kasetty,G., Morgelin,M. and Schmidtchen,A.<br>Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses<br>Nat Commun (2016) 7, 11567-11567. PubMed  Europe PubMed DOI
  38. Zhu,F., Liu,F., Wu,B. and He,B.<br>Efficient extracellular expression of metalloprotease for Z-aspartame synthesis<br>J Agric Food Chem (2016) 64, 9631-9638. PubMed  Europe PubMed DOI
    39. 2015
  39. Adekoya,O.A., Sjoli,S., Wuxiuer,Y., Bilto,I., Marques,S.M., Santos,M.A., Nuti,E., Cercignani,G., Rossello,A., Winberg,J.-O. and Sylte,I.<br>Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors<br>Eur J Med Chem (2015) 89, 340-348. PubMed  Europe PubMed DOI  I
  40. Bian,F., Yue,S., Peng,Z., Zhang,X., Chen,G., Yu,J., Xuan,N. and Bi,Y.<br>A comprehensive alanine-scanning mutagenesis study reveals roles for salt bridges in the structure and activity of Pseudomonas aeruginosa elastase<br>PLoS ONE (2015) 10, e0121108-e0121108. PubMed  Europe PubMed DOI  PMC  EPMC  S
  41. Casilag,F., Lorenz,A., Krueger,J., Klawonn,F., Weiss,S. and Haussler,S.<br>The LasB elastase of Pseudomonas aeruginosa acts in concert with alkaline protease AprA to prevent flagellin-mediated immune recognition<br>Infect Immun (2015) 84, 162-171. PubMed  Europe PubMed DOI
  42. Odunuga,O.O., Adekoya,O.A. and Sylte,I.<br>High-level expression of pseudolysin, the extracellular elastase of Pseudomonas aeruginosa, in Escherichia coli and its purification<br>Protein Expr Purif (2015) 113, 79-84. PubMed  Europe PubMed DOI  E
  43. Wei,G., Tian,N., Valery,A.C., Zhong,Y., Schuppan,D. and Helmerhorst,E.J.<br>Identification of pseudolysin (lasB) as an aciduric gluten-degrading enzyme with high therapeutic potential for celiac disease<br>Am J Gastroenterol (2015) 110, 899-908. PubMed  Europe PubMed DOI
  44. Yang,J., Zhao,H.L., Ran,L.Y., Li,C.Y., Zhang,X.Y., Su,H.N., Shi,M., Zhou,B.C., Chen,X.L. and Zhang,Y.Z.<br>Mechanistic insights into elastin degradation by pseudolysin, the major virulence factor of the opportunistic pathogen Pseudomonas aeruginosa<br>Sci Rep (2015) 5, 9936- PubMed  Europe PubMed DOI
  45. Zhu,F., Zhuang,Y. and He,B.<br>[Cloning and expression of protease PT121 from Pseudomonas aeruginosa and application in peptide synthesis]<br>Wei Sheng Wu Xue Bao (2015) 55, 67-72. PubMed  Europe PubMed
    46. 2014
  46. Golovkine,G., Faudry,E., Bouillot,S., Voulhoux,R., Attree,I. and Huber,P.<br>VE-Cadherin cleavage by LasB protease from Pseudomonas aeruginosa facilitates type III secretion system toxicity in endothelial cells<br>PLoS Pathog (2014) 10, e1003939-e1003939. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Han,M., Wang,X., Ding,H., Jin,M., Yu,L., Wang,J. and Yu,X.<br>The role of N-glycosylation sites in the activity, stability, and expression of the recombinant elastase expressed by Pichia pastoris<br>Enzyme Microb Technol (2014) 54, 32-37. PubMed  Europe PubMed DOI  E
  48. Han,M., Wang,W., Jiang,G., Wang,X., Liu,X., Cao,H., Tao,Y. and Yu,X.<br>Enhanced expression of recombinant elastase in Pichia pastoris through addition of N-glycosylation sites to the propeptide<br>Biotechnol Lett (2014) 36, 2467-2471. PubMed  Europe PubMed DOI  E
  49. Jovic,S., Shikhagaie,M., Morgelin,M., Kjellstrom,S., Erjefalt,J., Olin,A.I., Frick,I.M. and Egesten,A.<br>Expression of MIG/CXCL9 in cystic fibrosis and modulation of its activities by elastase of Pseudomonas aeruginosa<br>J Innate Immun (2014) 6, 846-859. PubMed  Europe PubMed DOI
  50. Kessler,E. and Safrin,M.<br>Elastinolytic and proteolytic enzymes<br>Methods Mol Biol (2014) 1149, 135-169. PubMed  Europe PubMed DOI  V
  51. Nomura,K., Obata,K., Keira,T., Miyata,R., Hirakawa,S., Takano,K., Kohno,T., Sawada,N., Himi,T. and Kojima,T.<br>Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells<br>Respir Res (2014) 15, 21-21. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Simard,M., Hill,L.A., Underhill,C.M., Keller,B.O., Villanueva,I., Hancock,R.E. and Hammond,G.L.<br>Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin<br>Endocrinology (2014) 155, 2900-2908. PubMed  Europe PubMed DOI
  53. Yu,H., He,X., Xie,W., Xiong,J., Sheng,H., Guo,S., Huang,C., Zhang,D. and Zhang,K.<br>Elastase LasB of Pseudomonas aeruginosa promotes biofilm formation partly through rhamnolipid-mediated regulation<br>Can J Microbiol (2014) 60, 227-235. PubMed  Europe PubMed DOI
    54. 2013
  54. Ali,M.S., Said,Z.S., Rahman,R.N., Chor,A.L., Basri,M. and Salleh,A.B.<br>Capillary-seeding crystallization and preliminary crystallographic analysis of a solvent-tolerant elastase from Pseudomonas aeruginosa strain K<br>Int J Mol Sci (2013) 14, 17608-17617. PubMed  Europe PubMed DOI
  55. Fullagar,J.L., Garner,A.L., Struss,A.K., Day,J.A., Martin,D.P., Yu,J., Cai,X., Janda,K.D. and Cohen,S.M.<br>Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase<br>Chem Commun (Camb) (2013) 49, 3197-3199. PubMed  Europe PubMed DOI  I
  56. Han,M., Ding,H., Wang,J., Jin,M. and Yu,X.<br>Expression of the lasB gene encoding an organic solvent-stable elastase in Pichia pastoris and potential applications of the recombinant enzymes in peptide synthesis<br>Biochem Eng J (2013) 77, 154-160. DOI  E
  57. Jaouadi,B., Zarai Jaouadi,N., Rekik,H., Naili,B., Beji,A., Dhouib,A. and Bejar,S.<br>Biochemical and molecular characterization of Pseudomonas aeruginosa CTM50182 organic solvent-stable elastase<br>Int J Biol Macromol (2013) 60, 165-177. PubMed  Europe PubMed DOI
  58. Raftari,M., Ghafourian,S., Sadeghifard,N. and Abu Bakar,F.<br>Cloning and overexpression of extracellular elastase from Pseudomonas aeruginosa<br>Eur J Inflamm (2013) 11, 55-60.  E
  59. Xu,J., Sun,H., He,X., Bai,Z. and He,B.<br>Highly efficient synthesis of endomorphin-2 under thermodynamic control catalyzed by organic solvent stable proteases with in situ product removal<br>Bioresour Technol (2013) 129, 663-666. PubMed  Europe PubMed DOI
    60. 2012
  60. Carson,L., Cathcart,G.R., Ceri,H., Walker,B. and Gilmore,B.F.<br>Comparison of the binding specificity of two bacterial metalloproteases, LasB of Pseudomonas aeruginosa and ZapA of Proteus mirabilis, using N-alpha mercaptoamide template-based inhibitor analogues<br>Biochem Biophys Res Commun (2012) 422, 316-320. PubMed  Europe PubMed DOI  I
  61. Kessler,E. and Ohman,D.E.<br>Pseudolysin<br>[ISSN:978-0-12-407744-7] (2012) 3, 582-592. DOI
  62. Lousa,D., Baptista,A.M. and Soares,C.M.<br>Analyzing the molecular basis of enzyme stability in ethanol/water mixtures using molecular dynamics simulations<br>J Chem Inf Model (2012) 52, 465-473. PubMed  Europe PubMed DOI
  63. Takenaka,S., Hano,S., Cheng,M., Yoshida,K. and Aoki,K.<br>Organic solvent-tolerant elastase efficiently hydrolyzes insoluble, cross-linked, protein fiber of eggshell membranes<br>Biotechnol Lett (2012) 34, 949-955. PubMed  Europe PubMed DOI
    64. 2011
  64. Beaufort,N., Corvazier,E., Hervieu,A., Choqueux,C., Dussiot,M., Louedec,L., Cady,A., de Bentzmann,S., Michel,J.B. and Pidard,D.<br>The thermolysin-like metalloproteinase and virulence factor LasB from pathogenic Pseudomonas aeruginosa induces anoikis of human vascular cells<br>Cell Microbiol (2011) 13, 1149-1167. PubMed  Europe PubMed DOI
  65. Cathcart,G.R., Quinn,D., Greer,B., Harriott,P., Lynas,J.F., Gilmore,B.F. and Walker,B.<br>Novel inhibitors of the Pseudomonas aeruginosa virulence factor LasB: a potential therapeutic approach for the attenuation of virulence mechanisms in pseudomonal infection<br>Antimicrob Agents Chemother (2011) 55, 2670-2678. PubMed  Europe PubMed DOI  I
  66. Kuang,Z., Hao,Y., Walling,B.E., Jeffries,J.L., Ohman,D.E. and Lau,G.W.<br>Pseudomonas aeruginosa elastase provides an escape from phagocytosis by degrading the pulmonary surfactant protein-A<br>PLoS ONE (2011) 6, e27091-e27091. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Pandeeti,E.V., Pitchika,G.K., Jotshi,J., Nilegaonkar,S.S., Kanekar,P.P. and Siddavattam,D.<br>Enzymatic depilation of animal hide: identification of elastase (LasB) from Pseudomonas aeruginosa MCM B-327 as a depilating protease<br>PLoS ONE (2011) 6, e16742-e16742. PubMed  Europe PubMed DOI  PMC  EPMC
  68. Sharma,R., Murty,N.A. and Gupta,R.<br>Molecular characterization of N-terminal pro-sequence of keratinase Ker P from Pseudomonas aeruginosa: identification of region with chaperone activity<br>Appl Biochem Biotechnol (2011) 165, 892-901. PubMed  Europe PubMed DOI
    69. 2010
  69. Beaufort,N., Seweryn,P., de Bentzmann,S., Tang,A., Kellermann,J., Grebenchtchikov,N., Schmitt,M., Sommerhoff,C.P., Pidard,D. and Magdolen,V.<br>Activation of human pro-urokinase by unrelated proteases secreted by Pseudomonas aeruginosa<br>Biochem J (2010) 428, 473-482. PubMed  Europe PubMed DOI
  70. Guyot,N., Bergsson,G., Butler,M.W., Greene,C.M., Weldon,S., Kessler,E., Levine,R.L., O'Neill,S.J., Taggart,C.C. and McElvaney,N.G.<br>Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases<br>Biol Chem (2010) 391, 705-716. PubMed  Europe PubMed DOI  P
  71. Ogino,H., Tsuchiyama,S., Yasuda,M. and Doukyu,N.<br>Enhancement of the aspartame precursor synthetic activity of an organic solvent-stable protease<br>Protein Eng Des Sel (2010) 23, 147-152. PubMed  Europe PubMed DOI
  72. Sharma,R. and Gupta,R.<br>Extracellular expression of keratinase Ker P from Pseudomonas aeruginosa in E. coli<br>Biotechnol Lett (2010) 32, 1863-1868. PubMed  Europe PubMed DOI
  73. Tang,X.Y., Wu,B., Ying,H.J. and He,B.F.<br>Biochemical properties and potential applications of a solvent-stable protease from the high-yield protease producer Pseudomonas aeruginosa PT121<br>Appl Biochem Biotechnol (2010) 160, 1017-1031. PubMed  Europe PubMed DOI
    74. 2009
  74. Cathcart,G.R., Gilmore,B.F., Greer,B., Harriott,P. and Walker,B.<br>Inhibitor profiling of the Pseudomonas aeruginosa virulence factor LasB using N-alpha mercaptoamide template-based inhibitors<br>Bioorg Med Chem Lett (2009) 19, 6230-6232. PubMed  Europe PubMed DOI  I
  75. Lin,X., Xu,W., Huang,K., Mei,X., Liang,Z., Li,Z., Guo,J. and Luo,Y.<br>Cloning, expression and characterization of recombinant elastase from Pseudomonas aeruginosa in Picha pastoris<br>Protein Expr Purif (2009) 63, 69-74. PubMed  Europe PubMed DOI  E
  76. Mun,J.J., Tam,C., Kowbel,D., Hawgood,S., Barnett,M.J., Evans,D.J. and Fleiszig,S.M.<br>Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model<br>Infect Immun (2009) 77, 2392-2398. PubMed  Europe PubMed DOI  PMC  EPMC
    77. 2008
  77. Gupta,A., Ray,S., Kapoor,S. and Khare,S.K.<br>Solvent-stable Pseudomonas aeruginosa PseA protease gene: identification, molecular characterization, phylogenetic and bioinformatic analysis to study reasons for solvent stability<br>J Mol Microbiol Biotechnol (2008) 15, 234-243. PubMed  Europe PubMed DOI
    78. 2007
  78. Elston,C., Wallach,J. and Saulnier,J.<br>New continuous and specific fluorometric assays for Pseudomonas aeruginosa elastase and LasA protease<br>Anal Biochem (2007) 368, 87-94. PubMed  Europe PubMed DOI  A
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